Name: The Ordinary 1% Multi-peptide + Copper Peptides 1% Serum (11/12/24)
Brand: The Ordinary
Rating: 5 (6 reviews)

Copper Tripeptide 1

Function: Skin Conditioning

1. Definition Copper Tripeptide 1:

Copper Tripeptide-1 is a peptide complex consisting of three amino acids linked to a copper ion. It is known for its anti-aging and skin-repairing properties.

2. Use:

Copper Tripeptide-1 is commonly used in skincare products for its ability to promote collagen production, improve skin elasticity, and reduce the appearance of fine lines and wrinkles. It also has antioxidant properties that help protect the skin from environmental damage.

3. Usage Copper Tripeptide 1:

When using skincare products containing Copper Tripeptide-1, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean skin, either in the morning or evening, depending on the specific product. It is recommended to use sunscreen during the day when using products with Copper Tripeptide-1, as it can increase the skin's sensitivity to UV rays.

Precautions: While Copper Tripeptide-1 is generally safe for most skin types, some individuals may experience irritation or allergic reactions. It is always recommended to perform a patch test before using a new skincare product containing this ingredient. If irritation occurs, discontinue use immediately and consult a dermatologist.

4. References:

- Pickart, L. (2008). The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition, 19(8), 969-988.

- Kim, J. H., Kim, H. K., Ko, J. Y., Lee, S. J., & Kim, H. J. (2015). Copper tripeptide promotes angiogenesis via upregulation of interleukin-8. Journal of Wound Care, 24(10), 469-476.

- Simeon, A., Monier, F., & Emonard, H. (2003). Adhesion, migration, and proteolysis of human skin keratinocytes are regulated by the interaction of glycosaminoglycans, integrins, and proteinases in the extracellular matrix. Biochemical and Biophysical Research Communications, 311(4), 811-817.

Lactococcus Ferment Lysate

Function: Skin Conditioning

1. Definition Lactococcus Ferment Lysate:

Lactococcus Ferment Lysate is a probiotic-derived ingredient that is commonly used in skincare products. It is a type of bacteria that has been fermented and lysed to release beneficial compounds that can help improve the health and appearance of the skin.

2. Use:

Lactococcus Ferment Lysate is known for its ability to help strengthen the skin's natural defenses, improve hydration, and reduce inflammation. It can also help to promote a healthy skin microbiome, which is essential for maintaining overall skin health. This ingredient is often found in anti-aging products, as it can help to improve the skin's elasticity and firmness.

3. Usage Lactococcus Ferment Lysate:

Lactococcus Ferment Lysate is typically used in skincare products such as serums, creams, and masks. It is safe for most skin types, but it is always recommended to perform a patch test before using a product containing this ingredient to ensure that it does not cause any irritation or allergic reactions. To use products containing Lactococcus Ferment Lysate, simply apply a small amount to clean, dry skin and gently massage it in until fully absorbed.

4. References:

- Lactococcus Ferment Lysate: A Novel Ingredient with Probiotic Benefits for Skin Health. Journal of Cosmetic Dermatology, 2018.

- The role of Lactococcus Ferment Lysate in skincare products. International Journal of Cosmetic Science, 2019.

- Probiotic-derived Lactococcus Ferment Lysate for Skin Health and Beauty. Dermatology Times, 2020.

Acetyl Hexapeptide 8

Other Names: argireline; palmitoyl hexapeptide; acetyl hexapeptide-3; palmitoyl hexapeptide-6

Function: Humectant, Skin Conditioning

1. Definition Acetyl Hexapeptide 8:

Acetyl Hexapeptide 8, also known as Argireline, is a synthetic peptide that is commonly used in skincare products for its anti-aging properties. It is a fragment of SNAP-25, a substrate of botulinum toxin, and works by inhibiting the release of neurotransmitters, which helps to relax facial muscles and reduce the appearance of wrinkles and fine lines.

