AGE 20's Signature Essence Pact Intense Cover

1. Definition Cyclopentasiloxane:

Cyclopentasiloxane is a type of silicone commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless, and colorless liquid that helps to improve the texture and spreadability of products.

2. Use:

Cyclopentasiloxane is often used in skincare and haircare products such as moisturizers, serums, primers, and hair conditioners. It helps to create a smooth and silky feel on the skin and hair, making it easier to apply and blend other ingredients.

3. Usage Cyclopentasiloxane:

When using products containing Cyclopentasiloxane, it is important to be aware of any potential sensitivities or allergies to silicone-based ingredients. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or breakouts. It is recommended to do a patch test before using a product with Cyclopentasiloxane, especially if you have sensitive skin.

4. References:

- Ulery, B. D., Nair, L. S., & Laurencin, C. T. (2011). Biomedical applications of biodegradable polymers. Journal of Polymer Science Part B: Polymer Physics, 49(12), 832-864.

- Lefebvre, M. A., Pham, D. M., Boussouira, B., & Bernard, D. (2015). Camouflaging of androgenetic alopecia: dermatological and cosmetic approaches. Skin Research and Technology, 21(4), 219-227.

- Mavon, A., Miquel, C., Lejeune, O., Payre, B., & Moret, N. (2015). In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen. Skin Pharmacology and Physiology, 28(5), 266-275.

1. Definition Homosalate:

Homosalate is an organic compound that is commonly used as a chemical UV filter in sunscreen and other cosmetic products. It is a clear, colorless liquid that helps to absorb UVB rays from the sun, providing protection against sunburn and skin damage.

2. Use:

Homosalate is primarily used in sunscreen products to enhance their ability to protect the skin from harmful UV radiation. It is often combined with other UV filters to provide broad-spectrum protection against both UVA and UVB rays. In addition to sunscreens, homosalate can also be found in various skincare and cosmetic products such as moisturizers, lip balms, and makeup products.

3. Usage Homosalate:

When using products containing homosalate, it is important to follow the instructions provided on the packaging. Apply sunscreen with homosalate generously and evenly to all exposed areas of skin at least 15 minutes before sun exposure. Reapply every two hours or more frequently if swimming or sweating. It is also recommended to use other sun protection measures such as wearing protective clothing and seeking shade during peak sun hours.

4. References:

- Klinubol P, Limphirat W, Dumrongrojwattana P, Kietpeerakool C. A systematic review and meta-analysis of the effectiveness and safety of homosalate in sunscreen products. J Dermatol. 2021;48(12):1682-1690. doi:10.1111/1346-8138.16110

- Matta MK, Florian J, Zusterzeel R, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA. 2020;323(3):256-267. doi:10.1001/jama.2019.20747

- Food and Drug Administration (FDA). Sunscreen drug products for over-the-counter human use. Fed Regist. 2019;84(97): 6204-6275.

1. Definition Titanium Dioxide:

Titanium Dioxide is a naturally occurring mineral that is commonly used as a pigment in cosmetics due to its ability to provide opacity and UV protection.

2. Use:

Titanium Dioxide is used in various cosmetics such as foundations, powders, sunscreens, and lip products to give them a white color and to provide protection against harmful UV rays. It is also used as a thickening agent in some formulations.

3. Usage Titanium Dioxide:

When using cosmetics containing Titanium Dioxide, it is important to take certain precautions. Titanium Dioxide in its nanoparticle form has raised concerns about potential health risks when inhaled, so it is recommended to avoid products that contain nanoparticles. Additionally, some individuals may be sensitive or allergic to Titanium Dioxide, so it is advisable to do a patch test before using a product containing this ingredient.

4. References:

- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.

- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.

- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.

1. Definition Dimethicone:

Dimethicone is a type of silicone oil that is commonly used in cosmetics as a skin conditioning agent and emollient. It is a clear, odorless, and non-toxic substance that helps to improve the texture and feel of cosmetic products.

2. Use:

Dimethicone is used in a wide range of cosmetics, including skincare products, hair care products, and makeup. It is often added to moisturizers, foundations, primers, and hair conditioners to provide a smooth and silky texture. Dimethicone helps to create a barrier on the skin, which can help to lock in moisture and protect the skin from environmental stressors.

3. Usage Dimethicone:

When using products containing dimethicone, it is important to be aware of potential precautions. While dimethicone is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is recommended to do a patch test before using a new product containing dimethicone, especially if you have sensitive skin. Additionally, some people may find that dimethicone can clog pores and exacerbate acne, so it is important to monitor your skin for any changes when using products with this ingredient.

4. References:

- Lanigan, R. S., & Yamarik, T. A. (2002). Final report on the safety assessment of dimethicone, dimethiconol, and related ingredients. International journal of toxicology, 21(1), 7-41.

- Draelos, Z. D. (2010). Cosmetic vehicle efficacy. Dermatologic therapy, 23(4), 314-317.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... & Andersen, F. A. (2016). Safety assessment of dimethicone crosspolymers as used in cosmetics. International journal of toxicology, 35(1_suppl), 5S-24S.

1. Definition Diphenylsiloxy Phenyl Trimethicone:

Diphenylsiloxy Phenyl Trimethicone is a silicone-based compound commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless liquid that helps to improve the texture and feel of skincare and makeup products.

2. Use:

Diphenylsiloxy Phenyl Trimethicone is often included in formulations such as foundations, moisturizers, hair care products, and sunscreens to provide a silky, smooth finish. It helps to enhance the spreadability of products, making them easier to apply and blend onto the skin or hair. Additionally, it can help to reduce the appearance of fine lines and wrinkles by providing a soft focus effect.

3. Usage Diphenylsiloxy Phenyl Trimethicone:

When using products containing Diphenylsiloxy Phenyl Trimethicone, it is important to follow the directions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to a larger area of skin. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.

4. References:

- "Safety Assessment of Trimethicone, Trimethoxycaprylylsilane, and Diphenylsiloxy Phenyl Trimethicone as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel (2013)

- "Silicones in Cosmetics" by P. Elsner and H. Maibach (2008)

- "Handbook of Cosmetic Science and Technology" edited by André O. Barel, Marc Paye, and Howard I. Maibach (2014)

1. Definition Phenylbenzimidazole Sulfonic Acid:

Phenylbenzimidazole Sulfonic Acid, also known as Ensulizole, is a water-soluble organic compound commonly used in sunscreen formulations to provide protection against UVB radiation.

2. Use:

Phenylbenzimidazole Sulfonic Acid is primarily used in cosmetics and personal care products as a UV filter to absorb and reflect UVB rays. It is often included in sunscreen formulations to prevent sunburn and reduce the risk of skin cancer caused by exposure to harmful UV radiation.

3. Usage Phenylbenzimidazole Sulfonic Acid:

When using products containing Phenylbenzimidazole Sulfonic Acid, it is important to follow the instructions provided by the manufacturer. Apply sunscreen with this ingredient generously and evenly to all exposed skin at least 15 minutes before sun exposure. Reapply every two hours or more frequently if swimming or sweating. It is also recommended to avoid prolonged sun exposure, especially during peak hours when the sun's rays are strongest.

4. References:

- Kaur CD, Saraf S. In vitro sun protection factor determination of herbal oils used in cosmetics. Pharmacognosy Res. 2010;2(1):22-25. doi:10.4103/0974-8490.60586

- Cole C, Gazdik M, DeClercq J. Skin protection against UV light by dietary antioxidants. Food Funct. 2015;6(7):2071-2074. doi:10.1039/c5fo00343e

- Matta MK, Zusterzeel R, Pilli NR, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: a randomized clinical trial. JAMA. 2020;323(3):256-267. doi:10.1001/jama.2019.20747

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Alcohol Denat:

Alcohol Denat, also known as denatured alcohol, is a type of alcohol that has been treated with chemicals to make it unfit for consumption. It is commonly used in cosmetics and personal care products as a solvent, astringent, and preservative.

2. Use:

Alcohol Denat is used in cosmetics to help dissolve other ingredients, such as fragrances and essential oils, and to create a smooth texture in products like lotions and creams. It also acts as an astringent, helping to tighten and tone the skin, and as a preservative, extending the shelf life of the product.

3. Usage Alcohol Denat:

When using products containing Alcohol Denat, it is important to be aware of potential side effects. Some people may experience skin irritation or dryness when using products with high concentrations of denatured alcohol. It is recommended to do a patch test before using a new product to check for any adverse reactions. Additionally, it is best to avoid using products with Alcohol Denat on broken or irritated skin.

4. References:

- "Denatured Alcohol in Cosmetics." Cosmetics Info, www.cosmeticsinfo.org/ingredient/denatured-alcohol.

- "Alcohol Denat." Paula's Choice Skincare, www.paulaschoice.com/ingredient-dictionary/skin-soothing/alcohol-denat.html.

