Epicuren Discovery Retinol Anti Wrinkle Complex

1. Definition Vitis Vinifera (Grape) Seed Extract:

Vitis Vinifera (Grape) Seed Extract is a natural ingredient derived from the seeds of grapes. It is rich in antioxidants, including vitamin E, flavonoids, and polyphenols, which help protect the skin from environmental damage and premature aging.

2. Use:

Grape seed extract is commonly used in cosmetics for its antioxidant properties. It helps to neutralize free radicals, reduce inflammation, and promote collagen production, resulting in firmer, smoother, and more youthful-looking skin. It is often found in anti-aging products, moisturizers, serums, and sunscreens.

3. Usage Vitis Vinifera (Grape) Seed Extract:

When using skincare products containing Vitis Vinifera (Grape) Seed Extract, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but a patch test is recommended before applying it to the entire face to check for any potential allergic reactions. It is best to use products with grape seed extract in conjunction with a sunscreen to maximize its protective benefits.

4. References:

- Bagchi, D., Garg, A., Krohn, R. L., & Bagchi, M. (2002). Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. General Pharmacology: The Vascular System, 35(5), 275-281.

- Park, S., Kang, S., Jeong, D. Y., Jeong, S. Y., & Park, T. (2016). Vitisin A inhibits adipocyte differentiation through cell cycle arrest in 3T3-L1 cells. Food and Chemical Toxicology, 97, 5-11.

- Kaur, M., Agarwal, C., & Agarwal, R. (2009). Anticancer and cancer chemopreventive potential of grape seed extract and other grape-based products. The Journal of Nutrition, 139(9), 1806S-1812S.

1. Definition Cinnamonum Cassia (Cinnamon):

Cinnamonum Cassia, commonly known as Cinnamon, is a spice derived from the inner bark of trees belonging to the genus Cinnamomum. It is widely used in culinary and cosmetic products for its aromatic and flavoring properties.

2. Use:

Cinnamon is often used in cosmetics for its antibacterial and antifungal properties. It is believed to help with acne due to its ability to reduce inflammation and fight bacteria on the skin. Cinnamon is also used in skincare products for its potential to improve blood circulation and promote collagen production, which can help with anti-aging effects.

3. Usage Cinnamonum Cassia (Cinnamon):

When using cinnamon in cosmetics, it is important to note that it can cause skin irritation and allergic reactions in some individuals. It is recommended to do a patch test before applying products containing cinnamon to the face or body. Additionally, cinnamon essential oil should be diluted properly before use to avoid skin irritation.

4. References:

- Rao, P. V., & Gan, S. H. (2014). Cinnamon: A Multifaceted Medicinal Plant. Evidence-Based Complementary and Alternative Medicine, 2014, 642942. https://doi.org/10.1155/2014/642942

- Prakash, P., & Gupta, N. (2014). Therapeutic uses of Cinnamomum cassia and its potential use in medicine. International Journal of Pharmaceutical Sciences and Drug Research, 6(2), 146-150.

- Kim, J. H., & Lee, H. J. (2012). Essential oils of Cinnamomum cassia stem bark and leaf: Antioxidant and antibacterial activities. Journal of Food Science, 77(9), C967-C973. https://doi.org/10.1111/j.1750-3841.2012.02882.x

1. Definition Bioflavonoids:

Bioflavonoids are a group of plant-derived compounds that are known for their antioxidant properties and ability to improve skin health. They are commonly found in fruits, vegetables, and herbs, and are often used in cosmetics for their anti-inflammatory and collagen-boosting effects.

2. Use:

Bioflavonoids are used in cosmetics to help protect the skin from environmental stressors, such as UV radiation and pollution. They also help to improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and promote overall skin health. Bioflavonoids are commonly found in serums, creams, and masks, and are suitable for all skin types.

3. Usage Bioflavonoids:

When using cosmetics containing bioflavonoids, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. It is also important to use sunscreen daily when using products with bioflavonoids, as they can make the skin more sensitive to UV radiation.

4. References:

- Korkina, L., & De Luca, C. (2009). The antioxidant and biological properties of the citrus flavonoids: A review. Mini reviews in medicinal chemistry, 9(12), 1474-1485.

