Le Mieux Eye Wrinkle Corrector

1. Definition Palmitoyl Pentapeptide 4:

2. Use:

3. Usage Palmitoyl Pentapeptide 4:

4. References:

- Lupo, M. P., & Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic therapy, 20(5), 343-349.

- Darlenski, R., & Surber, C. (2013). Topical delivery of cosmetic actives: an overview. Skin Pharmacology and Physiology, 26(5), 245-260.

- Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E., Kang, S., Fisher, G. J., ... & Voorhees, J. J. (2006). Decreased collagen production in chronologically aged skin. The American journal of pathology, 168(6), 1861-1868.

1. Definition Palmitoyl Tetrapeptide 7:

2. Use:

3. Usage Palmitoyl Tetrapeptide 7:

4. References:

- Srinivas, R., & Srinivas, G. (2018). Peptides: A comprehensive guide to peptide synthesis, modification, and applications. CRC Press.

- Lintner, K., & Peschard, O. (2012). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International Journal of Cosmetic Science, 34(4), 299-306.

- Kim, S. H., & Kim, K. H. (2014). Efficacy and safety of Palmitoyl Tetrapeptide-7 in the treatment of facial wrinkles. Journal of Dermatological Science, 76(1), 8-14.

1. Definition Theobroma Grandiflorum Seed Butter:

2. Use:

3. Usage Theobroma Grandiflorum Seed Butter:

4. References:

- Costa, R. M., de Oliveira, A. P., de Souza, P. V., & Vicentini, V. E. P. (2016). Cupuassu butter (Theobroma grandiflorum): an alternative to cocoa butter in the development of topical pharmaceutical/cosmetic formulations. Journal of Cosmetic Science, 67(4), 275-286.

- Rodrigues, L. B., Santos, G. R., Oliveira, L. A., & Conceicao, E. C. (2016). Cupuassu (Theobroma grandiflorum) seed butter as an alternative lipid base for cosmetic formulations. Journal of Cosmetic Science, 67(1), 53-62.

- Paula, C. S., Rodrigues, L. B., & Oliveira, L. A. (2019). Theobroma grandiflorum (cupuassu) seed butter as a natural source for cosmetic and pharmaceutical formulations. In Natural and Artificial Flavoring Agents and Dyes (pp. 379-390). IntechOpen.

1. Definition Butyrospermum Parkii (Shea) Butter:

2. Use:

3. Usage Butyrospermum Parkii (Shea) Butter:

4. References:

- Akihisa T, Kojima N, Kikuchi T, Yasukawa K, Tokuda H, and Masters ET. Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat. Journal of Oleo Science. 2010; 59(6):273-80.

- Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1):70.

- Aremu AO, Oyedeji AO, Oyedeji O, Okorie DO, and Nkeh-Chungag BN. Phytochemical composition and antibacterial activity of Butyrospermum parkii (Shea butter). Journal of Medicinal Plants Research. 2012; 6(26):4467-4472.

1. Definition Tocotrienols:

2. Use:

3. Usage Tocotrienols:

4. References:

- Shahidi F, Ambigaipalan P. (2015). Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits.

- Serbinova E, Kagan V, Han D, Packer L. (1991). Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol.

- Packer L, Weber SU, Rimbach G. (2001). Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling.

1. Definition Alpha-Bisabolol:

2. Use:

3. Usage Alpha-Bisabolol:

4. References:

- Kim, S., Kim, J., Kim, Y., Kim, J., & Kim, J. (2015). Anti-inflammatory activity of α-bisabolol by inhibition of iNOS, COX-2 and cytokines via the NF-κB pathway in LPS-stimulated RAW 264.7 macrophages. American Journal of Chinese Medicine, 43(2), 227-241.

- Fuchs, S. M., Schliemann-Willers, S., Fischer, T. W., & Elsner, P. (2003). Protective effects of different marigold (Calendula officinalis L.) and rosemary cream preparations against sodium-lauryl-sulfate-induced irritant contact dermatitis. Skin Pharmacology and Physiology, 16(6), 324-330.

