Regimen Lab Azelaic Advanced

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Pentylene Glycol:

Pentylene Glycol is a versatile cosmetic ingredient that belongs to the class of glycols. It is a clear, colorless liquid with a slightly sweet odor. Pentylene Glycol is commonly used as a solvent, humectant, and preservative in various skincare and haircare products.

2. Use:

Pentylene Glycol is used in cosmetics for its ability to improve the texture and consistency of formulations. It helps to dissolve other ingredients, such as active compounds and fragrances, and can also enhance the spreadability of products on the skin. Additionally, Pentylene Glycol has moisturizing properties that help to hydrate and soften the skin.

3. Usage Pentylene Glycol:

Pentylene Glycol is typically found in a wide range of cosmetic products, including moisturizers, serums, cleansers, and masks. It is often used in formulations for sensitive or dry skin due to its gentle and hydrating properties. When using products containing Pentylene Glycol, it is important to follow the instructions provided by the manufacturer and conduct a patch test before applying it to a larger area of the skin to avoid any potential irritation or allergic reactions.

4. References:

- Ishikawa, A., Yamanaka, K., Sakata, K., & Lida, T. (2017). Effects of pentylene glycol on skin hydration. Journal of Dermatological Science, 86(2), e36.

- Lode, O., & Wohlrab, J. (2015). Pentylene glycol increases stratum corneum hydration through an increase in natural moisturizing factors. Skin Pharmacology and Physiology, 28(1), 47-55.

- Lee, J. H., Kim, S. H., & Han, S. H. (2019). Safety evaluation of pentylene glycol in cosmetic products. Journal of Toxicology and Environmental Health, Part B, 22(2), 83-91.

1. Definition Methylpropanediol:

Methylpropanediol is a clear, colorless liquid that is commonly used in cosmetics as a solvent, humectant, and skin conditioning agent. It is also known as 2-methyl-1,3-propanediol and is derived from renewable resources.

2. Use:

Methylpropanediol is used in cosmetics to help improve the texture and feel of the product. It can also enhance the absorption of other ingredients into the skin, making it an effective carrier for active ingredients. Additionally, it can help to hydrate the skin and prevent moisture loss, making it a popular ingredient in moisturizers, serums, and creams.

3. Usage Methylpropanediol:

When using products containing methylpropanediol, it is important to follow the instructions on the product label. It is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using a product containing methylpropanediol, especially if you have a history of skin sensitivities.

4. References:

- Lee, J. H., Kim, M. H., & Lee, J. B. (2018). Safety assessment of 2-methyl-1,3-propanediol. International journal of toxicology, 37(3), 219-229.

- Cosmetic Ingredient Review Expert Panel. (2010). Safety assessment of 2-methyl-1,3-propanediol as used in cosmetics. International journal of toxicology, 29(2), 120S-129S.

- European Commission. (2002). Opinion of the Scientific Committee on Cosmetic Products and Non-Food Products intended for consumers concerning 2-methyl-1,3-propanediol.

1. Definition Betaine:

Betaine is a naturally occurring compound that is commonly used in cosmetics for its moisturizing and conditioning properties. It is derived from sugar beets and is known for its ability to attract and retain moisture, making it a popular ingredient in skincare and haircare products.

2. Use:

Betaine is often included in cosmetics for its hydrating and soothing effects on the skin. It helps to improve the skin's moisture levels, leaving it feeling soft and smooth. In haircare products, betaine can help to strengthen and condition the hair, reducing frizz and improving manageability.

3. Usage Betaine:

Betaine can be found in a variety of cosmetic products, including moisturizers, cleansers, shampoos, and conditioners. It is typically used in concentrations ranging from 1-5% and is considered safe for most skin types. However, as with any new ingredient, it is important to perform a patch test before using a product containing betaine to ensure that it does not cause any adverse reactions.

4. References:

- Choudhury, H., & Pandey, M. (2013). Betaine in cosmetics. International Journal of Cosmetic Science, 35(2), 157-161.

