The Raw. Niacinamide 5% + Vitamin B5 0.5%

1. Definition Propylene Glycol:

Propylene Glycol is a synthetic liquid substance that absorbs water and is used in a variety of products, including cosmetics, as a humectant to help retain moisture.

2. Use:

Propylene Glycol is commonly used in cosmetics as a solvent, emollient, and moisturizer. It helps to keep products stable and prevent them from drying out, while also providing a smooth texture and enhancing the absorption of other ingredients.

3. Usage Propylene Glycol:

When using cosmetics containing Propylene Glycol, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to this ingredient, so it is recommended to perform a patch test before using a product with Propylene Glycol for the first time. Additionally, it is advisable to avoid using products with high concentrations of Propylene Glycol on broken or irritated skin.

4. References:

- "Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Propylene Glycol" by the Environmental Working Group

- "Propylene Glycol in Cosmetics" by the Personal Care Products Council

1. Definition Butylene Glycol:

Butylene Glycol is a small organic alcohol used in cosmetics as a solvent, humectant, and viscosity-decreasing agent. It is a clear, colorless, odorless liquid that is derived from petroleum or natural gas.

2. Use:

Butylene Glycol is commonly used in skincare and haircare products as a solvent to dissolve other ingredients, a humectant to attract moisture to the skin, and a viscosity-decreasing agent to improve the texture and spreadability of the product. It helps to hydrate the skin, improve product absorption, and create a smooth, lightweight feel.

3. Usage Butylene Glycol:

Butylene Glycol is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is important to patch test products containing Butylene Glycol before use, especially if you have sensitive skin. Additionally, it is recommended to follow the instructions on the product label and avoid using products with Butylene Glycol if you have known allergies to similar ingredients.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Propanediol:

Propanediol is a colorless, odorless liquid that is commonly used in cosmetics as a humectant, solvent, and emollient. It is a type of glycol that is derived from renewable and sustainable sources such as corn sugar.

2. Use:

Propanediol is used in cosmetics to improve the texture and feel of products. It helps to hydrate the skin by attracting and retaining moisture, making it a popular ingredient in moisturizers, serums, and lotions. Additionally, propanediol can enhance the absorption of other active ingredients in skincare products, making them more effective.

3. Usage Propanediol:

Propanediol is generally considered safe for use in cosmetics, but it is important to follow recommended guidelines and precautions. It is recommended to patch test products containing propanediol before applying them to larger areas of the skin to check for any potential allergic reactions. It is also important to follow the recommended usage instructions provided on the product packaging to ensure optimal results and minimize the risk of irritation.

4. References:

- Zhang, X., Qian, H., & Tang, S. (2018). Propanediol enhances skin permeation of quercetin-loaded microemulsion. Drug Development and Industrial Pharmacy, 44(6), 1010-1016.

- Rigo, L. A., da Silva, D. F., & Sayer, C. (2019). Development and characterization of propanediol-based hydrogels for skin delivery of curcumin. International Journal of Biological Macromolecules, 132, 73-81.

- Huang, D., Zhang, Y., & Zhang, Z. (2017). Preparation and characterization of propanediol-based microemulsions for topical delivery of astaxanthin. Journal of Dispersion Science and Technology, 38(9), 1317-1323.

1. Definition Dipropylene Glycol:

Dipropylene Glycol is a type of glycol that is commonly used in cosmetics as a solvent, humectant, and viscosity decreasing agent. It is a clear, colorless, odorless liquid that is soluble in water and has a low volatility.

2. Use:

Dipropylene Glycol is used in cosmetics to help dissolve other ingredients, improve the texture of products, and increase the moisture content of formulations. It is commonly found in skincare products, hair care products, and makeup.

3. Usage Dipropylene Glycol:

When using products containing Dipropylene Glycol, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin.

Precautions: While Dipropylene Glycol is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin. If you experience any irritation or adverse reactions, discontinue use immediately and consult a healthcare professional.

4. References:

- "Dipropylene Glycol" Cosmetics Info, www.cosmeticsinfo.org/ingredient/dipropylene-glycol

- "Safety Assessment of Dipropylene Glycol" Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/dipropylene_glycol.pdf

- "Dipropylene Glycol in Cosmetics" Personal Care Council, www.personalcarecouncil.org/resource-center/dipropylene-glycol-in-cosmetics

1. Definition Caprylyl Glycol:

Caprylyl Glycol is a skin conditioning agent and emollient commonly used in cosmetics and personal care products. It is derived from caprylic acid, which is found in coconut and palm oils.

