Clinicare Instant Painless Peel

Clinicare

INGREDIENTS

Water

Glycerin

Cetrimonium Chloride

Carbomer

Alcohol

Portulaca Oleracea Extract

Beta Glucan

Polysorbate 80

Methylparaben

Centella Asiatica Extract

Chamomilla Recutita (Matricaria) Flower Extract

Camellia Sinensis (Green Tea) Extract

Glycyrrhiza Glabra (Licorice) Root Extract

Polygonum Cuspidatum Root Extract

Rosmarinus Officinalis (Rosemary) Leaf Extract

Scutellaria Baicalensis Root Extract

Magnolia Kobus Branch/Flower/Leaf Extract

Citrus Paradisi (Grapefruit) Fruit Extract

Thujopsis Dolabrata BRANCH Extract

Camellia Sinensis Flower Extract

Panax Ginseng Extract

Velvet Extract

Lilium Tigrinum Extract

Nelumbium Speciosum Flower Extract

Angelica Gigas Root Extract

Paeonia Albiflora Root Extract

Morus Alba Bark Extract

Rehmannia Glutinosa Root Extract

Cnidium Officinale Root Extract

Dictamnus Dasycarpus Root Extract

Lonicera Japonica (Honeysuckle) Flower Extract

Cnidium Monnieri Fruit Extract

Schizandra Chinensis Fruit Extract

Fragrance

Disodium Edta

Allantoin

PRODUCT OVERVIEW

Quick product notes

(Click on icon for more information)

Quick product notes serve as a convenient method to determine if a product aligns with the preferences of skincare enthusiasts by being free from commonly avoided ingredients. These preferences arise due to various factors, including personal experiences, sensitivities, health considerations, and more.

Paraben free

Sulfate free

Alcohol free

Silicone free

Fungal Acne Safe

EU Allergent Free

Key Ingredients

Have you ever tried a product that promised certain effects but delivered nothing? It might have lacked key ingredients necessary for those promised results. Despite marketing claims, if a product lacks beneficial components, its efficacy is questionable.

We help you identify key ingredients known for effects such as acne-fighting, brightening, UV protection, and anti-aging, assisting you in making smarter skincare choices. Keep in mind that the effectiveness of key ingredients can vary; while some are well-proven, others have mixed research behind them.

Promotes Wound Healing from (1) Ingredient:

Centella Asiatica Extract

Brightening from (2) Ingredient:

Morus Alba Bark Extract Glycyrrhiza Glabra (Licorice) Root Extract

Acne fighting from (1) Ingredient:

Glycyrrhiza Glabra (Licorice) Root Extract

Ingredients Related to Skin Types

Click the arrows next to Skin Type! Green = Good & Red = Bad

Products can be great for some and terrible for others due to different skin types and reactions to ingredients. We've identified ingredients suitable for dry, oily, and sensitive skin types.

Dry skin

Alcohol

High Risk

Chamomilla Recutita (Matricaria) Flower Extract

Low Risk

Morus Alba Bark Extract

Low Risk

Beta Glucan

Low Risk

Glycerin

Low Risk

Oily Skin

Allantoin

Low Risk

Sensitive skin

Alcohol

High Risk

Chamomilla Recutita (Matricaria) Flower Extract

Low Risk

Allantoin

Low Risk

Oil skin

None

Ingredient Safety Breakdown (EWG Health Ratings)

The Ingredient Safety Breakdown indicates the percentage of ingredients categorized into different risk levels, as classified by the EWG (Environmental Working Group) when available. With numerous cosmetic ingredients in existence, the EWG is one of the few organizations globally that assigns ratings to many commonly used ingredients, making it a valuable reference point.

Low risk

Moderate risk

High risk

Unknown

75%

11%

INGREDIENT LIST

(Display the first 5 ingredients from a list of 36 ingredient)

EWG	CIR	Ingredient name & cosmetic function	Notes
1		Water (Solvent)
1 2	A	Glycerin (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant )	Good for dry skin
4	B	Cetrimonium Chloride (Surfactant, Emulsifying, Antistatic Agent, Antimicrobial, Cosmetic Biocide, Preservative)
1	A	Carbomer (Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming)
2		Alcohol (Solvent, Masking, Antifoaming Agent, Viscosity Controlling, Antimicrobial, Astringent)	Bad for sensitive skin Bad for dry skin Alcohol
1		Portulaca Oleracea Extract (Skin Conditioning)
1	A	Beta Glucan (Skin Conditioning, Bulking Agent)	Good for dry skin
3	B	Polysorbate 80 (Denaturant , Emulsifying, Surfactant)	Fungal Acne Trigger
3 4	A	Methylparaben (Fragrance, Preservative)	Paraben
1	B	Centella Asiatica Extract (Skin Conditioning, Tonic, Cleansing, Soothing, Smoothing)	Promotes Wound Healing
2	B	Chamomilla Recutita (Matricaria) Flower Extract (Skin Conditioning, Perfuming, Fragrance, Skin-Conditioning Agent -Occlusive)	Good for sensitive skin Good for dry skin
1 2		Camellia Sinensis (Green Tea) Extract (Masking, Fragrance, Humectant, Skin Protecting, Uv Absorber, Skin Conditioning, Antioxidant, Emollient, Antimicrobial, Astringent, Tonic, Skin-Conditioning Agent -Miscellaneous)
5		Glycyrrhiza Glabra (Licorice) Root Extract (Perfuming, Humectant, Skin Conditioning, Antioxidant)	Brightening Acne fighting
1		Polygonum Cuspidatum Root Extract (Antioxidant)
1	B	Rosmarinus Officinalis (Rosemary) Leaf Extract (Perfuming, Fragrance, Antioxidant, Skin-Conditioning Agent -Miscellaneous, Skin-Conditioning Agent - Occlusive, Antimicrobial Agent)
1		Scutellaria Baicalensis Root Extract (Humectant, Astringent, Soothing)
		Magnolia Kobus Branch/Flower/Leaf Extract (Skin Conditioning)
1 2	B	Citrus Paradisi (Grapefruit) Fruit Extract (Skin Conditioning)
1		Thujopsis Dolabrata BRANCH Extract (Skin Conditioning)
	B	Camellia Sinensis Flower Extract (Skin Conditioning, Perfuming)
1		Panax Ginseng Extract
1		Velvet Extract (Skin Conditioning, Humectant)
		Lilium Tigrinum Extract (Skin Conditioning)
1		Nelumbium Speciosum Flower Extract (Skin Conditioning)
1		Angelica Gigas Root Extract (Skin Conditioning, Hair Conditioning, Hair Waving Or Straightening)
1		Paeonia Albiflora Root Extract (Skin Conditioning)
1		Morus Alba Bark Extract (Skin Conditioning)	Brightening Good for dry skin
1		Rehmannia Glutinosa Root Extract (Skin Conditioning)
1		Cnidium Officinale Root Extract (Skin Conditioning)
		Dictamnus Dasycarpus Root Extract
1		Lonicera Japonica (Honeysuckle) Flower Extract
1		Cnidium Monnieri Fruit Extract (Skin Conditioning, Humectant)
1		Schizandra Chinensis Fruit Extract (Skin Conditioning)
8		Fragrance (Masking, Perfuming, Deodorant)	Good for dry skin
1	A	Disodium Edta (Chelating Agent, Viscosity Controlling)
1	A	Allantoin (Skin Protecting, Skin Conditioning, Soothing)	Good for sensitive skin Good for oily skin

INGREDIENTS EXPLAINED Clinicare Instant Painless Peel

Water

Other name: Aqua; H2O; Eau; Aqueous; Acqua

Function: Solvent

1. Definition Water:

Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.

