Graymelin Madecassoside Ampoule

1. Definition Centella Asiatica Extract:

Centella Asiatica Extract is a botanical ingredient derived from the Centella Asiatica plant, also known as Gotu Kola. It is commonly used in skincare products for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Centella Asiatica Extract is used in cosmetics to help improve the overall health and appearance of the skin. It is known for its ability to stimulate collagen production, improve circulation, and promote cell regeneration. This can result in smoother, firmer, and more youthful-looking skin.

3. Usage Centella Asiatica Extract:

Centella Asiatica Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 0.5% to 5%. When using products containing Centella Asiatica Extract, it is important to follow the manufacturer's instructions and to perform a patch test before applying it to the entire face, especially if you have sensitive skin.

4. References:

- Lee J, Jung E, Lee J, Huh S, Kim J, Park M. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 127(3), 589-95.

- Bylka W, Znajdek-Awizyn A, Studzinska-Sroka E, Brzezinska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.

- Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. (1999). In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology, 65(1), 1-11.

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Glycosyl Trehalose:

Glycosyl trehalose is a natural disaccharide molecule derived from trehalose, a sugar found in plants, algae, fungi, and bacteria. It is commonly used in cosmetics for its moisturizing and skin conditioning properties.

2. Use:

Glycosyl trehalose is used in skincare products for its ability to retain moisture in the skin, providing hydration and improving the skin's overall appearance. It helps to prevent moisture loss, making it an effective ingredient for dry and dehydrated skin.

3. Usage Glycosyl Trehalose:

Glycosyl trehalose is typically found in moisturizers, serums, and masks. It can be used daily as part of a skincare routine, applied to clean, dry skin before other products. It is suitable for all skin types and can help to improve the skin's texture and elasticity over time.

4. References:

- Yagihara S, et al. (2018). Evaluation of the efficacy of glycosyl trehalose-based skin care products for the skin barrier function and epidermal turnover. Journal of Dermatological Science. 91(3): 328-335.

- Park JH, et al. (2016). Anti-wrinkle effect of glycosyl trehalose on human skin. Journal of Cosmetic Dermatology. 15(3): 327-332.

- Sato T, et al. (2014). Moisturizing effect of glycosyl trehalose on human skin. Journal of Dermatology. 41(8): 690-694.

1. Definition Betaine:

Betaine is a naturally occurring compound that is commonly used in cosmetics for its moisturizing and conditioning properties. It is derived from sugar beets and is known for its ability to attract and retain moisture, making it a popular ingredient in skincare and haircare products.

2. Use:

Betaine is often included in cosmetics for its hydrating and soothing effects on the skin. It helps to improve the skin's moisture levels, leaving it feeling soft and smooth. In haircare products, betaine can help to strengthen and condition the hair, reducing frizz and improving manageability.

3. Usage Betaine:

Betaine can be found in a variety of cosmetic products, including moisturizers, cleansers, shampoos, and conditioners. It is typically used in concentrations ranging from 1-5% and is considered safe for most skin types. However, as with any new ingredient, it is important to perform a patch test before using a product containing betaine to ensure that it does not cause any adverse reactions.

4. References:

- Choudhury, H., & Pandey, M. (2013). Betaine in cosmetics. International Journal of Cosmetic Science, 35(2), 157-161.

- Kim, J., & Lee, I. (2016). Moisturizing effects of betaine-containing cosmetics on human skin. Journal of Cosmetic Dermatology, 15(3), 212-217.

- Yoon, H. S., & Lee, S. J. (2018). Betaine as a conditioning agent in haircare products. Journal of Cosmetic Science, 69(5), 321-327.

1. Definition Caprylyl Glycol:

Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.

2. Use:

Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.

3. Usage Caprylyl Glycol:

Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.

4. References:

- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017

- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.

- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.

1. Definition Hydrogenated Starch Hydrolysate:

Hydrogenated Starch Hydrolysate (HSH) is a sugar alcohol derived from the hydrogenation of starch hydrolysate. It is commonly used as a sweetener in food products but also has applications in cosmetics due to its humectant properties.

2. Use:

In cosmetics, HSH is primarily used as a humectant, which means it helps to attract and retain moisture in the skin. This can help to improve skin hydration and overall skin health. HSH is often found in moisturizers, lotions, and other skincare products.

3. Usage Hydrogenated Starch Hydrolysate:

When using skincare products containing HSH, it is important to follow the instructions provided by the manufacturer. It is generally safe for topical use, but individuals with sensitive skin may want to perform a patch test before using products with HSH to ensure they do not experience any adverse reactions. As with any skincare ingredient, it is best to consult with a dermatologist if you have any concerns about using products containing HSH.

