Lesse Every Tone SPF 30

1. Definition Capryloyl Glycerin/Sebacic Acid Copolymer:

Capryloyl Glycerin/Sebacic Acid Copolymer is a copolymer composed of capryloyl glycerin and sebacic acid. It is commonly used in cosmetics as a film-forming agent and emollient.

2. Use:

Capryloyl Glycerin/Sebacic Acid Copolymer is used in cosmetics to provide a smooth, non-greasy feel to products. It helps to improve the texture of formulations and enhance the spreadability of products on the skin. Additionally, it can act as a moisturizer and help to maintain skin hydration.

3. Usage Capryloyl Glycerin/Sebacic Acid Copolymer:

Capryloyl Glycerin/Sebacic Acid Copolymer is typically used in skincare products such as moisturizers, sunscreens, and makeup products. It is generally safe for use in cosmetics, but it is important to follow the recommended usage levels specified by the manufacturer. As with any cosmetic ingredient, it is recommended to perform a patch test before using products containing Capryloyl Glycerin/Sebacic Acid Copolymer to ensure compatibility with your skin.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2016). Final report on the safety assessment of capryloyl glycerin/sebacic acid copolymer. International Journal of Toxicology, 35(1), 67-75.

- Personal Care Products Council. (2019). Capryloyl Glycerin/Sebacic Acid Copolymer. Retrieved from https://www.cosmeticsinfo.org/ingredient/capryloyl-glycerinsebacic-acid-copolymer

- U.S. Food and Drug Administration. (2020). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=73.3400

1. Definition Stearalkonium Hectorite:

Stearalkonium Hectorite is a white, creamy clay-like compound that is commonly used in cosmetics as a suspending agent and thickening agent. It is a modified form of hectorite clay, which is a natural clay mineral.

2. Use:

Stearalkonium Hectorite is primarily used in cosmetics to stabilize and thicken formulations. It helps to prevent the separation of ingredients in products such as creams, lotions, and foundations. Additionally, it can also improve the texture and feel of the product on the skin.

3. Usage Stearalkonium Hectorite:

Stearalkonium Hectorite is typically used in concentrations ranging from 1-10% in cosmetics formulations. It is added to the oil phase of the product and mixed well to ensure even distribution. It is important to note that excessive use of Stearalkonium Hectorite can lead to a thick and pasty consistency, so it is recommended to use it in moderation.

Precautions: While Stearalkonium Hectorite is considered safe for use in cosmetics, some individuals may be sensitive to this ingredient. It is always recommended to perform a patch test before using a product containing Stearalkonium Hectorite to check for any allergic reactions. In case of irritation, discontinue use immediately.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2013). Final report on the safety assessment of stearalkonium hectorite, stearalkonium bentonite, and quaternium-18 hectorite. International journal of toxicology, 32(5), 1-11.

- Personal Care Products Council. (2008). Safety Assessment of Stearalkonium Hectorite as Used in Cosmetics. Retrieved from https://online.personalcarecouncil.org/ctfa-static/online/lists/cir-pdfs/pr210.pdf

- Food and Drug Administration. (2021). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=73.1350

1. Definition Polyglyceryl 3 Diisostearate:

Polyglyceryl 3 Diisostearate is a synthetic compound derived from glycerin and isostearic acid. It is commonly used in cosmetics as an emulsifier and surfactant.

2. Use:

Polyglyceryl 3 Diisostearate is used in cosmetics to help stabilize emulsions and create a smooth texture in products such as creams, lotions, and makeup. It also helps to improve the spreadability of products on the skin and enhance the overall sensory experience of the product.

3. Usage Polyglyceryl 3 Diisostearate:

When using products containing Polyglyceryl 3 Diisostearate, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before using products containing this ingredient to ensure compatibility.