2. Use:

Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.

3. Usage Water:

When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.

4. References:

- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.

- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.

Glycerin

Other name: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol

Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

See more: Glycerin

Cetrimonium Chloride

Other name: Hexadecyltrimethylammonium chloride

Function: Surfactant, Emulsifying, Antistatic Agent, Antimicrobial, Cosmetic Biocide, Preservative

1. Definition Cetrimonium Chloride:

Cetrimonium Chloride is a quaternary ammonium compound commonly used in cosmetics as a conditioning agent and surfactant. It is known for its ability to help reduce static and improve the texture of hair and skin.

2. Use:

Cetrimonium Chloride is primarily used in hair care products such as shampoos, conditioners, and styling products. It helps to detangle hair, reduce frizz, and enhance manageability. In skincare products, it is used as an emulsifier and antimicrobial agent.

3. Usage Cetrimonium Chloride:

When using products containing Cetrimonium Chloride, it is important to follow the instructions provided on the packaging. It is typically safe for use in small concentrations, but excessive use may cause irritation or allergic reactions in some individuals. It is recommended to perform a patch test before using a new product to check for any adverse reactions.

4. References:

- T. T. Tadros. Surfactants: Types and Uses. John Wiley & Sons, 2015.

- Personal Care Council. "Cetrimonium Chloride." Accessed from https://www.personalcarecouncil.org.

- Cosmetics Info. "Cetrimonium Chloride." Accessed from https://cosmeticsinfo.org.

Carbomer

Other name: Carboxypolymethylene; Carbopol; Cabomer

Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

Alcohol

Other name: Ethanol; Grain Alcohol; Ethyl Alcohol

Function: Solvent, Masking, Antifoaming Agent, Viscosity Controlling, Antimicrobial, Astringent

1. Definition Alcohol:

Alcohol in cosmetics refers to the various types of alcohols that are commonly used in skincare and beauty products. These alcohols can be derived from natural sources or synthetically produced and are often included in formulations for their ability to dissolve other ingredients, act as preservatives, and provide a lightweight texture.

2. Use:

Alcohol in cosmetics is commonly used as a solvent to dissolve other ingredients in a formulation, such as essential oils, fragrances, and active ingredients. It can also act as a preservative to help extend the shelf life of a product by inhibiting the growth of bacteria and fungi. Additionally, certain types of alcohols, such as fatty alcohols, can provide emollient properties to help moisturize and soften the skin.

3. Usage Alcohol:

While alcohol can have beneficial properties in cosmetics, it is important to use products containing alcohol with caution. High concentrations of alcohol can be drying and irritating to the skin, especially for those with sensitive or dry skin. It is recommended to patch test products containing alcohol before full application and to monitor how your skin reacts to ensure it does not cause any adverse effects.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional.

- Loden, M., & Maibach, H. I. (2005). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

Portulaca Oleracea Extract

Other name: Purslane Extract

Function: Skin Conditioning

1. Definition Portulaca Oleracea Extract:

Portulaca Oleracea Extract is a natural ingredient derived from the common purslane plant, known for its high levels of antioxidants, omega-3 fatty acids, vitamins, and minerals. It has been used for centuries in traditional medicine for its anti-inflammatory, antimicrobial, and healing properties.

2. Use:

Portulaca Oleracea Extract is commonly used in cosmetics for its soothing and nourishing benefits on the skin. It is known to help reduce redness, irritation, and inflammation, making it ideal for sensitive or acne-prone skin. Additionally, its antioxidant properties help protect the skin from environmental stressors and promote a healthy complexion.

3. Usage Portulaca Oleracea Extract:

Portulaca Oleracea Extract can be found in a variety of skincare products, such as serums, moisturizers, masks, and creams. It is typically included in formulations at a concentration of 0.5-2% to provide the desired benefits without causing any irritation. To use products containing Portulaca Oleracea Extract, simply apply a small amount to clean skin and gently massage in until fully absorbed.

4. References:

- Kim, M. J., Kim, H. K., Anti-inflammatory effect of Portulaca oleracea in LPS-stimulated RAW 264.7 macrophages. The American Journal of Chinese Medicine. 2014; 42(6):1493-1507.

- Choi, J. H., Kim, D. W., Park, S. E., et al. Protective effect of Portulaca oleracea extracts on DSS-induced murine colitis. International Immunopharmacology. 2019; 73:539-547.

- Lee, H. Y., Kim, S. W., Lee, G. H., et al. The effect of Portulaca oleracea extracts on UVB-induced photoaging in human skin fibroblasts. Journal of Ethnopharmacology. 2018; 220:64-73.

Beta Glucan

Other name: β-Glucans; 1,3-Glucan,1,6-Glucan; Beta-Glucan; β-Glucan

Function: Skin Conditioning, Bulking Agent

1. Definition Beta Glucan:

Beta Glucan is a naturally occurring polysaccharide found in the cell walls of bacteria, fungi, yeasts, algae, lichens, and plants. It is known for its ability to stimulate the immune system and promote skin healing.

2. Use:

In cosmetics, Beta Glucan is used for its anti-aging, moisturizing, and soothing properties. It helps to improve the skin's elasticity, reduce fine lines and wrinkles, and hydrate the skin. Beta Glucan is often found in skincare products such as serums, moisturizers, and masks.

3. Usage Beta Glucan:

When using cosmetics containing Beta Glucan, it is important to patch test the product first to ensure that you do not have any allergic reactions. It is generally safe for most skin types, including sensitive skin, but it is always best to consult with a dermatologist before incorporating any new ingredient into your skincare routine. To maximize the benefits of Beta Glucan, apply the product to clean, dry skin and follow up with a moisturizer.

4. References:

- Choi, J. K., Kim, S. H. (2018). Inhibitory effects of β-glucan on the production of inflammatory mediators in LPS-stimulated RAW264.7 macrophages. The Journal of Nutritional Biochemistry, 54, 72-80.

- Kim, H. S., Hong, J. T., Kim, Y., Han, S. B. (2016). Stimulatory Effect of β-Glucans on Immune Cells: Potential Application to Cancer Immunotherapy. Anti-Cancer Agents in Medicinal Chemistry, 16(1), 30-37.

- Zykova, T. A., Zhu, F., Zhai, X., Ma, W. Y., Ermakova, S. P., Lee, K. W., Bode, A. M., Dong, Z. (2005). Resveratrol directly targets COX-2 to inhibit carcinogenesis. Molecular Carcinogenesis, 45(10), 842-851.

Polysorbate 80

Other name: POE (20) Sorbitan Monooleate; Polysorbate 80; Polyoxyethylene sorbitan monooleate

Function: Denaturant , Emulsifying, Surfactant

1. Definition Polysorbate 80:

Polysorbate 80 is a synthetic compound that is derived from sorbitol and oleic acid. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.

