DR. IMMUN 25-herb Hair Nourishing Oil

1. Definition Melissa Officinalis Leaf Extract:

2. Use:

3. Usage Melissa Officinalis Leaf Extract:

4. References:

- Naveed, M., Hejazi, V., Abbas, M., Kamboh, A. A., Khan, G. J., Shumzaid, M., ... & Khan, S. (2018). Chlorogenic acid (CGA): A pharmacological review and call for further research. Biomedicine & Pharmacotherapy, 97, 67-74.

- Dastmalchi, K., Dorman, H. D., Laakso, I., Hiltunen, R., & Tikkanen, M. J. (2008). Chemical composition and in vitro antioxidative activity of a lemon balm (Melissa officinalis L.) extract. LWT-Food Science and Technology, 41(3), 391-400.

- Shakeri, A., Sahebkar, A., Javadi, B., & Melissa officinalis, L. (2016). A review of its traditional uses, phytochemistry, and pharmacology. Journal of Ethnopharmacology, 188, 204-228.

1. Definition Aloe Barbadensis Extract:

2. Use:

3. Usage Aloe Barbadensis Extract:

4. References:

- Barel, A., Calomme, M., Timchenko, A., De Paepe, K., Demeester, N., Rogiers, V., ... & Clarys, P. (2001). Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails, and hair in women with photodamaged skin. Archives of dermatological research, 293(10), 509-516.

- Surjushe, A., Vasani, R., & Saple, D. G. (2008). Aloe vera: a short review. Indian journal of dermatology, 53(4), 163.

- Radha, M. H., & Laxmipriya, N. P. (2015). Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. Journal of traditional and complementary medicine, 5(1), 21-26.

1. Definition Juniperus Communis Fruit Extract:

2. Use:

3. Usage Juniperus Communis Fruit Extract:

4. References:

- Kwon, Y. S., Choi, W. G., Kim, W. J., Kim, W. K., Kim, M. J., Kang, W. H., ... & Kim, D. W. (2014). Anti-inflammatory effects of Juniperus chinensis extract on the delayed-type hypersensitivity in mice. Journal of Ethnopharmacology, 151(1), 113-121.

- Vlaisavljevic, S., Zlatkovic, B., Ristic, M., & Nikolic, V. (2016). Antimicrobial activity of Juniperus communis L. essential oil against uropathogenic bacteria. Journal of Applied Pharmaceutical Science, 6(11), 181-184.

- Reuter, J., Huyke, C., Casetti, F., Theek, C., Frank, U., Augustin, M., ... & Schempp, C. (2008). Anti-inflammatory potential of a lipolotion containing coriander oil in the ultraviolet erythema test. Journal of Dermal Science, 54(2), 98-105.

1. Definition Agrimonia Eupatoria Extract:

2. Use:

3. Usage Agrimonia Eupatoria Extract:

4. References:

- EMA/HMPC/621080/2013. Committee on Herbal Medicinal Products (HMPC). European Medicines Agency. Assessment report on Agrimonia eupatoria L., herba. 2014.

- Park, S. J., et al. "Anti-inflammatory effects of Agrimonia eupatoria L. ethanol extract on dextran sulfate sodium-induced acute colitis in mice by suppression of NF-κB and STAT3 activation." Journal of Ethnopharmacology 221 (2018): 56-64.

- Kim, S. R., et al. "Agrimonia eupatoria protects against chronic ethanol-induced liver injury in rats." Food and Chemical Toxicology 50.1 (2012): 344-351.

1. Definition Hypericum Perforatum Extract:

2. Use:

3. Usage Hypericum Perforatum Extract:

4. References:

- Schempp, C. M., & Windeck, T. (2003). Topical treatment of atopic dermatitis with St. John's Wort cream—a randomized, placebo controlled, double blind half-side comparison. Phytomedicine, 10(1), 31-37.

- Greeson, J. M., Sanford, B., Monti, D. A., & St. John's Wort Research Group. (2001). St. John's Wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature. Psychopharmacology, 153(4), 402-414.

- Müller, W. E., Rolli, M., Schäfer, C., Hafner, U., & Scavone, C. (2001). Hypericum extract: pharmacological properties and effects on the central nervous system. Neuropsychobiology, 36(1), 45-48.