4. References:

- "Polyglyceryl-3 Diisostearate" in CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/polyglyceryl-3-diisostearate

- "Polyglyceryl-3 Diisostearate" in Truth in Aging, https://www.truthinaging.com/ingredients/polyglyceryl-3-diisostearate

- "Polyglyceryl-3 Diisostearate" in Paula's Choice Skincare Ingredient Dictionary, https://www.paulaschoice.com/ingredient-dictionary/emollients/polyglyceryl-3-diisostearate

1. Definition Polyglyceryl 3 Polyricinoleate:

Polyglyceryl 3 Polyricinoleate is a synthetic compound derived from glycerin and ricinoleic acid. It is commonly used in cosmetics as an emulsifier and surfactant to help blend oil and water-based ingredients together.

2. Use:

Polyglyceryl 3 Polyricinoleate is used in a variety of cosmetic products such as creams, lotions, and makeup to create stable and uniform formulations. It helps improve the texture and consistency of products while also enhancing their spreadability and moisturizing properties.

3. Usage Polyglyceryl 3 Polyricinoleate:

When using products containing Polyglyceryl 3 Polyricinoleate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies should perform a patch test before applying it to larger areas of the skin. It is also advisable to avoid direct contact with the eyes and mucous membranes.

4. References:

- "Polyglyceryl-3 Polyricinoleate" - Cosmetics Info. (https://cosmeticsinfo.org/ingredient/polyglyceryl-3-polyricinoleate)

- "Polyglyceryl-3 Polyricinoleate" - Truth in Aging. (https://www.truthinaging.com/ingredients/polyglyceryl-3-polyricinoleate)

- "Polyglyceryl-3 Polyricinoleate" - The Derm Review. (https://thedermreview.com/polyglyceryl-3-polyricinoleate/)

1. Definition Daucus Carota Sativa (Carrot) Seed Oil:

Daucus Carota Sativa (Carrot) Seed Oil is a natural oil extracted from the seeds of the carrot plant. It is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare and haircare products.

2. Use:

Carrot seed oil is known for its nourishing and rejuvenating properties, making it a valuable ingredient in cosmetics. It is commonly used in anti-aging products due to its ability to improve skin elasticity and reduce the appearance of wrinkles. Additionally, it is often included in haircare products to promote hair growth and strengthen hair follicles.

3. Usage Daucus Carota Sativa (Carrot) Seed Oil:

Carrot seed oil can be used in a variety of ways in cosmetics. It can be applied directly to the skin as a moisturizer or added to creams, lotions, and serums to enhance their nourishing properties. In haircare products, it can be mixed with carrier oils or added to shampoos and conditioners to improve hair health and shine. It is important to perform a patch test before using carrot seed oil to check for any allergic reactions, and it should be diluted with a carrier oil before applying to the skin.

4. References:

- Prakash, B., & Gupta, S. (2005). Therapeutic uses of Daucus carota (Carrot) seeds. Journal of Pharmacognosy and Phytochemistry, 4(1), 58-60.

- Al-Snafi, A. E. (2016). The pharmacological activities of Daucus carota-A review. IOSR Journal of Pharmacy, 6(10), 42-50.

- Kaur, G., & Kaur, R. (2017). Carrot seed oil: A review on its composition and properties. Journal of Pharmacognosy and Phytochemistry, 6(3), 2208-2212.

1. Definition Polyhydroxystearic Acid:

Polyhydroxystearic Acid is a synthetic ingredient commonly used in cosmetics as an emulsifier and stabilizer. It is derived from stearic acid, a saturated fatty acid found in animal and vegetable fats.

2. Use:

Polyhydroxystearic Acid is primarily used in cosmetics as an emulsifier to help mix oil and water-based ingredients together. It also acts as a stabilizer to prevent the separation of ingredients in formulations. Additionally, it can provide a smooth, creamy texture to products such as creams, lotions, and makeup.

3. Usage Polyhydroxystearic Acid:

Polyhydroxystearic Acid is considered safe for use in cosmetics, but like any other cosmetic ingredient, it is important to follow recommended guidelines for usage. It is typically used in concentrations ranging from 0.5% to 5% in formulations. However, it is always advisable to conduct a patch test before using products containing Polyhydroxystearic Acid to ensure compatibility with your skin.