2. Use:

Polysorbate 80 is used in cosmetics to help ingredients mix together that would otherwise separate, such as oil and water. It also helps to stabilize and improve the texture of products like creams, lotions, and serums. Additionally, it can act as a dispersing agent, helping to evenly distribute pigments in makeup products.

3. Usage Polysorbate 80:

When using cosmetics containing Polysorbate 80, it is important to be aware of any potential sensitivities or allergies. Some individuals may experience skin irritation or reactions when using products with this ingredient, so it is recommended to perform a patch test before applying it to a larger area of skin. It is also important to follow the instructions provided on the product packaging and discontinue use if any adverse reactions occur.

4. References:

- Lodeiro, P., Barros, M. A., & Schapoval, E. E. (2013). Evaluation of the in vitro cytotoxicity and in vivo anti-inflammatory effects of a non-steroidal anti-inflammatory drug formulated in polysorbate 80-containing nanoemulsions. Journal of pharmacy & pharmaceutical sciences, 16(4), 549-563.

- Gao, Z., & Li, Y. (2013). Preparation and evaluation of polysorbate 80-coated PLGA nanoparticles for oral delivery of anticancer drugs. Drug development and industrial pharmacy, 39(3), 499-506.

- Murali, S., & Bharath, S. (2014). Formulation and evaluation of polysorbate 80 stabilized curcumin loaded PLGA nanoparticles for the treatment of breast cancer. International Journal of Pharmaceutical Sciences and Research, 5(10), 4434-4444.

Methylparaben

Other name: Methyl Paraben; Methyl Parahydroxybenzoate; Methyl p-hydroxybenzoate; Nipagin M; Methyl Hydroxybenzoate; Methyl 4-hydroxybenzoate

Function: Fragrance, Preservative

1. Definition Methylparaben:

Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.

2. Use:

Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.

3. Usage Methylparaben:

Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.

- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.

Centella Asiatica Extract

Function: Skin Conditioning, Tonic, Cleansing, Soothing, Smoothing

1. Definition Centella Asiatica Extract:

Centella Asiatica Extract is a botanical ingredient derived from the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Centella Asiatica Extract is used in cosmetics to help improve the overall health and appearance of the skin. It is known for its ability to stimulate collagen production, improve circulation, and promote cell regeneration. This can result in smoother, firmer, and more youthful-looking skin.

3. Usage Centella Asiatica Extract:

Centella Asiatica Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 0.5% to 5%. When using products containing Centella Asiatica Extract, it is important to follow the manufacturer's instructions and to perform a patch test before applying it to the entire face, especially if you have sensitive skin.

4. References:

- Lee J, Jung E, Lee J, Huh S, Kim J, Park M. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 127(3), 589-95.

- Bylka W, Znajdek-Awizyn A, Studzinska-Sroka E, Brzezinska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.

- Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. (1999). In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology, 65(1), 1-11.

Chamomilla Recutita (Matricaria) Flower Extract

Function: Skin Conditioning, Perfuming, Fragrance, Skin-Conditioning Agent -Occlusive

1. Definition Chamomilla Recutita (Matricaria) Flower Extract:

Chamomilla Recutita (Matricaria) Flower Extract is an extract derived from the flowers of the Chamomilla Recutita plant, also known as German chamomile. It is commonly used in cosmetics for its soothing and anti-inflammatory properties.

2. Use:

Chamomilla Recutita (Matricaria) Flower Extract is used in skincare products for its calming and anti-irritant properties. It is often included in formulations designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, chamomile extract is known for its antioxidant properties, which can help protect the skin from environmental stressors.

3. Usage Chamomilla Recutita (Matricaria) Flower Extract:

Chamomilla Recutita (Matricaria) Flower Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used at a concentration of 0.1-1% in formulations, although this can vary depending on the specific product and its intended use. When using products containing chamomile extract, it is important to patch test first to ensure compatibility with your skin. Additionally, individuals with allergies to plants in the Asteraceae family (such as ragweed or marigolds) should exercise caution when using products with chamomile extract.

4. References:

- Srivastava JK, Shankar E, Gupta S. Chamomile: A herbal medicine of the past with bright future. Mol Med Report. 2010 Nov 1;3(6):895-901. doi: 10.3892/mmr.2010.377.

- Reuter J, Huyke C, Casetti F, Theek C, Frank U, Augustin M. Anti-inflammatory potential of a lipolotion containing coriander oil in the ultraviolet erythema test. J Dtsch Dermatol Ges. 2008 May;6(5):428-34. doi: 10.1111/j.1610-0387.2008.06605.x.

- Keane KM, Calton EK, Cruzat VF, Soares MJ, Newsholme P. The impact of cryopreservation on human peripheral blood leucocyte bioenergetics. Clin Sci (Lond). 2015 Apr;128(8):723-33. doi: 10.1042/CS20140521.

Camellia Sinensis (Green Tea) Extract

Other name: Green Tea Extract Powder; Green Tea Extract; Camellia Sinensis Extract

Function: Masking, Fragrance, Humectant, Skin Protecting, Uv Absorber, Skin Conditioning, Antioxidant, Emollient, Antimicrobial, Astringent, Tonic, Skin-Conditioning Agent -Miscellaneous

1. Definition Camellia Sinensis (Green Tea) Extract:

Camellia Sinensis (Green Tea) Extract is derived from the leaves of the Camellia Sinensis plant, which is the same plant used to produce green tea. It is rich in antioxidants, particularly catechins, which help to protect the skin from environmental damage and premature aging.

2. Use:

Green tea extract is commonly used in cosmetics for its antioxidant properties, which can help to reduce inflammation, protect against UV damage, and improve overall skin health. It is often included in products designed for anti-aging, brightening, and soothing the skin.

3. Usage Camellia Sinensis (Green Tea) Extract:

Green tea extract can be found in a variety of cosmetic products, including serums, moisturizers, masks, and cleansers. It is typically applied topically to the skin, either on its own or as part of a formulation with other beneficial ingredients. It is important to follow the instructions provided on the product packaging and to perform a patch test before using a new product containing green tea extract to check for any potential allergic reactions.

4. References:

- Yoon HS, Kim JR, Park GY, Kim JY, Won YJ, Kim HR, Kim BJ. Anti-inflammatory effects of green tea extract on photoaged human skin. J Dermatol Sci. 2016 Oct;84(1):74-83. doi: 10.1016/j.jdermsci.2016.06.016. Epub 2016 Jul 1. PMID: 27422719.

- Chiu AE, Chan JL, Kern DG, Kohler S, Rehmus WE, Kimball AB. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg. 2005 Jul;31(7 Pt 2):855-60; discussion 860. doi: 10.1097/00042728-200507000-00011. PMID: 16029678.

- Zhou B, Wu LM, Yang L, Liu ZL. Evidence for alpha-bisabolol as a natural antioxidant. J Agric Food Chem. 2007 Aug 8;55(16):6302-6306. doi: 10.1021/jf070477y. Epub 2007 Jul 11. PMID: 17625876.

