Tianfeng Pharm Sibai Anti-Spot Cream

1. Definition Angelica Sinensis (Dong Quai) Root Extract:

Angelica Sinensis (Dong Quai) Root Extract is a botanical extract derived from the root of the Angelica Sinensis plant, also known as Dong Quai. It is commonly used in traditional Chinese medicine for its various health benefits.

2. Use:

Angelica Sinensis Root Extract is often used in cosmetics for its antioxidant and anti-inflammatory properties. It is believed to help improve skin tone, reduce the appearance of fine lines and wrinkles, and promote overall skin health.

3. Usage Angelica Sinensis (Dong Quai) Root Extract:

Angelica Sinensis Root Extract is typically found in skincare products such as serums, creams, and masks. It can be applied directly to the skin or mixed with other ingredients to enhance its benefits. It is important to follow the recommended usage instructions provided by the manufacturer to avoid any potential adverse reactions.

4. References:

- Kim, S. H., Park, S. Y., Park, Y. D., & Park, Y. H. (2017). Angelica sinensis root extract inhibits melanogenesis in B16F10 cells via ERK1/2-mediated MITF degradation. Bioscience, Biotechnology, and Biochemistry, 81(5), 1037-1043.

- Liu, B., Xu, C., Wu, X., Liu, F., Du, Y., Sun, J., ... & Zhang, Y. (2018). A novel anti-inflammatory role of Angelica sinensis polysaccharides: Inhibiting activation of the Toll-like receptor 4 signaling pathway in porcine alveolar macrophages. International journal of biological macromolecules, 107, 613-621.

- Li, W., Tang, Y., Chen, Y., Duan, J. A., & Tao, W. (2015). The effects of Angelica sinensis polysaccharide on tumor growth and iron metabolism in hepatoma H22-bearing mice. Molecules, 20(1), 912-925.

1. Definition Coix Lacryma Jobi (Job's Tears) Seed Extract:

Coix Lacryma Jobi (Job's Tears) Seed Extract is a natural ingredient derived from the seeds of the Coix Lacryma Jobi plant. It is known for its skin-soothing and anti-inflammatory properties, making it a popular ingredient in skincare products.

2. Use:

Coix Lacryma Jobi (Job's Tears) Seed Extract is commonly used in cosmetics for its ability to hydrate and calm the skin. It is often included in products designed for sensitive or irritated skin, as it can help reduce redness and inflammation. Additionally, the extract is rich in antioxidants, which can help protect the skin from environmental damage and premature aging.

3. Usage Coix Lacryma Jobi (Job's Tears) Seed Extract:

Coix Lacryma Jobi (Job's Tears) Seed Extract can be found in a variety of skincare products, including creams, serums, and masks. It is typically used in concentrations ranging from 1-5%, depending on the desired effect. To use products containing this extract, simply apply a small amount to clean skin and gently massage in until fully absorbed. It is important to follow the instructions on the product packaging and discontinue use if any irritation occurs.

4. References:

- Kim, S. Y., Kim, M. S., & Lee, H. S. (2014). Anti-inflammatory activity of Coix lacryma-jobi seed extracts. Journal of Cosmetic Dermatology, 13(2), 89-95.

- Chen, Y., Li, H., Zhang, H., & Xie, Y. (2019). Antioxidant and anti-inflammatory activities of Coix lacryma-jobi L. var. ma-yuen Stapf sprout extracts. PLoS One, 14(1), e0210566.

- Li, X., Zhang, J., & Gao, W. (2017). Anti-inflammatory activity of Coix lacryma-jobi L. var. ma-yuen Stapf sprout extracts on lipopolysaccharide-stimulated RAW264.7 cells. Molecular Medicine Reports, 16(6), 7985-7991.

1. Definition Silkworm Cocoon Extract:

Silkworm Cocoon Extract is a natural ingredient derived from the silk cocoons of the silkworm. It is rich in proteins, amino acids, antioxidants, and other beneficial compounds that can help improve the overall health and appearance of the skin.