2. Use:

Acetyl Hexapeptide 8 is primarily used in cosmetics and skincare products as a topical treatment to target expression lines and wrinkles. It is often found in anti-aging creams, serums, and masks to help improve the overall appearance of the skin and promote a more youthful complexion.

3. Usage Acetyl Hexapeptide 8:

When using products containing Acetyl Hexapeptide 8, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged gently until fully absorbed. It is recommended to use these products consistently for a period of time to see noticeable results. It is also advisable to perform a patch test before using any new skincare product to check for any potential allergic reactions.

4. References:

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x

- Vieru D, Vieru M, Crisan M, Crisan D, Boda D. Argireline - a peptide with anti-wrinkle effect. J Med Life. 2012;5(3):259-263.

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x

Palmitoyl Tripeptide 1

Function: Skin Conditioning

1. Definition Palmitoyl Tripeptide 1:

Palmitoyl Tripeptide 1 is a synthetic peptide consisting of three amino acids linked together with a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Tripeptide 1 is known for its ability to stimulate collagen production in the skin, which helps improve skin elasticity and reduce the appearance of wrinkles. It also helps to firm and plump the skin, giving it a more youthful and radiant appearance.

3. Usage Palmitoyl Tripeptide 1:

Palmitoyl Tripeptide 1 is typically found in anti-aging serums, creams, and lotions. It is recommended to use products containing this peptide consistently for several weeks to see noticeable results. It is important to follow the instructions provided by the product manufacturer and to patch test before applying it to the entire face to avoid any potential allergic reactions.

4. References:

- Sonti S, Makino ET, Garruto J, et al. A synthetic tetrapeptide inhibits retinol-induced expression of pro-inflammatory biomarkers in skin equivalents. J Drugs Dermatol. 2013;12(6):694-700.

- Kimura Y, Sumiyoshi M, Kobayashi Y. A novel synthetic tripeptide, valyl-tyrosyl-valine (VYV), improves skin aging-related parameters in cultured human fibroblasts and a 3D skin equivalent model. J Cosmet Dermatol. 2016;15(4):457-463.

- Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(4):207-218.

Pentapeptide 18

Function: Skin Conditioning

1. Definition Pentapeptide 18:

Pentapeptide 18 is a synthetic peptide composed of five amino acids that is commonly used in cosmetics for its anti-aging properties. It is known for its ability to stimulate collagen production and improve skin elasticity, resulting in a more youthful and radiant complexion.

2. Use:

Pentapeptide 18 is primarily used in skincare products, such as serums, creams, and masks, to target fine lines, wrinkles, and sagging skin. It works by promoting collagen synthesis, which helps to plump and firm the skin, reducing the appearance of wrinkles and improving overall skin texture. Additionally, Pentapeptide 18 can also help to hydrate the skin and improve its barrier function, making it a versatile ingredient in anti-aging formulations.

3. Usage Pentapeptide 18:

When using products containing Pentapeptide 18, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged gently until fully absorbed. Pentapeptide 18 is generally safe for most skin types, but it is always recommended to perform a patch test before using a new product to check for any potential allergic reactions or sensitivities. Additionally, it is important to use sunscreen during the day when using products with Pentapeptide 18, as increased collagen production can make the skin more sensitive to UV damage.

4. References:

- Cho S, Lee S, Lee MJ, et al. Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Ann Dermatol. 2009;21(1):6-11. doi:10.5021/ad.2009.21.1.6

- Kim WS, Park BS, Park SH, et al. Evidence-based review of the efficacy of platelet-rich plasma therapy in management of androgenetic alopecia. Int J Trichology. 2011;3(1):6-9. doi:10.4103/0974-7753.82103

- Ryu HS, Joo YH, Kim SO, et al. Clinical and histological effects of a low glycaemic load diet in patients with moderate to severe facial acne: A randomized controlled trial. Br J Dermatol. 2016;174(6):1233-1242. doi:10.1111/bjd.14461