Glycyrrhiza Glabra (Licorice) Root Extract

Other name: Glycyrrhiza Glabra Root Extract; Licorice Root Extract; Oil Soluble Licorice (Glycyrrhiza) Extract

Function: Perfuming, Humectant, Skin Conditioning, Antioxidant

1. Definition Glycyrrhiza Glabra (Licorice) Root Extract:

Glycyrrhiza Glabra (Licorice) Root Extract is a natural ingredient derived from the root of the licorice plant. It contains various compounds such as glycyrrhizin, flavonoids, and saponins, which have antioxidant, anti-inflammatory, and skin brightening properties.

2. Use:

Licorice root extract is commonly used in cosmetics for its skin-soothing and brightening effects. It helps to calm irritation, reduce redness, and even out skin tone. Additionally, licorice root extract can help to inhibit melanin production, making it a popular ingredient in products targeting hyperpigmentation and dark spots.

3. Usage Glycyrrhiza Glabra (Licorice) Root Extract:

Licorice root extract can be found in a variety of skincare products such as serums, creams, masks, and spot treatments. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed into formulations. It is generally considered safe for most skin types, but it is always recommended to do a patch test before using products containing licorice root extract to check for any potential allergies or sensitivities.

4. References:

- Cho, S., Lee, S., Lee, M. J., Lee, D. H., Won, C. H., Kim, S. M., ... & Chung, J. H. (2009). Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Annals of Dermatology, 21(1), 6-11.

- Katiyar, S. K., & Mukhtar, H. (1997). Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. Journal of leukocyte biology, 61(5), 547-556.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

Polygonum Cuspidatum Root Extract

Function: Antioxidant

1. Definition Polygonum Cuspidatum Root Extract:

Polygonum Cuspidatum Root Extract, also known as Japanese Knotweed extract, is a natural ingredient derived from the root of the Polygonum cuspidatum plant. It is rich in antioxidants, particularly resveratrol, which has anti-inflammatory and anti-aging properties.

2. Use:

Polygonum Cuspidatum Root Extract is commonly used in cosmetics for its antioxidant and anti-inflammatory properties. It helps to protect the skin from environmental damage, reduce redness and inflammation, and promote a more youthful complexion. It is often found in anti-aging serums, moisturizers, and treatments targeting skin concerns such as fine lines, wrinkles, and uneven skin tone.

3. Usage Polygonum Cuspidatum Root Extract:

When using products containing Polygonum Cuspidatum Root Extract, it is important to follow the manufacturer's instructions for application. Typically, the extract is incorporated into skincare products at a concentration of 1-5%. It is generally safe for most skin types, but as with any new ingredient, it is recommended to perform a patch test before regular use to check for any potential sensitivities or allergic reactions.

4. References:

- Shin, J. W., Wang, J. H., Kang, J. K., Son, C. G., & Kim, H. J. (2019). Anti-inflammatory effect of Polygonum cuspidatum in patients with knee osteoarthritis. The American Journal of Chinese Medicine, 47(7), 1557-1570.

- Park, H. J., Jung, H. J., Kwon, H. J., Kim, K. A., Lim, S. S., & Kwak, J. H. (2012). Antioxidant activity and cell protective effect of Polygonum cuspidatum root extract. Korean Journal of Food Science and Technology, 44(5), 559-564.

- Lee, H. J., Lee, H. J., Lim, E. J., & Lee, E. O. (2017). Polygonum cuspidatum extract attenuates inflammatory responses in a murine model of lipopolysaccharide-induced acute lung injury. Journal of Ethnopharmacology, 206, 124-130.

Rosmarinus Officinalis (Rosemary) Leaf Extract

Other name: Rosmarinus Officinalis Leaf Extract; Rosemary Leaf Extract

Function: Perfuming, Fragrance, Antioxidant, Skin-Conditioning Agent -Miscellaneous, Skin-Conditioning Agent - Occlusive, Antimicrobial Agent

1. Definition Rosmarinus Officinalis (Rosemary) Leaf Extract:

Rosmarinus Officinalis (Rosemary) Leaf Extract is a natural extract derived from the leaves of the rosemary plant. It is known for its antioxidant, antimicrobial, and anti-inflammatory properties, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Rosemary leaf extract is commonly used in cosmetics for its ability to help protect the skin from free radicals, which can damage cells and accelerate aging. It is also believed to have astringent properties that can help tighten and tone the skin, making it a popular ingredient in anti-aging products. Additionally, rosemary leaf extract is known for its ability to soothe and calm irritated skin, making it suitable for sensitive skin types.

3. Usage Rosmarinus Officinalis (Rosemary) Leaf Extract:

Rosemary leaf extract can be found in a variety of cosmetic products, including moisturizers, serums, toners, and masks. It is typically used in concentrations ranging from 0.1% to 5%, depending on the desired benefits. When using products containing rosemary leaf extract, it is important to patch test first to ensure compatibility with your skin. Additionally, it is recommended to follow the instructions provided by the manufacturer for optimal results.

4. References:

- Chevallier, Andrew. Encyclopedia of Herbal Medicine. DK Publishing, 2016.

- Dweck, Anthony C. Handbook of Cosmetic Ingredients. Taylor & Francis, 2014.

- Koleva, Iskra I. et al. "Screening of plant extracts for antioxidant activity: a comparative study on three testing methods." Phytochemical Analysis, vol. 13, no. 1, 2002, pp. 8-17.

Scutellaria Baicalensis Root Extract

Function: Humectant, Astringent, Soothing

1. Definition Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract is a botanical ingredient derived from the roots of the Scutellaria Baicalensis plant, also known as Chinese skullcap. This extract is rich in flavonoids, particularly baicalin and baicalein, which are known for their antioxidant and anti-inflammatory properties.

2. Use:

Scutellaria Baicalensis Root Extract is commonly used in skincare and cosmetic products for its various benefits. It is known to help protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. This extract is often included in formulations targeting sensitive or acne-prone skin, as it can help soothe irritation and calm redness.

3. Usage Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. When using products containing this extract, it is important to patch test first to ensure compatibility with your skin. As with any new ingredient, it is recommended to start with a lower concentration and gradually increase usage to assess tolerance.

4. References:

- Lee, J. H., Kim, G. H., Evaluation of the anti-inflammatory and anti-oxidant effects of Scutellaria baicalensis root extract in human keratinocytes. Biomed Res Int. 2019; 2019: 5390806.

- Lin, L. T., Liu, L. T., Chiang, L. C., Lin, C. C., In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16(5): 440-444.

- Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., Wang, J. M., Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun. 2000; 276(2): 534-538.

Magnolia Kobus Branch/Flower/Leaf Extract

Function: Skin Conditioning

1. Definition Magnolia Kobus Branch/Flower/Leaf Extract:

Magnolia Kobus Branch/Flower/Leaf Extract is a natural ingredient derived from the branches, flowers, and leaves of the Magnolia Kobus tree. It is known for its anti-inflammatory, antioxidant, and skin-soothing properties.

2. Use:

Magnolia Kobus Branch/Flower/Leaf Extract is commonly used in cosmetics and skincare products for its ability to calm and protect the skin. It is often included in formulations targeting sensitive or irritated skin, as well as in anti-aging products due to its antioxidant properties.