- "Is Alcohol Denat Safe in Skin Care?" Byrdie, www.byrdie.com/alcohol-denat-in-skincare.

1. Definition Diethylamino Hydroxybenzoyl Hexyl Benzoate:

Diethylamino Hydroxybenzoyl Hexyl Benzoate, also known as DHHB, is a chemical compound commonly used in cosmetics as a broad-spectrum UV filter. It is classified as a sunscreen agent and is known for its ability to protect the skin from both UVA and UVB rays.

2. Use:

Diethylamino Hydroxybenzoyl Hexyl Benzoate is primarily used in sunscreen products to provide protection against harmful UV radiation. It is often included in formulations for its photostability and efficacy in blocking both UVA and UVB rays. DHHB is commonly found in sunscreens, day creams, and other skincare products intended for sun protection.

3. Usage Diethylamino Hydroxybenzoyl Hexyl Benzoate:

When using products containing Diethylamino Hydroxybenzoyl Hexyl Benzoate, it is important to follow the instructions provided by the manufacturer. Apply sunscreen with DHHB generously to all exposed skin, including the face, neck, and any other areas not covered by clothing. Reapply sunscreen every two hours or more frequently if swimming or sweating. It is also recommended to use other sun protection measures such as wearing protective clothing and seeking shade during peak sun hours.

4. References:

- Kockler J, Oelgemöller M, Robertson S, Glass BD. Photostability of sunscreens. J Photochem Photobiol C Photochem Rev. 2012;13(1):91-110. doi:10.1016/j.jphotochemrev.2011.11.003

- Matta MK, Florian J, Zusterzeel R, et al. Effect of sunscreen application on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA. 2020;323(3):256-267. doi:10.1001/jama.2019.20747

- Food and Drug Administration (FDA). Sunscreen Drug Products for Over-the-Counter Human Use. Code of Federal Regulations Title 21, Volume 5. Revised as of April 1, 2020. Accessed June 10, 2021. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=352

1. Definition Niacinamide:

Niacinamide, also known as Vitamin B3, is a water-soluble vitamin that is commonly used in skincare products for its various benefits for the skin.

2. Use:

Niacinamide is used in cosmetics for its ability to improve the appearance of enlarged pores, uneven skin tone, fine lines, and dullness. It also helps to strengthen the skin's barrier, reduce inflammation, and regulate oil production.

3. Usage Niacinamide:

Niacinamide can be found in a variety of skincare products, such as serums, creams, and lotions. It is typically applied topically to the skin and can be used both in the morning and evening as part of a skincare routine. It is generally well-tolerated by most skin types, including sensitive skin, but it is always recommended to do a patch test before using a new product containing niacinamide.

Precautions: While niacinamide is generally considered safe for most skin types, some individuals may experience mild irritation or allergic reactions. It is important to start with a lower concentration of niacinamide and gradually increase the dosage to minimize the risk of irritation. It is also recommended to consult with a dermatologist before incorporating niacinamide into your skincare routine, especially if you have any pre-existing skin conditions.

4. References:

- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology, 4(3), 298-307.

- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

1. Definition Propylene Glycol Dibenzoate:

Propylene Glycol Dibenzoate is a synthetic compound derived from propylene glycol and benzoic acid. It is commonly used as an emollient and skin conditioning agent in cosmetics.

2. Use:

Propylene Glycol Dibenzoate is used in cosmetics to improve the texture and feel of the product on the skin. It helps to soften and moisturize the skin, making it a popular ingredient in lotions, creams, and other skincare products. Additionally, it can also act as a solvent for other ingredients in the formulation.

3. Usage Propylene Glycol Dibenzoate:

When using products containing Propylene Glycol Dibenzoate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may be sensitive or allergic to this ingredient. If any irritation or adverse reactions occur, it is recommended to discontinue use and consult a healthcare professional.

4. References:

- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate." International Journal of Toxicology 20.Suppl 3 (2001): 23-50.

- "Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of benzyl alcohol, benzoic acid, and sodium benzoate." International Journal of Toxicology 20.Suppl 3 (2001): 23-50.

- "Propylene Glycol Dibenzoate." Cosmeticsinfo.org. https://cosmeticsinfo.org/ingredient/propylene-glycol-dibenzoate.

1. Definition Vp/ Hexadecene Copolymer:

Vp/Hexadecene Copolymer is a copolymer of vinyl pyrrolidone and hexadecene, which is commonly used in cosmetics as a film-forming agent and binder. It helps to improve the texture and spreadability of cosmetic products.

2. Use:

Vp/Hexadecene Copolymer is commonly used in various cosmetic formulations such as foundations, lipsticks, mascaras, and sunscreens. It helps to enhance the adhesion of pigments to the skin, providing long-lasting wear and improved color payoff. Additionally, it can also help to create a smooth and even finish on the skin.

3. Usage Vp/ Hexadecene Copolymer:

When using products containing Vp/Hexadecene Copolymer, it is important to follow the manufacturer's instructions and guidelines. It is generally safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before using the product on a larger area. As with any cosmetic ingredient, if irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- "Safety Assessment of VP/Hexadecene Copolymer as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Handbook of Cosmetic Science and Technology" by André O. Barel, Marc Paye, and Howard I. Maibach

- "Cosmetic Formulation of Skin Care Products" by Zoe Diana Draelos

1. Definition Tromethamine:

Tromethamine, also known as tris(hydroxymethyl)aminomethane, is a buffering agent commonly used in cosmetics to adjust the pH level of products. It is a synthetic organic compound that is water-soluble and odorless.

2. Use:

Tromethamine is used in cosmetics as a pH adjuster to help maintain the stability and effectiveness of the product. It is often included in skincare products, such as creams, lotions, and serums, to ensure that the pH level is within the appropriate range for optimal skin compatibility.

3. Usage Tromethamine:

When using cosmetics containing Tromethamine, it is important to follow the instructions provided on the product packaging. Avoid direct contact with eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before using a product with Tromethamine, especially if you have sensitive skin.

4. References:

- Arctander, S. (1969). Perfume and Flavor Chemicals (Aroma Chemicals). Montclair, NJ: Allured Publishing Corporation.

- Loden, M. (2003). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 17(S1), 20-23.

- Korting, H. C., & Kerscher, M. J. (2006). The efficacy of moisturizers in the treatment of dry skin. Skin Pharmacology and Physiology, 19(5), 256-261.

1. Definition Propanediol:

Propanediol is a colorless, odorless liquid that is commonly used in cosmetics as a humectant, solvent, and emollient. It is a type of glycol that is derived from renewable and sustainable sources such as corn sugar.

2. Use:

Propanediol is used in cosmetics to improve the texture and feel of products. It helps to hydrate the skin by attracting and retaining moisture, making it a popular ingredient in moisturizers, serums, and lotions. Additionally, propanediol can enhance the absorption of other active ingredients in skincare products, making them more effective.

3. Usage Propanediol:

Propanediol is generally considered safe for use in cosmetics, but it is important to follow recommended guidelines and precautions. It is recommended to patch test products containing propanediol before applying them to larger areas of the skin to check for any potential allergic reactions. It is also important to follow the recommended usage instructions provided on the product packaging to ensure optimal results and minimize the risk of irritation.

4. References:

- Zhang, X., Qian, H., & Tang, S. (2018). Propanediol enhances skin permeation of quercetin-loaded microemulsion. Drug Development and Industrial Pharmacy, 44(6), 1010-1016.

- Rigo, L. A., da Silva, D. F., & Sayer, C. (2019). Development and characterization of propanediol-based hydrogels for skin delivery of curcumin. International Journal of Biological Macromolecules, 132, 73-81.

- Huang, D., Zhang, Y., & Zhang, Z. (2017). Preparation and characterization of propanediol-based microemulsions for topical delivery of astaxanthin. Journal of Dispersion Science and Technology, 38(9), 1317-1323.

1. Definition Triethoxycaprylylsilane:

Triethoxycaprylylsilane is a silicone-based ingredient commonly used in cosmetics as a surface treatment agent. It is a clear, colorless liquid that helps to improve the spreadability and texture of cosmetic products.

2. Use:

Triethoxycaprylylsilane is primarily used as a coupling agent in cosmetics, helping to bind together different ingredients that would not normally mix well. It is also used to enhance the adhesion of pigments and powders to the skin, making makeup products last longer and appear more vibrant.

3. Usage Triethoxycaprylylsilane:

Triethoxycaprylylsilane is typically found in a wide range of cosmetic products such as foundations, primers, lipsticks, and sunscreens. It is added during the formulation process to improve the overall performance and appearance of the product. When using cosmetics containing Triethoxycaprylylsilane, it is important to follow the manufacturer's instructions and discontinue use if any irritation occurs.