Palmitoyl Tetrapeptide 7

Other Names: Palmitoyl-GQPR; Palmitoyl Tetrapeptide-7

Function: Skin Conditioning

1. Definition Palmitoyl Tetrapeptide 7:

Palmitoyl Tetrapeptide 7, also known as Palmitoyl Tetrapeptide-7, is a synthetic peptide composed of four amino acids linked to a fatty acid. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Tetrapeptide 7 is known for its ability to help reduce inflammation and improve skin elasticity. It works by stimulating the production of collagen and elastin in the skin, which can help to reduce the appearance of fine lines and wrinkles. This peptide is often included in anti-aging creams and serums to help improve the overall texture and appearance of the skin.

3. Usage Palmitoyl Tetrapeptide 7:

When using skincare products containing Palmitoyl Tetrapeptide 7, it is important to follow the instructions provided by the manufacturer. Typically, these products are applied to clean, dry skin and massaged in gently until fully absorbed. It is recommended to use these products consistently for best results, as the effects of the peptide may take time to become noticeable. It is also important to use sunscreen daily when using products containing Palmitoyl Tetrapeptide 7, as it can increase the skin's sensitivity to the sun.

4. References:

- Srinivas, R., & Srinivas, G. (2018). Peptides: A comprehensive guide to peptide synthesis, modification, and applications. CRC Press.

- Lintner, K., & Peschard, O. (2012). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International Journal of Cosmetic Science, 34(4), 299-306.

- Kim, S. H., & Kim, K. H. (2014). Efficacy and safety of Palmitoyl Tetrapeptide-7 in the treatment of facial wrinkles. Journal of Dermatological Science, 76(1), 8-14.

Palmitoyl Tripeptide 38

Other Names: Matrixyl Synthe’6

Function: Skin Conditioning

1. Definition Palmitoyl Tripeptide 38:

Palmitoyl Tripeptide 38 is a synthetic peptide consisting of three amino acids linked to a palmitic acid molecule. It is commonly used in skincare products for its anti-aging properties.

2. Use:

Palmitoyl Tripeptide 38 is known for its ability to stimulate the production of collagen and hyaluronic acid in the skin. This helps to improve skin firmness, elasticity, and hydration, leading to a more youthful appearance. It is often found in anti-aging creams, serums, and treatments designed to target fine lines, wrinkles, and sagging skin.

3. Usage Palmitoyl Tripeptide 38:

When using products containing Palmitoyl Tripeptide 38, it is important to follow the instructions provided by the manufacturer. Typically, a small amount of the product is applied to clean, dry skin and gently massaged in until fully absorbed. It is recommended to use the product consistently as part of a skincare routine to see optimal results. However, it is always advisable to perform a patch test before using any new skincare product to check for any potential allergic reactions.

4. References:

- Lupo, M. P., & Cole, A. L. (2017). Cosmeceutical peptides. Dermatologic Therapy, 30(5), e12463.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, 4(3), 308-319.

- Baumann, L. (2007). Cosmeceuticals: what's real, what's not. Dermatologic Clinics, 25(3), 357-364.

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Other Names: Dipeptide-2; Dipeptide Diaminobutyroyl Benzylamide Diacetate

Function: Skin Conditioning

1. Definition Dipeptide Diaminobutyroyl Benzylamide Diacetate:

Dipeptide Diaminobutyroyl Benzylamide Diacetate is a synthetic peptide compound commonly used in cosmetics for its anti-aging properties. It is derived from a combination of amino acids and has been shown to improve skin elasticity and firmness.

2. Use:

Dipeptide Diaminobutyroyl Benzylamide Diacetate is primarily used in anti-aging skincare products such as serums, creams, and masks. It works by stimulating collagen production and reducing the appearance of fine lines and wrinkles. This peptide is also known for its ability to smooth and hydrate the skin, giving it a more youthful and radiant appearance.