1. Definition Salvia Officinalis (Sage) Extract:

2. Use:

3. Usage Salvia Officinalis (Sage) Extract:

4. References:

- Sánchez-Muniz, F. J., & Macho-González, A. (2017). Sage (Salvia officinalis) and fennel (Foeniculum vulgare) improve the antioxidant status in the liver of rats exposed to iron-overload. Food & Function, 8(2), 702-709.

- Tundis, R., Loizzo, M. R., Menichini, F., Statti, G. A., & Menichini, F. (2008). Biological and pharmacological activities of iridoids: recent developments. Mini reviews in medicinal chemistry, 8(4), 399-420.

- Baricevic, D., & Sosa, S. (2003). Comparative study of isotype content of sage (Salvia officinalis L.) essential oils. Journal of Essential Oil Research, 15(1), 59-62.

1. Definition Urtica Dioica (Nettle) Root Extract:

2. Use:

3. Usage Urtica Dioica (Nettle) Root Extract:

4. References:

- D. Kregiel, et al. "Nettle (Urtica dioica L.) as a source of antioxidant and anti-aging phytochemicals for cosmetic applications." International Journal of Cosmetic Science, 2020.

- M. Sharifi-Rad, et al. "Urtica spp.: Ordinary plants with extraordinary properties." Molecules, 2018.

- N. Kavalali, et al. "The effects of Urtica dioica L. (Urticaceae) extract on the hair growth promotion of the mouse." Phytotherapy Research, 2003.

1. Definition Urtica Dioica (Nettle) Leaf Extract:

2. Use:

3. Usage Urtica Dioica (Nettle) Leaf Extract:

4. References:

- Chrubasik, S., & Roufogalis, B. D. (2007). Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain. Phytotherapy Research, 21(7), 675-683.

- Kregiel, D., Pawlikowska, E., & Antolak, H. (2018). Urtica spp.: Ordinary plants with extraordinary properties. Molecules, 23(7), 1664.

- Stinging nettle. (n.d.). Retrieved from https://www.webmd.com/vitamins/ai/ingredientmono-664/stinging-nettle

1. Definition Calendula Officinalis Extract:

2. Use:

3. Usage Calendula Officinalis Extract:

4. References:

- Srivastava, J. K., Shankar, E., & Gupta, S. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular medicine reports, 3(6), 895-901.

- Della Loggia, R., Tubaro, A., Sosa, S., Becker, H., & Saar, S. (1994). The role of triterpenoids in the topical anti-inflammatory activity of Calendula officinalis flowers. Planta medica, 60(06), 516-520.

- Preethi, K. C., & Kuttan, R. (2009). Hepato and reno protective action of Calendula officinalis L. flower extract. Indian journal of experimental biology, 47(3), 163-168.

1. Definition Betula Alba Leaf Extract:

2. Use:

3. Usage Betula Alba Leaf Extract:

4. References:

- Jeong, Seung-Hee, et al. "Anti-inflammatory activity of Betula platyphylla var. japonica in vivo and in vitro." Journal of Ethnopharmacology 112.3 (2007): 516-519.

- Kim, Seung-Hyung, et al. "Anti-inflammatory effects of Betula platyphylla var. japonica in a model of allergic inflammation." BMC Complementary and Alternative Medicine 12.1 (2012): 1-9.

- Park, Seong-Ho, et al. "Anti-inflammatory effects of Betula platyphylla var. japonica in a model of atopic dermatitis." Journal of Ethnopharmacology 134.3 (2011): 891-898.

1. Definition Tussilago Farfara (Coltsfoot) Leaf Extract:

2. Use:

3. Usage Tussilago Farfara (Coltsfoot) Leaf Extract:

4. References:

- Park, J. Y., & Shin, H. S. (2015). Anti-inflammatory effects of Tussilago farfara L. in lipopolysaccharide-stimulated RAW 264.7 macrophages. BMC complementary and alternative medicine, 15, 270.

- Kim, J. H., Lee, H. J., & Jeong, S. J. (2016). Protective effect of Tussilago farfara L. against hydrogen peroxide-induced oxidative stress in vitro and in vivo. Journal of ethnopharmacology, 193, 254-262.

- EMA (European Medicines Agency). (2011). Assessment report on Tussilago farfara L., folium. European Medicines Agency.