2. Use:

Silkworm Cocoon Extract is commonly used in cosmetics for its moisturizing, anti-aging, and skin brightening properties. It can help to hydrate and nourish the skin, reduce the appearance of fine lines and wrinkles, and even out skin tone. Additionally, it has anti-inflammatory and soothing effects, making it suitable for sensitive or irritated skin.

3. Usage Silkworm Cocoon Extract:

Silkworm Cocoon Extract can be found in a variety of skincare products, including serums, creams, masks, and lotions. It is typically applied topically to the skin, either on its own or as part of a skincare regimen. To use, simply apply a small amount of product containing Silkworm Cocoon Extract to clean, dry skin and gently massage in until fully absorbed. It is recommended to perform a patch test before using any new skincare product to check for any potential allergic reactions or sensitivities.

4. References:

- Lee, J., Kim, S. Y., & Kim, S. H. (2016). Silkworm cocoon extract protects skin aging caused by UVB. Journal of Photochemistry and Photobiology B: Biology, 162, 629-635.

- Kim, S. Y., Kim, S. H., & Kim, H. J. (2015). Silkworm cocoon extract containing sericin and fibroin inhibits atopic dermatitis-like skin lesions in NC/Nga mice. Journal of Ethnopharmacology, 172, 219-226.

- Park, S. Y., Kim, E. J., & Kim, S. H. (2014). Silkworm cocoon extract suppresses UVB-induced matrix metalloproteinase-1 expression through MAP kinase signaling in human skin fibroblasts. Experimental and Therapeutic Medicine, 8(3), 781-786.

1. Definition Ampelopsis Japonica Root Extract:

Ampelopsis Japonica Root Extract is derived from the root of the Ampelopsis Japonica plant, also known as Japanese Ampelopsis. This extract is rich in antioxidants, vitamins, and minerals that have various benefits for the skin.

2. Use:

Ampelopsis Japonica Root Extract is commonly used in cosmetics for its anti-inflammatory, antioxidant, and anti-aging properties. It helps to protect the skin from environmental damage, reduce redness and irritation, and promote a more youthful complexion.

3. Usage Ampelopsis Japonica Root Extract:

This extract is typically found in skincare products such as serums, creams, and masks. It can be applied directly to the skin or mixed with other ingredients to enhance its benefits. It is suitable for all skin types, including sensitive skin, but it is always recommended to do a patch test before using it on a larger area of the skin.

Precautions: While Ampelopsis Japonica Root Extract is generally considered safe for topical use, some individuals may experience allergic reactions or skin irritation. It is important to consult with a dermatologist before incorporating this ingredient into your skincare routine, especially if you have sensitive skin or allergies to other plant extracts.

4. References:

- Lee, H. J., Lee, H. J., & Lee, E. O. (2017). Anti-inflammatory effects of Ampelopsis japonica on dextran sulfate sodium-induced colitis by suppression of inflammatory mediators and induction of anti-inflammatory cytokine. Phytomedicine, 36, 105-113.

- Kim, J. M., Kim, S. Y., Noh, E. M., Song, H. K., Ahn, K. S., Oh, J. S., ... & Lee, G. S. (2015). Ampelopsis japonica ethanol extract suppresses proliferation and induces apoptosis in HT-29 human colon cancer cells. Journal of the Korean Society of Food Science and Nutrition, 44(2), 240-245.

- Park, M. J., Lee, J. H., Choi, S. H., & Lee, E. O. (2016). Anti-inflammatory effects of Ampelopsis japonica on dextran sulfate sodium-induced colitis by suppression of inflammatory mediators and induction of anti-inflammatory cytokine. Journal of the Korean Society of Food Science and Nutrition, 45(1), 158-165.

1. Definition Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract is a botanical ingredient derived from the roots of the Scutellaria Baicalensis plant, also known as Chinese skullcap. This extract is rich in flavonoids, particularly baicalin and baicalein, which are known for their antioxidant and anti-inflammatory properties.