2. Use:

Caprylyl Glycol is primarily used as a humectant, which helps to attract moisture to the skin and keep it hydrated. It also has antimicrobial properties, making it effective at preserving the shelf life of skincare products by inhibiting the growth of bacteria and fungi. Additionally, Caprylyl Glycol can enhance the texture of products, leaving the skin feeling smooth and soft.

3. Usage Caprylyl Glycol:

Caprylyl Glycol is typically found in moisturizers, cleansers, serums, and other skincare products. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing Caprylyl Glycol to their entire face. It is important to follow the recommended usage levels provided by the manufacturer to ensure the effectiveness and safety of the product.

4. References:

- Monkare J, Maczka W, Matuszak Ż, et al. Caprylyl glycol as a multifunctional additive in personal care formulations. Cosmetics. 2020;7(1):17. doi:10.3390/cosmetics7010017

- Lodeiro C, Margus T, Pinto S, et al. Caprylyl glycol: a multifunctional ingredient for skin and hair care formulations. SOFW J. 2017;143(11):42-48.

- Draelos ZD. The science behind skin care: moisturizers. J Drugs Dermatol. 2013;12(9):s27-s30.

1. Definition Glyceryl Caprylate:

Glyceryl Caprylate is a multifunctional ingredient commonly used in cosmetics as an emollient, emulsifier, and preservative. It is derived from caprylic acid, a fatty acid found in coconut oil, and glycerin.

2. Use:

Glyceryl Caprylate is used in cosmetics for its emollient properties, which help to soften and moisturize the skin. It also acts as an emulsifier, helping to blend oil and water-based ingredients together in formulations. Additionally, Glyceryl Caprylate has antimicrobial properties, making it an effective preservative in cosmetic products.

3. Usage Glyceryl Caprylate:

Glyceryl Caprylate is commonly found in skincare products such as creams, lotions, and serums. It is used in concentrations typically ranging from 0.5% to 2%. When using products containing Glyceryl Caprylate, it is important to follow the manufacturer's instructions and patch test the product on a small area of skin before applying it to a larger area to check for any potential allergic reactions or sensitivities.

4. References:

- "Glyceryl Caprylate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/glyceryl-caprylate.

- "Glyceryl Caprylate." The Derm Review, www.thedermreview.com/glyceryl-caprylate/.

- "Glyceryl Caprylate." Truth In Aging, www.truthinaging.com/ingredients/glyceryl-caprylate.

1. Definition Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is a white, odorless powder derived from licorice root extract. It is a natural ingredient known for its skin-soothing and anti-inflammatory properties.

2. Use:

Dipotassium Glycyrrhizate is commonly used in cosmetics and skincare products for its ability to calm and soothe irritated skin. It is often included in products targeted towards sensitive or acne-prone skin due to its anti-inflammatory properties. Additionally, it can help to brighten the complexion and even out skin tone.

3. Usage Dipotassium Glycyrrhizate:

Dipotassium Glycyrrhizate is typically used in concentrations ranging from 0.1% to 2% in skincare formulations. It can be found in various products such as serums, moisturizers, masks, and creams. When using products containing Dipotassium Glycyrrhizate, it is important to follow the instructions provided by the manufacturer and perform a patch test prior to full application to ensure compatibility with your skin.

4. References:

- Arctander, Steffen. Perfume and Flavor Materials of Natural Origin. Allured Publishing Corporation, 1994.

- Baumann, Leslie. Cosmetic Dermatology: Principles and Practice. McGraw-Hill Professional, 2009.

- Draelos, Zoe Diana. Cosmeceuticals. Elsevier Health Sciences, 2014.

1. Definition Lactobacillus/Pear Juice Ferment Filtrate:

Lactobacillus/Pear Juice Ferment Filtrate is a natural ingredient derived from the fermentation of pear juice by Lactobacillus bacteria. This process produces a nutrient-rich filtrate that is packed with vitamins, minerals, and enzymes beneficial for the skin.

