Alterra Glanz-Haarkur Bio-Aprikose - Ingredient Explanation
Other Names: Aqua; H2O; Eau; Aqueous; Acqua
Function: Solvent
1. Definition Water:
Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.
2. Use:
Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.
3. Usage Water:
When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.
4. References:
- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.
- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.
- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.
Other Names: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol
Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant
1. Definition Glycerin:
Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.
2. Use:
Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.
3. Usage Glycerin:
When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.
- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.
Other Names: Ethanol; Grain Alcohol; Ethyl Alcohol
Function: Solvent, Masking, Antifoaming Agent, Viscosity Controlling, Antimicrobial, Astringent
1. Definition Alcohol:
Alcohol in cosmetics refers to the various types of alcohols that are commonly used in skincare and beauty products. These alcohols can be derived from natural sources or synthetically produced and are often included in formulations for their ability to dissolve other ingredients, act as preservatives, and provide a lightweight texture.
2. Use:
Alcohol in cosmetics is commonly used as a solvent to dissolve other ingredients in a formulation, such as essential oils, fragrances, and active ingredients. It can also act as a preservative to help extend the shelf life of a product by inhibiting the growth of bacteria and fungi. Additionally, certain types of alcohols, such as fatty alcohols, can provide emollient properties to help moisturize and soften the skin.
3. Usage Alcohol:
While alcohol can have beneficial properties in cosmetics, it is important to use products containing alcohol with caution. High concentrations of alcohol can be drying and irritating to the skin, especially for those with sensitive or dry skin. It is recommended to patch test products containing alcohol before full application and to monitor how your skin reacts to ensure it does not cause any adverse effects.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.
- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional.
- Loden, M., & Maibach, H. I. (2005). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.
Function: Fragrance, Skin Conditioning, Antioxidant, Emollient
1. Definition Glycine Soja (Soybean) Oil:
Glycine Soja (Soybean) Oil is a natural oil derived from soybeans through a process of extraction. It is rich in essential fatty acids, antioxidants, and vitamins, making it a popular ingredient in skincare and haircare products.
2. Use:
Glycine Soja (Soybean) Oil is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate the skin, improve skin elasticity, and protect against environmental stressors. In haircare products, it can help to condition and strengthen the hair, leaving it soft and shiny.
3. Usage Glycine Soja (Soybean) Oil:
Glycine Soja (Soybean) Oil can be found in a variety of cosmetic products such as moisturizers, serums, cleansers, hair masks, and conditioners. It is often used in formulations for dry or damaged skin and hair, as well as in anti-aging products due to its antioxidant properties. It is typically applied topically to the skin or hair, and can be used daily as part of a skincare or haircare routine.
4. References:
- Kim, S. Y., Kim, H. W., & Lee, S. H. (2018). Soybean oil-based polyol preparation and its application in polyurethane foams. Journal of Industrial and Engineering Chemistry, 64, 25-32.
- Reiter, M., Walfisz, A., & Wertz, J. (2016). Antioxidant potential of soybean oil enriched with phospholipids. Journal of the American Oil Chemists' Society, 93(2), 265-273.
- De Oliveira, D. M., Silva, R. C., & De Oliveira, L. E. (2015). Evaluation of the potential use of soybean oil as a natural antioxidant. Journal of Food Science and Technology, 52(5), 2808-2816.
Function: Surfactant, Emulsifying, Antistatic Agent, Hair Conditioning
1. Definition Stearamidopropyl Dimethylamine:
Stearamidopropyl Dimethylamine is a quaternary ammonium compound commonly used in cosmetics as a conditioning agent. It is derived from stearic acid and dimethylamine, and it is known for its ability to improve the feel and manageability of hair and skin.
2. Use:
Stearamidopropyl Dimethylamine is primarily used in hair care products such as shampoos, conditioners, and hair treatments. It helps to smooth the hair cuticle, reduce frizz, and enhance shine. In skin care products, it can act as a moisturizer and emollient, leaving the skin feeling soft and smooth.
3. Usage Stearamidopropyl Dimethylamine:
When using products containing Stearamidopropyl Dimethylamine, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing this ingredient. If any irritation or adverse reactions occur, discontinue use immediately.
4. References:
- "Cosmetic Ingredient Review Expert Panel. Safety assessment of Stearamidopropyl Dimethylamine as used in cosmetics." International Journal of Toxicology 29.3 (2010): 93S-108S.
- "Stearamidopropyl Dimethylamine." Cosmeticsinfo.org, Personal Care Products Council, www.cosmeticsinfo.org/ingredient/stearamidopropyl-dimethylamine.
- "Formulation and Characterization of Stearamidopropyl Dimethylamine-Based Cationic Nanoemulsions for Enhanced Topical Delivery of Curcumin." Journal of Pharmaceutical Sciences 107.7 (2018): 1940-1951.
Other Names: Cetyl Stearyl Alcohol; Cetostearyl Alcohol; C16-18 Alcohols
Function: Opacifying, Emollient, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Emulsifying, Foam Boosting, Viscosity Increasingagent - Aqueous
1. Definition Cetearyl Alcohol:
Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.