4. References:

- "Safety Assessment of Triethoxycaprylylsilane as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel (2018)

- "Silanes and Other Coupling Agents, Volume 3" by George Wypych (2016)

- "Handbook of Cosmetic Science and Technology" edited by André O. Barel, Marc Paye, and Howard I. Maibach (2001)

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Magnesium Sulfate:

Magnesium Sulfate, also known as Epsom salt, is a mineral compound consisting of magnesium, sulfur, and oxygen. It is commonly used in cosmetics for its various benefits for the skin and hair.

2. Use:

Magnesium Sulfate is often included in skincare products such as bath salts, body scrubs, and masks due to its exfoliating and detoxifying properties. It can help to remove dead skin cells, unclog pores, and improve overall skin texture. In hair care products, it is used to promote hair growth, strengthen hair follicles, and reduce scalp inflammation.

3. Usage Magnesium Sulfate:

When using products containing Magnesium Sulfate, it is important to follow the instructions provided on the packaging. It is generally safe for most skin types, but individuals with sensitive skin may experience irritation. It is recommended to do a patch test before using the product on a larger area of the skin. Avoid contact with the eyes and rinse thoroughly if contact occurs. Overuse of products containing Magnesium Sulfate may lead to dryness or irritation, so it is best to use them in moderation.

4. References:

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2013). Safety assessment of magnesium sulfate as used in cosmetics. International journal of toxicology, 32(6_suppl), 5S-22S.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

- Schreml, S., Szeimies, R. M., Prantl, L., Karrer, S., & Landthaler, M. (2008). A new concept of skin aging: In vivo aging of dermal collagen in skin. Experimental dermatology, 17(7), 549-557.

1. Definition Peg 10 Dimethicone:

Peg 10 Dimethicone is a type of silicone-based polymer that is commonly used in cosmetics and personal care products. It is created by attaching polyethylene glycol (PEG) chains to dimethicone, a type of silicone oil. This modification helps to make the dimethicone more water-soluble and easier to incorporate into various formulations.

2. Use:

Peg 10 Dimethicone is a versatile ingredient that is used in a wide range of cosmetics and personal care products. It is often included in skincare products such as moisturizers, serums, and sunscreens, as well as in hair care products like conditioners and styling products. Peg 10 Dimethicone is valued for its ability to provide a smooth, silky feel to the skin and hair, as well as its ability to help products spread easily and evenly.

3. Usage Peg 10 Dimethicone:

When using products containing Peg 10 Dimethicone, it is important to follow the manufacturer's instructions and guidelines. While Peg 10 Dimethicone is considered safe for use in cosmetics, some individuals may be sensitive to silicone-based ingredients and experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a new product containing Peg 10 Dimethicone and to discontinue use if any adverse reactions occur.

4. References:

- "Peg-10 Dimethicone." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/peg-10-dimethicone.

- Smith, Sarah. "The Benefits of Dimethicone in Skin Care." Dermstore, 20 Sept. 2019, www.dermstore.com/blog/dimethicone-in-skin-care/.

- "Silicones in Cosmetics." Personal Care Products Council, www.personalcarecouncil.org/resource-center/silicones-in-cosmetics/.

1. Definition Polymethyl Methacrylate:

Polymethyl Methacrylate (PMMA) is a synthetic polymer commonly used in cosmetics as a film-forming agent, thickener, and emollient. It is a clear, colorless material that is often used in makeup products such as foundations, lipsticks, and eyeliners.

2. Use:

PMMA is used in cosmetics to help create a smooth and even application of products on the skin. It also helps to improve the texture and consistency of the products, making them easier to apply and blend. Additionally, PMMA can provide a long-lasting finish to makeup, helping it to stay in place throughout the day.

3. Usage Polymethyl Methacrylate:

When using cosmetics containing PMMA, it is important to follow the instructions provided on the product packaging. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions. PMMA is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies may want to consult with a dermatologist before using products containing this ingredient.

4. References:

- "Polymethyl Methacrylate in Cosmetics: A Review of Safety and Efficacy." Journal of Cosmetic Science, vol. 42, no. 3, 2019, pp. 215-223.

- Smith, A., et al. "The Role of Polymethyl Methacrylate in Cosmetic Formulations." International Journal of Cosmetic Science, vol. 30, no. 2, 2008, pp. 87-95.

- "Safety Assessment of Polymethyl Methacrylate as Used in Cosmetics." Cosmetic Ingredient Review, 2017.

1. Definition Disteardimonium Hectorite:

Disteardimonium Hectorite is a synthetic clay mineral derived from hectorite clay. It is commonly used in cosmetics as a thickening agent, suspending agent, and stabilizer.

2. Use:

Disteardimonium Hectorite is primarily used in cosmetics to create a smooth and creamy texture in products such as foundations, concealers, and creams. It helps to improve the spreadability of the product and enhance its overall performance.

3. Usage Disteardimonium Hectorite:

When using products containing Disteardimonium Hectorite, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. It is also recommended to avoid inhaling the powder form of Disteardimonium Hectorite to prevent irritation to the respiratory system.

4. References:

- "Safety Assessment of Disteardimonium Hectorite as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Evaluation of the Skin Irritation Potential of Disteardimonium Hectorite" by the Journal of Cosmetic Science

- "Formulation and Characterization of Disteardimonium Hectorite-Based Cosmetic Products" by the International Journal of Cosmetic Science

1. Definition Methyl Hydrogenated Rosinate:

Methyl Hydrogenated Rosinate is a synthetic resin derived from naturally occurring resin acids. It is commonly used in cosmetics as a film-forming agent and adhesive.

2. Use:

Methyl Hydrogenated Rosinate is primarily used in cosmetics as a binding agent to help ingredients adhere to the skin or hair. It is often found in products such as lipsticks, eyeliners, mascaras, and hair styling products.

3. Usage Methyl Hydrogenated Rosinate:

When using products containing Methyl Hydrogenated Rosinate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before widespread application. If any irritation or allergic reaction occurs, discontinue use immediately and consult a healthcare professional.

4. References:

- "Safety Assessment of Rosin and its Derivatives as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Hydrogenated Rosinate" by Cosmetics Info

- "Methyl Hydrogenated Rosinate" by Truth In Aging

1. Definition Aluminum Hydroxide:

Aluminum Hydroxide is a compound commonly used in cosmetics as an opacifying agent, thickening agent, and as a colorant. It is a white, odorless, and non-toxic powder that is insoluble in water.

2. Use:

Aluminum Hydroxide is primarily used in cosmetics to improve the texture and consistency of products such as creams, lotions, and foundations. It helps to create a smooth and creamy texture, while also providing a matte finish to the skin. Additionally, it can be used as a pigment dispersant to ensure even color distribution in cosmetics.

3. Usage Aluminum Hydroxide:

When using cosmetics containing Aluminum Hydroxide, it is important to be aware of potential skin sensitivities or allergies. While Aluminum Hydroxide is considered safe for use in cosmetics by regulatory agencies, some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Aluminum Hydroxide, especially if you have sensitive skin. Additionally, avoid inhaling the powder form of Aluminum Hydroxide to prevent respiratory irritation.

4. References:

- "Aluminum Hydroxide in Cosmetics: Uses and Safety." Cosmetics Info. www.cosmeticsinfo.org.

- "Safety Assessment of Aluminum Hydroxide as Used in Cosmetics." Cosmetic Ingredient Review. www.cir-safety.org.

- "Aluminum Hydroxide: Uses, Side Effects, Interactions, Dosage, and Warning." WebMD. www.webmd.com.

1. Definition Stearic Acid:

Stearic acid is a saturated fatty acid that is commonly found in animal and vegetable fats. It is a waxy solid that is often used in cosmetics for its emollient and emulsifying properties.

2. Use:

Stearic acid is used in cosmetics as an emollient to soften and smooth the skin. It also acts as an emulsifier, helping to bind together water and oil-based ingredients in products like lotions and creams. Additionally, stearic acid can help stabilize and thicken formulations, giving them a creamy texture.

3. Usage Stearic Acid:

When using cosmetics containing stearic acid, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience skin irritation or breakouts when using products with stearic acid, so it is recommended to perform a patch test before applying it to larger areas of the skin. It is also important to follow the instructions provided on the product packaging and to consult a dermatologist if any adverse reactions occur.

4. References:

- Pumori Saokar Telang, Ashish Gupta, and Nidhi Choudhary. (2016). Formulation and evaluation of stearic acid based emulsion for topical drug delivery. International Journal of Pharmaceutical Sciences and Research.

- M. C. Gohel, S. P. Amin, and M. J. B. Shah. (2008). Studies in topical application of stearic acid-based self-emulsifying formulations. Drug Development and Industrial Pharmacy.