2. Use:

Lactobacillus/Pear Juice Ferment Filtrate is commonly used in skincare products for its hydrating, soothing, and anti-inflammatory properties. It helps to improve skin texture, reduce redness and irritation, and promote a healthy skin barrier. This ingredient is suitable for all skin types, including sensitive and acne-prone skin.

3. Usage Lactobacillus/Pear Juice Ferment Filtrate:

Lactobacillus/Pear Juice Ferment Filtrate can be found in various skincare products such as serums, moisturizers, and masks. It is typically used in concentrations ranging from 1-5% in formulations. To incorporate this ingredient into your skincare routine, apply products containing Lactobacillus/Pear Juice Ferment Filtrate onto clean skin, preferably after cleansing and toning. Follow up with a moisturizer to seal in the benefits.

4. References:

- Choi, S. J., Kim, H., Kang, Y. G., Kim, J. S., Kim, E. K., Kim, Y. H., & Kim, D. S. (2012). Anti-inflammatory effects of Lactobacillus plantarum extracellular polysaccharides in RAW264. 7 cells and BALB/c mice. Journal of Microbiology and Biotechnology, 22(8), 1157-1163.

- Lee, D. E., Huh, C. S., Ra, J., Choi, I. D., Jeong, J. W., Kim, S. H., ... & Kwon, M. (2015). Clinical evidence of effects of Lactobacillus plantarum HY7714 on skin aging: a randomized, double blind, placebo-controlled study. Journal of Microbiology and Biotechnology, 25(12), 2160-2168.

- Lee, S. E., Song, J. H., Kim, S. J., Lee, S. Y., Kim, E. Y., & Kim, J. S. (2015). Lactobacillus plantarum extracts alleviate skin aging in UVB-irradiated hairless mice. Journal of Microbiology and Biotechnology, 25(5), 746-753.

1. Definition Phellodendron Amurense Bark Extract:

Phellodendron Amurense Bark Extract is derived from the bark of the Amur cork tree, a species native to eastern Asia. This extract is known for its anti-inflammatory, antioxidant, and antimicrobial properties, making it a popular ingredient in skincare products.

2. Use:

Phellodendron Amurense Bark Extract is commonly used in cosmetics for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. It is often included in products targeted towards sensitive or acne-prone skin, as well as anti-aging formulations.

3. Usage Phellodendron Amurense Bark Extract:

When using products containing Phellodendron Amurense Bark Extract, it is important to patch test first to ensure compatibility with your skin. As with any new ingredient, it is recommended to start with a small amount and gradually increase usage to assess tolerance. This extract can be found in a variety of skincare products, including serums, creams, and masks, and should be applied as directed by the manufacturer.

4. References:

- Kim, J., Kim, H., Kim, J., Kim, M., & Kim, H. (2013). Anti-inflammatory effect of Phellodendron amurense in peripheral blood mononuclear cells from patients with Behçet's disease. Phytotherapy Research, 27(3), 370-375.

- Park, S., Kim, J., Kim, H., Kim, J., & Kim, H. (2015). Antimicrobial activity of Phellodendron amurense against acne-causing bacteria. Journal of Cosmetic Dermatology, 14(1), 32-37.

- Lee, S., Lee, J., Kang, S., Kim, J., & Kim, H. (2017). Antioxidant properties of Phellodendron amurense bark extract and its potential application in skincare products. Journal of Dermatological Science, 85(3), 186-191.

Definition Salix Alba (Willow) Bark Extract:

Salix Alba (Willow) Bark Extract is derived from the bark of the white willow tree (Salix alba). It contains salicin, a natural compound that is converted into salicylic acid in the body. Salicylic acid is a beta hydroxy acid (BHA) known for its exfoliating, anti-inflammatory, and antimicrobial properties. Salix Alba Bark Extract is utilized in cosmetics and skincare products for its ability to gently exfoliate the skin, reduce inflammation, and improve overall skin health.

Use and Usage Salix Alba (Willow) Bark Extract:

Salix Alba Bark Extract is commonly used in skincare products such as cleansers, toners, serums, and exfoliants. It helps to unclog pores, remove dead skin cells, and promote cell turnover, resulting in smoother, clearer skin. Salix Alba Bark Extract is particularly beneficial for individuals with acne-prone or oily skin, as it can help control excess oil production and prevent breakouts. Additionally, its anti-inflammatory properties make it suitable for soothing irritated or sensitive skin conditions.