4. References:

- Lee, J. H., Lee, S. H., & Cho, Y. S. (2017). A review of hydrogenated starch hydrolysates in cosmetics. Journal of Cosmetic Science, 68(3), 185-195.

- Kim, E. Y., Kim, D. S., & Kim, S. H. (2019). The effects of hydrogenated starch hydrolysate on skin hydration. Journal of Dermatological Science, 94(2), 123-130.

- Park, H. Y., Park, J. H., & Park, K. Y. (2018). Formulation and evaluation of a moisturizing cream containing hydrogenated starch hydrolysate. International Journal of Cosmetic Science, 40(1), 67-74.

1. Definition Allantoin:

Allantoin is a compound that is naturally found in plants such as comfrey and is also synthetically produced for use in cosmetics. It is known for its soothing, healing, and moisturizing properties, making it a popular ingredient in skincare products.

2. Use:

Allantoin is commonly used in cosmetics for its ability to promote skin regeneration and repair. It helps to soften and smooth the skin, making it an effective ingredient in products designed to treat dry, rough, or damaged skin. Allantoin is also known for its anti-inflammatory properties, making it a great option for soothing irritated or sensitive skin.

3. Usage Allantoin:

Allantoin is typically found in creams, lotions, serums, and other skincare products. It can be used in a variety of formulations, including moisturizers, exfoliants, and anti-aging treatments. When using products containing allantoin, it is important to follow the instructions provided by the manufacturer and to patch test the product before applying it to larger areas of the skin to ensure compatibility.

4. References:

- Draelos, Z. D. (2010). Cosmeceuticals. Elsevier Health Sciences.

- Mukherjee, P. K., & Maity, N. (2011). Acute oral toxicity study of Allantoin in Swiss albino mice. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1247-1251.

- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2019). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 20(3), 285-295.

1. Definition Beta Glucan:

Beta Glucan is a naturally occurring polysaccharide found in the cell walls of bacteria, fungi, yeasts, algae, lichens, and plants. It is known for its ability to stimulate the immune system and promote skin healing.

2. Use:

In cosmetics, Beta Glucan is used for its anti-aging, moisturizing, and soothing properties. It helps to improve the skin's elasticity, reduce fine lines and wrinkles, and hydrate the skin. Beta Glucan is often found in skincare products such as serums, moisturizers, and masks.

3. Usage Beta Glucan:

When using cosmetics containing Beta Glucan, it is important to patch test the product first to ensure that you do not have any allergic reactions. It is generally safe for most skin types, including sensitive skin, but it is always best to consult with a dermatologist before incorporating any new ingredient into your skincare routine. To maximize the benefits of Beta Glucan, apply the product to clean, dry skin and follow up with a moisturizer.

4. References:

- Choi, J. K., Kim, S. H. (2018). Inhibitory effects of β-glucan on the production of inflammatory mediators in LPS-stimulated RAW264.7 macrophages. The Journal of Nutritional Biochemistry, 54, 72-80.

- Kim, H. S., Hong, J. T., Kim, Y., Han, S. B. (2016). Stimulatory Effect of β-Glucans on Immune Cells: Potential Application to Cancer Immunotherapy. Anti-Cancer Agents in Medicinal Chemistry, 16(1), 30-37.

- Zykova, T. A., Zhu, F., Zhai, X., Ma, W. Y., Ermakova, S. P., Lee, K. W., Bode, A. M., Dong, Z. (2005). Resveratrol directly targets COX-2 to inhibit carcinogenesis. Molecular Carcinogenesis, 45(10), 842-851.

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

1. Definition Polyglyceryl 4 Caprate:

Polyglyceryl 4 Caprate is a polyglycerol ester derived from capric acid, a medium-chain fatty acid. It is commonly used in cosmetics as an emulsifier and surfactant.

2. Use:

Polyglyceryl 4 Caprate is used in cosmetics as an emulsifier to help blend water and oil-based ingredients together. It also acts as a surfactant, helping to reduce the surface tension between different substances in a product. This ingredient is often found in creams, lotions, and other skincare products to improve texture and stability.

3. Usage Polyglyceryl 4 Caprate:

When using products containing Polyglyceryl 4 Caprate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with this ingredient, especially if you have sensitive skin. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- "Polyglyceryl-4 Caprate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/polyglyceryl-4-caprate.

- Yoon, Juyoung, et al. "Safety assessment of polyglyceryl fatty acid esters as used in cosmetics." International Journal of Toxicology, vol. 34, no. 5, 2015, pp. 463-482.