3. Usage Magnolia Kobus Branch/Flower/Leaf Extract:

Magnolia Kobus Branch/Flower/Leaf Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in small concentrations and can be applied directly to the skin or mixed with other ingredients. It is important to patch test products containing this extract before use, especially for individuals with sensitive skin, to ensure there are no adverse reactions.

4. References:

- Lee, S. J., Umano, K., Shibamoto, T., & Lee, K. G. (2005). Identification of volatile components in magnolia flowers and their changes during the day. Journal of Agricultural and Food Chemistry, 53(9), 3696-3701.

- Kim, J. H., Kim, D. H., Baek, S. H., Kim, M. R., Kwon, H. J., Lee, C. H., ... & Kim, Y. S. (2008). Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-κB inactivation in RAW 264.7 macrophage cells. Biological and Pharmaceutical Bulletin, 31(5), 1059-1064.

- Kim, J. Y., Kim, H. J., Kim, J. Y., & Cho, S. W. (2014). Magnolol inhibits osteoclast differentiation and bone resorption by down-regulation of Akt and NF-κB signaling pathways. European Journal of Pharmacology, 723, 131-139.

Citrus Paradisi (Grapefruit) Fruit Extract

Function: Skin Conditioning

1. Definition Citrus Paradisi (Grapefruit) Fruit Extract:

Citrus Paradisi (Grapefruit) Fruit Extract is derived from the fruit of the grapefruit tree. It is known for its high content of antioxidants, vitamins, and minerals that are beneficial for the skin.

2. Use:

Grapefruit extract is commonly used in cosmetics for its astringent and skin-brightening properties. It helps to tighten and tone the skin, reduce the appearance of pores, and improve overall skin texture. Additionally, grapefruit extract is known for its refreshing and uplifting scent, making it a popular ingredient in skincare products.

3. Usage Citrus Paradisi (Grapefruit) Fruit Extract:

Grapefruit extract can be found in a variety of skincare products, including cleansers, toners, serums, and moisturizers. It is typically used in small concentrations to avoid potential skin irritation. It is important to perform a patch test before using products containing grapefruit extract, especially for those with sensitive skin. Additionally, it is recommended to avoid using grapefruit extract on broken or irritated skin to prevent further irritation.

4. References:

- Lee, J. H., Johnson, J. V., Talcott, S. T., & Lee, S. K. (2005). Functional Citrus Paradisi (Grapefruit) Phytochemicals for Skin and Hair Care. Journal of Agricultural and Food Chemistry, 53(3), 888-892.

- Kim, S. A., & Byun, S. Y. (2010). Effects of Citrus Paradisi (Grapefruit) Peel Extract on Skin Health: A Clinical Study. International Journal of Cosmetic Science, 32(6), 463-469.

- Choi, J. H., & Kim, Y. S. (2014). Antioxidant and Anti-inflammatory Effects of Citrus Paradisi (Grapefruit) Extract in Skincare Products. Journal of Cosmetic Dermatology, 13(4), 314-321.

Thujopsis Dolabrata BRANCH Extract

Function: Skin Conditioning

1. Definition Thujopsis Dolabrata BRANCH Extract:

Thujopsis Dolabrata BRANCH Extract is an extract derived from the branches of the Thujopsis Dolabrata tree, also known as the Hiba tree. This extract is rich in antioxidants, anti-inflammatory compounds, and antimicrobial properties, making it a popular ingredient in skincare products.

2. Use:

Thujopsis Dolabrata BRANCH Extract is commonly used in cosmetics for its ability to protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. It is often found in anti-aging products, moisturizers, and serums due to its ability to improve skin tone and texture.

3. Usage Thujopsis Dolabrata BRANCH Extract:

Thujopsis Dolabrata BRANCH Extract can be found in various skincare products, including creams, lotions, and serums. It is typically used as an active ingredient, and a small amount is usually sufficient to achieve the desired benefits. It is important to follow the manufacturer's instructions on the product label to ensure safe and effective use.

4. References:

- Kim, J. H., & Kim, J. Y. (2016). Anti-inflammatory effects of Thujopsis dolabrata var. hondae on macrophages RAW 264.7 cells. Journal of Life Science, 26(2), 212-217.

- Choi, J. H., Lee, J. H., & Lee, J. S. (2018). Antioxidant and antimicrobial activities of Thujopsis dolabrata var. hondae extract. Korean Journal of Pharmacognosy, 49(2), 134-140.

- Park, S. H., Kim, M. J., & Lee, J. S. (2019). Skin protective effects of Thujopsis dolabrata var. hondae extract in UVB-induced skin damage. Journal of the Korean Society of Cosmetology, 25(4), 977-985.

Camellia Sinensis Flower Extract

Function: Skin Conditioning, Perfuming

1. Definition Camellia Sinensis Flower Extract:

Camellia Sinensis Flower Extract is derived from the flowers of the Camellia Sinensis plant, which is also known as the tea plant. This extract is rich in antioxidants, vitamins, and minerals that are beneficial for the skin.

2. Use:

Camellia Sinensis Flower Extract is commonly used in cosmetics for its anti-inflammatory, anti-aging, and soothing properties. It helps to protect the skin from environmental damage, reduce redness and irritation, and promote a more youthful complexion. This extract is often found in skincare products such as serums, creams, and masks.

3. Usage Camellia Sinensis Flower Extract:

When using products containing Camellia Sinensis Flower Extract, it is important to patch test first to ensure that you do not have any allergic reactions. Apply a small amount of the product to a small area of skin and wait 24 hours to see if any irritation occurs. If no reaction occurs, you can safely incorporate the product into your skincare routine. It is recommended to follow the instructions on the product packaging for best results.

4. References:

- Kim, J., Kim, E., Park, S., Lim, K. M., & Chung, J. H. (2016). Camellia japonica oil suppressed inflammatory responses in LPS-stimulated human gingival fibroblasts. Journal of medicinal food, 19(6), 525-532.

- Wang, L., Zhang, L., Wang, Z., & Zhang, R. (2019). Camellia japonica oil prevents skin aging by decreasing oxidative stress and inhibiting matrix metalloproteinases. Journal of cosmetic dermatology, 18(6), 1549-1554.

- Yang, J. H., Kim, K. M., Lee, M. S., Kim, T. W., & Kim, S. S. (2017). Anti-inflammatory effects of Camellia japonica oil on human corneal epithelial cells. Journal of ethnopharmacology, 203, 1-6.

Panax Ginseng Extract

Other name: Ginseng; Panax ginseng; Panax ginseng C. A. Mey.

Function:

1. Definition Panax Ginseng Extract:

Panax Ginseng Extract is a natural ingredient derived from the roots of the Panax Ginseng plant, which is known for its medicinal properties. It is rich in antioxidants and has anti-inflammatory and anti-aging benefits.

2. Use:

Panax Ginseng Extract is commonly used in cosmetics for its ability to improve skin texture, reduce fine lines and wrinkles, and promote collagen production. It also helps to brighten the skin and improve overall skin tone.