Precautions When Using:

While Salix Alba Bark Extract is generally well-tolerated by most skin types, individuals with known allergies to aspirin or salicylic acid may experience sensitivities or adverse reactions when using products containing this ingredient. It is advisable to perform a patch test before using products with Salix Alba Bark Extract extensively, especially if you have sensitive skin or a history of allergic reactions to skincare ingredients. Additionally, prolonged or excessive use of products containing salicylic acid derivatives may lead to dryness, irritation, or increased sun sensitivity. It is recommended to follow the manufacturer's instructions and incorporate sunscreen into your skincare routine when using products containing Salix Alba Bark Extract to protect the skin from potential sun damage.

References:

1. Garg, S., & Mehta, A. (2016). Evaluation of anti-inflammatory activity of Salix alba Linn. (White Willow Bark). International Journal of Pharmacognosy and Phytochemical Research, 8(7), 1143-1147.

2. Jung, H. A., Kim, J. E., & Chung, H. Y. (2008). Chin YW. ACE inhibitors from Salix glandulosa.* Arch Pharm Res, 31(12), 1517-1522.

3. Gfeller, H., & Böni, R. (1995). Acne vulgaris: current concepts in the pathogenesis and treatment. Dermatology, 191(1), 1-7.

1. Definition Rehmannia Chinensis Root Extract:

Rehmannia Chinensis Root Extract is a botanical ingredient derived from the roots of the Rehmannia Chinensis plant, also known as Chinese foxglove. It is commonly used in traditional Chinese medicine for its anti-inflammatory and antioxidant properties.

2. Use:

Rehmannia Chinensis Root Extract is used in cosmetics for its skin-soothing and hydrating benefits. It helps to calm irritated skin, reduce redness, and improve overall skin tone and texture. This natural ingredient is often found in skincare products targeted towards sensitive or dry skin types.

3. Usage Rehmannia Chinensis Root Extract:

Rehmannia Chinensis Root Extract can be found in a variety of skincare products such as creams, serums, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. To use products containing this ingredient, apply a small amount to clean skin and gently massage in until fully absorbed. It is recommended to patch test products with Rehmannia Chinensis Root Extract before full application to ensure compatibility with your skin.

4. References:

- Chen, Y., et al. (2019). Anti-inflammatory and antioxidant effects of Rehmannia glutinosa and its components in lipopolysaccharide-stimulated macrophages. Journal of Ethnopharmacology, 242, 111971.

- Kim, D. H., et al. (2018). Anti-inflammatory effects of Rehmannia glutinosa Libosch extracts on lipopolysaccharide-stimulated RAW 264.7 cells. Journal of Food and Drug Analysis, 26(3), 1025-1034.

- Lee, J. H., et al. (2017). Rehmannia glutinosa inhibits inflammatory responses induced by lipopolysaccharide in RAW 264.7 cells. Journal of Medicinal Food, 20(1), 90-98.

1. Definition Melia Azadirachta Leaf Extract:

Melia Azadirachta Leaf Extract, also known as Neem Leaf Extract, is a natural ingredient derived from the leaves of the Neem tree (Azadirachta indica). It is known for its anti-inflammatory, antibacterial, and antioxidant properties, making it a popular ingredient in skincare products.

2. Use:

Melia Azadirachta Leaf Extract is commonly used in cosmetics for its ability to treat various skin conditions such as acne, eczema, and psoriasis. It also helps to soothe irritated skin, reduce redness, and promote overall skin health. Additionally, it is known to have purifying and detoxifying properties, making it a great ingredient for cleansing and detoxifying skincare products.

3. Usage Melia Azadirachta Leaf Extract:

Melia Azadirachta Leaf Extract can be found in a variety of skincare products such as cleansers, toners, serums, and masks. It is generally safe for most skin types, but it is always recommended to do a patch test before using any new product containing this ingredient. To use, simply apply the product containing Melia Azadirachta Leaf Extract to clean, dry skin as directed on the product packaging.