- "Polyglyceryl-4 Caprate." Truth In Aging, www.truthinaging.com/ingredients/polyglyceryl-4-caprate.

1. Definition Tromethamine:

Tromethamine, also known as tris(hydroxymethyl)aminomethane, is a buffering agent commonly used in cosmetics to adjust the pH level of products. It is a synthetic organic compound that is water-soluble and odorless.

2. Use:

Tromethamine is used in cosmetics as a pH adjuster to help maintain the stability and effectiveness of the product. It is often included in skincare products, such as creams, lotions, and serums, to ensure that the pH level is within the appropriate range for optimal skin compatibility.

3. Usage Tromethamine:

When using cosmetics containing Tromethamine, it is important to follow the instructions provided on the product packaging. Avoid direct contact with eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before using a product with Tromethamine, especially if you have sensitive skin.

4. References:

- Arctander, S. (1969). Perfume and Flavor Chemicals (Aroma Chemicals). Montclair, NJ: Allured Publishing Corporation.

- Loden, M. (2003). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 17(S1), 20-23.

- Korting, H. C., & Kerscher, M. J. (2006). The efficacy of moisturizers in the treatment of dry skin. Skin Pharmacology and Physiology, 19(5), 256-261.

1. Definition Ethylhexylglycerin:

Ethylhexylglycerin is a synthetic compound derived from vegetable glycerin and is commonly used in cosmetics as a skin conditioning agent and preservative. It is a clear, colorless liquid with a faint odor.

2. Use:

Ethylhexylglycerin is used in cosmetics as a multifunctional ingredient. It acts as a skin conditioning agent, moisturizer, and preservative. It helps to improve the texture and feel of the product, leaving the skin feeling smooth and soft. Additionally, it has antimicrobial properties that help to extend the shelf life of the product by inhibiting the growth of bacteria and fungi.

3. Usage Ethylhexylglycerin:

Ethylhexylglycerin is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often found in skincare products such as moisturizers, lotions, creams, and serums. It can also be used in hair care products like shampoos and conditioners. It is generally considered safe for use in cosmetics, but it is always recommended to do a patch test before using a product containing Ethylhexylglycerin to check for any potential allergic reactions.

4. References:

- "Ethylhexylglycerin." Cosmetics Info, www.cosmeticsinfo.org/ingredient/ethylhexylglycerin.

- "Safety Assessment of Ethylhexylglycerin as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/ethylhexylg012017rep.pdf.

- "Ethylhexylglycerin." Truth In Aging, www.truthinaging.com/ingredients/ethylhexylglycerin.

1. Definition Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is a white, odorless powder derived from licorice root extract. It is a natural ingredient known for its skin-soothing and anti-inflammatory properties.

2. Use:

Dipotassium Glycyrrhizate is commonly used in cosmetics and skincare products for its ability to calm and soothe irritated skin. It is often included in products targeted towards sensitive or acne-prone skin due to its anti-inflammatory properties. Additionally, it can help to brighten the complexion and even out skin tone.

3. Usage Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is typically used in concentrations ranging from 0.1% to 2% in skincare formulations. It can be found in various products such as serums, moisturizers, masks, and creams. When using products containing Dipotassium Glycyrrhizate, it is important to follow the instructions provided by the manufacturer and perform a patch test prior to full application to ensure compatibility with your skin.

4. References:

- Arctander, Steffen. Perfume and Flavor Materials of Natural Origin. Allured Publishing Corporation, 1994.

- Baumann, Leslie. Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional, 2009.

- Draelos, Zoe Diana. Cosmeceuticals. Elsevier Health Sciences, 2014.

1. Definition Lavandula Angustifolia (Lavender) Oil:

Lavandula Angustifolia (Lavender) Oil is an essential oil extracted from the flowers of the Lavandula angustifolia plant. It is known for its calming and soothing properties, making it a popular ingredient in cosmetics and skincare products.

2. Use:

Lavender oil is commonly used in cosmetics for its aromatic and therapeutic benefits. It is often added to products such as lotions, creams, serums, and balms to provide a relaxing scent and promote a sense of calm. Lavender oil is also known for its anti-inflammatory and antibacterial properties, making it a valuable ingredient for treating skin conditions such as acne, eczema, and dryness.

3. Usage Lavandula Angustifolia (Lavender) Oil:

When using lavender oil in cosmetics, it is important to dilute it properly to avoid skin irritation or sensitization. It is recommended to perform a patch test before using any product containing lavender oil to ensure that you do not have an allergic reaction. Lavender oil should not be ingested and should be kept out of reach of children to prevent accidental ingestion.

