Oligopeptide-51

1. Definition Oligopeptide-51:

Oligopeptide-51 is a synthetic peptide consisting of a short chain of amino acids that has been designed to target specific skin concerns such as hyperpigmentation, uneven skin tone, and age spots.

2. Use:

Oligopeptide-51 is commonly used in skincare products for its ability to inhibit melanin production in the skin, leading to a brighter and more even complexion. It works by blocking the activity of tyrosinase, an enzyme involved in the production of melanin. This can help reduce the appearance of dark spots and discoloration caused by sun damage, aging, or hormonal changes.

3. Usage Oligopeptide-51:

Oligopeptide-51 is typically found in serums, creams, and treatments designed to target hyperpigmentation and uneven skin tone. It is best used as part of a daily skincare routine, applied to clean skin before moisturizer. It is important to follow the instructions on the product packaging and to use sunscreen during the day when using products containing oligopeptide-51, as it can make the skin more sensitive to UV rays.

4. References:

- Lee, J. H., Kim, G. M., Han, S. C., Mun, S. K., & Kim, D. S. (2016). Oligopeptide-34, a Peptide Inhibitor of Melanogenesis, Ameliorates Ultraviolet-Induced Hyperpigmentation in Brown Guinea Pigs. Biomolecules & Therapeutics, 24(2), 183–189. https://doi.org/10.4062/biomolther.2015.097

- Choi, J. H., Lee, J. Y., Choi, H. R., Kim, K. H., Park, K. C., & Youn, S. W. (2011). Oligopeptide-34, a fragment of lumican, inhibits melanogenesis in B16F10 mouse melanoma cells. British Journal of Dermatology, 165(5), 1171–1176. https://doi.org/10.1111/j.1365-2133.2011.10549.x

- Park, S. Y., Kim, H. J., Kim, J. Y., & Kim, J. E. (2019). Oligopeptide-34 inhibits melanin synthesis by blocking the activation of cAMP signaling pathway in α-MSH-stimulated B16F10 melanoma cells. Journal of Dermatological Science, 93(3), 161–168. https://doi.org/10.1016/j.jdermsci.2018.12.007