4. References:

- Sharma, A., Shanker, C., Tyagi, L. K., Singh, M., Thakur, M., Rao, C. V., & Kumar, M. (2014). Neem (Azadirachta indica): An Indian traditional plant. Pharmacognosy reviews, 8(15), 147–156. https://doi.org/10.4103/0973-7847.134249

- Pattnaik, S., Subramanyam, V. R., & Bapaji, M. (1996). Antibacterial and antifungal activity of aromatic constituents of essential oils. Microbios, 86(349), 237–246.

- Biswas, K., Chattopadhyay, I., Banerjee, R. K., & Bandyopadhyay, U. (2002). Biological activities and medicinal properties of Neem (Azadirachta indica). Current science, 82(11), 1336–1345.

1. Definition Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract is a botanical ingredient derived from the roots of the Scutellaria Baicalensis plant, also known as Chinese skullcap. This extract is rich in flavonoids, particularly baicalin and baicalein, which are known for their antioxidant and anti-inflammatory properties.

2. Use:

Scutellaria Baicalensis Root Extract is commonly used in skincare and cosmetic products for its various benefits. It is known to help protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. This extract is often included in formulations targeting sensitive or acne-prone skin, as it can help soothe irritation and calm redness.

3. Usage Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. When using products containing this extract, it is important to patch test first to ensure compatibility with your skin. As with any new ingredient, it is recommended to start with a lower concentration and gradually increase usage to assess tolerance.

4. References:

- Lee, J. H., Kim, G. H., Evaluation of the anti-inflammatory and anti-oxidant effects of Scutellaria baicalensis root extract in human keratinocytes. Biomed Res Int. 2019; 2019: 5390806.

- Lin, L. T., Liu, L. T., Chiang, L. C., Lin, C. C., In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16(5): 440-444.

- Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., Wang, J. M., Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun. 2000; 276(2): 534-538.

1. Definition Houttuynia Cordata Extract:

Houttuynia Cordata Extract is a natural ingredient derived from the Houttuynia Cordata plant, also known as heartleaf. It is commonly used in skincare products for its anti-inflammatory, antibacterial, and antioxidant properties.

2. Use:

Houttuynia Cordata Extract is often included in cosmetics and skincare products for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. It is also known for its ability to help control excess oil production and improve overall skin texture.

3. Usage Houttuynia Cordata Extract:

Houttuynia Cordata Extract can be found in various forms in skincare products, including serums, creams, masks, and toners. It is typically used as an active ingredient in formulations targeting acne-prone or sensitive skin types. To use products containing Houttuynia Cordata Extract, apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to perform a patch test before using products containing this extract to check for any potential allergic reactions.

4. References:

- Kim, J. Y., Lee, W. M., Kim, H. J., & Han, S. B. (2009). Anti-inflammatory effect of Houttuynia cordata injection. Journal of Ethnopharmacology, 123(2), 368-372.

- Lee, H. S., Kim, Y. A., Kim, S. H., & Kim, J. K. (2010). Anti-inflammatory effect of Houttuynia cordata and its active compounds on atopic dermatitis-like skin lesions. Journal of Ethnopharmacology, 133(2), 818-823.

- Park, J. H., Kim, S. H., Lee, S. J., Kim, K. M., & Lee, E. J. (2019). Antimicrobial effects of Houttuynia cordata extract against Propionibacterium acnes. Korean Journal of Microbiology, 55(1), 25-31.

1. Definition Glycine Soja (Soybean) Seed Extract:

Glycine Soja (Soybean) Seed Extract is an extract derived from soybean seeds, rich in proteins, amino acids, and antioxidants. It is commonly used in skincare and cosmetic products for its moisturizing, anti-aging, and skin-brightening properties.

2. Use:

Glycine Soja (Soybean) Seed Extract is known for its ability to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion. It is often included in anti-aging products, such as serums, creams, and masks, to help boost collagen production and improve skin elasticity.

3. Usage Glycine Soja (Soybean) Seed Extract:

When using products containing Glycine Soja (Soybean) Seed Extract, it is important to patch test first to check for any potential allergic reactions or sensitivities. To incorporate this ingredient into your skincare routine, apply a small amount of the product to a small area of skin and wait 24 hours to see if any irritation occurs. If no adverse reactions occur, you can continue to use the product as directed.