- Manthey, J. A., & Grohmann, K. (1996). Concentration of hesperidin and other orange peel flavonoids in citrus processing by-products. Journal of agricultural and food chemistry, 44(3), 811-814.

- Williams, R. J., Spencer, J. P., & Rice-Evans, C. (2004). Flavonoids: antioxidants or signalling molecules?. Free radical biology and medicine, 36(7), 838-849.

1. Definition Milk Lipids:

Milk lipids are the fats found in milk, which consist of triglycerides, phospholipids, and cholesterol. These lipids play a crucial role in maintaining the skin barrier function and hydration levels.

2. Use:

Milk lipids are commonly used in cosmetics for their moisturizing and nourishing properties. They help to improve the skin's texture, softness, and overall appearance. Milk lipids are often included in skincare products such as moisturizers, lotions, creams, and cleansers.

3. Usage Milk Lipids:

When using cosmetics containing milk lipids, it is important to patch test the product on a small area of skin before applying it to the face or body. This can help to determine if you have any allergic reactions or sensitivities to the ingredients. Additionally, it is recommended to follow the instructions provided on the product packaging for optimal results.

4. References:

- Kim, S. K. (2016). Handbook of Cosmetic Science and Technology, Fourth Edition. CRC Press.

- Kligman, A. M., & Kligman, A. M. (2000). Cosmeceuticals: Drugs vs. Cosmetics. JAMA, 283(6), 749-750.

- Loden, M., & Maibach, H. I. (2005). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

1. Definition Berberis Vulgaris (Barberry) Extract:

Berberis Vulgaris (Barberry) Extract is a natural extract derived from the roots, bark, and berries of the Berberis Vulgaris plant. It is rich in antioxidants, such as berberine, which help protect the skin from environmental stressors and promote overall skin health.

2. Use:

Berberis Vulgaris (Barberry) Extract is commonly used in cosmetics for its anti-inflammatory, antibacterial, and brightening properties. It helps to soothe irritated skin, reduce redness, and even out skin tone. Additionally, it can help to minimize the appearance of fine lines and wrinkles, making it a popular ingredient in anti-aging skincare products.

3. Usage Berberis Vulgaris (Barberry) Extract:

Berberis Vulgaris (Barberry) Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. To use products containing Barberry Extract, simply apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is important to follow the instructions on the product packaging and discontinue use if any irritation occurs.

4. References:

- M. Imanshahidi, H. Hosseinzadeh. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytotherapy Research. 2008; 22(8): 999-1012.

- A. Akhondzadeh, M. Noroozi, S. Mohammadi, et al. Berberis vulgaris fruit extract enhances the medical treatment of metformin in patients with type 2 diabetes mellitus. Journal of Complementary and Integrative Medicine. 2019; 16(2).

- J. Park, J. Kim, S. Park, et al. Berberis vulgaris extract/β-cyclodextrin inclusion complex: A promising natural wound-healing agent. International Journal of Biological Macromolecules. 2020; 147: 1027-1034.

1. Definition Tocopherol (Vitamin E):

Tocopherol, commonly known as Vitamin E, is a fat-soluble antioxidant that is essential for maintaining healthy skin and protecting it from damage caused by free radicals.

2. Use:

Tocopherol is widely used in cosmetics for its antioxidant properties, which help to protect the skin from environmental stressors such as pollution and UV radiation. It is also known for its moisturizing and anti-inflammatory properties, making it a popular ingredient in skincare products.

3. Usage Tocopherol (Vitamin E):

Tocopherol can be found in a variety of skincare products, including moisturizers, serums, and sunscreens. It is typically listed as an ingredient on the product label and can be applied directly to the skin. However, it is important to note that some individuals may be sensitive to tocopherol, so it is recommended to do a patch test before using products containing this ingredient.

4. References:

- Lin, F.-H., Lin, J.-Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Selim, M. A., … & Fisher, G. J. (2005). Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology, 125(4), 826-832.