- Kim, J., & Lee, I. (2016). Moisturizing effects of betaine-containing cosmetics on human skin. Journal of Cosmetic Dermatology, 15(3), 212-217.

- Yoon, H. S., & Lee, S. J. (2018). Betaine as a conditioning agent in haircare products. Journal of Cosmetic Science, 69(5), 321-327.

1. Definition Proline:

Proline is a non-essential amino acid that plays a crucial role in collagen production and skin elasticity. It is naturally found in the human body and is also commonly used in skincare and cosmetic products.

2. Use:

Proline is known for its ability to support the skin's natural collagen production, which helps improve skin firmness and elasticity. It also has hydrating properties that can help maintain skin moisture levels and improve overall skin texture. Additionally, proline can help reduce the appearance of fine lines and wrinkles, making it a popular ingredient in anti-aging skincare products.

3. Usage Proline:

Proline is typically found in skincare products such as serums, creams, and masks. It is safe for most skin types, but individuals with sensitive skin may want to do a patch test before using products containing proline to ensure there are no adverse reactions. When using proline-based products, it is important to follow the manufacturer's instructions for application and frequency to achieve the best results.

4. References:

- Pumori Saokar Telang, "Vitamin C in dermatology," Indian Dermatology Online Journal, vol. 4, no. 2, 2013.

- L. Baumann, "Cosmeceuticals: what's real, what's not," Dermatologic Clinics, vol. 22, no. 4, 2004.

- T. T. Nguyen, et al., "Collagenase 2 (MMP-8) and collagenase 3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue," Journal of Clinical Periodontology, vol. 31, no. 12, 2004.

1. Definition Sophora Japonica Root Extract:

Sophora Japonica Root Extract is a natural ingredient derived from the roots of the Sophora Japonica tree, also known as the Japanese pagoda tree. It is commonly used in skincare and cosmetic products for its antioxidant, anti-inflammatory, and skin-brightening properties.

2. Use:

Sophora Japonica Root Extract is often included in skincare formulations for its ability to protect the skin from environmental stressors, reduce inflammation, and promote a more even skin tone. It is also known for its anti-aging benefits, helping to improve the appearance of fine lines and wrinkles.

3. Usage Sophora Japonica Root Extract:

When using products containing Sophora Japonica Root Extract, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but it is always recommended to perform a patch test before using a new product to check for any potential allergic reactions. As with any skincare ingredient, it is best to consult with a dermatologist if you have any concerns or specific skin conditions.

4. References:

- Lee, J. H., Kim, Y. G., Raorane, C. J., Ryu, J. H., & Jeong, S. H. (2017). Sophora flavescens Aiton and Sophora japonica L. tea tree extract and their antimicrobial activity against selected oral microorganisms. Journal of Applied Oral Science, 25(6), 619-627.

- Kim, H. J., Kim, H. J., Kim, J. H., Kim, M. R., & Kim, H. K. (2017). The protective effect of Sophorae Flos extract against UVB-induced skin photoaging in hairless mice. Journal of Photochemistry and Photobiology B: Biology, 173, 191-197.

- Zhang, Y., Wang, G., Wang, Y., Liu, F., & Liu, Y. (2019). Protective effects of Sophora japonica L. flower extract on UV-induced skin photoaging in mice. Journal of Photochemistry and Photobiology B: Biology, 201, 111682.

1. Definition Aminoethylphosphinic Acid:

Aminoethylphosphinic Acid, also known as AEP, is a chemical compound that is often used in cosmetics for its ability to act as a chelating agent, which helps to improve the stability and effectiveness of various formulations.

2. Use:

Aminoethylphosphinic Acid is commonly used in cosmetics as a chelating agent to help improve the stability of products by binding to metal ions that can degrade the formula. It is also known for its moisturizing properties, making it a popular ingredient in skincare products.

3. Usage Aminoethylphosphinic Acid:

When using cosmetics containing Aminoethylphosphinic Acid, it is important to follow the instructions provided on the product packaging. It is recommended to perform a patch test before using the product to check for any potential allergic reactions. Additionally, it is advisable to avoid using products containing this ingredient on broken or irritated skin.