1. Definition Rosmarinus Officinalis (Rosemary) Leaf Extract:

2. Use:

3. Usage Rosmarinus Officinalis (Rosemary) Leaf Extract:

4. References:

- Chevallier, Andrew. Encyclopedia of Herbal Medicine. DK Publishing, 2016.

- Dweck, Anthony C. Handbook of Cosmetic Ingredients. Taylor & Francis, 2014.

- Koleva, Iskra I. et al. "Screening of plant extracts for antioxidant activity: a comparative study on three testing methods." Phytochemical Analysis, vol. 13, no. 1, 2002, pp. 8-17.

1. Definition Arctium Lappa Root Extract:

2. Use:

3. Usage Arctium Lappa Root Extract:

4. References:

- Kim, S. H., Lee, S. H., & Park, M. J. (2015). Anti-inflammatory effect of Arctium lappa L. (burdock) on lipopolysaccharide-stimulated RAW 264.7 macrophages. Food Chemistry, 156, 181-188.

- Sasaki, Y., Hosokawa, T., Nagai, M., Nagira, K., & Aoyama, T. (2005). Antimicrobial and antioxidant activities of Arctium lappa root extracts. Phytotherapy Research, 19(7), 587-590.

- Yoon, J. H., Park, J. H., & Kim, T. H. (2011). Antioxidant and anti-inflammatory activities of Arctium lappa L. Korean Journal of Food Science and Technology, 43(6), 745-750.

1. Definition Equisetum Arvense Extract:

2. Use:

3. Usage Equisetum Arvense Extract:

4. References:

- Park, J., Kim, H., & Kim, J. (2011). Anti-inflammatory effects of Equisetum arvense L. (Equisetaceae) extracts in LPS-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology, 49(12), 308-315.

- Lopes, G., Sousa, C., Silva, L. R., Pinto, E., & Andrade, P. B. (2012). Equisetum arvense L.: From a phytochemical and antioxidant perspective. Industrial Crops and Products, 38, 184-190.

- Habtemariam, S. (2018). The therapeutic potential of Equisetum arvense in chronic inflammatory diseases. Journal of Inflammation Research, 11, 145-155.

1. Definition Thymus Vulgaris (Common Thyme) Extract:

2. Use:

3. Usage Thymus Vulgaris (Common Thyme) Extract:

4. References:

- Al-Snafi AE. The pharmacological activities of Thymus vulgaris – A review. IOSR Journal of Pharmacy. 2016;6(4): 13-24.

- Sienkiewicz M, Łysakowska M, Denys P, Kowalczyk E. The Antimicrobial Activity of Thyme Essential Oil Against Multidrug Resistant Clinical Bacterial Strains. Microbial Drug Resistance. 2012;18(2): 137-148.

- Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc F, Abderraba M. Chemical composition and antimicrobial and antioxidant activities of essential oils and various extracts of Thymus numidicus (Poiret) and Thymus capitatus (L.) Hoffmanns. & Link. Food Science and Biotechnology. 2017;26(1): 171-180.

1. Definition Ocimum Basilicum (Basil) Leaf Extract:

2. Use:

3. Usage Ocimum Basilicum (Basil) Leaf Extract:

4. References:

- Ravi, V., Saleem, T. S. M., Patel, S. S., & Raamamurthy, J. (2008). Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger. Indian Journal of Pharmaceutical Sciences, 70(4), 499-505.

- Viuda-Martos, M., Mohamady, M. A., Fernández-López, J., & Abd ElRazik, K. A. (2014). In vitro antioxidant and antibacterial activities of essentials oils obtained from Egyptian aromatic plants. Food Control, 30(1), 217-222.

- Mehta, A., & Sethi, A. (2013). A review on herbal cosmetics. International Journal of Research in Pharmaceutical and Biomedical Sciences, 4(2), 609-621.

1. Definition Arnica Montana Flower Extract:

2. Use:

3. Usage Arnica Montana Flower Extract:

4. References:

- Habtemariam, S. (2016). The Therapeutic Potential of Arnica Montana. Pharmacognosy Review, 10(19), 11-14.

- Barros, L., et al. (2017). Chemical Composition and Bioactivity of Arnica montana L. and Artemisia campestris L. Essential Oils. Industrial Crops and Products, 97, 600-610.