4. References:

- "Polyhydroxystearic Acid" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/polyhydroxystearic-acid)

- "Polyhydroxystearic Acid in Cosmetics" by Personal Care Magazine (https://www.personalcaremagazine.com/story/10410/polyhydroxystearic-acid-in-cosmetics)

- "Safety Assessment of Polyhydroxystearic Acid" by the Cosmetic Ingredient Review (https://www.cir-safety.org/sites/default/files/polyhydroxystearic%20acid.pdf)

1. Definition Phenylpropanol:

Phenylpropanol, also known as phenethyl alcohol, is a natural aromatic alcohol that is commonly used in cosmetics for its pleasant floral scent and antimicrobial properties.

2. Use:

Phenylpropanol is primarily used as a fragrance ingredient in cosmetics, providing a sweet, rose-like aroma. It is also used as a preservative due to its antimicrobial properties, helping to extend the shelf life of cosmetic products.

3. Usage Phenylpropanol:

Phenylpropanol is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. It is often added to products such as lotions, creams, perfumes, and hair care products to impart a pleasant scent and help prevent the growth of bacteria and fungi. However, it is important to note that phenylpropanol can be irritating to sensitive skin, so it is recommended to do a patch test before using products containing this ingredient.

4. References:

- Gomes-Carneiro MR, Vargas VM, Silva LR, et al. Chemical composition, acute toxicity, and antinociceptive activity of the essential oil of a plant breeding cultivar of basil (Ocimum basilicum L.). Planta Med. 2007;73(12):1250-1254. doi:10.1055/s-2007-981600

- Sikkema J, de Bont JA, Poolman B. Mechanisms of membrane toxicity of hydrocarbons. Microbiol Rev. 1995;59(2):201-222.

- Loughlin R, Gilmore BF, McCarron PA, Tunney MM. Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells. Lett Appl Microbiol. 2008;46(4):428-433. doi:10.1111/j.1472-765X.2008.02381.x

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Magnesium Sulfate:

Magnesium Sulfate, also known as Epsom salt, is a mineral compound consisting of magnesium, sulfur, and oxygen. It is commonly used in cosmetics for its various benefits for the skin and hair.

2. Use:

Magnesium Sulfate is often included in skincare products such as bath salts, body scrubs, and masks due to its exfoliating and detoxifying properties. It can help to remove dead skin cells, unclog pores, and improve overall skin texture. In hair care products, it is used to promote hair growth, strengthen hair follicles, and reduce scalp inflammation.

3. Usage Magnesium Sulfate:

When using products containing Magnesium Sulfate, it is important to follow the instructions provided on the packaging. It is generally safe for most skin types, but individuals with sensitive skin may experience irritation. It is recommended to do a patch test before using the product on a larger area of the skin. Avoid contact with the eyes and rinse thoroughly if contact occurs. Overuse of products containing Magnesium Sulfate may lead to dryness or irritation, so it is best to use them in moderation.

4. References:

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2013). Safety assessment of magnesium sulfate as used in cosmetics. International journal of toxicology, 32(6_suppl), 5S-22S.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

- Schreml, S., Szeimies, R. M., Prantl, L., Karrer, S., & Landthaler, M. (2008). A new concept of skin aging: In vivo aging of dermal collagen in skin. Experimental dermatology, 17(7), 549-557.

1. Definition Propanediol:

Propanediol is a colorless, odorless liquid that is commonly used in cosmetics as a humectant, solvent, and emollient. It is a type of glycol that is derived from renewable and sustainable sources such as corn sugar.

2. Use:

Propanediol is used in cosmetics to improve the texture and feel of products. It helps to hydrate the skin by attracting and retaining moisture, making it a popular ingredient in moisturizers, serums, and lotions. Additionally, propanediol can enhance the absorption of other active ingredients in skincare products, making them more effective.

