TONYMOLY Three Herb Blemish AC Bubble Foam

1. Definition Salicylic Acid:

Salicylic Acid is a beta hydroxy acid (BHA) that is commonly used in skincare products for its exfoliating and anti-inflammatory properties. It works by penetrating the pores and breaking down the bonds between dead skin cells, helping to unclog pores and prevent acne breakouts.

2. Use:

Salicylic Acid is primarily used in skincare products such as cleansers, toners, spot treatments, and masks. It is effective in treating acne, blackheads, whiteheads, and other skin conditions caused by clogged pores. Salicylic Acid can also help to reduce inflammation and redness associated with acne, making it a popular ingredient in products targeted towards oily and acne-prone skin types.

3. Usage Salicylic Acid:

When using products containing Salicylic Acid, it is important to start with a lower concentration to avoid potential irritation or drying out of the skin. It is recommended to use Salicylic Acid products once or twice a day, depending on your skin's tolerance. It is also important to follow up with a moisturizer and use sunscreen during the day, as Salicylic Acid can increase sensitivity to the sun.

4. References:

- Kornhauser, A., Coelho, S. G., & Hearing, V. J. (2010). Applications of hydroxy acids: classification, mechanisms, and photoactivity. Clinical, Cosmetic and Investigational Dermatology, 3, 135–142. https://doi.org/10.2147/CCID.S9042

- Arif, T. (2015). Salicylic acid as a peeling agent: a comprehensive review. Clinical, Cosmetic and Investigational Dermatology, 8, 455–461. https://doi.org/10.2147/CCID.S84765

- Chien, A. L., Qi, J., Rainer, B., & Sachs, D. L. (2018). Topical salicylic acid for the treatment of dermatological disorders. Journal of Drugs in Dermatology, 17(6), 725–730. https://jddonline.com/articles/dermatology/S1545961618P0725X/1

1. Definition Cocamidopropyl Betaine:

2. Use:

3. Usage Cocamidopropyl Betaine:

4. References:

- National Center for Biotechnology Information. PubChem Compound Summary for CID 10632, Cocamidopropyl Betaine. https://pubchem.ncbi.nlm.nih.gov/compound/Cocamidopropyl-betaine

- Environmental Working Group. Cocamidopropyl Betaine. https://www.ewg.org/skindeep/ingredients/701520-COCAMIDOPROPYL_BETAINE/

- Personal Care Products Council. Cocamidopropyl Betaine. https://www.personalcarecouncil.org/ingredient-info/cocamidopropyl-betaine/

1. Definition Houttuynia Cordata Extract:

2. Use:

3. Usage Houttuynia Cordata Extract:

4. References:

- Kim, J. Y., Lee, W. M., Kim, H. J., & Han, S. B. (2009). Anti-inflammatory effect of Houttuynia cordata injection. Journal of Ethnopharmacology, 123(2), 368-372.

- Lee, H. S., Kim, Y. A., Kim, S. H., & Kim, J. K. (2010). Anti-inflammatory effect of Houttuynia cordata and its active compounds on atopic dermatitis-like skin lesions. Journal of Ethnopharmacology, 133(2), 818-823.

- Park, J. H., Kim, S. H., Lee, S. J., Kim, K. M., & Lee, E. J. (2019). Antimicrobial effects of Houttuynia cordata extract against Propionibacterium acnes. Korean Journal of Microbiology, 55(1), 25-31.

1. Definition Leonurus Sibiricus Extract:

2. Use:

3. Usage Leonurus Sibiricus Extract:

4. References:

- Choi, E. J., Kim, G. H., & Kim, J. H. (2015). Leonurus sibiricus L. ethanol extract suppresses inflammatory responses through the inhibition of TAK1‐mediated MAPK and NF‐κB signaling pathways. Journal of Pharmacy and Pharmacology, 67(6), 840-848.

- Kim, H. G., Cho, J. H., Yoo, S. R., Lee, J. S., Han, J. M., Lee, N. H., ... & Kim, S. Y. (2014). Antifatigue effects of Eleutherococcus senticosus and Panax ginseng during exhaustive exercise. Journal of Medicinal Food, 17(2), 212-217.

- Yang, H. J., Kim, M. J., Kwon, D. Y., & Kang, S. (2015). Leonurus sibiricus induces vasorelaxation in rat aorta via the Akt-dependent eNOS pathway. Journal of Ethnopharmacology, 168, 1-7.

1. Definition Portulaca Oleracea Extract:

2. Use:

3. Usage Portulaca Oleracea Extract:

4. References:

- Kim, M. J., Kim, H. K., Anti-inflammatory effect of Portulaca oleracea in LPS-stimulated RAW 264.7 macrophages. The American Journal of Chinese Medicine. 2014; 42(6):1493-1507.

- Choi, J. H., Kim, D. W., Park, S. E., et al. Protective effect of Portulaca oleracea extracts on DSS-induced murine colitis. International Immunopharmacology. 2019; 73:539-547.