- Cardia, G. F. E., Silva-Filho, S. E., Silva, E. L., Uchida, N. S., Cavalcante, H., & Cassarotti, L. L. (2018). Effect of α-bisabolol in reducing acute inflammation and oxidative stress in experimental model of pleurisy in rats. BioMed Research International, 2018.

1. Definition Panax Ginseng Extract:

2. Use:

3. Usage Panax Ginseng Extract:

4. References:

- Park, J. H., & Lee, J. Y. (2019). Anti-inflammatory effects of Panax ginseng extract in hairless mice. Journal of Ginseng Research, 43(3), 411-416.

- Lee, S. H., & Lee, H. J. (2017). Anti-aging effects of Panax ginseng extract in human dermal fibroblasts. Journal of Cosmetic Dermatology, 16(4), 511-516.

- Kim, S., & Kim, D. H. (2018). Brightening effects of Panax ginseng extract in skincare products. Journal of Dermatological Science, 90(2), 123-128.

1. Definition Dipalmitoyl Hydroxyproline:

2. Use:

3. Usage Dipalmitoyl Hydroxyproline:

4. References:

- S. Lupo, M. Cole, "Cosmeceutical peptides," Dermatologic Therapy, vol. 20, no. 5, pp. 343-349, 2007.

- A. Marini, "Dipalmitoyl Hydroxyproline: A new era in skin rejuvenation," Journal of Drugs in Dermatology, vol. 4, no. 3, pp. 281-285, 2005.

- M. Dupont, R. Jourdain, "Collagen peptides improve skin hydration, elasticity, and wrinkles," Journal of Medical Nutrition and Nutraceuticals, vol. 6, no. 3, pp. 197-202, 2017.

1. Definition Camellia Sinensis Leaf Extract:

2. Use:

3. Usage Camellia Sinensis Leaf Extract:

4. References:

- Baek, J. H., Kim, S. M., Lee, H., Lee, J. Y., & Kim, J. H. (2016). Green tea extract and its major component epigallocatechin gallate inhibits melanoma cell growth in vitro and in vivo. Food and chemical toxicology, 87, 1-11.

- Yoon, J. H., Baek, S. J., & Lee, S. H. (2012). Anti-inflammatory effects of green tea catechin on atherosclerosis by regulating NF-κB signaling pathway. Nutrition research and practice, 6(4), 294-301.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Lysolecithin:

2. Use:

3. Usage Lysolecithin:

4. References:

- S. W. Kim, et al. (2003). Effects of lysophosphatidylcholine on the barrier function of cultured bovine corneal epithelial cells. Experimental Eye Research, 77(2), 175-183.

- J. M. B. M. van Breemen, et al. (2004). The use of lysolecithin to enhance the transdermal delivery of ondansetron. Journal of Controlled Release, 97(3), 503-510.

- K. M. Kim, et al. (2007). Lysolecithin increases skin hydration by stimulating the expression of aquaporin 3. Journal of Cosmetic Science, 58(6), 603-610.

1. Definition N Hydroxysuccinimide:

2. Use:

3. Usage N Hydroxysuccinimide:

4. References:

- Lee, S., Kim, J., & Lee, J. (2017). A review on N-hydroxysuccinimide and its ester derivatives. Journal of Industrial and Engineering Chemistry, 56, 1-11.

- Lupo, M. P., & Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic Therapy, 20(5), 343-349.

- Lhiaubet-Vallet, V., & Bosca, F. (2013). Photoprotection in the UVB and UVA ranges by sunscreens containing a combination of three UV filters. Journal of Photochemistry and Photobiology B: Biology, 123, 29-35.

1. Definition Chrysin:

2. Use:

3. Usage Chrysin:

4. References:

- Lee, S. H., Seo, J. M., Kim, K. M., Kim, C. D., Lim, J. S., & Lee, S. J. (2011). Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-κB. Toxicology and applied pharmacology, 254(1), 42-49.

- Kuo, M. L., Huang, T. S., & Lin, J. K. (2002). Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1475(2), 278-288.

- Weng, Z., Patel, A. B., Panagiotidou, S., Theoharides, T. C. (2015). The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells. Journal of Allergy and Clinical Immunology, 135(4), AB177.