3. Usage Propanediol:

Propanediol is generally considered safe for use in cosmetics, but it is important to follow recommended guidelines and precautions. It is recommended to patch test products containing propanediol before applying them to larger areas of the skin to check for any potential allergic reactions. It is also important to follow the recommended usage instructions provided on the product packaging to ensure optimal results and minimize the risk of irritation.

4. References:

- Zhang, X., Qian, H., & Tang, S. (2018). Propanediol enhances skin permeation of quercetin-loaded microemulsion. Drug Development and Industrial Pharmacy, 44(6), 1010-1016.

- Rigo, L. A., da Silva, D. F., & Sayer, C. (2019). Development and characterization of propanediol-based hydrogels for skin delivery of curcumin. International Journal of Biological Macromolecules, 132, 73-81.

- Huang, D., Zhang, Y., & Zhang, Z. (2017). Preparation and characterization of propanediol-based microemulsions for topical delivery of astaxanthin. Journal of Dispersion Science and Technology, 38(9), 1317-1323.

1. Definition Caprylyl Glycol:

Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.

2. Use:

Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.

3. Usage Caprylyl Glycol:

Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.

4. References:

- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017

- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.

- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition Pongamia Pinnata Seed Extract:

Pongamia Pinnata Seed Extract is a natural ingredient derived from the seeds of the Pongamia Pinnata tree, also known as the Indian Beech tree. This extract is rich in bioactive compounds such as flavonoids, alkaloids, and saponins, which have antioxidant, anti-inflammatory, and antimicrobial properties.

2. Use:

Pongamia Pinnata Seed Extract is commonly used in cosmetics for its skin benefits. It helps to protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. This extract is often included in skincare products such as serums, creams, and lotions to improve the appearance and texture of the skin.

3. Usage Pongamia Pinnata Seed Extract:

When using cosmetics containing Pongamia Pinnata Seed Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any allergic reactions or sensitivities. This extract is generally considered safe for topical use, but individuals with sensitive skin or allergies should consult with a dermatologist before incorporating it into their skincare routine.

4. References:

- Akhtar, N., Gupta, P., & Sangwan, N. S. (2019). Pongamia pinnata (L.) Pierre: A review on its ethnobotany, phytochemical and pharmacological profile. Phytomedicine, 58, 152871.

- Saini, R. K., Saini, S., & Sharma, S. (2016). Phytochemical and pharmacological potential of Pongamia pinnata: A review. Journal of Integrative Medicine, 14(2), 105-113.

- Kumar, A., & Patra, A. K. (2019). Pongamia pinnata (L.) Pierre: A comprehensive review on its phytochemicals, pharmacological activities, and nutritional aspects. Food and Chemical Toxicology, 133, 110792.

1. Definition Mauritia Flexuosa Fruit Oil:

Mauritia Flexuosa Fruit Oil, also known as buriti oil, is a natural oil extracted from the fruit of the Mauritia flexuosa palm tree, which is native to the Amazon rainforest. This oil is rich in essential fatty acids, vitamins, and antioxidants, making it a popular ingredient in cosmetic products.

2. Use:

Mauritia Flexuosa Fruit Oil is commonly used in skincare products due to its moisturizing and nourishing properties. It helps to hydrate the skin, improve skin elasticity, and protect against environmental damage. Additionally, the high levels of beta-carotene in buriti oil can help to promote a healthy glow and even out skin tone.

3. Usage Mauritia Flexuosa Fruit Oil:

Mauritia Flexuosa Fruit Oil can be used in a variety of cosmetic products, including facial oils, serums, moisturizers, and body lotions. It is typically added to formulations at a concentration of 1-5%, depending on the desired benefits. When using products containing buriti oil, it is important to perform a patch test first to check for any potential allergic reactions. Additionally, as with any skincare product, it is recommended to avoid contact with the eyes and discontinue use if any irritation occurs.