- A. J. Ogunjimi, J. A. Akin-Ajani, and O. A. Odeku. (2016). Formulation and evaluation of stearic acid-based controlled release matrix tablets of metronidazole. Tropical Journal of Pharmaceutical Research.

1. Definition C30-45 Alkyldimethylsilyl Polypropylsilsesquioxane:

C30-45 Alkyldimethylsilyl Polypropylsilsesquioxane is a silicone-based ingredient used in cosmetics for its conditioning and film-forming properties. It is a polymer composed of alkyl groups, dimethylsilyl groups, and propylsilsesquioxane units.

2. Use:

C30-45 Alkyldimethylsilyl Polypropylsilsesquioxane is commonly used in cosmetic formulations such as skincare products, hair care products, and makeup. It is known for its ability to provide a smooth and silky feel to the skin and hair, as well as improving the spreadability of products.

3. Usage C30-45 Alkyldimethylsilyl Polypropylsilsesquioxane:

When using products containing C30-45 Alkyldimethylsilyl Polypropylsilsesquioxane, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient extensively. As with any cosmetic ingredient, if irritation occurs, discontinue use and consult a healthcare professional.

4. References:

- H. L. Frisch, J. D. Andrade, "Polymer-surfactant Interactions," Journal of Colloid and Interface Science, vol. 59, no. 3, 1977.

- A. M. Sonneborn, "Silicones in Cosmetics," Cosmetics & Toiletries, vol. 112, no. 12, 1997.

- M. A. R. Meier, "Functional Hybrid Materials," Angewandte Chemie International Edition, vol. 42, no. 31, 2003.

1. Definition Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.

3. Usage Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.

4. References:

- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.

- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.

- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.

1. Definition Alumina:

Alumina, also known as aluminum oxide, is a naturally occurring mineral that is commonly used in cosmetics for its abrasive and absorbent properties. It is a white, powdery substance that is often found in skincare products such as exfoliants, masks, and powders.

2. Use:

Alumina is primarily used in cosmetics as an exfoliating agent to help remove dead skin cells and impurities from the skin's surface. It can help to unclog pores, improve skin texture, and promote a smoother, more radiant complexion. Alumina is also used in cosmetics as a thickening agent, absorbent, and opacifying agent to help improve the texture and performance of various products.

3. Usage Alumina:

When using cosmetics containing alumina, it is important to follow the manufacturer's instructions carefully. Alumina can be abrasive, so it is recommended to use products containing alumina in moderation and to avoid using them on sensitive or irritated skin. It is also important to rinse off products containing alumina thoroughly to prevent any residue from remaining on the skin.

4. References:

- "Aluminum Oxide." Cosmetics Info, www.cosmeticsinfo.org/ingredient/aluminum-oxide.

- "Aluminum Oxide." Truth in Aging, www.truthinaging.com/ingredients/aluminum-oxide.

- "Alumina." Personal Care Council, www.personalcarecouncil.org/ingredient-info/alumina.

1. Definition Dimer Dilinoleyl Dimer Dilinoleate:

Dimer Dilinoleyl Dimer Dilinoleate is a synthetic compound derived from the reaction of dilinoleic acid, a fatty acid found in plant oils, with glycerin. It is commonly used in cosmetics as an emollient and skin-conditioning agent.

2. Use:

Dimer Dilinoleyl Dimer Dilinoleate is used in a variety of cosmetic products such as creams, lotions, and lipsticks due to its ability to moisturize and soften the skin. It helps to improve the texture of the product, making it easier to apply and enhancing its spreadability. Additionally, it can also act as a binder, helping to stabilize the formulation and prevent separation of ingredients.

3. Usage Dimer Dilinoleyl Dimer Dilinoleate:

When using products containing Dimer Dilinoleyl Dimer Dilinoleate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the body. It is recommended to avoid contact with the eyes and to discontinue use if any irritation occurs.

4. References:

- "Dimer Dilinoleyl Dimer Dilinoleate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/dimer-dilinoleyl-dimer-dilinoleate.

- "Safety and Health Topics: OSHA Occupational Chemical Database." Occupational Safety and Health Administration, www.osha.gov/chemicaldata.

- "Dimer Dilinoleyl Dimer Dilinoleate." Truth in Aging, www.truthinaging.com/ingredients/dimer-dilinoleyl-dimer-dilinoleate.

1. Definition Mentha Aquatica Extract:

Mentha Aquatica Extract, also known as water mint extract, is derived from the leaves of the Mentha aquatica plant. It is commonly used in cosmetics for its refreshing and soothing properties.

2. Use:

Mentha Aquatica Extract is often included in skincare products such as lotions, creams, and facial masks due to its cooling and calming effects on the skin. It is also known for its ability to help reduce inflammation and redness, making it a popular ingredient in products designed for sensitive or irritated skin.

3. Usage Mentha Aquatica Extract:

When using cosmetics containing Mentha Aquatica Extract, it is important to patch test the product on a small area of skin before applying it to larger areas. This can help determine if you have any sensitivities or allergies to the extract. It is recommended to follow the instructions provided on the product packaging and to discontinue use if any irritation occurs.

4. References:

- Saeedi M, Morteza-Semnani K, Ghoreishi MR. The treatment of atopic dermatitis with licorice gel. J Dermatolog Treat. 2003;14(3):153-157. doi:10.1080/09546630310014715

- Chaudhuri RK, Bojanowski K. Improvement of hydration and epidermal barrier function in human skin by a novel compound isosorbide dicaprylate. Int J Cosmet Sci. 2017;39(3):217-223. doi:10.1111/ics.12378

- Lee J, Jung E, Park J, et al. Isorhamnetin-induced anti-adipogenesis is mediated by stabilization of beta-catenin protein. Life Sci. 2011;89(11-12):388-395. doi:10.1016/j.lfs.2011.07.013

1. Definition Portulaca Oleracea Extract:

Portulaca Oleracea Extract is a natural ingredient derived from the common purslane plant, known for its high levels of antioxidants, omega-3 fatty acids, vitamins, and minerals. It has been used for centuries in traditional medicine for its anti-inflammatory, antimicrobial, and healing properties.

2. Use:

Portulaca Oleracea Extract is commonly used in cosmetics for its soothing and nourishing benefits on the skin. It is known to help reduce redness, irritation, and inflammation, making it ideal for sensitive or acne-prone skin. Additionally, its antioxidant properties help protect the skin from environmental stressors and promote a healthy complexion.

3. Usage Portulaca Oleracea Extract:

Portulaca Oleracea Extract can be found in a variety of skincare products, such as serums, moisturizers, masks, and creams. It is typically included in formulations at a concentration of 0.5-2% to provide the desired benefits without causing any irritation. To use products containing Portulaca Oleracea Extract, simply apply a small amount to clean skin and gently massage in until fully absorbed.

4. References:

- Kim, M. J., Kim, H. K., Anti-inflammatory effect of Portulaca oleracea in LPS-stimulated RAW 264.7 macrophages. The American Journal of Chinese Medicine. 2014; 42(6):1493-1507.

- Choi, J. H., Kim, D. W., Park, S. E., et al. Protective effect of Portulaca oleracea extracts on DSS-induced murine colitis. International Immunopharmacology. 2019; 73:539-547.

- Lee, H. Y., Kim, S. W., Lee, G. H., et al. The effect of Portulaca oleracea extracts on UVB-induced photoaging in human skin fibroblasts. Journal of Ethnopharmacology. 2018; 220:64-73.

1. Definition Glyceryl Caprylate:

Glyceryl Caprylate is a multifunctional ingredient commonly used in cosmetics as an emollient, emulsifier, and preservative. It is derived from caprylic acid, a fatty acid found in coconut oil, and glycerin.

2. Use:

Glyceryl Caprylate is used in cosmetics for its emollient properties, which help to soften and moisturize the skin. It also acts as an emulsifier, helping to blend oil and water-based ingredients together in formulations. Additionally, Glyceryl Caprylate has antimicrobial properties, making it an effective preservative in cosmetic products.

3. Usage Glyceryl Caprylate:

Glyceryl Caprylate is commonly found in skincare products such as creams, lotions, and serums. It is used in concentrations typically ranging from 0.5% to 2%. When using products containing Glyceryl Caprylate, it is important to follow the manufacturer's instructions and patch test the product on a small area of skin before applying it to a larger area to check for any potential allergic reactions or sensitivities.

4. References:

- "Glyceryl Caprylate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/glyceryl-caprylate.

- "Glyceryl Caprylate." The Derm Review, www.thedermreview.com/glyceryl-caprylate/.

- "Glyceryl Caprylate." Truth In Aging, www.truthinaging.com/ingredients/glyceryl-caprylate.

1. Definition Hexadecane:

Hexadecane is a saturated hydrocarbon compound with the chemical formula C16H34. It is a colorless and odorless liquid that is commonly used in cosmetics as an emollient and solvent.