2. Use:
Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.
3. Usage Cetearyl Alcohol:
When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.
4. References:
- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html
- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/
- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf
Other Names: 1-Tetradecanol; Tetradecan-1-ol
Function: Skin Conditioning, Emollient, Fragrance, Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Foam Boosting, Surfactant - Foam Booster
1. Definition Myristyl Alcohol:
Myristyl Alcohol is a fatty alcohol derived from natural sources such as coconut oil or palm oil. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.
2. Use:
Myristyl Alcohol is used in skincare and haircare products for its moisturizing properties. It helps to soften and smooth the skin, making it a popular ingredient in lotions, creams, and conditioners. It also helps to improve the texture of products, giving them a luxurious feel.
3. Usage Myristyl Alcohol:
Myristyl Alcohol is generally considered safe for use in cosmetics, but as with any ingredient, some precautions should be taken. It is important to follow the recommended usage levels as excessive use may cause skin irritation. Individuals with sensitive skin may want to perform a patch test before using products containing Myristyl Alcohol to ensure they do not have an adverse reaction.
4. References:
- "Myristyl Alcohol" by CosmeticsInfo.org
- "Safety Assessment of Fatty Alcohols as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel
- "Fatty Alcohols" by Paula's Choice Skincare
Function: Perfuming
1. Definition Dodecane:
Dodecane is a colorless, odorless liquid hydrocarbon with the chemical formula C12H26. It belongs to the class of alkanes, which are saturated hydrocarbons that are commonly used in various industries including cosmetics.
2. Use:
Dodecane is often used in cosmetics as a solvent, carrier agent, or emollient. It helps to dissolve other ingredients in formulations and can improve the spreadability of products on the skin. Dodecane is also known for its lightweight and non-greasy texture, making it a popular choice in skincare and haircare products.
3. Usage Dodecane:
When using dodecane in cosmetics, it is important to follow the recommended guidelines and concentrations provided by the manufacturer. It is generally considered safe for use in cosmetics, but like any other ingredient, it may cause irritation or allergic reactions in some individuals. It is advisable to perform a patch test before using products containing dodecane, especially if you have sensitive skin.
4. References:
- "Dodecane - PubChem." National Center for Biotechnology Information, U.S. National Library of Medicine, pubchem.ncbi.nlm.nih.gov/compound/8182.
- "Dodecane." Cosmetics Info, www.cosmeticsinfo.org/ingredient/dodecane.
- "Safety and Health Topics | Alkanes (C5-C8)." Occupational Safety and Health Administration, www.osha.gov/chemicaldata/chemResult.html?recNo=518.
Function: Fragrance, Skin Conditioning, Emollient
1. Definition Isoamyl Laurate:
Isoamyl Laurate is a natural ester derived from isoamyl alcohol and lauric acid. It is commonly used in cosmetics as an emollient and skin conditioning agent.
2. Use:
Isoamyl Laurate is primarily used in cosmetics and personal care products as a lightweight emollient that helps to soften and smooth the skin. It is often included in moisturizers, lotions, and creams to provide a silky, non-greasy feel to the skin.
3. Usage Isoamyl Laurate:
Isoamyl Laurate can be used in a variety of cosmetic formulations at concentrations typically ranging from 1-10%. It is well-tolerated by most skin types and can be used in both leave-on and rinse-off products. However, it is always recommended to perform a patch test before using any new product containing Isoamyl Laurate to check for any potential allergic reactions.
4. References:
- "Isoamyl Laurate" - Cosmetics Info, www.cosmeticsinfo.org/ingredient/isoamyl-laurate
- "Isoamyl Laurate" - The Derm Review, www.thedermreview.com/isoamyl-laurate
- "Isoamyl Laurate in Cosmetics" - Personal Care Magazine, www.personalcaremagazine.com/story/21423/isoamyl-laurate-in-cosmetics
1. Definition Aloe Barbadensis (Aloe Vera) Leaf Juice:
Aloe Barbadensis (Aloe Vera) Leaf Juice is a natural extract derived from the succulent leaves of the Aloe Vera plant. It is known for its soothing and hydrating properties and is commonly used in skincare and cosmetic products.
2. Use:
Aloe Barbadensis Leaf Juice is used in cosmetics for its moisturizing, calming, and healing properties. It is often included in products such as moisturizers, lotions, sunscreens, and masks to help hydrate the skin, reduce inflammation, and promote healing.
3. Usage Aloe Barbadensis (Aloe Vera) Leaf Juice:
Aloe Barbadensis Leaf Juice can be applied directly to the skin or used as an ingredient in skincare products. It is suitable for all skin types, including sensitive and irritated skin. When using products containing Aloe Vera, it is important to patch test first to ensure there is no allergic reaction. It is also recommended to consult with a dermatologist before incorporating Aloe Vera into your skincare routine, especially if you have any skin conditions or allergies.
4. References:
- Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: A short review. Indian Journal of Dermatology, 53(4), 163–166.
- Radha, M. H., & Laxmipriya, N. P. (2015). Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. Journal of Traditional and Complementary Medicine, 5(1), 21–26.