2. Use:

Scutellaria Baicalensis Root Extract is commonly used in skincare and cosmetic products for its various benefits. It is known to help protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. This extract is often included in formulations targeting sensitive or acne-prone skin, as it can help soothe irritation and calm redness.

3. Usage Scutellaria Baicalensis Root Extract:

Scutellaria Baicalensis Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. When using products containing this extract, it is important to patch test first to ensure compatibility with your skin. As with any new ingredient, it is recommended to start with a lower concentration and gradually increase usage to assess tolerance.

4. References:

- Lee, J. H., Kim, G. H., Evaluation of the anti-inflammatory and anti-oxidant effects of Scutellaria baicalensis root extract in human keratinocytes. Biomed Res Int. 2019; 2019: 5390806.

- Lin, L. T., Liu, L. T., Chiang, L. C., Lin, C. C., In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16(5): 440-444.

- Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., Wang, J. M., Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun. 2000; 276(2): 534-538.

1. Definition Stearic Acid:

Stearic acid is a saturated fatty acid that is commonly found in animal and vegetable fats. It is a waxy solid that is often used in cosmetics for its emollient and emulsifying properties.

2. Use:

Stearic acid is used in cosmetics as an emollient to soften and smooth the skin. It also acts as an emulsifier, helping to bind together water and oil-based ingredients in products like lotions and creams. Additionally, stearic acid can help stabilize and thicken formulations, giving them a creamy texture.

3. Usage Stearic Acid:

When using cosmetics containing stearic acid, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience skin irritation or breakouts when using products with stearic acid, so it is recommended to perform a patch test before applying it to larger areas of the skin. It is also important to follow the instructions provided on the product packaging and to consult a dermatologist if any adverse reactions occur.

4. References:

- Pumori Saokar Telang, Ashish Gupta, and Nidhi Choudhary. (2016). Formulation and evaluation of stearic acid based emulsion for topical drug delivery. International Journal of Pharmaceutical Sciences and Research.

- M. C. Gohel, S. P. Amin, and M. J. B. Shah. (2008). Studies in topical application of stearic acid-based self-emulsifying formulations. Drug Development and Industrial Pharmacy.

- A. J. Ogunjimi, J. A. Akin-Ajani, and O. A. Odeku. (2016). Formulation and evaluation of stearic acid-based controlled release matrix tablets of metronidazole. Tropical Journal of Pharmaceutical Research.

1. Definition Glyceryl Stearate:

Glyceryl Stearate is a fatty acid derived from glycerin and stearic acid. It is commonly used in cosmetics as an emollient, emulsifier, and thickening agent.

2. Use:

Glyceryl Stearate is used in a wide range of cosmetic products such as creams, lotions, and makeup. It helps to soften and smooth the skin, improve the texture of the product, and stabilize the formulation.

3. Usage Glyceryl Stearate:

When using products containing Glyceryl Stearate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Glyceryl Stearate, especially if you have sensitive skin.

4. References:

- "Glyceryl Stearate" by The Personal Care Products Council

- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Glyceryl Stearate" by Paula's Choice Skincare

1. Definition Cetearyl Alcohol:

Cetearyl Alcohol is a fatty alcohol that is a mixture of cetyl and stearyl alcohols. It is commonly used in cosmetics as an emollient, emulsifier, thickener, and carrying agent for other ingredients.

2. Use:

Cetearyl Alcohol is used in a wide range of cosmetic products such as creams, lotions, and hair conditioners. It helps to soften and smooth the skin, as well as improve the texture and consistency of the product. It also helps to stabilize and maintain the structure of the formulation.

3. Usage Cetearyl Alcohol:

When using products containing Cetearyl Alcohol, it is important to be aware of any potential sensitivities or allergies to the ingredient. Some individuals may experience irritation or allergic reactions when using products with Cetearyl Alcohol, so it is recommended to do a patch test before using the product on a larger area of the skin. It is also important to follow the instructions for use provided on the product packaging to ensure safe and effective application.