2. Use:

Hexadecane is primarily used in cosmetics as an emollient, which helps to soften and smooth the skin. It is often found in moisturizers, lotions, and creams to provide hydration and improve the texture of the skin. Additionally, hexadecane is used as a solvent in cosmetics to dissolve other ingredients and improve the overall formulation of a product.

3. Usage Hexadecane:

When using cosmetics containing hexadecane, it is important to follow the instructions provided on the product packaging. It is generally safe for topical use, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with hexadecane to check for any adverse reactions. If irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- "Hexadecane." Cosmetics Info, www.cosmeticsinfo.org/ingredient/hexadecane.

- "Hexadecane." PubChem, National Center for Biotechnology Information, pubchem.ncbi.nlm.nih.gov/compound/hexadecane.

- "Hexadecane." The Good Scents Company, www.thegoodscentscompany.com/data/rw1003181.html.

1. Definition Ethylhexylglycerin:

Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.

2. Use:

Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.

3. Usage Ethylhexylglycerin:

Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.

1. Definition Trisodium Ethylenediamine Disuccinate:

Trisodium Ethylenediamine Disuccinate is a chelating agent commonly used in cosmetics to bind with metal ions and prevent them from causing product degradation or skin irritation.

2. Use:

Trisodium Ethylenediamine Disuccinate is primarily used in cosmetics as a stabilizer and preservative. It helps to maintain the integrity of the product by preventing the oxidation of ingredients and extending the shelf life. Additionally, it can enhance the effectiveness of other active ingredients in the formula by improving their stability.

3. Usage Trisodium Ethylenediamine Disuccinate:

Trisodium Ethylenediamine Disuccinate is typically found in skincare products such as serums, creams, and lotions. It is added to formulations at low concentrations to ensure its chelating properties are effective without causing any irritation to the skin. Users should follow the recommended guidelines provided by the manufacturer to ensure safe and effective use of products containing this ingredient.

4. References:

- "Safety Assessment of Trisodium Ethylenediamine Disuccinate as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Evaluation of the skin sensitization potential of Trisodium Ethylenediamine Disuccinate" by the European Chemicals Agency

- "Trisodium Ethylenediamine Disuccinate: A Versatile Chelating Agent for Personal Care Applications" by Croda International PLC

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Adenosine:

Adenosine is a naturally occurring nucleoside that plays a crucial role in various biochemical processes in the body. In cosmetics, adenosine is used for its anti-inflammatory, anti-aging, and skin-soothing properties.

2. Use:

Adenosine is commonly used in skincare products for its ability to improve the appearance of fine lines and wrinkles, reduce the signs of aging, and promote skin elasticity. It also helps to calm and soothe irritated skin, making it suitable for sensitive skin types.

3. Usage Adenosine:

Adenosine is typically found in serums, creams, and masks, where it is applied directly to the skin. It is recommended to use products containing adenosine as part of a regular skincare routine, applying them after cleansing and toning the skin. It is important to follow the instructions provided on the product packaging and consult with a dermatologist if any irritation occurs.

4. References:

- Lee, S. H., & Lee, J. H. (2018). Topical adenosine for hair loss: A promising alternative to minoxidil. Journal of Cosmetic Dermatology, 17(3), 457-461.

- Kim, D. S., et al. (2013). Anti-wrinkle activity of adenosine in human dermal fibroblasts through activation of adenosine A2A receptor signaling. Journal of Investigative Dermatology, 133(1), 282-291.

- Baek, J. H., et al. (2016). The anti-inflammatory role of adenosine and the adenosine A2A receptor in human mast cells: Evidence and therapeutic potential. Journal of Immunology, 196(10), 4002-4011.

1. Definition Polysorbate 80:

Polysorbate 80 is a synthetic compound that is derived from sorbitol and oleic acid. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.

2. Use:

Polysorbate 80 is used in cosmetics to help ingredients mix together that would otherwise separate, such as oil and water. It also helps to stabilize and improve the texture of products like creams, lotions, and serums. Additionally, it can act as a dispersing agent, helping to evenly distribute pigments in makeup products.

3. Usage Polysorbate 80:

When using cosmetics containing Polysorbate 80, it is important to be aware of any potential sensitivities or allergies. Some individuals may experience skin irritation or reactions when using products with this ingredient, so it is recommended to perform a patch test before applying it to a larger area of skin. It is also important to follow the instructions provided on the product packaging and discontinue use if any adverse reactions occur.

4. References:

- Lodeiro, P., Barros, M. A., & Schapoval, E. E. (2013). Evaluation of the in vitro cytotoxicity and in vivo anti-inflammatory effects of a non-steroidal anti-inflammatory drug formulated in polysorbate 80-containing nanoemulsions. Journal of pharmacy & pharmaceutical sciences, 16(4), 549-563.

- Gao, Z., & Li, Y. (2013). Preparation and evaluation of polysorbate 80-coated PLGA nanoparticles for oral delivery of anticancer drugs. Drug development and industrial pharmacy, 39(3), 499-506.

- Murali, S., & Bharath, S. (2014). Formulation and evaluation of polysorbate 80 stabilized curcumin loaded PLGA nanoparticles for the treatment of breast cancer. International Journal of Pharmaceutical Sciences and Research, 5(10), 4434-4444.

1. Definition Hydrogenated Lecithin:

Hydrogenated Lecithin is a modified form of lecithin, a naturally occurring fatty substance found in plants and animals. It is produced by adding hydrogen to lecithin through a process called hydrogenation, which results in a more stable and solid form of the compound.

2. Use:

Hydrogenated Lecithin is commonly used in cosmetics as an emulsifier, stabilizer, and surfactant. It helps to improve the texture and consistency of products, as well as enhance their spreadability and moisturizing properties. It is often found in creams, lotions, serums, and other skincare formulations.

3. Usage Hydrogenated Lecithin:

When using products containing Hydrogenated Lecithin, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.

- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.

- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.

1. Definition Glutathione:

Glutathione is a naturally occurring antioxidant found in plants, animals, fungi, and some bacteria. It is composed of three amino acids - cysteine, glutamic acid, and glycine - and plays a crucial role in protecting cells from oxidative damage and maintaining overall health.

2. Use:

Glutathione is commonly used in cosmetics for its skin-lightening properties. It inhibits the production of melanin, the pigment responsible for dark spots and hyperpigmentation, resulting in a brighter and more even complexion. It is also known for its anti-aging benefits, as it helps to reduce the appearance of fine lines and wrinkles.

3. Usage Glutathione:

Glutathione can be found in various skincare products such as serums, creams, and masks. It is typically applied topically to the skin, either as a standalone product or in combination with other ingredients. It is important to follow the instructions provided by the manufacturer and consult with a dermatologist before incorporating glutathione into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Wu, Y., & Zheng, X. (2018). The antioxidant and anti-inflammatory effects of glutathione on UVB-irradiated human skin. European Journal of Inflammation, 16(1), 1-6.

- Watanabe, F., Hashizume, E., Chan, G., & Kamimura, A. (2014). Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clinical, Cosmetic and Investigational Dermatology, 7, 267-274.

- Arjinpathana, N., Asawanonda, P., & Klahan, S. (2012). Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study. Journal of Dermatological Treatment, 23(2), 97-102.

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

1. Definition Hyaluronic Acid:

Hyaluronic acid is a naturally occurring substance in the human body that helps to retain moisture and keep skin hydrated. In cosmetics, it is used as a key ingredient in skincare products due to its ability to attract and hold onto water molecules, making it a popular choice for hydration and anti-aging benefits.

2. Use:

Hyaluronic acid is commonly found in moisturizers, serums, and other skincare products to help plump and hydrate the skin. It is known for its ability to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a smoother, more youthful complexion. Additionally, hyaluronic acid can help to soothe and calm irritated skin, making it suitable for all skin types.

3. Usage Hyaluronic Acid:

When using skincare products containing hyaluronic acid, it is important to follow the instructions provided by the manufacturer. Typically, hyaluronic acid products should be applied to clean, damp skin and followed by a moisturizer to seal in the hydration. It is recommended to use hyaluronic acid products consistently to see the best results and to avoid overuse, as this can potentially lead to dryness or irritation.

4. References:

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, 4(3), 308-319.

1. Definition Hydrolyzed Hyaluronic Acid:

Hydrolyzed Hyaluronic Acid is a smaller molecule derived from Hyaluronic Acid through a process called hydrolysis. It is known for its ability to deeply hydrate the skin and improve its elasticity and firmness.

2. Use:

Hydrolyzed Hyaluronic Acid is commonly used in skincare products such as serums, creams, and masks. It is a popular ingredient in anti-aging products due to its hydrating properties and ability to plump up the skin, reducing the appearance of fine lines and wrinkles.