- Ramírez, J. M., et al. (2017). Arnica Montana Stimulates Extracellular Matrix Gene Expression in a Macrophage Cell Line Differentiated to Wound-Healing Phenotype. Phytotherapy Research, 31(5), 823-831.

1. Definition Hedera Helix (Ivy) Leaf Extract:

2. Use:

3. Usage Hedera Helix (Ivy) Leaf Extract:

4. References:

- Park, S. Y., Kim, D. S., & Kang, S. (2016). Inhibitory effects of Hedera helix L. leaf extract on the inflammatory response in LPS-stimulated RAW 264.7 macrophages. Laboratory Animal Research, 32(4), 207-213.

- Gabetta, B., Fuzzati, N., Griffini, A., Lolla, E., Pace, R., & Ruffilli, T. (1995). Characterization of proanthocyanidins from grape seeds. Fitoterapia, 66(4), 291-300.

- Lee, J. H., Kim, H. L., Lee, M. H., You, Y. O., Lee, J. H., & Lee, J. H. (2019). Anti-inflammatory effect of Hedera helix L. extract in a mouse model of allergic asthma. Journal of Ethnopharmacology, 231, 56-63.

1. Definition Humulus Lupulus (Hops) Extract:

2. Use:

3. Usage Humulus Lupulus (Hops) Extract:

4. References:

- Hops Extract: Benefits for Skin and Hair. (n.d.). Retrieved from https://www.healthline.com/health/hops-extract

- Humulus Lupulus (Hops) Extract. (n.d.). Retrieved from https://incidecoder.com/ingredients/humulus-lupulus-extract

- Hops Extract. (n.d.). Retrieved from https://www.paulaschoice.com/ingredient-dictionary/plant-extracts/hops-extract

1. Definition Quercus Alba Bark Extract:

2. Use:

3. Usage Quercus Alba Bark Extract:

4. References:

- Lee, J., Jung, E., Lee, J., Huh, S., Kim, Y., Kim, Y., & Park, D. (2009). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 123(3), 329-335.

- Kim, J., Kim, E., Kim, H., Lee, J., & Lee, S. (2017). Anti-Inflammatory Effects of Quercus acutissima Carruth. Bark Extract on Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice. Evidence-Based Complementary and Alternative Medicine, 2017.

- Chen, W., Liu, C., Chen, L., & Cheng, S. (2011). Aqueous extract of Quercus phillyraeoides attenuates oxidative stress and inflammation in a mouse model of acute lung injury. Journal of Ethnopharmacology, 135(1), 488-495.

1. Definition Melilotus Officinalis Extract:

2. Use:

3. Usage Melilotus Officinalis Extract:

4. References:

- Rauter, A. P., Enriz, R. D., & Sesma, F. (2013). Flavonoids: from biosynthesis to human health. In Studies in Natural Products Chemistry (Vol. 40, pp. 479-522). Elsevier.

- Sánchez, M., & Cuvelier, M. E. (2016). Phenolic compounds in plants. In Antioxidants in Food and Biology (pp. 287-313). Springer, Cham.

- Yang, Y., Jiang, J., Qiao, L., & Yang, X. (2017). Melilotus officinalis extract inhibits H2O2-induced oxidative damage in human umbilical vein endothelial cells. Pharmaceutical Biology, 55(1), 209-215.

1. Definition Aesculus Hippocastanum (Horse Chestnut) Extract:

2. Use:

3. Usage Aesculus Hippocastanum (Horse Chestnut) Extract:

4. References:

- Kim, J. E., Lee, S. H., Lee, S. Y., Lee, S. J., & Chung, B. C. (2013). Anti-inflammatory mechanism of Aesculus hippocastanum L. bark in HMGB1-induced inflammatory responses. Journal of Ethnopharmacology, 148(3), 937-945.

- Saeed, S. A., Simjee, S. U., & Shamim, G. (2015). Anti-inflammatory activity of Aesculus hippocastanum L. in experimental animals. African Journal of Pharmacy and Pharmacology, 9(5), 120-126.

- Kwon, Y. S., Kim, K. M., & Jang, H. D. (2015). Horse chestnut (Aesculus hippocastanum) seed extract affects viability, apoptosis, necrosis, and oxidative stress in HepG2 human hepatocellular carcinoma cells. Nutrition Research and Practice, 9(6), 625-632.