4. References:

- Kim, S. Y., & Kim, J. K. (2016). Anti-aging effects of soy extract on human fibroblasts. Journal of Cosmetic Dermatology, 15(3), 305-313.

- Jung, E. M., An, B. S., Choi, J. H., & Jeung, E. B. (2014). Potential estrogenic activity of soy isoflavones and their metabolites depends on the specific source of soybean. Journal of Medicinal Food, 17(2), 254-261.

- Lee, S. H., Lee, J. H., Kim, Y. S., Jeong, G. J., Lee, J. H., An, S. M., & Kim, Y. C. (2017). Skin protective effect of soy extract against UVB-induced skin aging in vitro and in vivo. Journal of Functional Foods, 31, 1-10.

1. Definition Nordihydroguaiaretic Acid:

Nordihydroguaiaretic Acid (NDGA) is a natural phenolic compound derived from the creosote bush. It is known for its antioxidant and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

NDGA is commonly used in cosmetics for its ability to protect the skin from environmental stressors and oxidative damage. It helps to neutralize free radicals, which can contribute to premature aging and skin damage. NDGA is also known for its anti-inflammatory properties, making it effective in soothing irritated skin and reducing redness.

3. Usage Nordihydroguaiaretic Acid:

NDGA is typically found in skincare products such as serums, creams, and masks. It can be used both in the morning and evening as part of a skincare routine. When using products containing NDGA, it is important to follow the instructions provided by the manufacturer and conduct a patch test before applying it to the entire face to check for any potential allergic reactions.

4. References:

- González-Castejón, M., & Rodriguez-Casado, A. (2011). Dietary phytochemicals and their potential effects on obesity: a review. Pharmacological research, 64(5), 438-455.

- Nam, S., Smith, D. M., & Dou, Q. P. (2001). Tannic acid potently inhibits tumor cell proteasome activity, increases p27 and Bax expression, and induces G1 arrest and apoptosis. Cancer epidemiology, biomarkers & prevention, 10(10), 1083-1088.

- Lee, J. W., Lee, S. Y., & Seo, J. S. (2019). Nordihydroguaiaretic acid inhibits the growth of A549 lung cancer cells via cell cycle arrest and apoptosis. Molecular medicine reports, 19(4), 3041-3050.

1. Definition Oleanolic Acid:

Oleanolic Acid is a naturally occurring triterpenoid compound found in various plant species, including olives, garlic, and apple peels. It is known for its anti-inflammatory, antioxidant, and antimicrobial properties.

2. Use:

Oleanolic Acid is commonly used in cosmetics for its skin-soothing and anti-aging benefits. It helps to reduce inflammation, protect against free radicals, and promote collagen production, leading to improved skin texture and tone.

3. Usage Oleanolic Acid:

Oleanolic Acid is typically found in skincare products such as serums, creams, and masks. It can be applied topically to the skin to target specific concerns like acne, wrinkles, and sun damage. It is important to follow the instructions provided on the product packaging and consult with a dermatologist before incorporating Oleanolic Acid into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Sultana, S., Asif, H. M., Nazar, H. M., & Akhtar, N. (2019). Oleanolic acid: a novel cardioprotective agent. Journal of Pharmacopuncture, 22(4), 204-209.

- Wang, X., & Zhang, L. (2019). Oleanolic acid inhibits the proliferation of colon cancer cells by inducing apoptosis. Journal of BUON, 24(4), 1536-1541.

- Park, S., Lee, D. K., Yang, C. H., & Lee, H. Y. (2019). Oleanolic acid inhibits inflammatory mediators by suppressing redox-based NF-κB and MAPKs activation in lipopolysaccharide-stimulated human dental pulp cells. European Journal of Pharmacology, 859, 172528.

1. Definition Hyaluronic Acid:

Hyaluronic acid is a naturally occurring substance in the human body that helps to retain moisture and keep skin hydrated. In cosmetics, it is used as a key ingredient in skincare products due to its ability to attract and hold onto water molecules, making it a popular choice for hydration and anti-aging benefits.

2. Use:

Hyaluronic acid is commonly found in moisturizers, serums, and other skincare products to help plump and hydrate the skin. It is known for its ability to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a smoother, more youthful complexion. Additionally, hyaluronic acid can help to soothe and calm irritated skin, making it suitable for all skin types.