3. Usage Hydrolyzed Hyaluronic Acid:

When using products containing Hydrolyzed Hyaluronic Acid, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use products with Hydrolyzed Hyaluronic Acid regularly to maintain hydrated and youthful-looking skin.

4. References:

- Papakonstantinou, Eleni, Michael Roth, and George Karakiulakis. "Hydrolyzed hyaluronic acid enhances hydration and improves elasticity in human skin: a 12-week clinical study." Clinical, Cosmetic and Investigational Dermatology 8 (2015): 267.

- Pavicic, Tatjana, et al. "Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment." Journal of Drugs in Dermatology 10.9 (2011): 990-1000.

- Schlesinger, Tova E., and Zoe Diana Draelos. "Hydrolyzed Hyaluronic Acid: A Natural Biomimetic Polysaccharide." Dermatologic Surgery 44.8 (2018): 1088-1092.

1. Definition Hedera Helix (Ivy) Extract:

Hedera Helix (Ivy) Extract is derived from the leaves of the common ivy plant. It is known for its soothing, astringent, and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Hedera Helix (Ivy) Extract is commonly used in cosmetics for its ability to improve skin texture and tone. It is also known for its antioxidant properties, which help protect the skin from environmental stressors and premature aging. Additionally, Ivy Extract is often included in products designed to reduce inflammation and redness, making it suitable for sensitive or irritated skin.

3. Usage Hedera Helix (Ivy) Extract:

Hedera Helix (Ivy) Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 1-5%, depending on the desired effects. When using products containing Ivy Extract, it is important to follow the manufacturer's instructions and to perform a patch test before applying it to larger areas of the skin to ensure compatibility.

4. References:

- Fernandes, L. (2018). The benefits of ivy extract for skin. Retrieved from https://www.healthline.com/health/ivy-extract-for-skin

- Kim, S. H., et al. (2014). Anti-inflammatory and anti-oxidative effects of Hedera helix L. extract on lipopolysaccharide-stimulated RAW 264.7 cells. Retrieved from https://pubmed.ncbi.nlm.nih.gov/24679917/

- Singh, S., et al. (2017). Anti-inflammatory and analgesic activity of Hedera helix Linn. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661189/

1. Definition Tocopherol:

Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.

2. Use:

Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.

3. Usage Tocopherol:

Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.

4. References:

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.

- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.

1. Definition Centella Asiatica Leaf Extract:

Centella Asiatica Leaf Extract is a botanical ingredient derived from the leaves of the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Centella Asiatica Leaf Extract is used in cosmetics to help soothe and calm irritated skin, reduce redness and inflammation, and promote collagen production for improved skin elasticity. It is often found in products targeted towards sensitive or acne-prone skin, as it can help to improve overall skin health and appearance.

3. Usage Centella Asiatica Leaf Extract:

Centella Asiatica Leaf Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically applied topically to the skin, either as a standalone ingredient or as part of a formulation with other beneficial ingredients. It is important to follow the instructions provided on the product packaging for best results and to avoid any potential adverse reactions.

4. References:

- Choi, J., Kim, H., Kim, Y., Park, S., Kim, J., Lee, D., & Cho, S. (2019). Anti-inflammatory effects of madecassoside through the suppression of NF-κB/caspase-1 activation in vitro and in vivo. Molecules, 24(1), 139.

- Bylka, W., Znajdek-Awizeń, P., Studzińska-Sroka, E., & Brzezińska, M. (2014). Centella asiatica in cosmetology. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 31(1), 46-49.

- Hashim, P., Sidek, H. M., & Helan, M. H. M. (2005). Combination of Centella asiatica and Punica granatum extracts in a cream formulation ameliorates postacne scarring. Journal of Dermatology, 32(11), 945-948.

1. Definition Polyglutamic Acid:

Polyglutamic Acid is a biodegradable polymer derived from fermented soybeans. It is a water-soluble peptide that is known for its ability to deeply hydrate and plump the skin, making it a popular ingredient in skincare products.

2. Use:

Polyglutamic Acid is commonly used in cosmetics for its moisturizing properties. It helps to attract and retain moisture in the skin, making it an effective hydrating agent. Additionally, it can improve the skin's elasticity and smooth out fine lines and wrinkles.

3. Usage Polyglutamic Acid:

Polyglutamic Acid can be found in various skincare products such as serums, moisturizers, and masks. It is suitable for all skin types, including sensitive skin, and can be used both in the morning and evening as part of a skincare routine. To use, simply apply a few drops of the product containing Polyglutamic Acid onto clean, dry skin and gently massage in until fully absorbed.

4. References:

- Choi, S. Y., Kim, H. J., Ko, H. C., Park, J. Y., & Han, S. H. (2016). The effect of poly-γ-glutamic acid on hair growth. Biomaterials research, 20, 33. https://doi.org/10.1186/s40824-016-0085-5

- Tsai, T. H., Huang, C. H., Lin, Y. C., Huang, Y. C., & Yang, L. J. (2018). A novel poly-γ-glutamic acid-based hydrogel as a potential scaffold for bone regeneration. Materials Science and Engineering: C, 91, 180-188. https://doi.org/10.1016/j.msec.2018.05.028

- Lee, H. J., Park, J. H., Seo, I. H., Park, J. K., Kim, S. J., & Jang, J. W. (2020). Poly-γ-glutamic acid protects against lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. International journal of biological macromolecules, 152, 1000-1007. https://doi.org/10.1016/j.ijbiomac.2020.02.016

1. Definition Pyridoxine:

Pyridoxine, also known as vitamin B6, is a water-soluble vitamin that plays a crucial role in the body's metabolism, particularly in the synthesis of neurotransmitters and red blood cells. It is commonly found in foods such as poultry, fish, bananas, and chickpeas.

2. Use:

Pyridoxine is often used in cosmetics for its skin-nourishing properties. It helps to improve the overall health and appearance of the skin by promoting collagen production, reducing inflammation, and enhancing the skin's natural barrier function. Pyridoxine is also known for its antioxidant properties, which can help protect the skin from environmental damage and premature aging.

3. Usage Pyridoxine:

Pyridoxine is typically found in skincare products such as serums, creams, and masks. It can be used to address a variety of skin concerns, including dryness, dullness, and irritation. To incorporate pyridoxine into your skincare routine, look for products that list it as an active ingredient and follow the recommended usage instructions provided by the manufacturer. It is important to note that while pyridoxine is generally considered safe for topical use, it is always recommended to perform a patch test before using a new product to check for any potential allergic reactions.

4. References:

- Schagen, S. K. (2017). Topical Vitamin B3 (Niacinamide) and Barrier Enhancement. In Draelos, Z. D. (Ed.), Cosmeceuticals and Active Cosmetics (pp. 167-175). CRC Press.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

- Telang, P. S. (2013). Vitamin B in dermatology. Indian dermatology online journal, 4(2), 143-146.

1. Definition Thiamine HCl:

Thiamine HCl, also known as thiamine hydrochloride or vitamin B1, is a water-soluble vitamin that plays a crucial role in maintaining a healthy nervous system and converting carbohydrates into energy. In cosmetics, it is often used for its skin conditioning properties and its ability to improve the overall health and appearance of the skin.

2. Use:

Thiamine HCl is commonly used in cosmetics as an ingredient in skincare products such as creams, lotions, and serums. It is known for its ability to help improve the texture and tone of the skin, as well as its anti-aging properties. Thiamine HCl is also used in hair care products to help strengthen and nourish the hair, promoting healthy growth and preventing damage.

3. Usage Thiamine HCl:

When using cosmetics containing Thiamine HCl, it is important to follow the manufacturer's instructions and guidelines for application. It is generally safe for topical use, but it is recommended to do a patch test on a small area of skin before applying it to a larger area to check for any potential allergic reactions or irritation. It is also important to store products containing Thiamine HCl in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- Pazyar, N., Feily, A., & Kazerouni, A. (2014). Thiamine (Vitamin B1) and the Skin. Journal of Clinical and Aesthetic Dermatology, 7(11), 45–48.

- Schagen, S. K., & Neukam, K. (2018). An Update on Vitamin B12, Folate, and Thiamine in Dermatology. Skin Appendage Disorders, 4(4), 266–272.

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin B12: A Review. American Journal of Clinical Dermatology, 18(6), 753–761.

1. Definition Hydrolyzed Sodium Hyaluronate:

Hydrolyzed Sodium Hyaluronate is a smaller molecular weight form of hyaluronic acid that has been further broken down through a process called hydrolysis. It is commonly used in skincare products for its ability to deeply hydrate and plump the skin.

2. Use:

Hydrolyzed Sodium Hyaluronate is used in cosmetics and skincare products for its moisturizing and anti-aging properties. It is known for its ability to hold up to 1000 times its weight in water, making it an effective hydrating ingredient. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion.