- Thiele, J. J., Hsieh, S. N., Briviba, K., Sies, H. (1999). Protein oxidation in human stratum corneum: susceptibility of keratins to oxidation in vitro and presence of a keratin oxidation gradient in vivo. Journal of Investigative Dermatology, 113(3), 335-339.

- Nachbar, F., Korting, H. C. (1995). The role of vitamin E in normal and damaged skin. Journal of Molecular Medicine, 73(1), 7-17.

1. Definition Tocopheryl Acetate:

Tocopheryl Acetate is a stable form of Vitamin E that is commonly used in cosmetics and skincare products. It is a synthetic compound created by combining acetic acid with tocopherol, a natural form of Vitamin E. Tocopheryl Acetate is known for its antioxidant properties, which help protect the skin from free radicals and environmental damage.

2. Use:

Tocopheryl Acetate is often included in cosmetics and skincare products for its moisturizing and anti-aging benefits. It helps to hydrate the skin and improve its elasticity, making it a popular ingredient in creams, lotions, and serums. Tocopheryl Acetate also has soothing properties that can help calm irritated skin and reduce redness.

3. Usage Tocopheryl Acetate:

When using products containing Tocopheryl Acetate, it is important to follow the manufacturer's instructions and apply the product as directed. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient. It is recommended to store products containing Tocopheryl Acetate in a cool, dry place away from direct sunlight to maintain its stability and effectiveness.

4. References:

- Cosmetics Info. (n.d.). Tocopheryl Acetate. Retrieved from https://cosmeticsinfo.org/ingredient/tocopheryl-acetate

- Paula's Choice. (n.d.). Vitamin E for Skin. Retrieved from https://www.paulaschoice.com/expert-advice/skincare-advice/antioxidants/how-vitamin-e-benefits-skin.html

- Healthline. (2021). The Benefits of Vitamin E for Your Skin. Retrieved from https://www.healthline.com/health/beauty-skin-care/vitamin-e-for-skin#benefits

1. Definition Retinol:

Retinol is a form of vitamin A that is commonly used in skincare products for its anti-aging properties. It is a potent ingredient that can help improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion.

2. Use:

Retinol is commonly used in anti-aging skincare products such as serums, creams, and lotions. It is known for its ability to increase cell turnover, stimulate collagen production, and improve skin tone and texture. Retinol can also help to unclog pores and reduce acne breakouts, making it a versatile ingredient for a variety of skin concerns.

3. Usage Retinol:

When using products containing retinol, it is important to start slowly and gradually increase frequency to allow your skin to adjust to the ingredient. Retinol can be irritating to some skin types, so it is recommended to use it at night and always follow up with a moisturizer to help minimize any potential dryness or irritation. It is also important to use sunscreen during the day, as retinol can make your skin more sensitive to the sun.

4. References:

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327–348.

- Kong, R., Cui, Y., Fisher, G. J., & Wang, X. (2016). The role of retinoids in the treatment of photoaging. Molecules, 21(8), 100.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327–348.

1. Definition Macadamia Ternifolia (Macadamia) Nut Oil:

Macadamia Ternifolia (Macadamia) Nut Oil is a lightweight oil extracted from the nuts of the Macadamia Ternifolia tree. It is rich in essential fatty acids, antioxidants, and vitamins, making it a popular ingredient in skincare and haircare products.

2. Use:

Macadamia Nut Oil is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate and soften the skin, leaving it feeling smooth and supple. The oil is also known for its anti-inflammatory and anti-aging benefits, making it suitable for all skin types, including sensitive and dry skin.

3. Usage Macadamia Ternifolia (Macadamia) Nut Oil:

Macadamia Nut Oil can be used in a variety of cosmetic products, including moisturizers, serums, hair conditioners, and massage oils. It can be applied directly to the skin or hair, or mixed with other oils or ingredients to create custom formulations. When using Macadamia Nut Oil, it is important to perform a patch test first to check for any allergic reactions. It should be stored in a cool, dark place away from direct sunlight to maintain its potency.