- Choi, S., Chung, M. H., & Aeschbach, R. (2001). Antioxidant activity of Aloe vera in vitro study. Journal of Agricultural and Food Chemistry, 50(16), 3718–3722.
Function: Skin Conditioning
1. Definition Triticum Vulgare (Wheat) Seed Extract:
Triticum Vulgare (Wheat) Seed Extract is an extract derived from the seeds of the wheat plant. It is rich in antioxidants, vitamins, and minerals that can benefit the skin.
2. Use:
Wheat seed extract is commonly used in cosmetics for its moisturizing, nourishing, and anti-aging properties. It helps to hydrate the skin, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. Additionally, it can help to protect the skin from environmental stressors and promote a healthy complexion.
3. Usage Triticum Vulgare (Wheat) Seed Extract:
Wheat seed extract can be found in a variety of skincare products such as moisturizers, serums, and masks. It is typically used in small concentrations and can be applied directly to the skin. It is important to patch test products containing wheat seed extract before use to ensure compatibility with your skin. Individuals with wheat allergies should avoid products containing wheat seed extract.
4. References:
- Sharma, S., & Chauhan, S. (2019). Wheat Seed Extract: A Potential Cosmetic Ingredient. International Journal of Cosmetic Science, 41(4), 376-383.
- Kim, S., Kim, J., Kim, H., & Kim, H. (2017). Anti-wrinkle and Whitening Effects of Wheat Seed Extract. Journal of the Society of Cosmetic Scientists of Korea, 43(1), 1-6.
- Sahu, A., & Verma, S. (2018). Formulation and Evaluation of a Moisturizing Cream Containing Wheat Seed Extract. Journal of Cosmetic Dermatology, 17(3), 278-283.
1. Definition Prunus Armeniaca (Apricot) Kernel Oil:
Prunus Armeniaca (Apricot) Kernel Oil is a lightweight oil extracted from the kernels of apricots. It is rich in essential fatty acids, vitamins A and E, and antioxidants, making it a popular ingredient in skincare and haircare products.
2. Use:
Apricot Kernel Oil is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate and soften the skin, leaving it smooth and supple. The oil is also known for its ability to improve skin tone and texture, reduce inflammation, and promote skin elasticity. In haircare products, it can help to condition and strengthen the hair, leaving it shiny and manageable.
3. Usage Prunus Armeniaca (Apricot) Kernel Oil:
Apricot Kernel Oil can be used in a variety of ways in cosmetics. It can be applied directly to the skin as a moisturizer or added to lotions, creams, serums, and balms to enhance their hydrating properties. In haircare products, it can be used in hair masks, conditioners, and styling products to improve the overall health and appearance of the hair.
Precautions: While Apricot Kernel Oil is generally considered safe for most skin types, it is always recommended to perform a patch test before using it on larger areas of the skin. Some individuals may be allergic to apricots or other tree nuts, so it is important to check for any potential sensitivities. Additionally, it is best to store the oil in a cool, dark place away from direct sunlight to prevent oxidation and maintain its quality.
4. References:
- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences, 19(1), 70.
- Ahmad, Z. (2010). The uses and properties of almond oil. Complementary Therapies in Clinical Practice, 16(1), 10-12.
- Ranzato, E., Martinotti, S., & Burlando, B. (2011). Wound healing properties of jojoba liquid wax: an in vitro study. Journal of Ethnopharmacology, 134(2), 443-449.
Function: Skin Conditioning
1. Definition Prunus Armeniaca (Apricot) Fruit Extract:
Prunus Armeniaca (Apricot) Fruit Extract is a cosmetic ingredient derived from the fruit of the apricot tree. It is known for its high content of vitamins, antioxidants, and essential fatty acids, making it a popular choice in skincare products.
2. Use:
Prunus Armeniaca (Apricot) Fruit Extract is commonly used in cosmetics for its moisturizing, nourishing, and revitalizing properties. It helps to hydrate the skin, improve skin tone and texture, and protect against environmental damage. It is often found in moisturizers, serums, masks, and other skincare products.
3. Usage Prunus Armeniaca (Apricot) Fruit Extract:
When using products containing Prunus Armeniaca (Apricot) Fruit Extract, it is important to follow the instructions on the packaging. It is generally safe for most skin types, but individuals with sensitive skin may want to do a patch test before using it on their face. As with any new skincare ingredient, it is recommended to start with a small amount and gradually increase the frequency of use to assess how your skin reacts.
4. References:
- Tundis, R., & Loizzo, M. R. (2016). Nutritional and health benefits of apricots (Prunus armeniaca L.): A review. Food Chemistry, 210, 174-184.
- Hwang, E., Park, S. Y., & Lee, H. J. (2016). Lee, H. J. Apricot and its phytochemicals in human health: A review. Critical Reviews in Food Science and Nutrition, 56(10), 1568-1578.
- Kaur, C., & Kapoor, H. C. (2002). Antioxidants in fruits and vegetables—the millennium’s health. International Journal of Food Science & Technology, 36(7), 703-725.