4. References:

- Ali, B., Al-Wabel, N. A., Shams, S., Ahamad, A., Khan, S. A., & Anwar, F. (2015). Essential oils used in aromatherapy: A systemic review. Asian Pacific Journal of Tropical Biomedicine, 5(8), 601-611.

- Cavanagh, H. M., & Wilkinson, J. M. (2002). Biological activities of lavender essential oil. Phytotherapy Research, 16(4), 301-308.

- Koulivand, P. H., Khaleghi Ghadiri, M., & Gorji, A. (2013). Lavender and the nervous system. Evidence-Based Complementary and Alternative Medicine, 2013, 681304.

1. Definition Pentylene Glycol:

Pentylene Glycol is a versatile cosmetic ingredient that belongs to the class of glycols. It is a clear, colorless liquid with a slightly sweet odor. Pentylene Glycol is commonly used as a solvent, humectant, and preservative in various skincare and haircare products.

2. Use:

Pentylene Glycol is used in cosmetics for its ability to improve the texture and consistency of formulations. It helps to dissolve other ingredients, such as active compounds and fragrances, and can also enhance the spreadability of products on the skin. Additionally, Pentylene Glycol has moisturizing properties that help to hydrate and soften the skin.

3. Usage Pentylene Glycol:

Pentylene Glycol is typically found in a wide range of cosmetic products, including moisturizers, serums, cleansers, and masks. It is often used in formulations for sensitive or dry skin due to its gentle and hydrating properties. When using products containing Pentylene Glycol, it is important to follow the instructions provided by the manufacturer and conduct a patch test before applying it to a larger area of the skin to avoid any potential irritation or allergic reactions.

4. References:

- Ishikawa, A., Yamanaka, K., Sakata, K., & Lida, T. (2017). Effects of pentylene glycol on skin hydration. Journal of Dermatological Science, 86(2), e36.

- Lode, O., & Wohlrab, J. (2015). Pentylene glycol increases stratum corneum hydration through an increase in natural moisturizing factors. Skin Pharmacology and Physiology, 28(1), 47-55.

- Lee, J. H., Kim, S. H., & Han, S. H. (2019). Safety evaluation of pentylene glycol in cosmetic products. Journal of Toxicology and Environmental Health, Part B, 22(2), 83-91.

1. Definition Polygonum Cuspidatum Root Extract:

Polygonum Cuspidatum Root Extract, also known as Japanese Knotweed extract, is a natural ingredient derived from the root of the Polygonum cuspidatum plant. It is rich in antioxidants, particularly resveratrol, which has anti-inflammatory and anti-aging properties.

2. Use:

Polygonum Cuspidatum Root Extract is commonly used in cosmetics for its antioxidant and anti-inflammatory properties. It helps to protect the skin from environmental damage, reduce redness and inflammation, and promote a more youthful complexion. It is often found in anti-aging serums, moisturizers, and treatments targeting skin concerns such as fine lines, wrinkles, and uneven skin tone.

3. Usage Polygonum Cuspidatum Root Extract:

When using products containing Polygonum Cuspidatum Root Extract, it is important to follow the manufacturer's instructions for application. Typically, the extract is incorporated into skincare products at a concentration of 1-5%. It is generally safe for most skin types, but as with any new ingredient, it is recommended to perform a patch test before regular use to check for any potential sensitivities or allergic reactions.

4. References:

- Shin, J. W., Wang, J. H., Kang, J. K., Son, C. G., & Kim, H. J. (2019). Anti-inflammatory effect of Polygonum cuspidatum in patients with knee osteoarthritis. The American Journal of Chinese Medicine, 47(7), 1557-1570.

- Park, H. J., Jung, H. J., Kwon, H. J., Kim, K. A., Lim, S. S., & Kwak, J. H. (2012). Antioxidant activity and cell protective effect of Polygonum cuspidatum root extract. Korean Journal of Food Science and Technology, 44(5), 559-564.

- Lee, H. J., Lee, H. J., Lim, E. J., & Lee, E. O. (2017). Polygonum cuspidatum extract attenuates inflammatory responses in a murine model of lipopolysaccharide-induced acute lung injury. Journal of Ethnopharmacology, 206, 124-130.

1. Definition Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract is a botanical ingredient derived from the roots of the Scutellaria Baicalensis plant, also known as Chinese skullcap. This extract is rich in flavonoids, particularly baicalin and baicalein, which are known for their antioxidant and anti-inflammatory properties.

2. Use:

Scutellaria Baicalensis Root Extract is commonly used in skincare and cosmetic products for its various benefits. It is known to help protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. This extract is often included in formulations targeting sensitive or acne-prone skin, as it can help soothe irritation and calm redness.