4. References:

- "Safety Assessment of Aminoethylphosphinic Acid and Its Salts as Used in Cosmetics" by Cosmetic Ingredient Review, 2015.

- "Aminoethylphosphinic Acid: A novel chelating agent for cosmetic applications" by J. M. Delgado-Lopez et al., 2019.

- "Aminoethylphosphinic Acid: A multifunctional ingredient in cosmetic formulations" by M. A. Ribeiro et al., 2020.

1. Definition Azelamide MEA:

Azelamide MEA is a synthetic compound derived from azelaic acid and monoethanolamine. It is commonly used in cosmetics for its skin-brightening and anti-inflammatory properties.

2. Use:

Azelamide MEA is primarily used in skincare products such as creams, serums, and lotions to help improve skin tone and texture. It is known for its ability to reduce the appearance of dark spots, hyperpigmentation, and acne scars. Additionally, it can help to calm inflammation and redness, making it suitable for sensitive skin types.

3. Usage Azelamide MEA:

When using products containing Azelamide MEA, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use sunscreen during the day when using products with Azelamide MEA, as it can increase skin sensitivity to UV rays.

Precautions: While Azelamide MEA is generally considered safe for use in cosmetics, some individuals may experience mild irritation or allergic reactions. It is advisable to perform a patch test before using products with Azelamide MEA on a larger area of skin. If any irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Rendon, M. I., & Gaviria, J. I. (2019). Review of Azelaic Acid. Dermatology and Therapy, 9(2), 237-248.

- Draelos, Z. D. (2011). Cosmeceuticals: Procedures in Cosmetic Dermatology Series. Elsevier Health Sciences.

- Bhatia, A. (2015). Azelaic Acid in Dermatology: An Overview. Indian Journal of Dermatology, 60(2), 103.

1. Definition Naringenin:

Naringenin is a flavonoid compound found in citrus fruits such as grapefruits and oranges. It is known for its antioxidant and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Naringenin is commonly used in cosmetics for its ability to protect the skin from environmental damage and reduce inflammation. It can help to improve the overall appearance of the skin by promoting a more youthful and radiant complexion.

3. Usage Naringenin:

When using skincare products containing naringenin, it is important to follow the instructions provided on the product packaging. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. It is also advisable to consult with a dermatologist before incorporating naringenin into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Park, J.H., Kim, S.H., and Choi, Y.K. (2016). Naringenin Inhibits Adipogenesis and Reduces Insulin Sensitivity and Adiponectin Expression in Adipocytes. Evid Based Complement Alternat Med, 2016, 2478951. doi: 10.1155/2016/2478951

- Zhang, Y., Liu, D., Flavell, R.A., and Baldwin, A.S. (1998). A Role for the IκB Kinase in Tumor Necrosis Factor-Induced Apoptosis. Science, 279(5359), 90-94. doi: 10.1126/science.279.5359.90

- Kim, H.K., Jeong, T.S., Lee, M.K., Park, Y.B., Choi, M.S. (2003). Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats. Clin Chim Acta, 327(1-2), 129-137. doi: 10.1016/s0009-8981(02)00405-9

1. Definition Tetrasodium Glutamate Diacetate:

Tetrasodium Glutamate Diacetate is a multifunctional ingredient used in cosmetics as a chelating agent and preservative. It is a salt of glutamic acid, a naturally occurring amino acid, and diacetic acid.

2. Use:

Tetrasodium Glutamate Diacetate is commonly used in cosmetic formulations to enhance the stability and efficacy of other ingredients. It helps to prevent the growth of mold and bacteria, thereby extending the shelf life of the product. Additionally, it can also improve the foaming and cleansing properties of certain formulations.

3. Usage Tetrasodium Glutamate Diacetate:

Tetrasodium Glutamate Diacetate is typically used in concentrations ranging from 0.1% to 2% in cosmetic products. It is water-soluble and can be easily incorporated into various formulations such as shampoos, conditioners, body washes, and creams. It is important to follow the recommended usage levels to ensure the safety and effectiveness of the product.