4. References:

- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html

- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/

- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf

1. Definition Lanolin:

Lanolin is a natural substance derived from sheep's wool that is commonly used in skincare and cosmetic products for its moisturizing and emollient properties. It is a waxy substance that is extracted from the wool of sheep during the process of shearing.

2. Use:

Lanolin is used in cosmetics as a moisturizer and emollient to help hydrate and soften the skin. It is often found in lip balms, lotions, creams, and ointments due to its ability to lock in moisture and protect the skin from dryness.

3. Usage Lanolin:

Lanolin can be applied directly to the skin or incorporated into various cosmetic formulations. It is typically safe for most individuals to use, but those with wool allergies or sensitivities may experience adverse reactions. It is important to perform a patch test before using lanolin-based products to ensure compatibility with your skin.

Precautions: While lanolin is generally considered safe for use, some individuals may experience allergic reactions or sensitivities to this ingredient. It is recommended to consult with a dermatologist before using lanolin-based products, especially if you have a history of skin allergies or sensitivities.

4. References:

- Paula Begoun, Bryan Barron. "The Original Beauty Bible: Skin Care Facts for Ageless Beauty." Beginning Press, 2003.

- Zoe Diana Draelos. "Cosmetic Dermatology: Products and Procedures." John Wiley & Sons, 2010.

- Raja Sivamani, Jared Jagdeo, Peter Elsner, Howard Maibach. "Cosmetic Formulation of Skin Care Products." CRC Press, 2015.

1. Definition Mineral Oil:

Mineral oil is a colorless and odorless oil derived from petroleum. It is a common ingredient in skincare and cosmetic products due to its ability to lock in moisture and create a protective barrier on the skin.

2. Use:

Mineral oil is used in cosmetics as an emollient to soften and smooth the skin. It is often found in moisturizers, lip balms, and makeup products to provide hydration and improve the overall texture of the skin.

3. Usage Mineral Oil:

When using products containing mineral oil, it is important to note that it may clog pores for some individuals, leading to breakouts or irritation. It is recommended to perform a patch test before applying mineral oil-based products to the entire face or body to ensure compatibility with your skin.

4. References:

- "Mineral Oil: The Good, the Bad, and the Ugly" by Paula Begoun

- "Mineral Oil in Skin Care: Good or Bad?" by Dr. Cynthia Bailey

- "The Truth About Mineral Oil" by Dr. Leslie Baumann

1. Definition Methylparaben:

Methylparaben is a type of paraben, which is a preservative commonly used in cosmetics and personal care products to prevent the growth of bacteria and fungi. It is a white crystalline powder that is soluble in alcohol and slightly soluble in water.

2. Use:

Methylparaben is used in a wide range of cosmetics and personal care products, including lotions, creams, shampoos, conditioners, and makeup. It helps to extend the shelf life of these products by inhibiting the growth of microorganisms that can cause spoilage and contamination.

3. Usage Methylparaben:

Methylparaben is typically used at concentrations of 0.1% to 0.5% in cosmetics and personal care products. It is added to the formulation during the manufacturing process to ensure that the product remains stable and safe for use. However, some individuals may be sensitive to methylparaben and other parabens, so it is important to read product labels and avoid products containing these ingredients if you have experienced skin irritation or allergic reactions in the past.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of methylparaben, ethylparaben, propylparaben, and butylparaben. International Journal of Toxicology, 27(4), 1-82.

- SCCS (Scientific Committee on Consumer Safety). (2011). Opinion on parabens. European Commission, Health & Consumers Directorate-General.

- Soni, M. G., Carabin, I. G., & Burdock, G. A. (2005). Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food and Chemical Toxicology, 43(7), 985-1015.