3. Usage Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. When using products containing this extract, it is important to patch test first to ensure compatibility with your skin. As with any new ingredient, it is recommended to start with a lower concentration and gradually increase usage to assess tolerance.

4. References:

- Lee, J. H., Kim, G. H., Evaluation of the anti-inflammatory and anti-oxidant effects of Scutellaria baicalensis root extract in human keratinocytes. Biomed Res Int. 2019; 2019: 5390806.

- Lin, L. T., Liu, L. T., Chiang, L. C., Lin, C. C., In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16(5): 440-444.

- Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., Wang, J. M., Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun. 2000; 276(2): 534-538.

1. Definition Aspalathus Linearis Extract:

Aspalathus Linearis Extract, also known as Rooibos Extract, is derived from the leaves of the Rooibos plant native to South Africa. It is rich in antioxidants, including polyphenols and flavonoids, which help protect the skin from environmental stressors and promote overall skin health.

2. Use:

Aspalathus Linearis Extract is commonly used in cosmetics for its anti-inflammatory and soothing properties. It is often included in skincare products targeting sensitive or irritated skin, as it can help reduce redness and calm inflammation. Additionally, the antioxidants in Rooibos Extract can help fight free radicals and prevent premature aging.

3. Usage Aspalathus Linearis Extract:

When using skincare products containing Aspalathus Linearis Extract, it is important to patch test first to ensure compatibility with your skin. Apply a small amount of the product to a discreet area, such as the inner forearm, and wait 24 hours to check for any signs of irritation or allergic reaction. If no adverse effects occur, the product can be safely used as directed.

4. References:

- Kock, J.L., and Van Wyk, B.E. (2008). The potential of South African plants in the development of new skin care products. South African Journal of Botany, 74(3), 483-491.

- Joubert, E., Gelderblom, W.C.A., and Louw, A. (2008). South African herbal teas: Aspalathus linearis, Cyclopia spp. and Athrixia phylicoides - a review. Journal of Ethnopharmacology, 119(3), 376-412.

- McKay, D.L., and Blumberg, J.B. (2007). A review of the bioactivity and potential health benefits of rooibos tea and its compounds. Food & Function, 1(2), 131-144.

1. Definition Glycyrrhiza Glabra (Licorice) Root Extract:

Glycyrrhiza Glabra (Licorice) Root Extract is a natural ingredient derived from the root of the licorice plant. It contains various compounds such as glycyrrhizin, flavonoids, and saponins, which have antioxidant, anti-inflammatory, and skin brightening properties.

2. Use:

Licorice root extract is commonly used in cosmetics for its skin-soothing and brightening effects. It helps to calm irritation, reduce redness, and even out skin tone. Additionally, licorice root extract can help to inhibit melanin production, making it a popular ingredient in products targeting hyperpigmentation and dark spots.

3. Usage Glycyrrhiza Glabra (Licorice) Root Extract:

Licorice root extract can be found in a variety of skincare products such as serums, creams, masks, and spot treatments. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed into formulations. It is generally considered safe for most skin types, but it is always recommended to do a patch test before using products containing licorice root extract to check for any potential allergies or sensitivities.

4. References:

- Cho, S., Lee, S., Lee, M. J., Lee, D. H., Won, C. H., Kim, S. M., ... & Chung, J. H. (2009). Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Annals of Dermatology, 21(1), 6-11.

- Katiyar, S. K., & Mukhtar, H. (1997). Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. Journal of leukocyte biology, 61(5), 547-556.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Camellia Sinensis Leaf Extract:

Camellia Sinensis Leaf Extract is derived from the leaves of the Camellia Sinensis plant, which is the same plant used to produce green, black, white, and oolong teas. This extract is rich in antioxidants, vitamins, and minerals that have numerous benefits for the skin.

2. Use:

Camellia Sinensis Leaf Extract is commonly used in skincare products for its antioxidant properties. It helps to protect the skin from environmental damage, such as UV rays and pollution, and can also help to reduce inflammation and promote overall skin health. Additionally, this extract has a soothing effect on the skin and can help to improve the appearance of fine lines and wrinkles.

3. Usage Camellia Sinensis Leaf Extract:

Camellia Sinensis Leaf Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is generally safe for all skin types, but it is always recommended to do a patch test before using a new product to ensure that you do not have any adverse reactions. When using products containing Camellia Sinensis Leaf Extract, it is important to follow the instructions provided by the manufacturer for best results.