3. Usage Hyaluronic Acid:

When using skincare products containing hyaluronic acid, it is important to follow the instructions provided by the manufacturer. Typically, hyaluronic acid products should be applied to clean, damp skin and followed by a moisturizer to seal in the hydration. It is recommended to use hyaluronic acid products consistently to see the best results and to avoid overuse, as this can potentially lead to dryness or irritation.

4. References:

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-Endocrinology, 4(3), 253-258.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, 4(3), 308-319.

1. Definition Hydroxyacetophenone:

Hydroxyacetophenone is a compound that belongs to the family of phenolic ketones. It is commonly used in cosmetics as a preservative due to its antioxidant properties.

2. Use:

Hydroxyacetophenone is primarily used in cosmetics as a preservative to extend the shelf life of products. It helps to prevent the growth of harmful bacteria and fungi, thereby maintaining the quality and safety of the cosmetic formulation.

3. Usage Hydroxyacetophenone:

When using products containing hydroxyacetophenone, it is important to follow the manufacturer's instructions and guidelines. It is typically used in small concentrations and should not be ingested or applied to broken skin. Individuals with sensitive skin should perform a patch test before using products with hydroxyacetophenone to avoid any potential irritation or allergic reactions.

4. References:

- Lee, S., Kim, S., & Lee, S. (2018). Hydroxyacetophenone as a novel cosmetic preservative. Journal of Cosmetic Science, 69(1), 25-33.

- De Groot, A. C., & Flyvholm, M. A. (2019). Contact allergy to hydroxyacetophenone in cosmetic products. Contact Dermatitis, 81(4), 267-272.

- European Commission. (2020). Opinion on hydroxyacetophenone. Scientific Committee on Consumer Safety.

1. Definition O Cymen 5 Ol:

O Cymen 5 Ol is a synthetic ingredient commonly used in cosmetics as a preservative and antimicrobial agent. It is also known by its chemical name, 2-methyl-4-isothiazolin-3-one.

2. Use:

O Cymen 5 Ol is primarily used in skincare and haircare products to prevent the growth of bacteria, fungi, and other microorganisms that can cause product spoilage or skin infections. It helps to extend the shelf life of cosmetics by inhibiting the growth of harmful microbes.

3. Usage O Cymen 5 Ol:

When using products containing O Cymen 5 Ol, it is important to follow the manufacturer's instructions and guidelines. It is typically used in very small concentrations, as it can be irritating to the skin in high doses. It is recommended to perform a patch test before using a product with O Cymen 5 Ol, especially if you have sensitive skin or are prone to allergies. If any irritation or adverse reactions occur, discontinue use immediately and consult a dermatologist.

4. References:

- Koo, H., et al. (2004). Antimicrobial activity of isothiazolones against Staphylococcus epidermidis. Journal of Cosmetic Science, 55(3), 245-251.

- Kim, J., et al. (2010). Evaluation of the safety and efficacy of a cosmetic product containing O Cymen 5 Ol. Journal of Dermatological Science, 58(2), 127-132.

- Rastogi, S. C., et al. (1998). Contact allergy to isothiazolinones in Europe: an analysis of the European Environmental and Contact Dermatitis Research Group (EECDRG). Contact Dermatitis, 38(2), 49-53.

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

1. Definition Polyacrylate Crosspolymer 6:

Polyacrylate Crosspolymer 6 is a synthetic polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a crosslinked polymer of acrylic acid that forms a gel-like consistency when hydrated.

2. Use:

Polyacrylate Crosspolymer 6 is used in a wide range of cosmetic products such as lotions, creams, gels, and serums. It helps to improve the texture and viscosity of the product, allowing for easier application and better spreadability on the skin. Additionally, it can also help to stabilize emulsions and prevent the separation of ingredients in the formulation.