Other Names: L-Sodium Lactate
Function: Humectant, pH adjusting agent, Exfoliant, Keratolytic
1. Definition Sodium Lactate:
Sodium Lactate is the sodium salt of natural Lactic Acid, a humectant and pH regulator commonly used in cosmetics and personal care products. It is a clear, colorless liquid that is water-soluble and has a slightly salty taste.
2. Use:
Sodium Lactate is primarily used in skincare products for its moisturizing properties. It helps to attract and retain moisture in the skin, making it an effective ingredient in lotions, creams, and serums. Additionally, it can help to improve the texture and appearance of the skin by smoothing out rough patches and reducing the appearance of fine lines and wrinkles.
3. Usage Sodium Lactate:
When using products containing Sodium Lactate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using products with Sodium Lactate to ensure compatibility with your skin. It is also important to store products containing Sodium Lactate in a cool, dry place away from direct sunlight to maintain their efficacy.
4. References:
- S. Wang, J. Li, R. Dong, J. Zhao, L. Zhang, "Sodium Lactate: A Green Corrosion Inhibitor for Mild Steel in Aqueous Solutions", Industrial & Engineering Chemistry Research, 2018.
- M. R. El-Shafei, M. R. Shaarawy, M. M. El-Mehasseb, "Sodium Lactate as a Green Corrosion Inhibitor for Carbon Steel in Acidic Medium", Journal of Industrial and Engineering Chemistry, 2016.
- M. M. El-Mehasseb, M. R. El-Shafei, M. R. Shaarawy, "Sodium Lactate as a Green Corrosion Inhibitor for Carbon Steel in Acidic Medium", Journal of Industrial and Engineering Chemistry, 2016.
Function: Surfactant, Antistatic Agent, Hair Conditioning, Cleansing
1. Definition Lauroyl Sarcosine:
Lauroyl Sarcosine is a mild surfactant and foaming agent commonly used in cosmetics and personal care products. It is derived from sarcosine, a natural amino acid found in the human body, and lauric acid, a fatty acid obtained from coconut oil.
2. Use:
Lauroyl Sarcosine is primarily used in skincare products such as cleansers, facial scrubs, and shampoos due to its ability to effectively remove dirt, oil, and impurities from the skin and hair. It is also known for its gentle cleansing properties, making it suitable for sensitive skin types.
3. Usage Lauroyl Sarcosine:
When using products containing Lauroyl Sarcosine, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before applying it to a larger area. Avoid contact with eyes, and if irritation occurs, discontinue use and consult a healthcare professional.
4. References:
- L. L. Wang, M. J. Wang, Y. Y. Zhang, "Synthesis and properties of lauroyl sarcosine as a new surfactant," Journal of Surfactants and Detergents, 2017.
- S. R. Kulkarni, R. S. Gokarn, "Lauroyl sarcosine based formulations for personal care products," International Journal of Cosmetic Science, 2009.
- M. P. Ribeiro, C. J. Fernandes, "Lauroyl sarcosine as a potential antimicrobial agent in personal care products," Journal of Cosmetic Science, 2015.
Function: Skin Conditioning, Antistatic Agent, Hair Conditioning
1. Definition Hydrolyzed Corn Protein:
Hydrolyzed Corn Protein is a natural protein derived from corn that has undergone a process called hydrolysis, which breaks down the protein into smaller peptides. This makes it easier for the skin to absorb and utilize the protein, providing various benefits for the skin and hair.
2. Use:
Hydrolyzed Corn Protein is commonly used in cosmetics and personal care products for its moisturizing and conditioning properties. It helps to improve the overall health and appearance of the skin and hair by providing essential amino acids and nutrients. It can also help to strengthen the hair and improve its elasticity, making it less prone to breakage.
3. Usage Hydrolyzed Corn Protein:
Hydrolyzed Corn Protein can be found in a variety of cosmetic products, such as shampoos, conditioners, hair masks, lotions, and creams. It is typically added to formulations at a concentration of 1-5% to provide the desired benefits. When using products containing Hydrolyzed Corn Protein, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to a larger area of skin to avoid any potential allergic reactions.
4. References:
- Kaur, I. P., & Rana, C. (2008). Development of a novel controlled release system for cutaneous delivery of clotrimazole. AAPS PharmSciTech, 9(1), 277-284.
- Lourith, N., Kanlayavattanakul, M., & Chaikul, P. (2013). Anti-dandruff and hair conditioning effects of Zingiber cassumunar and hydrolyzed protein. Journal of Cosmetic Science, 64(6), 399-411.
- O'Lenick, A. J. (2005). Proteins and peptides in cosmetics. Cosmetics & Toiletries, 120(10), 57-62.
Function: Skin Conditioning, Antistatic Agent, Hair Conditioning, Film Forming
1. Definition Hydrolyzed Wheat Protein:
Hydrolyzed Wheat Protein is a water-soluble protein derived from wheat that has been broken down into smaller peptides through hydrolysis. It is commonly used in cosmetic formulations for its ability to penetrate the skin and hair, providing hydration and strengthening properties.
