Poloxamers

1. Definition Poloxamers:

Poloxamers are nonionic surfactants that are commonly used in cosmetics for their emulsifying, solubilizing, and stabilizing properties. They are copolymers of polyoxyethylene and polyoxypropylene, which give them unique amphiphilic properties.

2. Use:

Poloxamers are widely used in cosmetics as emulsifiers to help blend water and oil-based ingredients together. They also act as solubilizers, helping to dissolve ingredients that are not easily soluble in water. Additionally, Poloxamers are used as stabilizers to prevent the separation of ingredients in cosmetic formulations.

3. Usage Poloxamers:

When using Poloxamers in cosmetics, it is important to follow the recommended usage levels provided by the manufacturer. Overuse of Poloxamers can lead to skin irritation or sensitization in some individuals. It is also important to conduct a patch test before using a product containing Poloxamers to ensure that you do not have an allergic reaction.

4. References:

- Almeida, A. J., & Souto, E. B. (2007). Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Advanced drug delivery reviews, 59(6), 478-490.

- Zloh, M., & Gibbons, S. (2008). Molecular modeling of the interactions of surfactants with skin penetration enhancers. Journal of Molecular Graphics and Modelling, 26(3), 497-506.

- Ribeiro, L. N. M., Breitkreitz, M. C., Guilherme, V. A., Da Silva, C. B., & De Araujo, D. R. (2015). Poloxamer: A versatile pharmaceutical excipient with great promise. Journal of Pharmacy & Pharmaceutical Sciences, 18(4), 683-705.