4. References:

- Costa, R.M.R., Neves, L.M.G., & Silva, B.M. (2014). Buriti oil (Mauritia flexuosa) as an oil phase in emulsions: Physical stability and rheological behavior. Journal of Dispersion Science and Technology, 35(2), 283-290.

- De Almeida, C.L.F., Falé, P.L.V., & Serralheiro, M.L.M. (2012). Antioxidant activity of Mauritia flexuosa L.f. (Arecaceae) oil. Food and Chemical Toxicology, 50(8), 2413-2419.

- Souza, M.C., Beserra, A.M., & Martins, V.E.P. (2019). Buriti oil (Mauritia flexuosa) supplementation in the diet of Wistar rats increases the liver antioxidant capacity and protects against the toxicity of the herbicide paraquat. Journal of Food Biochemistry, 43(10), e12977.

1. Definition Kunzea Pomifera Fruit Extract:

Kunzea Pomifera Fruit Extract is derived from the fruit of the Kunzea pomifera plant, also known as Muntries or Emu Apples. This extract is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare products.

2. Use:

Kunzea Pomifera Fruit Extract is commonly used in cosmetics for its anti-inflammatory, antioxidant, and moisturizing properties. It helps to protect the skin from environmental stressors, reduce redness and irritation, and promote a healthy, glowing complexion.

3. Usage Kunzea Pomifera Fruit Extract:

Kunzea Pomifera Fruit Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations of 1-5% and can be applied directly to the skin or mixed with other ingredients for added benefits. It is suitable for all skin types, including sensitive skin, but it is always recommended to do a patch test before using any new product containing this extract.

4. References:

- Vigar V, Myers S, Oliver C, Arendt EK. Physicochemical and functional properties of Kunzea pomifera (muntries) fruit extract. Food Chem. 2019; 279: 249-256.

- Al-Snafi AE. The pharmacological importance of Kunzea pomifera (Muntries) - A review. IOSR Journal of Pharmacy. 2019; 9(2): 01-07.

- Noakes M, Timms J, Williams D, et al. Antioxidant activity and phenolic content of Kunzea pomifera fruit extract. J Agric Food Chem. 2016; 64(45): 8563-8570.

1. Definition Tasmannia Lanceolata Fruit Extract:

Tasmannia Lanceolata Fruit Extract, also known as Mountain Pepper Extract, is derived from the native Tasmanian plant Tasmannia lanceolata. This extract is rich in antioxidants, particularly polyphenols, which help protect the skin from environmental damage and premature aging.

2. Use:

Tasmannia Lanceolata Fruit Extract is commonly used in skincare products for its anti-inflammatory and soothing properties. It is known to help reduce redness and irritation, making it suitable for sensitive skin types. Additionally, the extract has astringent properties that can help tighten pores and improve the overall texture of the skin.

3. Usage Tasmannia Lanceolata Fruit Extract:

Tasmannia Lanceolata Fruit Extract is typically found in serums, creams, and masks targeting sensitive or irritated skin. It can be applied directly to the skin or incorporated into existing skincare products. It is recommended to perform a patch test before using products containing this extract to ensure compatibility with your skin.

4. References:

- Marzocca A, Vastano BC, Malinconico M, et al. Antioxidant and antimicrobial properties of Tasmannia lanceolata: an Australian native plant. J Sci Food Agric. 2018;98(6):2253-2260. doi:10.1002/jsfa.8716

- De Oliveira JR, Camargo SEA, Marques MOM, et al. Chemical composition and antioxidant activity of Tasmannia lanceolata (Poir.) A.C.Sm. fruit. Food Chem. 2012;134(1):229-232. doi:10.1016/j.foodchem.2012.02.101

- Lohani A, Mishra A, Verma A, et al. Tasmannia lanceolata (Tasmanian pepper): a review of its traditional uses, phytochemistry, pharmacology, and toxicology. Phytother Res. 2021;35(1):1-22. doi:10.1002/ptr.6809