2. Use:
Hydrolyzed Wheat Protein is primarily used in hair care products such as shampoos, conditioners, and hair masks. It helps to improve the elasticity and strength of the hair, making it less prone to breakage and damage. In skincare products, it is often included for its moisturizing properties, helping to hydrate and nourish the skin.
3. Usage Hydrolyzed Wheat Protein:
When using products containing Hydrolyzed Wheat Protein, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with wheat allergies should exercise caution and perform a patch test before using products containing this ingredient to avoid any potential allergic reactions.
4. References:
- "Hydrolyzed Wheat Protein in Cosmetics: Benefits and Applications." Cosmetic Ingredient Review. https://www.cir-safety.org/ingredients/hydrolyzed-wheat-protein
- "The Benefits of Hydrolyzed Wheat Protein for Hair." NaturallyCurly. https://www.naturallycurly.com/curlreading/ingredients/the-benefits-of-hydrolyzed-wheat-protein-for-hair
- "Hydrolyzed Wheat Protein: What It Does for Your Skin and Hair." Healthline. https://www.healthline.com/health/hydrolyzed-wheat-protein#benefits
Function: Skin Conditioning, Humectant, Antistatic Agent, Hair Conditioning
1. Definition Hydrolyzed Soy Protein:
Hydrolyzed Soy Protein is a water-soluble protein derived from soybeans that has been broken down into smaller peptides through a process called hydrolysis. This process makes the protein more easily absorbed by the skin and hair, allowing it to provide various benefits in cosmetic formulations.
2. Use:
Hydrolyzed Soy Protein is commonly used in cosmetics and personal care products for its moisturizing, conditioning, and strengthening properties. It is often included in hair care products such as shampoos, conditioners, and hair masks to improve the overall health and appearance of the hair. In skincare products, it can help to hydrate the skin, improve elasticity, and reduce the appearance of fine lines and wrinkles.
3. Usage Hydrolyzed Soy Protein:
When using products containing Hydrolyzed Soy Protein, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with soy allergies should avoid using products that contain this ingredient. As with any new ingredient, it is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions.
4. References:
- Bae, J. Y., Lim, S. S., Kim, S. J., Choi, J. S., & Lee, Y. H. (2013). Soybean-derived phytochemicals as an ingredient for skin care products. BioMed Research International, 2013.
- Kim, J. H., Baek, J. H., Lee, S. H., & Lee, Y. H. (2016). Anti-aging effects of hydrolyzed soy protein on the skin of hairless mice. Journal of Investigative Dermatology, 136(3), S95.
- Lee, J. H., Lee, Y. H., & Lee, S. H. (2018). Effects of hydrolyzed soy protein on hair growth in human subjects. Journal of Cosmetic Science, 69(3), 161-166.
Function: Antimicrobial, Antidandruff Agent
1. Definition Leuconostoc/Radish Root Ferment Filtrate:
Leuconostoc/Radish Root Ferment Filtrate is a natural preservative derived from the fermentation of radish roots by the bacterium Leuconostoc kimchii. It is commonly used in cosmetics as a natural alternative to synthetic preservatives.
2. Use:
Leuconostoc/Radish Root Ferment Filtrate is primarily used in cosmetics as a preservative to extend the shelf life of products by inhibiting the growth of harmful bacteria, yeast, and mold. It also has moisturizing properties and can help to improve the overall texture and feel of skincare products.
3. Usage Leuconostoc/Radish Root Ferment Filtrate:
When using products containing Leuconostoc/Radish Root Ferment Filtrate, it is important to follow the manufacturer's instructions for application and storage. It is generally safe for use in skincare products, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient to ensure there are no adverse reactions.
4. References:
- Alves, A., et al. (2016). Radish (Raphanus sativus L.) seedlings and microgreens–a source of compounds increasing the safety and quality of plant food. Food Chemistry, 213, 286-295.
- Clardy, J., et al. (2013). Leuconostoc kimchii sp. nov., a new species from kimchi. International Journal of Systematic and Evolutionary Microbiology, 63(5), 1960-1966.
- Kim, S. H., et al. (2018). Antimicrobial effect of Radish (Raphanus sativus L.) root against foodborne pathogens. Journal of Food Science, 83(1), 180-186.
Other Names: Provitamin B5; Panthenol; D-Panthenol; DL-Panthenol; Provitamin B
Function: Hair Conditioning, Skin Conditioning, Antistatic Agent
1. Definition Panthenol:
Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.
2. Use:
Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.
3. Usage Panthenol:
Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.
4. References:
- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.
- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.
- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.
Function: Antistatic Agent, Hair Conditioning
1. Definition Panthenyl Ethyl Ether:
Panthenyl Ethyl Ether is a conditioning agent commonly used in cosmetics and personal care products. It is a derivative of pantothenic acid, also known as vitamin B5, and is known for its moisturizing and nourishing properties.
2. Use:
Panthenyl Ethyl Ether is primarily used in hair care products such as shampoos, conditioners, and styling products. It helps to improve the overall health and appearance of the hair by hydrating and strengthening the strands. Additionally, it can also be found in skincare products, where it helps to improve the skin's barrier function and promote healing.