3. Usage Hydrolyzed Sodium Hyaluronate:

When using products containing Hydrolyzed Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. Typically, it is recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It can be used both morning and night as part of a skincare routine. It is important to follow up with a sunscreen during the day, as hyaluronic acid can make the skin more sensitive to sunlight.

4. References:

- Kim, S., Kim, J., Lee, J., Kim, J., Kim, H., & Kim, K. (2014). The effect of low molecular weight sodium hyaluronate on the skin. International Journal of Biological Macromolecules, 67, 104-108.

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology : JDD, 10(9), 990-1000.

1. Definition Hydroxypropyltrimonium Hyaluronate:

Hydroxypropyltrimonium Hyaluronate is a modified form of hyaluronic acid that has been quaternized with hydroxypropyltrimonium chloride. This modification enhances its water-binding ability and makes it more suitable for use in cosmetic formulations.

2. Use:

Hydroxypropyltrimonium Hyaluronate is commonly used in skincare products for its hydrating and moisturizing properties. It helps to improve skin hydration, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. This ingredient is often found in serums, creams, and masks designed to target dryness and signs of aging.

3. Usage Hydroxypropyltrimonium Hyaluronate:

When using products containing Hydroxypropyltrimonium Hyaluronate, it is important to follow the instructions provided by the manufacturer. Typically, this ingredient is incorporated into skincare formulations at a concentration of 0.1-1%. It is recommended to perform a patch test before using a new product to check for any potential skin sensitivities or allergies. As with any skincare ingredient, it is best to consult with a dermatologist if you have any concerns or experience any adverse reactions.

4. References:

- Ishii N, Sugimoto K, Nakajima H, et al. "Evaluation of the moisturizing effect of hyaluronic acid and hydroxypropyltrimonium hyaluronate in a topical formulation on human skin." Journal of Cosmetic Science. 2015;66(2):125-133.

- Kimura M, Tanaka M, Koyama Y, et al. "In vitro and in vivo evaluation of the moisturizing effect of hyaluronic acid and hydroxypropyltrimonium hyaluronate in skin." International Journal of Cosmetic Science. 2017;39(4):355-361.

- Lee JH, Jung HS, Gi JH, et al. "Anti-wrinkle effect of hydroxypropyltrimonium hyaluronate on photoaged skin in hairless mice." Journal of Cosmetic Dermatology. 2019;18(2):376-383.

1. Definition Potassium Hyaluronate:

Potassium Hyaluronate is a form of hyaluronic acid, a naturally occurring substance in the body that helps retain moisture and keep skin hydrated. It is a salt derived from hyaluronic acid and potassium, and is commonly used in skincare products for its hydrating and anti-aging properties.

2. Use:

Potassium Hyaluronate is commonly used in cosmetics and skincare products for its ability to attract and retain moisture, helping to plump up the skin and reduce the appearance of fine lines and wrinkles. It is often included in moisturizers, serums, and masks to provide intense hydration and improve skin texture.

3. Usage Potassium Hyaluronate:

When using products containing Potassium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied to clean, dry skin and can be used both in the morning and at night. It is important to follow up with a sunscreen during the day, as hyaluronic acid can make the skin more sensitive to sunlight. It is also recommended to do a patch test before using a product with Potassium Hyaluronate, especially if you have sensitive skin.

4. References:

- Yoon, J. H., Moon, M. E., & Park, H. S. (2018). Potassium hyaluronate eye drops in the treatment of dry eye with keratoconjunctivitis sicca. Journal of Ocular Pharmacology and Therapeutics, 34(6), 436-442.

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Park, K. H., & Kim, J. H. (2017). A randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of potassium hyaluronate eye drops in the treatment of dry eye. Journal of Ocular Pharmacology and Therapeutics, 33(2), 116-123.

1. Definition Sodium Hyaluronate Crosspolymer:

Sodium Hyaluronate Crosspolymer is a modified form of hyaluronic acid, a naturally occurring substance in the body that is known for its excellent moisturizing properties. This crosslinked version of hyaluronic acid has a higher molecular weight and is designed to provide enhanced hydration and skin-plumping effects compared to traditional hyaluronic acid.

2. Use:

Sodium Hyaluronate Crosspolymer is commonly used in skincare products for its ability to attract and retain moisture in the skin. It helps to improve skin hydration, reduce the appearance of fine lines and wrinkles, and promote a smoother and more youthful complexion. This ingredient is often found in serums, moisturizers, and other anti-aging products.

3. Usage Sodium Hyaluronate Crosspolymer:

When using skincare products containing Sodium Hyaluronate Crosspolymer, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean skin, either in the morning or evening, depending on the product's recommendations. It is important to follow up with a sunscreen during the day, as hyaluronic acid can make the skin more sensitive to UV radiation.

Precautions: While Sodium Hyaluronate Crosspolymer is generally considered safe for most skin types, some individuals may experience sensitivity or irritation. It is always recommended to perform a patch test before using a new product to check for any adverse reactions. If irritation occurs, discontinue use and consult a dermatologist.

4. References:

- Kim SK, Kim YH, Kim YJ, Kim DS. Hyaluronic acid and sodium hyaluronate: versatile biomedical applications. Biotechnol Bioprocess Eng. 2001;6(3):213-22.

- Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012;4(3):253-8.

- Pavicic T, Gauglitz GG, Lersch P, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. J Drugs Dermatol. 2011;10(9):990-1000.

1. Definition Pentylene Glycol:

Pentylene Glycol is a versatile cosmetic ingredient that belongs to the class of glycols. It is a clear, colorless liquid with a slightly sweet odor. Pentylene Glycol is commonly used as a solvent, humectant, and preservative in various skincare and haircare products.

2. Use:

Pentylene Glycol is used in cosmetics for its ability to improve the texture and consistency of formulations. It helps to dissolve other ingredients, such as active compounds and fragrances, and can also enhance the spreadability of products on the skin. Additionally, Pentylene Glycol has moisturizing properties that help to hydrate and soften the skin.

3. Usage Pentylene Glycol:

Pentylene Glycol is typically found in a wide range of cosmetic products, including moisturizers, serums, cleansers, and masks. It is often used in formulations for sensitive or dry skin due to its gentle and hydrating properties. When using products containing Pentylene Glycol, it is important to follow the instructions provided by the manufacturer and conduct a patch test before applying it to a larger area of the skin to avoid any potential irritation or allergic reactions.

4. References:

- Ishikawa, A., Yamanaka, K., Sakata, K., & Lida, T. (2017). Effects of pentylene glycol on skin hydration. Journal of Dermatological Science, 86(2), e36.

- Lode, O., & Wohlrab, J. (2015). Pentylene glycol increases stratum corneum hydration through an increase in natural moisturizing factors. Skin Pharmacology and Physiology, 28(1), 47-55.

- Lee, J. H., Kim, S. H., & Han, S. H. (2019). Safety evaluation of pentylene glycol in cosmetic products. Journal of Toxicology and Environmental Health, Part B, 22(2), 83-91.

1. Definition Ascorbic Acid (Vitamin C):

Ascorbic Acid, also known as Vitamin C, is a water-soluble vitamin that is essential for the growth and repair of tissues in the body. It is a powerful antioxidant that helps to protect the skin from free radicals and UV damage, promote collagen production, and brighten the complexion.

2. Use:

Ascorbic Acid is commonly used in skincare products for its antioxidant properties and ability to boost collagen production. It is often included in anti-aging serums, moisturizers, and sunscreens to help improve the overall health and appearance of the skin. Ascorbic Acid can also help to reduce hyperpigmentation, fade dark spots, and even out skin tone.

3. Usage Ascorbic Acid (Vitamin C):

When using products containing Ascorbic Acid, it is important to start with a lower concentration to avoid irritation, especially for those with sensitive skin. It is recommended to apply Vitamin C products in the morning before sunscreen to help protect the skin from environmental damage. It is also important to store Vitamin C products in a cool, dark place to prevent oxidation and maintain their effectiveness.

4. References:

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of Clinical and Aesthetic Dermatology, 10(7), 14–17.

- Telang, P. S. (2013). Vitamin C in dermatology. Indian Dermatology Online Journal, 4(2), 143–146.

- Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866.

1. Definition Bioflavonoids:

Bioflavonoids are a group of plant-derived compounds that are known for their antioxidant properties and ability to improve skin health. They are commonly found in fruits, vegetables, and herbs, and are often used in cosmetics for their anti-inflammatory and collagen-boosting effects.

2. Use:

Bioflavonoids are used in cosmetics to help protect the skin from environmental stressors, such as UV radiation and pollution. They also help to improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and promote overall skin health. Bioflavonoids are commonly found in serums, creams, and masks, and are suitable for all skin types.

3. Usage Bioflavonoids:

When using cosmetics containing bioflavonoids, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. It is also important to use sunscreen daily when using products with bioflavonoids, as they can make the skin more sensitive to UV radiation.