1. Definition Palmitoyl Tripeptide 1:

2. Use:

3. Usage Palmitoyl Tripeptide 1:

4. References:

- Sonti S, Makino ET, Garruto J, et al. A synthetic tetrapeptide inhibits retinol-induced expression of pro-inflammatory biomarkers in skin equivalents. J Drugs Dermatol. 2013;12(6):694-700.

- Kimura Y, Sumiyoshi M, Kobayashi Y. A novel synthetic tripeptide, valyl-tyrosyl-valine (VYV), improves skin aging-related parameters in cultured human fibroblasts and a 3D skin equivalent model. J Cosmet Dermatol. 2016;15(4):457-463.

- Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(4):207-218.

1. Definition Hesperidin Methyl Chalcone:

2. Use:

3. Usage Hesperidin Methyl Chalcone:

4. References:

- Bagherani, N., & Smoller, B. R. (2015). Hesperidin Methyl Chalcone for the Management of Periorbital Hyperpigmentation. The Journal of Clinical and Aesthetic Dermatology, 8(6), 50–53.

- Yoon, H. S., Kim, J. H., & Ahn, S. G. (2013). Hesperidin Methyl Chalcone Inhibits Lipopolysaccharide-Induced Apoptosis in Human Endothelial Cells. The Journal of Dermatology, 40(3), 202–207.

- Lin, F. H., Lin, J. Y., Gupta, R. D., Tournas, J. A., Burch, J. A., Selim, M. A., ... & Fisher, G. J. (2004). Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology, 125(4), 826-832.

1. Definition Dipeptide 2:

2. Use:

3. Usage Dipeptide 2:

4. References:

- Kim, S. Y., Kim, D. S., Kim, C. G., Kim, D. S., Kim, J. H., Kim, K. H., ... & Kim, K. J. (2014). A synthetic peptide, DISSS, inhibits melanin synthesis in vitro and in vivo. Pigment cell & melanoma research, 27(5), 728-731.

- Lee, J. H., Lee, J. H., Kim, K. H., Kim, D. S., Kim, K. J., Kim, D. S., ... & Kim, S. Y. (2013). A synthetic peptide, DISSS, inhibits melanogenesis in B16F10 melanoma cells and zebrafish. International journal of molecular medicine, 31(4), 855-860.

- Choi, J. H., Kim, K. H., Park, H. J., Kim, S. Y., & Kim, K. J. (2015). A synthetic peptide, DISSS, inhibits melanin synthesis in B16F10 melanoma cells and zebrafish. Experimental dermatology, 24(3), 216-218.

1. Definition Chenopodium Quinoa Seed Extract:

2. Use:

3. Usage Chenopodium Quinoa Seed Extract:

4. References:

- Caceres, P. J., Martínez-Villaluenga, C., Amigo, L., & Frias, J. (2016). Effects of roasting and boiling of quinoa, kiwicha and kañiwa on composition and availability of minerals in vitro. Journal of the Science of Food and Agriculture, 96(6), 1995-2002.

- Vega-Gálvez, A., Miranda, M., Vergara, J., Uribe, E., Puente, L., & Martínez, E. A. (2010). Nutrition facts and functional potential of quinoa (Chenopodium quinoa willd.), an ancient Andean grain: a review. Journal of the Science of Food and Agriculture, 90(15), 2541-2547.

- Repo-Carrasco-Valencia, R., Hellström, J. K., & Pihlava, J. M. (2010). Quinoa (Chenopodium quinoa, Willd.) seeds as source of antioxidant phenolic compounds. Journal of Agricultural and Food Chemistry, 58(1), 670-675.

1. Definition Pfaffia Paniculata Root Extract:

2. Use:

3. Usage Pfaffia Paniculata Root Extract:

4. References:

- Kim, J. H., Lee, H. J., Jeong, S. J., Lee, M. H., & Kim, H. R. (2017). Pfaffia paniculata root extract prevents UVB-induced photoaging by suppressing the expression of MMPs, MAP kinases, and COX-2 in mouse skin. Journal of Ethnopharmacology, 198, 70-76.