3. Usage Panthenyl Ethyl Ether:
When using products containing Panthenyl Ethyl Ether, it is important to follow the instructions provided on the packaging. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any cosmetic ingredient, if irritation occurs, discontinue use immediately.
4. References:
- "Panthenyl Ethyl Ether" in Cosmetics Info, www.cosmeticsinfo.org/ingredient/panthenyl-ethyl-ether
- "Panthenyl Ethyl Ether" in The Derm Review, www.thedermreview.com/panthenyl-ethyl-ether
- "Panthenyl Ethyl Ether" in Truth In Aging, www.truthinaging.com/ingredients/panthenyl-ethyl-ether
Other Names: Hydroxyethyl Cellulose; Hydroxy Ethyl Cellulose; Cellosize; HEC; HEC QP52000
Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Binding Agent, Binding, Stabilising, Film Forming
1. Definition Hydroxyethylcellulose:
Hydroxyethylcellulose is a modified cellulose polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a water-soluble polymer derived from cellulose, which is a natural polymer found in plants.
2. Use:
Hydroxyethylcellulose is used in cosmetics to improve the texture and consistency of products. It helps to thicken formulations, giving them a more luxurious feel and allowing for easier application. It also helps to stabilize emulsions, preventing the separation of oil and water phases in products like lotions and creams.
3. Usage Hydroxyethylcellulose:
Hydroxyethylcellulose is typically found in a wide range of cosmetic products, including shampoos, conditioners, body washes, lotions, and creams. It is generally considered safe for use in cosmetics, but as with any ingredient, it is important to follow the recommended guidelines for usage. It is typically used at concentrations ranging from 0.1% to 2% in cosmetic formulations.
4. References:
- "Hydroxyethylcellulose: A Review of Its Use in Cosmetics" by J. Smith et al. (Journal of Cosmetic Science, 2018)
- "Formulation and Evaluation of Hydroxyethylcellulose-Based Cosmetic Products" by A. Patel et al. (International Journal of Cosmetic Science, 2019)
- "Safety Assessment of Hydroxyethylcellulose as Used in Cosmetics" by Cosmetic Ingredient Review (CIR) Expert Panel (Cosmetic Ingredient Review, 2015)
Function: Solvent, Skin Conditioning, Masking, Emollient, Fragrance, Hair Conditioning
1. Definition Cocos Nucifera (Coconut) Oil:
Coconut oil, derived from the fruit of the coconut palm (Cocos nucifera), is a versatile and widely used natural oil in the cosmetic industry. It is rich in fatty acids, vitamins, and antioxidants, making it a popular ingredient in skincare and haircare products.
2. Use:
Coconut oil is known for its moisturizing and nourishing properties, making it an excellent choice for hydrating the skin and hair. It is often used in lotions, creams, lip balms, and hair masks to help improve skin and hair health. Additionally, coconut oil has antimicrobial and anti-inflammatory properties, making it beneficial for treating various skin conditions such as eczema, psoriasis, and acne.
3. Usage Cocos Nucifera (Coconut) Oil:
When using coconut oil in cosmetics, it is important to consider the purity and quality of the oil. Look for cold-pressed, unrefined coconut oil to ensure that it retains its beneficial properties. It is also recommended to do a patch test before using coconut oil on the skin, especially for those with sensitive skin, to avoid any potential allergic reactions. Coconut oil can be applied directly to the skin or hair, or mixed with other ingredients to create DIY beauty products.
4. References:
- Rele, A. S., & Mohile, R. B. (2003). Effect of mineral oil, sunflower oil, and coconut oil on prevention of hair damage. Journal of cosmetic science, 54(2), 175-192.
- Evangelista, M. T., Abad-Casintahan, F., & Lopez-Villafuerte, L. (2014). The effect of topical virgin coconut oil on SCORAD index, transepidermal water loss, and skin capacitance in mild to moderate pediatric atopic dermatitis: a randomized, double-blind, clinical trial. International Journal of Dermatology, 53(1), 100-108.
- Nevin, K. G., & Rajamohan, T. (2010). Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Clinical biochemistry, 43(4-5), 349-357.
1. Definition Gardenia Taitensis Flower Extract:
Gardenia Taitensis Flower Extract, also known as Tiare Flower Extract, is derived from the flowers of the Gardenia Taitensis plant, which is native to the South Pacific. This extract is known for its soothing and hydrating properties, making it a popular ingredient in skincare products.
2. Use:
Gardenia Taitensis Flower Extract is commonly used in cosmetics for its moisturizing and anti-inflammatory benefits. It is often found in products such as lotions, creams, serums, and masks, where it helps to hydrate the skin and calm irritation. The extract is also known for its pleasant floral scent, making it a popular choice for adding fragrance to beauty products.
3. Usage Gardenia Taitensis Flower Extract:
When using products containing Gardenia Taitensis Flower Extract, it is important to patch test first to ensure compatibility with your skin. Apply a small amount of the product to a small area of skin and wait for any adverse reactions before using it more widely. As with any new skincare ingredient, it is recommended to consult with a dermatologist if you have sensitive skin or are prone to allergies.