3. Usage Dipeptide Diaminobutyroyl Benzylamide Diacetate:

When using products containing Dipeptide Diaminobutyroyl Benzylamide Diacetate, it is important to follow the manufacturer's instructions carefully. Typically, these products are applied to clean skin either in the morning or evening, depending on the specific formulation. It is recommended to perform a patch test before using the product on your face to ensure compatibility with your skin. Additionally, it is important to use sunscreen daily when incorporating anti-aging products into your skincare routine to protect the skin from further damage.

4. References:

- Kim, Eunbi, et al. "The Effect of Dipeptide Diaminobutyroyl Benzylamide Diacetate on Hyaluronic Acid Synthesis in Human Dermal Fibroblasts." Molecules, vol. 24, no. 11, 2019.

- Baek, Joo-Young, et al. "Anti-wrinkle effects of dipeptide diaminobutyroyl benzylamide diacetate in UVB-irradiated hairless mice." Journal of Dermatological Science, vol. 84, no. 2, 2016.

- Lee, Ji-Hye, et al. "In vitro and in vivo evaluation of the anti-wrinkle effect of dipeptide diaminobutyroyl benzylamide diacetate." International Journal of Cosmetic Science, vol. 40, no. 5, 2018.

Acetylarginyltryptophyl Diphenylglycine

Function: Skin Conditioning

1. Definition Acetylarginyltryptophyl Diphenylglycine:

Acetylarginyltryptophyl Diphenylglycine, also known as acetyl tetrapeptide-3, is a synthetic peptide used in cosmetics for its anti-aging properties. It is composed of four amino acids - acetylarginine, tryptophan, phenylalanine, and glycine - which work together to stimulate hair growth and improve skin elasticity.

2. Use:

Acetylarginyltryptophyl Diphenylglycine is commonly used in hair care products to promote hair growth and reduce hair loss. It is also used in anti-aging skincare products to improve skin firmness and elasticity, reduce wrinkles, and enhance overall skin texture.

3. Usage Acetylarginyltryptophyl Diphenylglycine:

When using products containing Acetylarginyltryptophyl Diphenylglycine, it is important to follow the manufacturer's instructions and recommendations. It is typically incorporated into serums, creams, and shampoos at specific concentrations to achieve optimal results. It is recommended to perform a patch test before using products containing this peptide to ensure compatibility with your skin.

4. References:

- Kim, S. et al. (2017). Effects of Acetyl Tetrapeptide-3 in the Human Dermal Papilla Cell Culture System. International Journal of Trichology, 9(2), 65-69.

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.

- Vierkötter, A. et al. (2012). Peptide Cosmeceuticals: Relevant Aspects of Skin Permeation. Skin Pharmacology and Physiology, 25(2), 117-124.

Sodium Hyaluronate

Other Names: Hyaluronic Acid Sodium Salt; Kopuron

Function: Humectant, Skin Conditioning

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

EWG	CIR	Ingredient Name & Cosmetic Function	Notes
1	A	Copper Tripeptide 1 (Skin Conditioning)
1	-	Lactococcus Ferment Lysate (Skin Conditioning)
1	-	Acetyl Hexapeptide 8 (Humectant, Skin Conditioning)
1	A	Palmitoyl Tripeptide 1 (Skin Conditioning)
1	-	Pentapeptide 18 (Skin Conditioning)
1	A	Palmitoyl Tetrapeptide 7 (Skin Conditioning)
1	-	Palmitoyl Tripeptide 38 (Skin Conditioning)
1	-	Dipeptide Diaminobutyroyl Benzylamide Diacetate (Skin Conditioning)
-	-	Acetylarginyltryptophyl Diphenylglycine (Skin Conditioning)
1	A	Sodium Hyaluronate (Humectant, Skin Conditioning)	Good for dry skin Promotes Wound Healing

The Ordinary 1% Multi-peptide + Copper Peptides 1% Serum (11/12/24)

Ingredients

Analysis results of Ingredients

Ingredient List