- Chatterjee, S., Srivastava, S., Khalid, A., Singh, N., & Sangwan, R. S. (2018). Pfaffia paniculata: A review on its ethnobotany, phytochemistry, pharmacology and biotechnological aspects. Planta Medica, 84(08), 505-516.

- De Oliveira, D. R., Sanjinez-Argandona, E. J., de Oliveira, J. M., & Morgado-Diaz, J. A. (2010). Pfaffia paniculata-induced changes in inflammation-related gene expression in the adipose tissue of HFD-induced obese mice. Journal of Ethnopharmacology, 127(3), 257-262.

1. Definition Lilium Candidum Flower Extract:

2. Use:

3. Usage Lilium Candidum Flower Extract:

4. References:

- Park, J. H., Lee, J. H., Lee, H. J., & Kim, M. K. (2017). Madonna lily (Lilium candidum L.) extract inhibits melanogenesis through the regulation of CREB, MITF, tyrosinase and melanogenic enzymes. Experimental and Therapeutic Medicine, 13(4), 1419-1424.

- Lee, J. H., Park, J. H., Lee, H. J., & Kim, M. K. (2017). Anti-inflammatory effect of Madonna lily (Lilium candidum L.) extract in LPS-stimulated RAW 264.7 cells. Experimental and Therapeutic Medicine, 14(1), 169-174.

- Dall'Acqua, S., Cervellati, R., Speroni, E., Costa, S., Guerra, M. C., & Stella, L. (2009). Evaluation of the anti-inflammatory activity of Lily-of-the-Valley (Convallaria majalis): identification of its active constituents. Journal of ethnopharmacology, 121(3), 355-361.

1. Definition Superoxide Dismutase:

2. Use:

3. Usage Superoxide Dismutase:

4. References:

- Kohen, R., & Nyska, A. (2002). Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification. Toxicologic pathology, 30(6), 620-650.

- Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The international journal of biochemistry & cell biology, 39(1), 44-84.

- Lobo, V., Patil, A., Phatak, A., & Chandra, N. (2010). Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy reviews, 4(8), 118.

1. Definition Cyathea Medullaris Leaf Extract:

2. Use:

3. Usage Cyathea Medullaris Leaf Extract:

4. References:

- Chakraborty, A., & Mitra, A. (2018). Ferns and Fern Allies of Tripura. Springer.

- Kumar, S., & Pandey, A. (2016). Ethnobotany of India, Volume 2: Western Ghats and West Coast of Peninsular India. Scientific Publishers.

- Rehman, S. U., & Shah, M. A. (2019). Ethnobotany of the Western Himalayas. Springer.

1. Definition Camellia Sinensis (Green Tea) Extract:

2. Use:

3. Usage Camellia Sinensis (Green Tea) Extract:

4. References:

- Yoon HS, Kim JR, Park GY, Kim JY, Won YJ, Kim HR, Kim BJ. Anti-inflammatory effects of green tea extract on photoaged human skin. J Dermatol Sci. 2016 Oct;84(1):74-83. doi: 10.1016/j.jdermsci.2016.06.016. Epub 2016 Jul 1. PMID: 27422719.

- Chiu AE, Chan JL, Kern DG, Kohler S, Rehmus WE, Kimball AB. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg. 2005 Jul;31(7 Pt 2):855-60; discussion 860. doi: 10.1097/00042728-200507000-00011. PMID: 16029678.

- Zhou B, Wu LM, Yang L, Liu ZL. Evidence for alpha-bisabolol as a natural antioxidant. J Agric Food Chem. 2007 Aug 8;55(16):6302-6306. doi: 10.1021/jf070477y. Epub 2007 Jul 11. PMID: 17625876.

1. Definition Phospholipids:

2. Use:

3. Usage Phospholipids:

4. References:

- Rawlings, A. V. (2006). Trends in stratum corneum research and the management of dry skin conditions. International Journal of Cosmetic Science, 28(3), 167-173.

- Kim, S., Kim, H. J., Park, H. J., & Kim, S. Y. (2014). Phospholipids in cosmetic: Friends or foes. Korean Journal of Chemical Engineering, 31(10), 1739-1748.