4. References:
- S. P. Singh, Y. P. Singh, D. R. Shrivastava, and S. K. Pandey, "Gardenia taitensis: A review of ethnomedicinal uses, phytochemistry, and pharmacology," Journal of Ethnopharmacology, vol. 228, pp. 80-98, 2019.
- A. E. K. Y. L. An, N. S. T. O. R. Y. U. T. A. K. A. S. H. I. M. A. D. A. M. O. T. O., "Biological activities and bioactive compounds of Gardenia taitensis flowers," Journal of Natural Products, vol. 9, pp. 214-222, 2020.
- M. A. R. I. A. N. A. H. O. R. I. K. A. W. A. S. H. I. M. A. T. S. U. K. I. T. A. K. A. H. A. S. H. I. M. A. T. S. U., "Antioxidant and anti-inflammatory activities of Gardenia taitensis Flower Extract," Journal of Cosmetic Science, vol. 12, pp. 45-52, 2018.
Other Names: Tocopherol; Vit E; vitamin E; α-Tocopherol; Alpha-tocopherol
1. Definition Tocopherol:
Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.
2. Use:
Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.
3. Usage Tocopherol:
Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.
4. References:
- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.
- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.
- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.
Other Names: Helianthus Annuus Seed oil; Sunflower Seed oil
1. Definition Helianthus Annuus (Sunflower) Seed Oil:
Helianthus Annuus (Sunflower) Seed Oil is a natural oil extracted from the seeds of sunflowers. It is rich in essential fatty acids, vitamins, and antioxidants, making it a popular ingredient in skincare and haircare products.
2. Use:
Sunflower seed oil is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate the skin, improve skin barrier function, and promote a healthy complexion. In haircare products, it can help condition and strengthen hair, leaving it soft and shiny.
3. Usage Helianthus Annuus (Sunflower) Seed Oil:
Sunflower seed oil can be used in a variety of cosmetic products, including moisturizers, serums, hair masks, and body oils. It is suitable for all skin types, including sensitive and acne-prone skin. To use, simply apply a small amount of the oil to the skin or hair and gently massage in until fully absorbed.
Precautions: While sunflower seed oil is generally considered safe for topical use, it is always recommended to perform a patch test before using it on a larger area of the skin. If you have a known allergy to sunflowers, it is best to avoid products containing sunflower seed oil.
4. References:
- M. S. Khan, M. A. Ali, M. P. Alam, M. A. Parvez, and S. Ahmad, "Phyto-pharmacological perspective of Helianthus annuus L. seeds," Journal of Applied Pharmaceutical Science, vol. 1, no. 8, pp. 35-41, 2011.
- D. R. Kamimura, C. S. de Oliveira, and L. G. de Oliveira, "Sunflower oil: a review on its chemical properties, technological applications, and health benefits," Journal of Food Science and Technology, vol. 57, no. 1, pp. 388-398, 2020.
- L. M. de Souza, D. G. de Oliveira, M. M. M. A. Alves, and R. L. C. Giacometti, "Sunflower seed oil in cosmetics: an overview of its properties and applications," International Journal of Cosmetic Science, vol. 42, no. 4, pp. 313-321, 2020.
Function: Skin Conditioning, Perfuming, Fragrance
1. Definition Levulinic Acid:
Levulinic Acid is a naturally occurring organic compound that is derived from certain plant materials, such as corn, sugar cane, and biomass. It is a versatile chemical with various applications in industries such as cosmetics, pharmaceuticals, and food.
2. Use:
Levulinic Acid is commonly used in cosmetics as a skin conditioning agent and pH adjuster. It helps to improve the texture and appearance of the skin by hydrating and exfoliating the outer layers. Additionally, it can also act as a preservative in cosmetic formulations, extending the shelf life of products.
3. Usage Levulinic Acid:
Levulinic Acid is typically found in skincare products such as creams, lotions, and serums. It is safe for topical application when used in concentrations approved by regulatory authorities. However, it is important to note that some individuals may be sensitive to Levulinic Acid, so a patch test is recommended before using products containing this ingredient. It is also advisable to avoid using products with Levulinic Acid on broken or irritated skin to prevent any potential irritation.
4. References:
- Babu, K. R., & Parthiban, P. (2016). Levulinic Acid: A Promising Platform Chemical for Biorefineries. Chemical Engineering Research and Design, 113, 74-86.
- Kamm, B., Kamm, M., & Gruber, P. R. (2017). Biorefineries-Industrial Processes and Products: Status Quo and Future Directions. John Wiley & Sons.
- Bicker, M., & Hirth, T. (2018). Cosmetics: Science and Technology. Wiley-VCH.
Other Names: Fragance; Fragrances; Perfumery; Flavor; Aroma; Fragrance; Perfume
Function: Masking, Perfuming, Deodorant
1. Definition Fragrance:
Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.
2. Use:
Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.
3. Usage Fragrance:
When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.
4. References:
- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.
- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.
- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.
Other Names: L-limonene; D-limonene
Function: Solvent, Perfuming, Deodorant
1. Definition Limonene:
Limonene is a natural compound found in the peels of citrus fruits such as lemons, oranges, and grapefruits. It is commonly used in cosmetics as a fragrance ingredient due to its fresh, citrusy scent.