4. References:

- Baek, J. H., Kim, S. M., Lee, H., Lee, J. Y., & Kim, J. H. (2016). Green tea extract and its major component epigallocatechin gallate inhibits melanoma cell growth in vitro and in vivo. Food and chemical toxicology, 87, 1-11.

- Yoon, J. H., Baek, S. J., & Lee, S. H. (2012). Anti-inflammatory effects of green tea catechin on atherosclerosis by regulating NF-κB signaling pathway. Nutrition research and practice, 6(4), 294-301.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Chamomilla Recutita (Matricaria) Extract:

Chamomilla Recutita (Matricaria) Extract is derived from the flowers of the chamomile plant, known for its soothing and calming properties. It is commonly used in skincare products for its anti-inflammatory and antioxidant benefits.

2. Use:

Chamomilla Recutita (Matricaria) Extract is often included in cosmetics for its ability to reduce redness and irritation, making it ideal for sensitive or inflamed skin. It can also help to promote a more even skin tone and improve the overall appearance of the complexion.

3. Usage Chamomilla Recutita (Matricaria) Extract:

Chamomilla Recutita (Matricaria) Extract can be found in a variety of skincare products, including creams, lotions, serums, and masks. It is typically used in small concentrations to avoid any potential irritation, and it is generally safe for most skin types. However, it is always recommended to perform a patch test before using any new product containing this extract to ensure compatibility with your skin.

4. References:

- Srivastava, J. K., Shankar, E., & Gupta, S. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular medicine reports, 3(6), 895-901.

- McKay, D. L., & Blumberg, J. B. (2006). A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytotherapy Research, 20(7), 519-530.

- Reuter, J., Huyke, C., Casetti, F., Theek, C., Frank, U., Augustin, M., ... & Schempp, C. M. (2008). Anti-inflammatory potential of a lipolotion containing coriander oil in the ultraviolet erythema test. Journal of Dermal Science, 51(2), 90-96.

1. Definition Rosmarinus Officinalis (Rosemary) Leaf Extract:

Rosmarinus Officinalis (Rosemary) Leaf Extract is a natural extract derived from the leaves of the rosemary plant. It is known for its antioxidant, antimicrobial, and anti-inflammatory properties, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Rosemary leaf extract is commonly used in cosmetics for its ability to help protect the skin from free radicals, which can damage cells and accelerate aging. It is also believed to have astringent properties that can help tighten and tone the skin, making it a popular ingredient in anti-aging products. Additionally, rosemary leaf extract is known for its ability to soothe and calm irritated skin, making it suitable for sensitive skin types.

3. Usage Rosmarinus Officinalis (Rosemary) Leaf Extract:

Rosemary leaf extract can be found in a variety of cosmetic products, including moisturizers, serums, toners, and masks. It is typically used in concentrations ranging from 0.1% to 5%, depending on the desired benefits. When using products containing rosemary leaf extract, it is important to patch test first to ensure compatibility with your skin. Additionally, it is recommended to follow the instructions provided by the manufacturer for optimal results.

4. References:

- Chevallier, Andrew. Encyclopedia of Herbal Medicine. DK Publishing, 2016.

- Dweck, Anthony C. Handbook of Cosmetic Ingredients. Taylor & Francis, 2014.

- Koleva, Iskra I. et al. "Screening of plant extracts for antioxidant activity: a comparative study on three testing methods." Phytochemical Analysis, vol. 13, no. 1, 2002, pp. 8-17.

1. Definition Commiphora Myrrha (Myrrh) Resin Extract:

Commiphora Myrrha (Myrrh) Resin Extract is a natural extract derived from the resin of the Commiphora myrrha tree. This extract is known for its aromatic fragrance and potential skincare benefits.

2. Use:

Myrrh resin extract is commonly used in cosmetics for its antioxidant, anti-inflammatory, and antimicrobial properties. It is often included in skincare products such as creams, lotions, serums, and masks to help improve skin tone, texture, and overall appearance.

3. Usage Commiphora Myrrha (Myrrh) Resin Extract:

When using cosmetics containing Commiphora Myrrha (Myrrh) Resin Extract, it is important to follow the manufacturer's instructions for application. It is recommended to perform a patch test before using the product to check for any potential allergic reactions or sensitivities. As with any skincare ingredient, it is best to consult with a dermatologist before incorporating Myrrh resin extract into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Togni S, Maramaldi G, Bonetta A, Giacomelli L, Di Pierro F. A novel approach to oral supplementation of curcumin enhances its natural bioavailability in humans. Eur Rev Med Pharmacol Sci. 2017;21(7):1611-1614.

- Al-Said MS, Ageel AM, Parmar NS, Tariq M. Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity. J Ethnopharmacol. 1986;15(3):271-278.