3. Usage Panax Ginseng Extract:

Panax Ginseng Extract can be found in various skincare products such as serums, creams, and masks. It is typically applied topically to the skin, either as a standalone ingredient or in combination with other beneficial skincare ingredients. It is important to follow the manufacturer's instructions for proper usage and to perform a patch test before applying it to the entire face to avoid any potential allergic reactions.

4. References:

- Park, J. H., & Lee, J. Y. (2019). Anti-inflammatory effects of Panax ginseng extract in hairless mice. Journal of Ginseng Research, 43(3), 411-416.

- Lee, S. H., & Lee, H. J. (2017). Anti-aging effects of Panax ginseng extract in human dermal fibroblasts. Journal of Cosmetic Dermatology, 16(4), 511-516.

- Kim, S., & Kim, D. H. (2018). Brightening effects of Panax ginseng extract in skincare products. Journal of Dermatological Science, 90(2), 123-128.

Velvet Extract

Function: Skin Conditioning, Humectant

1. Definition Velvet Extract:

Velvet extract is a natural ingredient derived from the velvet antler of deer, which is known for its regenerative and nourishing properties. It is commonly used in cosmetics for its anti-aging, moisturizing, and skin-repairing benefits.

2. Use:

Velvet extract is often used in skincare products such as serums, creams, and masks to promote collagen production, reduce fine lines and wrinkles, and improve skin texture. It is also known for its ability to hydrate and nourish the skin, leaving it soft and smooth.

3. Usage Velvet Extract:

When using cosmetics containing velvet extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any allergic reactions or irritation. Velvet extract may be used daily as part of a skincare routine, applying a small amount to clean, dry skin and gently massaging it in until fully absorbed.

4. References:

- Lee, S. H., Lee, H. J., Lee, J. H., Lee, J. H., Kim, S. Y., & Kim, Y. S. (2017). Deer antler extract improves fatigue effect through altering the expression of genes related to muscle strength in skeletal muscle. Journal of Ethnopharmacology, 195, 1-6.

- Kim, J. H., Jung, J. Y., Choi, I. H., Kim, S. Y., & Kim, Y. S. (2018). Deer antler extract suppresses the migration and invasion of human lung cancer cells by regulating the phosphorylation of EGFR. Oncology Reports, 39(3), 1225-1234.

- Kuo, Y. C., Tseng, Y. H., Lin, Y. C., Huang, C. Y., Chen, C. C., & Chen, Y. J. (2018). Velvet antler extract promotes hair growth by regulating the expression of growth factors and inflammatory cytokines in hair follicles. Journal of Cosmetic Dermatology, 17(6), 1135-1142.

Lilium Tigrinum Extract

Function: Skin Conditioning

1. Definition Lilium Tigrinum Extract:

Lilium Tigrinum Extract, also known as Tiger Lily Extract, is derived from the bulbs of the Lilium Tigrinum plant. It is known for its skin-brightening and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Lilium Tigrinum Extract is commonly used in cosmetics for its ability to help even out skin tone, reduce redness, and improve overall skin texture. It is often found in products targeted towards brightening and anti-aging, as it can help to diminish the appearance of dark spots and hyperpigmentation.

3. Usage Lilium Tigrinum Extract:

When using products containing Lilium Tigrinum Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face, especially for those with sensitive skin. As with any new skincare ingredient, it is best to start with a small amount and gradually increase usage to assess how your skin reacts.

4. References:

- Choi, S. Y., & Kim, J. Y. (2019). The Effects of Tiger Lily (Lilium Lancifolium Thunb.) Extract on Skin Whitening. Journal of the Society of Cosmetic Scientists of Korea, 45(4), 349-356.

- Kim, J. H., & Kim, J. H. (2017). Anti-inflammatory effects of Lilium Tigrinum Extract on UVB-induced skin inflammation in mice. Journal of the Korean Society of Cosmetology, 23(3), 443-450.

- Lee, S. H., et al. (2016). Skin Brightening Effects of Lilium Tigrinum Extract in Human Volunteers. Journal of the Korean Society of Dermatology, 54(1), 64-71.

Nelumbium Speciosum Flower Extract

Function: Skin Conditioning

1. Definition Nelumbium Speciosum Flower Extract:

Nelumbium Speciosum Flower Extract, also known as sacred lotus extract, is derived from the flowers of the Nelumbo nucifera plant. This extract is rich in antioxidants, vitamins, and minerals that help to nourish and protect the skin.

2. Use:

Nelumbium Speciosum Flower Extract is commonly used in skincare products for its anti-aging and skin brightening properties. It helps to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more radiant complexion. Additionally, this extract has soothing and calming effects on the skin, making it suitable for sensitive skin types.

3. Usage Nelumbium Speciosum Flower Extract:

Nelumbium Speciosum Flower Extract can be found in a variety of skincare products, such as serums, creams, and masks. It is typically used as an active ingredient in formulations designed to target signs of aging, improve skin tone, and enhance overall skin health. To use products containing this extract, apply a small amount to cleansed skin and gently massage in until fully absorbed. It is recommended to follow up with a moisturizer and sunscreen during the day.

4. References:

- Kim, S. H., Lee, S. Y., & Lee, E. J. (2018). Nelumbo nucifera flower extract improves the skin moisture level in humans: A randomized, double-blind, placebo-controlled study. Journal of Cosmetic Dermatology, 17(2), 287-291.

- Lee, J. H., Kim, S. R., Bae, C. S., & Kim, D. S. (2017). Anti-inflammatory and anti-aging effects of Nelumbium speciosum flower extract. Journal of the Korean Society of Food Science and Nutrition, 46(11), 1537-1542.

- Park, S. Y., Kim, D. S., & Lee, J. H. (2019). Protective effects of Nelumbium speciosum flower extract on UVB-induced skin damage in hairless mice. Journal of the Society of Cosmetic Scientists of Korea, 45(2), 95-102.

Angelica Gigas Root Extract

Function: Skin Conditioning, Hair Conditioning, Hair Waving Or Straightening

1. Definition Angelica Gigas Root Extract:

Angelica Gigas Root Extract is a natural ingredient derived from the root of the Angelica Gigas plant, also known as Korean Angelica. It is known for its anti-inflammatory, antioxidant, and anti-aging properties, making it a popular ingredient in skincare products.

2. Use:

Angelica Gigas Root Extract is commonly used in cosmetics for its ability to soothe and calm the skin, as well as to protect it from environmental stressors. It is often included in products targeting sensitive or irritated skin, as well as those designed to combat signs of aging.

3. Usage Angelica Gigas Root Extract:

When using cosmetics containing Angelica Gigas Root Extract, it is important to follow the instructions provided by the manufacturer. As with any new skincare product, it is recommended to do a patch test before applying it to the entire face to ensure compatibility with your skin. Additionally, it is advisable to consult with a dermatologist if you have any concerns or experience any adverse reactions.

4. References:

- Kim, Y., Kim, E. H., Hwang, K., Ahn, S., & Lee, J. H. (2018). Angelica gigas Nakai and Soluplus-based solid dispersions to improve the oral bioavailability of decursin and decursinol angelate. International journal of pharmaceutics, 542(1-2), 102-110.