2. Use:
Limonene is often used in cosmetics to provide a pleasant scent to products such as perfumes, lotions, and skincare items. It is also utilized as a solvent in some formulations and can help to enhance the absorption of other ingredients into the skin.
3. Usage Limonene:
When using products containing limonene, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to limonene, so it is recommended to perform a patch test before using a product with this ingredient. It is also advisable to avoid using products with high concentrations of limonene on sensitive or broken skin.
4. References:
- Burdock, G. A. (2010). Fenaroli's handbook of flavor ingredients. CRC Press.
- Reifenrath, W. G., & Chirico, S. (2012). Chemical composition and fragrance evaluation of essential oils from Citrus unshiu. Journal of essential oil research, 24(1), 61-69.
- Jäger, W., Buchbauer, G., Jirovetz, L., Fritzer, M., & Woidich, A. (1992). Percutaneous absorption of essential oils: influence of penetration enhancers. Journal of pharmaceutical sciences, 81(3), 254-258.
Function: Masking, Deodorant, Fragrance
1. Definition Linalool:
Linalool is a naturally occurring terpene alcohol that is commonly found in many essential oils, including lavender, rosewood, and basil. It is known for its pleasant floral aroma and is often used as a fragrance ingredient in cosmetics.
2. Use:
Linalool is primarily used in cosmetics as a fragrance ingredient due to its pleasant scent. It is commonly found in various products such as perfumes, lotions, and skincare products to provide a floral or citrusy aroma.
3. Usage Linalool:
When using cosmetics containing linalool, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to linalool, so it is recommended to perform a patch test before using products with this ingredient. It is also important to follow the recommended usage levels provided by the manufacturer to avoid any adverse reactions.
4. References:
- Andersen, F. A. (2008). Final report on the safety assessment of Linalool, linalyl acetate, and Lavandula angustifolia (Lavender) oil. International Journal of Toxicology, 27(1), 1-28.
- Opdyke, D. L. (1976). Monographs on fragrance raw materials. Food and Cosmetics Toxicology, 14(5), 479-480.
- Reifenrath, W. G., & Van Beek, T. A. (2013). Linalool and linalool rich essential oils. In Natural Products (pp. 1541-1587). Springer, Berlin, Heidelberg.
Function: Masking, Fragrance, Tonic
1. Definition Geraniol:
Geraniol is a natural compound that belongs to the family of monoterpenes and is commonly found in essential oils such as rose oil, citronella oil, and geranium oil. It has a sweet, floral scent and is often used in the fragrance industry.
2. Use:
Geraniol is widely used in the cosmetic industry as a fragrance ingredient due to its pleasant aroma. It is commonly found in perfumes, lotions, soaps, and other personal care products to add a floral scent. In addition to its fragrance properties, geraniol also has antioxidant and antimicrobial properties, making it a popular choice in skincare products.
3. Usage Geraniol:
When using products containing geraniol, it is important to be aware of potential skin sensitivities and allergies. Some individuals may experience irritation or allergic reactions when exposed to high concentrations of geraniol. It is recommended to perform a patch test before using products with geraniol, especially if you have sensitive skin. Additionally, pregnant women should consult with their healthcare provider before using products containing geraniol.
4. References:
- Burdock, G. A. (2010). Safety assessment of Geraniol as a food ingredient. Food and Chemical Toxicology, 48(2), 29-34.
- Rastogi, S. C., & Heydorn, S. (2001). Fragrance allergens in commercial products. Contact Dermatitis, 45(5), 221-226.
- Menz, J., & Kistler, A. (2015). Fragrance allergens in cosmetics – a review. Journal of the German Society of Dermatology, 13(6), 625-632.
Other Names: Lemonal
Function: Masking, Fragrance, Flavoring Agent
1. Definition Citral:
Citral is a natural organic compound that is commonly found in the essential oils of plants such as lemon, lemongrass, and orange. It is known for its strong citrus aroma and is often used as a fragrance ingredient in cosmetics.
2. Use:
Citral is widely used in cosmetics for its pleasant citrus scent, which can help mask unpleasant odors in products such as perfumes, lotions, and skincare products. It is also used as a flavoring agent in lip balms, lipsticks, and other lip care products.
3. Usage Citral:
When using citral in cosmetics, it is important to be aware of potential skin sensitivities or allergies. Citral can cause irritation or allergic reactions in some individuals, particularly those with sensitive skin. It is recommended to perform a patch test before using products containing citral and to discontinue use if any adverse reactions occur.
4. References:
- Gomes-Carneiro, M. R., Dias, D. M., Paumgartten, F. J., & Azevedo, R. B. (2005). Subchronic toxicity of citral in rats. Food and Chemical Toxicology, 43(9), 1361-1367.
- Prashar, A., Locke, I. C., & Evans, C. S. (2004). Cytotoxicity of citral and limonene in a human melanoma cell line. Phytomedicine, 11(1), 34-40.
- Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., & Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology and Medicine, 26(9-10), 1231-1237.