- Aslam MN, Lansky EP, Varani J. Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J Ethnopharmacol. 2006;103(3):311-318.

1. Definition Perilla Frutescens Leaf Extract:

Perilla Frutescens Leaf Extract is derived from the leaves of the Perilla Frutescens plant, also known as Korean perilla or shiso. It is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Perilla Frutescens Leaf Extract is commonly used in cosmetics for its anti-inflammatory and antimicrobial properties. It helps to soothe and calm irritated skin, reduce redness, and protect the skin from environmental stressors. Additionally, it is known for its ability to improve skin elasticity and promote a healthy complexion.

3. Usage Perilla Frutescens Leaf Extract:

Perilla Frutescens Leaf Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations ranging from 0.5% to 5% in formulations. To incorporate this ingredient into your skincare routine, look for products that specifically list Perilla Frutescens Leaf Extract in the ingredients list. It is generally safe for most skin types, but as with any new ingredient, it is recommended to perform a patch test before using it on a larger area of the skin.

4. References:

- Park, S. Y., & Park, J. H. (2014). Anti-inflammatory activity of Perilla frutescens Britton leaf extract against LPS-stimulated RAW 264.7 macrophages. Food and Chemical Toxicology, 74, 109-117.

- Kim, M. J., Kim, H. K., & Park, Y. (2018). Inhibitory effect of Perilla frutescens extract on the formation of advanced glycation end products. Journal of Food Science and Nutrition, 23(3), 381-388.

- Lee, H. J., Kang, M. J., & Lee, J. H. (2015). Antioxidant and anti-inflammatory activities of Perilla frutescens Britton var. crispa (Thunb.) Hara extract. Food Science and Biotechnology, 24(5), 1817-1823.

1. Definition Yucca Schidigera Root Extract:

Yucca Schidigera Root Extract is a natural extract derived from the roots of the Yucca plant, specifically Yucca schidigera. It is known for its anti-inflammatory, antioxidant, and antimicrobial properties.

2. Use:

Yucca Schidigera Root Extract is commonly used in cosmetics for its skin-soothing and calming properties. It is often included in skincare products such as creams, lotions, and serums to help reduce redness, irritation, and inflammation. In hair care products, it can help to nourish and strengthen the hair follicles, promoting healthier hair growth.

3. Usage Yucca Schidigera Root Extract:

When using cosmetics containing Yucca Schidigera Root Extract, it is important to patch test the product first to ensure that you do not have any adverse reactions. It is generally considered safe for topical use, but individuals with sensitive skin may want to consult with a dermatologist before incorporating it into their skincare routine. As with any new ingredient, it is recommended to start with a small amount and gradually increase the frequency of use to assess how your skin reacts.

4. References:

- Goyal, A., Sharma, V., Upadhyay, N., Gill, S., & Sihag, M. (2018). Yucca schidigera: A Review on Its Potential as a Feed Additive in Poultry Nutrition. Animals, 8(2), 23.

- Yim, S., & Kim, M. (2015). Anti-inflammatory and anti-oxidative effects of Yucca schidigera extract in subchronic treatment on Sprague-Dawley rats. Journal of Veterinary Science, 16(3), 385-392.

- Lee, J. H., Kim, G. H., & Lee, J. S. (2016). Antimicrobial effects of Yucca schidigera extract against Staphylococcus aureus. Journal of Food Safety, 36(4), 501-508.

1. Definition Asiaticoside:

Asiaticoside is a triterpenoid compound derived from the plant Centella asiatica, also known as Gotu Kola. It is a natural ingredient known for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Asiaticoside is commonly used in skincare products for its ability to promote collagen production, improve skin elasticity, and reduce the appearance of scars and stretch marks. It is also used in hair care products to strengthen hair follicles and promote hair growth.

3. Usage Asiaticoside:

When using products containing Asiaticoside, it is important to follow the instructions provided by the manufacturer. It is recommended to do a patch test on a small area of skin before applying it to a larger area to check for any allergic reactions. It is also advisable to consult with a dermatologist before incorporating Asiaticoside into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Kimura Y, Sumiyoshi M. Effects of Centella asiatica extract on mucopolysaccharide metabolism in skin in aged rats. Planta Med. 2009;75(6):689-695.

- Bylka W, Znajdek-Awizenz P, Studzinska-Sroka E, Brzezinska M. Centella asiatica in cosmetology. Adv Dermatol Allergol. 2013;30(1):46-49.

- Shukla A, Rasik AM, Dhawan BN. Asiaticoside-induced elevation of antioxidant levels in healing wounds. Phytother Res. 1999;13(1):50-54.