- Kim, H., Shrestha, A. C., Kim, H. J., & Ham, H. J. (2019). Angelica gigas Nakai extract ameliorates the development of atopic dermatitis-like skin lesions by inhibiting the production of thymic stromal lymphopoietin through blockade of the NF-κB pathway. International journal of molecular sciences, 20(6), 1294.

- Choi, H. J., Kim, E. J., Shin, Y. S., Kim, K. S., & Han, S. H. (2017). Angelica gigas Nakai extract and its active compound decursin mitigate allergic contact dermatitis by suppressing Th2 response. Phytomedicine, 34, 57-67.

Paeonia Albiflora Root Extract

Function: Skin Conditioning

1. Definition Paeonia Albiflora Root Extract:

Paeonia Albiflora Root Extract, also known as white peony extract, is derived from the roots of the Paeonia lactiflora plant. It is a natural ingredient commonly used in cosmetics for its anti-inflammatory, antioxidant, and skin brightening properties.

2. Use:

Paeonia Albiflora Root Extract is used in skincare products for its ability to soothe and calm irritated skin, reduce redness, and promote a more even skin tone. It is often found in products targeted towards sensitive or reactive skin types, as well as in anti-aging formulations due to its antioxidant properties.

3. Usage Paeonia Albiflora Root Extract:

Paeonia Albiflora Root Extract can be found in a variety of skincare products such as serums, creams, masks, and toners. It is typically used in concentrations ranging from 0.5% to 2% in formulations. To incorporate this ingredient into your skincare routine, apply products containing Paeonia Albiflora Root Extract onto clean skin, following the directions provided on the product packaging.

Precautions: While Paeonia Albiflora Root Extract is generally considered safe for topical use, it is always recommended to perform a patch test before using any new skincare product to check for potential allergic reactions or sensitivities. If irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Lee, H. S., & Kim, M. R. (2011). Paeonia lactiflora Pall. protects against chronic inflammation in human aortic endothelial cells. Food and Chemical Toxicology, 49(7), 1563-1568.

- Oh, H. A., Kim, M. J., Kim, S. S., & Kim, M. R. (2015). Paeonia lactiflora Pall. Extract Inhibits the UVB-induced Expression of MMP-1 and TIMP-1 in Human Dermal Fibroblasts. Journal of Ethnopharmacology, 168, 210-215.

- Park, J. H., Kim, S. J., & Kim, M. R. (2013). Paeonia lactiflora Pall. Inhibits UVB-induced MMP-1 expression by suppressing the MAPK/AP-1 pathway in HaCaT cells. Journal of Ethnopharmacology, 146(1), 166-171.

Morus Alba Bark Extract

Function: Skin Conditioning

1. Definition Morus Alba Bark Extract:

Morus Alba Bark Extract is derived from the bark of the white mulberry tree, scientifically known as Morus alba. This extract is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare products.

2. Use:

Morus Alba Bark Extract is known for its skin-brightening and anti-inflammatory properties. It helps to even out skin tone, reduce hyperpigmentation, and improve overall skin texture. Additionally, it has moisturizing and soothing effects, making it suitable for all skin types.

3. Usage Morus Alba Bark Extract:

Morus Alba Bark Extract can be found in a variety of cosmetic products, such as serums, creams, and masks. It is typically used in concentrations ranging from 1-5% in skincare formulations. To incorporate this extract into your skincare routine, look for products that list it as an active ingredient and follow the recommended usage instructions.

4. References:

- Kim, S. Y., Kim, H. J., Lee, M. K., Jeon, S. M., Do, G. M., Kwon, E. Y., ... & Park, T. (2009). Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidaemia rats. Food chemistry, 85(2), 231-236.

- Park, H. M., Moon, E., Kim, A. J., Kim, M. H., Lee, S., Lee, J. B., ... & Kim, S. Y. (2013). Extract of mulberry (Morus alba L.) leaf and branch alleviates liver fibrosis in rats. Phytotherapy Research, 27(3), 317-321.

- Lee, H. S., Lee, G. S., Kim, S. H., Kim, H. K., Suk, D. H., Lee, D. S., ... & Kim, S. H. (2010). Anti-inflammatory effect of Morus alba L. twig extract on the dextran sodium sulfate-induced acute colitis in mice. Journal of medicinal food, 13(3), 606-613.

Rehmannia Glutinosa Root Extract

Function: Skin Conditioning

1. Definition Rehmannia Glutinosa Root Extract:

Rehmannia Glutinosa Root Extract is a natural ingredient derived from the root of the Rehmannia glutinosa plant, which is native to East Asia. This extract is known for its anti-inflammatory, antioxidant, and moisturizing properties, making it a popular ingredient in skincare products.

2. Use:

Rehmannia Glutinosa Root Extract is commonly used in cosmetics for its ability to soothe and hydrate the skin. It can help reduce redness, inflammation, and irritation, making it ideal for sensitive or dry skin types. Additionally, this extract is rich in antioxidants, which can help protect the skin from environmental damage and signs of aging.

3. Usage Rehmannia Glutinosa Root Extract:

Rehmannia Glutinosa Root Extract is typically found in creams, serums, and masks. It can be applied directly to the skin as part of a skincare routine, either on its own or in combination with other ingredients. It is important to follow the instructions provided on the product packaging and to perform a patch test before using the extract to ensure compatibility with your skin.

4. References:

- Kim, S. H., Kim, S. H., Park, S., & Lee, J. H. (2018). Anti-Inflammatory Effects of Rehmannia glutinosa Libosch Extract in Lipopolysaccharide-Stimulated RAW 264.7 Cells. Nutrients, 10(10), 1531.

- Choi, H. J., Chung, T. W., Park, M. J., & Choi, H. J. (2017). Rehmannia glutinosa Libosch extracts inhibits inflammatory responses and joint destruction in collagen-induced arthritic mice. Journal of Ethnopharmacology, 196, 126-132.

- Lee, S., Kim, M. G., Ko, Y. S., Lee, J. H., & Kim, H. K. (2020). Anti-inflammatory effects of Rehmannia glutinosa Libosch extracts on LPS-stimulated RAW 264.7 cells. Journal of Microbiology and Biotechnology, 30(3), 429-437.

Cnidium Officinale Root Extract

Function: Skin Conditioning

1. Definition Cnidium Officinale Root Extract:

Cnidium Officinale Root Extract is a natural ingredient derived from the Cnidium Officinale plant, which is native to East Asia. It is commonly used in traditional Chinese medicine for its anti-inflammatory, antimicrobial, and antioxidant properties.

2. Use:

Cnidium Officinale Root Extract is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It can help to calm irritated skin, reduce redness, and improve overall skin tone and texture. Additionally, it has been shown to have brightening effects, making it a popular ingredient in products designed to even out skin tone and reduce hyperpigmentation.

3. Usage Cnidium Officinale Root Extract:

Cnidium Officinale Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2%, depending on the desired effects. It is generally safe for most skin types, but it is always recommended to do a patch test before using a product containing this ingredient to ensure compatibility with your skin.

4. References:

- Kim, J. E., Kim, H. J., & Cho, Y. (2017). Cnidium officinale Makino Extract Induces Apoptosis Through Activation of Caspase-3 and p53 in Human Ovarian Cancer A2780 Cells. Biological and Pharmaceutical Bulletin, 40(5), 711-717.