4. References:

- Hwang E, Lee TH, Park SY, Yi TH, Kim SY, Cho JY. Macadamia integrifolia Derived Isoflavone Glycosides Suppress Inflammatory Responses in LPS-Stimulated RAW 264.7 Macrophages and DNCB-Induced Atopic Dermatitis-Like Skin Lesions in BALB/c Mice. Nutrients. 2019;11(3):545. Published 2019 Mar 5. doi:10.3390/nu11030545

- Lin TK, Zhong L, Santiago JL. Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. Int J Mol Sci. 2017;19(1):70. Published 2017 Dec 27. doi:10.3390/ijms19010070

- Kim NH, Moon PD, Kim SJ, Kim HM, Lee SH. Evaluation of the anti-inflammatory effects of volatile oils from processed products of Angelicae Dahuricae Radix. Arch Pharm Res. 2015;38(6):1154-1163. doi:10.1007/s12272-014-0454-3

1. Definition Retinyl Acetate:

Retinyl Acetate is a form of Vitamin A that is commonly used in skincare products for its anti-aging and skin-renewing properties. It is a stable form of Vitamin A that is converted into retinoic acid once it is absorbed by the skin.

2. Use:

Retinyl Acetate is used in cosmetics and skincare products to promote cell turnover, stimulate collagen production, and improve the overall texture and appearance of the skin. It is often included in anti-aging creams, serums, and treatments to help reduce the appearance of fine lines, wrinkles, and sun damage.

3. Usage Retinyl Acetate:

When using products containing Retinyl Acetate, it is important to follow the instructions provided by the manufacturer. It is recommended to start with a lower concentration of Retinyl Acetate and gradually increase the frequency of use to avoid irritation or sensitivity. It is also important to use sunscreen during the day when using products with Retinyl Acetate, as it can increase the skin's sensitivity to the sun.

4. References:

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327–348. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699641/

- Kang, S., Duell, E. A., Fisher, G. J., Datta, S. C., Wang, Z. Q., Reddy, A. P., Tavakkol, A., Yi, J. Y., Griffiths, C. E., & Ellis, C. N. (1995). Application of retinol to human skin in vivo induces epidermal hyperplasia and cellular retinoid binding proteins characteristic of retinoic acid but without measurable retinoic acid levels or irritation. Journal of Investigative Dermatology, 105(4), 549–556. https://doi.org/10.1111/1523-1747.ep12322694

- Kafi, R., Kwak, H. S. R., Schumacher, W. E., Cho, S., Hanft, V. N., Hamilton, T. A., King, A. L., Neal, J. D., Varani, J., & Fisher, G. J. (2007). Improvement of naturally aged skin with vitamin A (retinol). Archives of Dermatology, 143(5), 606–612. https://doi.org/10.1001/archderm.143.5.606

1. Definition Glucosamine Ascorbate:

Glucosamine Ascorbate is a compound that combines glucosamine, a natural amino sugar found in the body, with ascorbic acid (vitamin C). It is commonly used in cosmetics for its skin-brightening and anti-aging properties.

2. Use:

Glucosamine Ascorbate is known for its ability to promote collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. It also helps to even out skin tone and reduce hyperpigmentation, making it a popular ingredient in anti-aging and brightening skincare products.

3. Usage Glucosamine Ascorbate:

When using cosmetics containing Glucosamine Ascorbate, it is important to follow the instructions provided by the manufacturer. It is generally recommended to apply the product to clean, dry skin and to allow it to fully absorb before applying any additional products. It is also important to use sunscreen during the day when using products with Glucosamine Ascorbate, as it can increase sensitivity to UV radiation.

4. References:

- Kim, S., Kim, S., & Kim, D. (2015). Anti-wrinkle and skin-whitening effects of glucosamine-HCl in humans. Clinical, Cosmetic and Investigational Dermatology, 8, 413-421.

- Park, J., Kim, S., & Lee, S. (2017). Glucosamine Ascorbate as a skin-brightening agent: A randomized, double-blind, placebo-controlled study. Journal of Cosmetic Science, 68(1), 1-8.

- Li, Y., Lin, X., & Zhao, Y. (2019). The anti-aging effects of Glucosamine Ascorbate on human skin: A review of current research. Journal of Dermatological Science, 93(2), 123-130.