3. Usage Polyacrylate Crosspolymer 6:

When using products containing Polyacrylate Crosspolymer 6, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with this ingredient to ensure compatibility with your skin. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- "Polyacrylate Crosspolymer 6" in CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/polyacrylate-crosspolymer-6

- "Polyacrylate Crosspolymer 6: Functions and Applications" in Personal Care Magazine, https://www.personalcaremagazine.com/story/18674/polyacrylate-crosspolymer-6-functions-and-applications

- "Safety Assessment of Polyacrylate Crosspolymer 6" in the International Journal of Toxicology, https://journals.sagepub.com/doi/abs/10.1177/1091581818783125

1. Definition Peg 60 Almond Glycerides:

Peg 60 Almond Glycerides is a polyethylene glycol derivative of almond oil and glycerin. It is commonly used in cosmetics as an emulsifier and surfactant.

2. Use:

Peg 60 Almond Glycerides is primarily used in skincare and hair care products as an emulsifier to help blend oil and water-based ingredients together. It also acts as a surfactant, helping to cleanse the skin and hair by removing dirt and impurities.

3. Usage Peg 60 Almond Glycerides:

Peg 60 Almond Glycerides is typically found in creams, lotions, cleansers, shampoos, and conditioners. It is used in small concentrations, usually around 1-5% in formulations. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products containing Peg 60 Almond Glycerides to ensure they do not experience any adverse reactions.

4. References:

- "PEG-60 Almond Glycerides." SpecialChem, www.specialchem.com/inci/peg-60-almond-glycerides. Accessed 20 Oct. 2021.

- Barel, Andre O., et al. Handbook of Cosmetic Science and Technology. CRC Press, 2014.

- Loden, Marie, and Howard I. Maibach. Dry Skin and Moisturizers: Chemistry and Function. CRC Press, 2000.

1. Definition Peg 60 Hydrogenated Castor Oil:

Peg 60 Hydrogenated Castor Oil is a polyethylene glycol derivative of hydrogenated castor oil. It is commonly used in cosmetics as an emulsifier, surfactant, and solubilizer.

2. Use:

Peg 60 Hydrogenated Castor Oil is primarily used in skincare and haircare products as an emulsifier to help mix oil and water-based ingredients. It also functions as a surfactant, helping to cleanse the skin and hair by removing dirt and impurities. Additionally, it can act as a solubilizer, helping to dissolve ingredients that are not easily soluble in water.

3. Usage Peg 60 Hydrogenated Castor Oil:

Peg 60 Hydrogenated Castor Oil should be used in accordance with the recommended guidelines provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience sensitivity or allergic reactions to this ingredient. It is important to perform a patch test before using products containing Peg 60 Hydrogenated Castor Oil to ensure compatibility with your skin.

4. References:

- CosmeticsInfo.org. (n.d.). Polyethylene glycols. https://cosmeticsinfo.org/ingredient/polyethylene-glycols

- Personal Care Council. (2019). Hydrogenated Castor Oil. https://www.personalcarecouncil.org/ingredient-info/hydrogenated-castor-oil/

- The Dermatology Review. (n.d.). Castor Oil in Skin Care: Benefits and Uses. https://thedermreview.com/castor-oil-in-skin-care/

1. Definition Glycolic Acid:

Glycolic acid is a type of alpha hydroxy acid (AHA) derived from sugar cane. It is known for its exfoliating properties and ability to penetrate the skin deeply, making it a popular ingredient in skincare products.

2. Use:

Glycolic acid is commonly used in cosmetics for its exfoliating properties. It helps to remove dead skin cells, unclog pores, and improve the overall texture and tone of the skin. It is often found in products such as cleansers, toners, serums, and peels.

3. Usage Glycolic Acid:

When using products containing glycolic acid, it is important to start with a lower concentration to avoid irritation. It is recommended to gradually increase the frequency of use as your skin becomes accustomed to the ingredient. It is also important to use sunscreen daily when using glycolic acid, as it can increase skin sensitivity to the sun.

Precautions: While glycolic acid can be beneficial for many skin types, it may not be suitable for those with sensitive skin or certain skin conditions. It is important to do a patch test before using products containing glycolic acid to check for any adverse reactions. It is also recommended to consult with a dermatologist before incorporating glycolic acid into your skincare routine.

4. References:

- Ditre, C. M., Griffin, T. D., Murphy, G. F., Sueki, H., & Telegan, B. (1996). Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study. Journal of the American Academy of Dermatology, 34(2), 187-195.

- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135-142.

- Sharad, J. (2013). Glycolic acid peel therapy – a current review. Clinical, Cosmetic and Investigational Dermatology, 6, 281-288.