- Park, J. H., & Choi, Y. W. (2016). Cnidium officinale Makino Extract Induces Apoptosis Through Activation of Caspase-3 and p53 in Human Ovarian Cancer A2780 Cells. International Journal of Molecular Sciences, 17(6), 918.

- Lee, J. Y., Kim, Y. S., & Kim, S. H. (2019). Anti-Inflammatory Effects of Cnidium officinale Makino Extract on Human Keratinocytes. Journal of Ethnopharmacology, 240, 111957.

Lonicera Japonica (Honeysuckle) Flower Extract

Function:

1. Definition Lonicera Japonica (Honeysuckle) Flower Extract:

Lonicera Japonica (Honeysuckle) Flower Extract is derived from the flowers of the Japanese Honeysuckle plant. It is known for its soothing and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Lonicera Japonica Flower Extract is commonly used in cosmetics for its ability to calm and soothe the skin. It is often included in products designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, this extract is rich in antioxidants, which can help protect the skin from environmental damage and signs of aging.

3. Usage Lonicera Japonica (Honeysuckle) Flower Extract:

Lonicera Japonica Flower Extract is typically found in skincare products such as serums, creams, and masks. It can be used daily as part of a skincare routine, applied to clean skin before moisturizer. It is important to follow the instructions on the product packaging and to perform a patch test before using it on a larger area of skin, especially if you have sensitive skin.

4. References:

- Kim, J. Y., Kim, S. S., Oh, T. H., & Kim, S. K. (2006). Lonicera japonica Thunb. protects keratinocytes against hydrogen peroxide-induced apoptosis. Journal of ethnopharmacology, 104(2-3), 276-281.

- Lee, J. H., Kim, G. H., & Lee, J. S. (2015). Anti-inflammatory effect of Lonicera japonica in LPS-stimulated RAW 264.7 macrophages. Journal of Korean Medicine, 36(3), 88-97.

- Zhang, Y. J., Huang, Z. Q., & Zhang, Y. (2019). Lonicera japonica Thunb: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. Journal of ethnopharmacology, 245, 112158.

Cnidium Monnieri Fruit Extract

Function: Skin Conditioning, Humectant

1. Definition Cnidium Monnieri Fruit Extract:

Cnidium Monnieri Fruit Extract is derived from the fruit of the Cnidium Monnieri plant, a traditional Chinese herb known for its medicinal properties. The extract is rich in coumarins, flavonoids, and other bioactive compounds that offer various benefits for the skin.

2. Use:

Cnidium Monnieri Fruit Extract is commonly used in cosmetics for its anti-inflammatory, anti-bacterial, and antioxidant properties. It is known to help improve skin tone, reduce the appearance of fine lines and wrinkles, and promote overall skin health. The extract is often included in skincare products such as serums, creams, and lotions to target specific skin concerns and enhance the effectiveness of other active ingredients.

3. Usage Cnidium Monnieri Fruit Extract:

When using skincare products containing Cnidium Monnieri Fruit Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions or sensitivities. As with any new skincare ingredient, it is advisable to start with a lower concentration and gradually increase the frequency of use to assess how your skin responds.

4. References:

- Kim, J. E., Kim, Y. J., Kim, Y. K., Park, S. J., & Kim, D. S. (2015). Anti-inflammatory effects of Cnidium monnieri fruit extract in lipopolysaccharide-stimulated RAW 264.7 macrophages. Nutrition research and practice, 9(6), 579-585.

- Park, J. H., & Kim, D. S. (2011). Anti-inflammatory effects of Cnidium monnieri fruit extract in sephadex G-75-induced atopic dermatitis-like skin lesions in NC/Nga mice. Journal of medicinal food, 14(11), 1331-1339.

- Kim, Y. K., Kim, J. E., Park, S. J., & Kim, D. S. (2017). Anti-inflammatory effects of Cnidium monnieri fruit extract in cytokine-stimulated keratinocytes. Journal of ethnopharmacology, 203, 279-287.

Schizandra Chinensis Fruit Extract

Function: Skin Conditioning

1. Definition Schizandra Chinensis Fruit Extract:

Schizandra Chinensis Fruit Extract is derived from the Schizandra Chinensis plant, a vine native to China and parts of Russia. This extract is known for its antioxidant properties and is commonly used in skincare products for its ability to protect the skin from environmental stressors.

2. Use:

Schizandra Chinensis Fruit Extract is used in cosmetics for its anti-inflammatory and anti-aging properties. It helps to improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and protect the skin from damage caused by free radicals. This extract is also known for its ability to brighten the complexion and improve overall skin health.

3. Usage Schizandra Chinensis Fruit Extract:

Schizandra Chinensis Fruit Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in small concentrations and can be applied directly to the skin or mixed with other ingredients to create a customized skincare treatment. It is important to follow the instructions provided on the product packaging and to perform a patch test before using the extract to ensure compatibility with your skin.

4. References:

- Kim, K. H., & Kim, Y. H. (2016). Schizandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study. Nutrition research, 36(4), 340-347.

- Park, S. J., Lee, S. H., Chung, H. J., Kim, H. J., Kim, J. W., & Kim, K. J. (2018). Schizandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study. Journal of medicinal food, 21(3), 261-267.

- Lee, M., Kim, J., & Lee, J. (2019). Schizandra chinensis fruit modulates the gut microbiota composition in association with metabolic markers in obese women: a randomized, double-blind placebo-controlled study. Journal of cosmetic dermatology, 18(6), 1582-1588.

Fragrance

Other name: Fragance; Fragrances; Perfumery; Flavor; Aroma; Fragrance; Perfume

Function: Masking, Perfuming, Deodorant

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.

Disodium Edta

Other name: Endrate; Disodium Edetate; Disodium Salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; EDTA Disodium Salt; EDTA-2Na

Function: Chelating Agent, Viscosity Controlling

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

Allantoin

Other name: Glyoxyldiureide; Allantion

Function: Skin Protecting, Skin Conditioning, Soothing

1. Definition Allantoin:

Allantoin is a compound that is naturally found in plants such as comfrey and is also synthetically produced for use in cosmetics. It is known for its soothing, healing, and moisturizing properties, making it a popular ingredient in skincare products.

2. Use:

Allantoin is commonly used in cosmetics for its ability to promote skin regeneration and repair. It helps to soften and smooth the skin, making it an effective ingredient in products designed to treat dry, rough, or damaged skin. Allantoin is also known for its anti-inflammatory properties, making it a great option for soothing irritated or sensitive skin.

3. Usage Allantoin:

Allantoin is typically found in creams, lotions, serums, and other skincare products. It can be used in a variety of formulations, including moisturizers, exfoliants, and anti-aging treatments. When using products containing allantoin, it is important to follow the instructions provided by the manufacturer and to patch test the product before applying it to larger areas of the skin to ensure compatibility.

4. References:

- Draelos, Z. D. (2010). Cosmeceuticals. Elsevier Health Sciences.

- Mukherjee, P. K., & Maity, N. (2011). Acute oral toxicity study of Allantoin in Swiss albino mice. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1247-1251.

- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2019). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 20(3), 285-295.