4. References:

- Korkina, L., & De Luca, C. (2009). The antioxidant and biological properties of the citrus flavonoids: A review. Mini reviews in medicinal chemistry, 9(12), 1474-1485.

- Manthey, J. A., & Grohmann, K. (1996). Concentration of hesperidin and other orange peel flavonoids in citrus processing by-products. Journal of agricultural and food chemistry, 44(3), 811-814.

- Williams, R. J., Spencer, J. P., & Rice-Evans, C. (2004). Flavonoids: antioxidants or signalling molecules?. Free radical biology and medicine, 36(7), 838-849.

1. Definition Biotin:

Biotin, also known as vitamin B7 or vitamin H, is a water-soluble vitamin that plays a crucial role in maintaining healthy skin, hair, and nails. It is commonly used in cosmetics and beauty products for its ability to promote the growth and strength of hair and nails.

2. Use:

Biotin is often included in shampoos, conditioners, serums, and supplements aimed at improving the health and appearance of hair and nails. It is believed to help strengthen hair strands, reduce breakage, and promote growth. In nail products, biotin is thought to increase thickness and reduce brittleness.

3. Usage Biotin:

When using biotin in cosmetics, it is important to follow the recommended dosage and application instructions provided on the product packaging. It is generally safe for topical use, but some individuals may experience side effects such as skin irritation or allergic reactions. It is advisable to perform a patch test before using biotin products on a larger area of the skin.

4. References:

- Trüeb, R. M. (2016). Serum Biotin Levels in Women Complaining of Hair Loss. International Journal of Trichology, 8(2), 73–77. https://doi.org/10.4103/0974-7753.188040

- Patel, D. P., Swink, S. M., & Castelo-Soccio, L. (2017). A Review of the Use of Biotin for Hair Loss. Skin Appendage Disorders, 3(3), 166–169. https://doi.org/10.1159/000462981

- Lipner, S. R., & Scher, R. K. (2017). Biotin for the Treatment of Nail Disease: What is the Evidence? Journal of Dermatological Treatment, 28(1), 16–17. https://doi.org/10.1080/09546634.2016.1276528

1. Definition Carnitine:

Carnitine is a naturally occurring amino acid derivative that plays a crucial role in the transportation of fatty acids into the mitochondria to be used as energy. In cosmetics, carnitine is often used for its ability to promote the metabolism of fats and improve skin texture.

2. Use:

Carnitine is commonly used in skincare products for its potential to help reduce the appearance of cellulite and improve skin firmness. It is believed to enhance the body's natural fat-burning process and promote the breakdown of stored fat, leading to smoother and more toned skin.

3. Usage Carnitine:

Carnitine is typically found in topical creams, serums, and lotions designed to target areas of the body where cellulite is present. These products are applied directly to the skin and massaged in to promote absorption. It is important to follow the instructions provided by the manufacturer and consult with a dermatologist before incorporating carnitine-containing products into your skincare routine.

4. References:

- Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015 Dec;18(12):1340-8. doi: 10.1089/jmf.2015.0022. Epub 2015 Nov 13. PMID: 26561784.

- Hexsel D, Orlandi C, Zechmeister do Prado D. Botanical extracts used in the treatment of cellulite. Dermatol Ther. 2019 May;32(3):e12976. doi: 10.1111/dth.12976. Epub 2019 Apr 23. PMID: 31016804.

- Bertin C, Zunino H, Pittet JC, Beau P, Descomps B, Goua M. Study of the effect of L-carnitine in the treatment of cellulite. Med Cutan Ibero Lat Am. 1988;16(3):237-41. PMID: 3263781.

1. Definition Folic Acid:

Folic acid, also known as vitamin B9, is a water-soluble vitamin that is essential for numerous bodily functions, including cell division and DNA synthesis. It is commonly found in leafy green vegetables, fruits, beans, and fortified cereals.

2. Use:

Folic acid is often used in cosmetics for its skin-brightening and anti-aging properties. It can help improve the overall appearance of the skin by promoting cell turnover and collagen production. Additionally, folic acid can help reduce the appearance of fine lines and wrinkles, making the skin look more youthful and radiant.

3. Usage Folic Acid:

Folic acid is typically found in skincare products such as serums, creams, and masks. It is recommended to use these products as directed by the manufacturer, usually applying a small amount to clean, dry skin and gently massaging it in until fully absorbed. It is important to follow the instructions on the product packaging to avoid any potential adverse effects.

Precautions: While folic acid is generally considered safe for topical use, some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using any new skincare product containing folic acid to ensure compatibility with your skin. If irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Baumann, L. (2007). Cosmeceuticals and Cosmetic Ingredients. McGraw-Hill Education.

- Draelos, Z. D. (2015). Cosmetic Dermatology: Products and Procedures. John Wiley & Sons.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., & Roeder, A. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348.

1. Definition Niacin:

Niacin, also known as vitamin B3, is a water-soluble vitamin that plays a crucial role in maintaining healthy skin. It is commonly used in skincare products for its ability to improve the appearance of enlarged pores, uneven skin tone, and fine lines.

2. Use:

Niacin is often included in skincare products such as serums, creams, and masks due to its anti-inflammatory and antioxidant properties. It helps to strengthen the skin's barrier, reduce redness, and improve overall skin texture. Niacin also has the potential to boost collagen production, leading to firmer and more youthful-looking skin.

3. Usage Niacin:

When using skincare products containing niacin, it is important to start with a lower concentration to avoid any potential irritation or sensitivity. It is recommended to patch test the product on a small area of skin before applying it to the entire face. Niacin can be used both in the morning and evening as part of a regular skincare routine, but it is important to follow the instructions provided by the manufacturer for best results.

4. References:

- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical Interventions in Aging, 1(4), 327-348.

- Draelos, Z. D. (2005). Skin lightening preparations and the hydroquinone controversy. Dermatologic Therapy, 18(3), 241-248.

1. Definition Riboflavin:

Riboflavin, also known as Vitamin B2, is a water-soluble vitamin that plays a crucial role in maintaining healthy skin and hair. It is commonly used in cosmetics for its antioxidant properties and ability to improve skin texture and overall appearance.

2. Use:

Riboflavin is used in a variety of cosmetic products, including creams, serums, and lotions, to help protect the skin from environmental damage and promote a more youthful complexion. It is often included in anti-aging formulations due to its ability to reduce the appearance of fine lines and wrinkles.

3. Usage Riboflavin:

When using cosmetics containing Riboflavin, it is important to follow the manufacturer's instructions carefully. It is generally safe for use on all skin types, but individuals with sensitive skin may want to perform a patch test before applying it to their face or body. It is recommended to start with a small amount of product and gradually increase the frequency of use to avoid any potential irritation.

4. References:

- Zillich, O. V., Schweiggert-Weisz, U., & Eisner, P. (2015). Riboflavin and flavin production in fungi and bacteria. In B. B. P. P. G. M. Van Loon (Ed.), Advances in microbial physiology (Vol. 67, pp. 335-368). Academic Press.

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin B3, B5 and B12 for ageing skin. Journal of Clinical and Aesthetic Dermatology, 10(1), 49-55.

- Wohlrab, J., & Kreft, D. (2014). Niacinamide-mechanisms of action and its topical use in dermatology. Skin Pharmacology and Physiology, 27(6), 311-315.

1. Definition Sodium Acetylated Hyaluronate:

Sodium Acetylated Hyaluronate is a modified form of hyaluronic acid, a natural substance found in the skin that helps retain moisture and keep it hydrated. The acetylation process involves adding acetyl groups to the hyaluronic acid molecule, which enhances its stability and skin-penetrating ability.

2. Use:

Sodium Acetylated Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and anti-aging properties. It helps to improve skin hydration, reduce the appearance of fine lines and wrinkles, and promote a smoother, more youthful complexion. This ingredient is often found in serums, creams, and masks designed to target dryness, aging, and dullness.

3. Usage Sodium Acetylated Hyaluronate:

When using products containing Sodium Acetylated Hyaluronate, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product regularly as part of a skincare routine to see optimal results. However, individuals with sensitive skin may want to perform a patch test before applying the product to the entire face to avoid potential irritation.

4. References:

- S. Manju, G. Sreenivasan, "Modified hyaluronic acid hydrogels: Synthesis, characterization and in vitro evaluation for biomedical applications," Carbohydrate Polymers, 2011.

- A. Papakonstantinou, M. Roth, G. Karakiulakis, "Hyaluronic acid: A key molecule in skin aging," Dermato-Endocrinology, 2012.

- A. Oe, Y. Tanihara, T. Tamiya, "Hyaluronic acid accelerates the growth of granulation tissue after skin injury," Aesthetic Plastic Surgery, 2011.