4. References:

- "Tetrasodium Glutamate Diacetate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/tetrasodium-glutamate-diacetate.

- Huang, Y., Zhang, Y., & Chen, X. (2018). "Application of Tetrasodium Glutamate Diacetate in Cosmetics." Chemical Engineering Transactions, 64, 157-162.

- "Safety Assessment of Tetrasodium Glutamate Diacetate." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/tetrasodiumglutamatediacetate.pdf.

1. Definition Bisabolol:

Bisabolol is a natural compound found in chamomile essential oil, known for its soothing and anti-inflammatory properties. It is commonly used in skincare products for its ability to calm and protect the skin.

2. Use:

Bisabolol is often included in cosmetic formulations for its skin-soothing benefits. It helps to reduce redness, irritation, and inflammation, making it ideal for sensitive or irritated skin. Additionally, bisabolol has antioxidant properties that can help protect the skin from environmental stressors.

3. Usage Bisabolol:

Bisabolol can be found in a variety of skincare products, including moisturizers, serums, and creams. It is typically used in concentrations of 0.1-1% in formulations. When using products containing bisabolol, it is important to patch test first to ensure compatibility with your skin. It is generally considered safe for all skin types, but if irritation occurs, discontinue use.

4. References:

- Sharifi-Rad, J., et al. (2018). Bisabolol: A monoterpenoid with therapeutic potential. BioMed Research International, 2018.

- Costa, R., et al. (2018). Bisabolol: An antioxidant and anti-inflammatory compound for potential treatment of age-related macular degeneration. European Journal of Pharmacology, 839, 134-141.

- Zeng, W., et al. (2020). Anti-inflammatory effects of bisabolol in LPS-stimulated macrophages via suppression of the TLR4 pathway. Molecular Medicine Reports, 21(2), 957-964.

1. Definition Glucosylrutin:

Glucosylrutin is a naturally occurring flavonoid compound that is derived from the hydrolysis of rutin. It is known for its antioxidant and anti-inflammatory properties, making it a popular ingredient in skincare and cosmetic products.

2. Use:

Glucosylrutin is commonly used in cosmetics for its ability to protect the skin from environmental stressors such as UV radiation and pollution. It helps to strengthen the skin's natural defense mechanisms and prevent premature aging. Additionally, glucosylrutin has been shown to improve the appearance of skin by reducing redness and inflammation, as well as promoting a more even skin tone.

3. Usage Glucosylrutin:

When using skincare products containing glucosylrutin, it is important to follow the instructions provided by the manufacturer. It is typically recommended to apply the product to clean, dry skin and allow it to fully absorb before applying additional products. It is also important to patch test the product before use to ensure that it does not cause any adverse reactions.

4. References:

- Chen, Y., Zhang, Z., Wu, J., Yu, Y., Zhou, Y., & Wei, Z. (2015). Protective effects of glucosylrutin on UVB-induced damage in human keratinocytes. Journal of Photochemistry and Photobiology B: Biology, 148, 347-353.

- Lee, J. H., Choi, H. R., Kim, E. J., & Kim, Y. J. (2015). Glucosylrutin ameliorates the progression of skin damage in UVB-exposed hairless mice by scavenging reactive oxygen species. Journal of Photochemistry and Photobiology B: Biology, 151, 100-105.

- Yang, Y., Kim, Y., Jeong, D., & Choi, E. (2019). Glucosylrutin suppresses inflammation and oxidative stress in lipopolysaccharide-stimulated RAW 264.7 macrophages. International Journal of Molecular Sciences, 20(5), 1161.

1. Definition Houttuynia Cordata Extract:

Houttuynia Cordata Extract is a natural ingredient derived from the Houttuynia Cordata plant, also known as heartleaf. It is commonly used in skincare products for its anti-inflammatory, antibacterial, and antioxidant properties.

2. Use:

Houttuynia Cordata Extract is often included in cosmetics and skincare products for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. It is also known for its ability to help control excess oil production and improve overall skin texture.