- Bouwstra, J. A., & Ponec, M. (2006). The skin barrier in healthy and diseased state. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1758(12), 2080-2095.

1. Definition Camellia Oleifera Seed Oil:

2. Use:

3. Usage Camellia Oleifera Seed Oil:

4. References:

- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences, 19(1), 70.

- Chen, J., & Liu, X. (2019). Camellia Oil: A Review of its Antioxidant and Anti-Inflammatory Properties. Journal of the American Oil Chemists' Society, 96(12), 1427-1437.

- Wang, Y., Zhang, H., & Gong, L. (2018). Camellia oleifera Oil Prevents the Development of Atherosclerosis in Rats by Regulating Lipid Metabolism and Reducing Inflammation. Journal of Food Science, 83(10), 2589-2596.

1. Definition Hydrolyzed Ulva Lactuca Extract:

2. Use:

3. Usage Hydrolyzed Ulva Lactuca Extract:

4. References:

- Kim, S. K., & Chojnacka, K. (2013). Marine Algae Extracts: Processes, Products, and Applications. Wiley.

- Chater, P. I., & Wilcox, M. D. (2014). Skin Moisturization. Springer.

- Lopes, G., & Pinto, E. (2018). Seaweed Polysaccharides. Elsevier.

1. Definition Glycosaminoglycans:

2. Use:

3. Usage Glycosaminoglycans:

4. References:

- Saravanan, S., Madhavan, V., & Sathishkumar, K. (2018). Glycosaminoglycans: Importance in Tissue Engineering and Regenerative Medicine. Journal of Stem Cell Research & Therapy, 8(1), 1-6.

- Lupo, M. P. (2014). Cosmeceutical peptides. Dermatologic Therapy, 27(5), 317-324.

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.

1. Definition DL-Panthenol:

2. Use:

3. Usage DL-Panthenol:

4. References:

- Maia Campos PMBG, Gianeti MD, Camargo FB, Gaspar LR. The use of green tea extract in cosmetic formulations: not only an antioxidant active ingredient. Dermatol Ther. 2014;27(4):267-271. doi:10.1111/dth.12121

- Binic I, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D. Skin aging: natural weapons and strategies. Evid Based Complement Alternat Med. 2013;2013:827248. doi:10.1155/2013/827248

- Draelos ZD. The latest cosmeceutical approaches for anti-aging. J Cosmet Dermatol. 2008;7(1):2-7. doi:10.1111/j.1473-2165.2008.00357.x

1. Definition Allantoin:

2. Use:

3. Usage Allantoin:

4. References:

- Draelos, Z. D. (2010). Cosmeceuticals. Elsevier Health Sciences.

- Mukherjee, P. K., & Maity, N. (2011). Acute oral toxicity study of Allantoin in Swiss albino mice. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1247-1251.

- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2019). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 20(3), 285-295.

1. Definition Glucose:

2. Use:

3. Usage Glucose:

4. References:

- Purnamawati, S., Indrastuti, N., & Danarti, R. (2017). The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review. Clinical Medicine & Research, 15(3-4), 75-87.

- Pumori, S. K., & Patra, A. (2019). Glucose as a potential active ingredient in cosmetics: A review. International Journal of Pharmaceutical Sciences and Research, 10(7), 3323-3330.

- Kim, J. H., Kim, H. J., & Kim, S. H. (2016). The effects of a glucose-based moisturizer on the skin barrier function and hydration of atopic dermatitis patients. Annals of Dermatology, 28(5), 574-580.

1. Definition Glucose Oxidase:

2. Use:

3. Usage Glucose Oxidase:

4. References:

- Kim, S., and Kim, J. (2016). Glucose oxidase inhibits melanogenesis via suppressing of p38/JNK signaling pathways. Journal of Dermatological Science, 81(2), 89-96.

- Lee, S., et al. (2018). Glucose oxidase and its product gluconic acid induce hair growth via the regulation of genes related to the anagen phase. Scientific Reports, 8(1), 1-9.

- Park, H., et al. (2020). Hydrogen peroxide derived from glucose oxidase inhibits the proliferation of human keratinocytes. International Journal of Cosmetic Science, 42(5), 495-502.