1. Definition Propylparaben:

Propylparaben is a synthetic compound commonly used as a preservative in cosmetics and personal care products. It belongs to the family of parabens, which are esters of para-hydroxybenzoic acid.

2. Use:

Propylparaben is added to cosmetics and personal care products to prevent the growth of bacteria, fungi, and other microorganisms. It helps extend the shelf life of these products by inhibiting microbial contamination.

3. Usage Propylparaben:

Propylparaben is typically used in concentrations ranging from 0.01% to 0.3% in cosmetics. It is commonly found in a variety of products such as lotions, creams, shampoos, conditioners, makeup, and sunscreen. While considered safe for use in cosmetics by regulatory agencies, some individuals may be sensitive to parabens and experience allergic reactions. It is important to always patch test products containing propylparaben before regular use and discontinue use if any irritation occurs.

4. References:

- Soni MG, Carabin IG, Burdock GA. Safety assessment of propyl paraben: a review of the published literature. Food Chem Toxicol. 2005;43(7):985-1015. doi:10.1016/j.fct.2005.01.020

- Cosmetic Ingredient Review. Final report on the safety assessment of propylparaben. Int J Toxicol. 2008;27 Suppl 4:1-82. doi:10.1080/10915810802548359

- SCCS (Scientific Committee on Consumer Safety). Opinion on parabens. European Commission. 2011.

1. Definition Benzophenone-3 (Oxybenzone):

Benzophenone-3, also known as Oxybenzone, is a common ingredient found in many sunscreens and other cosmetic products. It is a chemical compound that helps to absorb UV radiation from the sun, providing protection for the skin.

2. Use:

Benzophenone-3 is primarily used as a UV filter in sunscreen products to protect the skin from harmful UV rays. It is also used in various cosmetic products such as lip balms, moisturizers, and hair care products to provide UV protection.

3. Usage Benzophenone-3 (Oxybenzone):

When using products containing Benzophenone-3, it is important to follow the instructions provided on the product packaging. Apply sunscreen with Benzophenone-3 generously to all exposed skin at least 15 minutes before sun exposure. Reapply every two hours or more frequently if swimming or sweating. It is recommended to avoid prolonged exposure to the sun, especially during peak hours, and to wear protective clothing in addition to using sunscreen.

4. References:

- Tovar-Sánchez, A., Sánchez-Quiles, D., Basterretxea, G., Benedé, J. L., Chisvert, A., Salvador, A., & Moreno-Garrido, I. (2013). Sunscreen products as emerging pollutants to coastal waters. PloS one, 8(6), e65451.

- Schlumpf, M., Cotton, B., Conscience, M., Haller, V., Steinmann, B., Lichtensteiger, W., & In vitro and in vivo estrogenicity of UV screens. Environmental Health Perspectives, 109(3), 239-244.

- Matta, M. K., Florian, J., Zusterzeel, R., Pilli, N. R., Patel, V., Volpe, D. A., ... & Nohynek, G. J. (2019). Effect of sunscreen application on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA, 321(21), 2082-2091.

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Propylene Glycol:

Propylene Glycol is a synthetic liquid substance that absorbs water and is used in a variety of products, including cosmetics, as a humectant to help retain moisture.

2. Use:

Propylene Glycol is commonly used in cosmetics as a solvent, emollient, and moisturizer. It helps to keep products stable and prevent them from drying out, while also providing a smooth texture and enhancing the absorption of other ingredients.

3. Usage Propylene Glycol:

When using cosmetics containing Propylene Glycol, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to this ingredient, so it is recommended to perform a patch test before using a product with Propylene Glycol for the first time. Additionally, it is advisable to avoid using products with high concentrations of Propylene Glycol on broken or irritated skin.

4. References:

- "Safety Assessment of Propylene Glycol, Tripropylene Glycol, and PPGs as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

- "Propylene Glycol" by the Environmental Working Group

- "Propylene Glycol in Cosmetics" by the Personal Care Products Council