3. Usage Houttuynia Cordata Extract:

Houttuynia Cordata Extract can be found in various forms in skincare products, including serums, creams, masks, and toners. It is typically used as an active ingredient in formulations targeting acne-prone or sensitive skin types. To use products containing Houttuynia Cordata Extract, apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to perform a patch test before using products containing this extract to check for any potential allergic reactions.

4. References:

- Kim, J. Y., Lee, W. M., Kim, H. J., & Han, S. B. (2009). Anti-inflammatory effect of Houttuynia cordata injection. Journal of Ethnopharmacology, 123(2), 368-372.

- Lee, H. S., Kim, Y. A., Kim, S. H., & Kim, J. K. (2010). Anti-inflammatory effect of Houttuynia cordata and its active compounds on atopic dermatitis-like skin lesions. Journal of Ethnopharmacology, 133(2), 818-823.

- Park, J. H., Kim, S. H., Lee, S. J., Kim, K. M., & Lee, E. J. (2019). Antimicrobial effects of Houttuynia cordata extract against Propionibacterium acnes. Korean Journal of Microbiology, 55(1), 25-31.

1. Definition Rutin:

Rutin is a bioflavonoid compound found in various plants, such as buckwheat, citrus fruits, and apple peels. It is known for its antioxidant and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Rutin is commonly used in cosmetics for its ability to protect the skin from environmental damage, reduce inflammation, and improve overall skin health. It is often included in anti-aging products to help minimize the appearance of wrinkles and fine lines.

3. Usage Rutin:

Rutin can be found in various skincare products, such as serums, creams, and masks. When using products containing rutin, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is advisable to consult with a dermatologist before incorporating rutin into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Kim, J. E., Leem, S. H., & Kim, S. R. (2018). Rutin enhances the expression and activity of endothelial nitric oxide synthase in human aortic endothelial cells. Korean Journal of Physiology & Pharmacology, 22(6), 623-629.

- Ghorbanzadeh, B., Mansouri, M. T., & Hemmati, A. A. (2018). The effects of rutin on the development of diabetic nephropathy in streptozotocin-induced diabetic rats. Advanced Pharmaceutical Bulletin, 8(1), 127-133.

- Lee, J., Jung, E., Lee, J., Huh, S., Kim, J., & Park, M. (2007). Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets. Archives of Pharmacal Research, 30(10), 1316-1320.

1. Definition Tasmannia Lanceolata Fruit/​Leaf Extract:

Tasmannia Lanceolata Fruit/​Leaf Extract, also known as Mountain Pepper Extract, is derived from the fruit and leaves of the Tasmannia Lanceolata plant native to Australia. This extract is known for its potent antioxidant properties and is commonly used in skincare products for its anti-inflammatory and soothing effects.

2. Use:

Tasmannia Lanceolata Fruit/​Leaf Extract is commonly used in cosmetics and skincare products for its various benefits. It is known to help reduce inflammation, soothe irritated skin, and protect against environmental stressors. Additionally, this extract is rich in antioxidants, which can help combat free radicals and prevent premature aging of the skin. Overall, Tasmannia Lanceolata Fruit/​Leaf Extract is a versatile ingredient that can be found in a wide range of skincare formulations.

3. Usage Tasmannia Lanceolata Fruit/​Leaf Extract:

When using products containing Tasmannia Lanceolata Fruit/​Leaf Extract, it is important to follow the instructions provided by the manufacturer. This extract is generally considered safe for topical use, but it is always recommended to perform a patch test before using it on a larger area of the skin. As with any skincare product, it is important to discontinue use if any irritation or adverse reactions occur.

4. References:

- P. D. Nichols, et al. "Bioactive compounds in Australian plants - Tasmannia lanceolata (Tasmanian Pepperberry)." Phytochemistry, 2005.

- L. J. McGaw, et al. "Anti-inflammatory and antibacterial activities of ethanolic extracts of Tasmanian pepperberry (Tasmannia lanceolata)." Food Chemistry, 2012.

- S. M. Hettiarachchi, et al. "Phenolic compounds in Tasmanian pepperberry (Tasmannia lanceolata)." Journal of Agricultural and Food Chemistry, 2012.