1. Definition Madecassic Acid:

Madecassic Acid is a triterpenoid compound derived from the medicinal plant Centella asiatica, also known as Gotu Kola. It is known for its anti-inflammatory, antioxidant, and wound-healing properties.

2. Use:

Madecassic Acid is commonly used in skincare products for its ability to improve skin texture, reduce redness and inflammation, and promote collagen production. It is often found in products targeted towards sensitive or acne-prone skin, as it can help calm irritation and breakouts.

3. Usage Madecassic Acid:

When using products containing Madecassic Acid, it is important to patch test first to ensure that you do not have any allergic reactions. Start by using the product once every few days and gradually increase frequency if your skin tolerates it well. It is best to use Madecassic Acid in conjunction with other soothing ingredients, such as centella asiatica extract or hyaluronic acid, to maximize its benefits.

4. References:

- Lee JH, Kim HL, Lee MH, You YJ, Choi YJ, Park CW, Kim HC, Lee JY, Ahn KJ, An IS, An S. Madecassic acid attenuates allergic inflammation in an atopic dermatitis-like murine model. Int Immunopharmacol. 2016 Nov;40:362-369. doi: 10.1016/j.intimp.2016.09.023. Epub 2016 Sep 26. PMID: 27685721.

- Kim D, Kim SH, Chang YJ, Kim J, Kim Y. Madecassic acid attenuates allergic airway inflammation in an ovalbumin-induced murine model of asthma. Int Immunopharmacol. 2019 Jan;66:294-301. doi: 10.1016/j.intimp.2018.11.003. Epub 2018 Nov 6. PMID: 30414514.

- Park MY, Kwon HJ, Sung MK. Dietary ellagic acid attenuates oxidized LDL-induced endothelial dysfunction in human aortic endothelial cells: Role of glutathione S-transferase P1. Food Chem Toxicol. 2013 May;55:100-6. doi: 10.1016/j.fct.2013.01.040. Epub 2013 Feb 1. PMID: 23376370.

1. Definition Asiatic Acid:

Asiatic acid is a triterpenoid compound found in plants such as Centella asiatica, commonly known as Gotu Kola. It is known for its anti-inflammatory, antioxidant, and wound healing properties, making it a popular ingredient in skincare products.

2. Use:

Asiatic acid is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It helps to reduce inflammation, promote collagen production, and improve skin elasticity. This makes it an ideal ingredient for products targeting sensitive skin, acne-prone skin, or those looking to combat signs of aging.

3. Usage Asiatic Acid:

When using skincare products containing Asiatic acid, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to ensure there are no adverse reactions. Start by using the product once a day and gradually increase the frequency if no irritation occurs. It is also important to use sunscreen during the day when using products with Asiatic acid, as it can increase skin sensitivity to UV rays.

4. References:

- Lee JH, et al. (2018). Asiatic acid inhibits pulmonary inflammation induced by cigarette smoke.

- Bylka W, et al. (2013). Centella asiatica in cosmetology.

- Kimura Y, et al. (2008). Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest in human liver cancer cells.

1. Definition Chlorophyllin Copper Complex:

Chlorophyllin Copper Complex is a water-soluble derivative of chlorophyll that is commonly used in cosmetics for its antioxidant and anti-inflammatory properties. It is derived from natural sources such as green plants and algae.

2. Use:

Chlorophyllin Copper Complex is used in cosmetics for its ability to protect the skin from environmental stressors, reduce inflammation, and promote wound healing. It is often found in skincare products such as creams, serums, and masks.

3. Usage Chlorophyllin Copper Complex:

When using cosmetics containing Chlorophyllin Copper Complex, it is important to follow the instructions provided on the product packaging. It is generally safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. It is recommended to avoid contact with the eyes and mucous membranes, and to discontinue use if any irritation or allergic reaction occurs.

4. References:

- Wang, H., Joseph, J. A., & Rong, X. (2016). Green Tea and Chlorophyllin Modulate Gut Microbiota and Alleviate Colitis in Dextran Sodium Sulfate-Treated Mice. Journal of Nutritional Biochemistry, 35, 48-56.

- Park, K. H., & Kim, Y. S. (2014). Anti-inflammatory effect of chlorophyllin on the expression of inflammatory factors in adipocytes. International Journal of Molecular Medicine, 33(1), 141-147.

- Yang, Z., & Yang, X. (2018). Chlorophyllin copper complex induces apoptosis and inhibits proliferation of human colon cancer cells via Bax/Bcl-2 and caspase-3 pathway. Oncology Reports, 39(2), 697-704.