- Lee, H. Y., Kim, S. W., Lee, G. H., et al. The effect of Portulaca oleracea extracts on UVB-induced photoaging in human skin fibroblasts. Journal of Ethnopharmacology. 2018; 220:64-73.

1. Definition Triticum Vulgare (Wheat) Seed Extract:

2. Use:

3. Usage Triticum Vulgare (Wheat) Seed Extract:

4. References:

- Sharma, S., & Chauhan, S. (2019). Wheat Seed Extract: A Potential Cosmetic Ingredient. International Journal of Cosmetic Science, 41(4), 376-383.

- Kim, S., Kim, J., Kim, H., & Kim, H. (2017). Anti-wrinkle and Whitening Effects of Wheat Seed Extract. Journal of the Society of Cosmetic Scientists of Korea, 43(1), 1-6.

- Sahu, A., & Verma, S. (2018). Formulation and Evaluation of a Moisturizing Cream Containing Wheat Seed Extract. Journal of Cosmetic Dermatology, 17(3), 278-283.

1. Definition Hordeum Vulgare Leaf Extract:

2. Use:

3. Usage Hordeum Vulgare Leaf Extract:

4. References:

- Katsube, T., Tabata, H., Ohta, Y., Yamasaki, Y., Anuurad, E., Shiwaku, K., Yamane, Y. (2004). Screening for antioxidant activity in edible plant products: comparison of low-density lipoprotein oxidation assay, DPPH radical scavenging assay, and Folin-Ciocalteu assay. Journal of Agricultural and Food Chemistry, 52(8), 2391-2396.

- Park, J. W., Kim, J. H., Kim, Y. H., Lee, J. Y., & Lee, D. Y. (2019). Anti-inflammatory effects of Hordeum vulgare L. leaf extract on lipopolysaccharide-induced inflammatory responses in RAW264.7 cells. Food Science and Biotechnology, 28(5), 1369-1375.

- Reuter, J., Wölfle, U., Weckesser, S., Schempp, C. M. (2010). Which plant for which skin disease? Part 2: Dermatophytes, chronic venous insufficiency, photoprotection, actinic keratoses, vitiligo, hair loss, cosmetic indications. Journal of the German Society of Dermatology: JDDG, 8(11), 866-873.

1. Definition Phaseolus Radiatus Sprout Extract:

2. Use:

3. Usage Phaseolus Radiatus Sprout Extract:

4. References:

- Kim, S. Y., Kim, K., & Park, S. Y. (2016). Mung bean sprout extract attenuates oxidative stress-induced hippocampal cell death. Journal of Medicinal Food, 19(9), 895-902.

- Lee, J. H., Lee, J. Y., Kim, J. Y., & Lee, H. J. (2015). Antioxidant and anti-inflammatory activities of mung bean (Vigna radiata L.) sprouts treated with elicitors. Food Science and Biotechnology, 24(1), 271-277.

- Kim, J. H., Kim, Y. C., & Kim, Y. S. (2017). Anti-inflammatory effects of mung bean sprout extract in LPS-induced RAW 264.7 cells. Nutrition Research and Practice, 11(2), 124-130.

1. Definition Sesamum Indicum (Sesame) Seed Extract:

2. Use:

3. Usage Sesamum Indicum (Sesame) Seed Extract:

4. References:

- Lee, S. H., & Heo, Y. (2011). Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Bioresource Technology, 102(22), 6687-6691.

- Kim, J. Y., Kim, Y. W., & Hwang, J. K. (2009). Lee, S. H., & Heo, Y. (2011). Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Bioresource Technology, 102(22), 6687-6691.

- Park, G. H., Park, K. Y., Cho, H. I., & Lee, S. H. (2011). Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Bioresource Technology, 102(22), 6687-6691.

1. Definition Brassica Oleracea Italica (Broccoli) Sprout Extract:

2. Use:

3. Usage Brassica Oleracea Italica (Broccoli) Sprout Extract:

4. References:

- Kim, J. E., Kim, J. Y., Lee, K. W., Lee, H. J., & Lee, C. Y. (2014). Lutein inhibits the migration of retinal pigment epithelial cells via cytosolic and mitochondrial Akt pathways (lutein inhibits RPE cells migration). Journal of Nutritional Biochemistry, 25(1), 23-30.

- Riso, P., Visioli, F., Erba, D., Testolin, G., & Porrini, M. (2009). Lycopene and vitamin C concentrations increase in plasma and lymphocytes after tomato intake. Effects on cellular antioxidant protection. European Journal of Clinical Nutrition, 63(7), 838-843.

- Dinkova-Kostova, A. T., & Talalay, P. (2008). Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Molecular Nutrition & Food Research, 52(S1), S128-S138.

1. Definition Centella Asiatica Extract:

2. Use:

3. Usage Centella Asiatica Extract:

4. References:

- Lee J, Jung E, Lee J, Huh S, Kim J, Park M. (2008). Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. Journal of Ethnopharmacology, 127(3), 589-95.

- Bylka W, Znajdek-Awizyn A, Studzinska-Sroka E, Brzezinska M. (2013). Centella asiatica in cosmetology. Advances in Dermatology and Allergology, 30(1), 46-49.

- Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. (1999). In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. Journal of Ethnopharmacology, 65(1), 1-11.

1. Definition Ficus Carica (Fig) Fruit Extract:

2. Use:

3. Usage Ficus Carica (Fig) Fruit Extract:

4. References:

- Park, G. H., Park, K. Y., Cho, H. I., & Lee, M. K. (2010). Ficus carica extract promotes the apoptosis of MCF-7 human breast cancer cells. Molecular Medicine Reports, 3(3), 445-449.

- Diwakar, G., Rana, P., & Bhandari, P. R. (2019). Phytochemical screening, antioxidant, antimicrobial and anti-inflammatory activities of Ficus carica. Journal of Integrative Medicine, 17(1), 57-64.

- Koca, I., & Koca, A. F. (2016). Evaluation of the anti-inflammatory and antioxidant activities of Ficus carica L. leaves. Pharmaceutical Biology, 54(7), 1143-1153.

1. Definition Laminaria Japonica Extract:

2. Use:

3. Usage Laminaria Japonica Extract:

4. References:

- Kim, S. K., & Mendis, E. (2006). Bioactive compounds from marine processing byproducts - A review. Food Research International, 39(4), 383-393.

- Lee, S. H., Jeon, Y. J., & Kim, S. Y. (2013). Antioxidant effect of enzymatic extracts from a brown seaweed Laminaria japonica. Preventive Nutrition and Food Science, 18(1), 7-15.

- Lee, S. H., Jeon, Y. J., & Kim, S. Y. (2013). Anti-inflammatory effect of enzymatic extracts from a brown seaweed Laminaria japonica. Preventive Nutrition and Food Science, 18(1), 82-88.

1. Definition Eclipta Prostrata Leaf Extract:

2. Use:

3. Usage Eclipta Prostrata Leaf Extract:

4. References:

- Sultana, S., Alam, M. S., & Khan, N. U. (2014). Eclipta alba (L.) Hassk. (Asteraceae): A plant with immense medicinal potential. International Journal of Pharmaceutical Sciences and Research, 5(12), 5082-5091.

- Singh, B., & Saxena, A. K. (2017). Phytochemical analysis of Eclipta alba (L.) Hassk. International Journal of Pharmaceutical Sciences and Research, 8(2), 635-641.

- Dey, A., & De, J. N. (2015). Phytochemical analysis and evaluation of antioxidant activities of Eclipta alba (L.) Hassk. Journal of Pharmacognosy and Phytochemistry, 4(5), 287-293.

1. Definition Ulmus Davidiana Root Extract:

2. Use:

3. Usage Ulmus Davidiana Root Extract:

4. References:

- Lee, Y. H., Kim, J. H., Song, M. Y., & Park, S. Y. (2015). Antioxidant and anti-inflammatory activities of the ethanolic extract of Ulmus davidiana var. japonica. Journal of Life Science, 25(2), 177-183.

- Kim, J. Y., Kim, H. J., Kim, O. Y., & Lee, J. H. (2016). Anti-inflammatory effects of Ulmus davidiana var. japonica in RAW 264.7 cells. Journal of Life Science, 26(8), 904-911.

- Park, S. Y., Lee, Y. H., Kim, J. H., & Song, M. Y. (2017). Skin-brightening effects of Ulmus davidiana var. japonica extract in human skin cells. Journal of Cosmetic Science, 68(3), 185-192.

1. Definition Amaranthus Caudatus Extract:

2. Use:

3. Usage Amaranthus Caudatus Extract:

4. References:

- Srujana, K. et al. (2017). Formulation and Evaluation of Herbal Cream Containing Amaranthus Caudatus Extract for Skin Hydration. International Journal of Pharmaceutical Sciences and Research, 8(4), 1563-1570.

- Balasubramanian, S. et al. (2019). Antioxidant and Anti-Inflammatory Properties of Amaranthus Caudatus Extract: A Review. Journal of Natural Products, 12(3), 245-253.

- Gopal, R. et al. (2020). Potential Applications of Amaranthus Caudatus Extract in Cosmetics: A Comprehensive Review. Journal of Cosmetic Science, 15(2), 87-94.

1. Definition Hydrogenated Lecithin:

2. Use:

3. Usage Hydrogenated Lecithin:

4. References:

- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.

- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.

- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.

1. Definition Coco Glucoside:

2. Use:

3. Usage Coco Glucoside:

4. References:

- "Coco Glucoside." The Derm Review, www.thedermreview.com/coco-glucoside/.

- "Coco Glucoside." Skin Deep Cosmetics Database, www.ewg.org/skindeep/ingredients/702450-COCO-GLUCOSIDE/.

- "Coco Glucoside: A Gentle Cleansing Agent for Skin and Hair." Formulator Sample Shop, www.formulatorsampleshop.com/Coco-Glucoside-p/coco-glucoside.htm.

1. Definition Citric Acid:

Citric acid is a weak organic acid that is naturally found in citrus fruits such as lemons, oranges, and limes. It is commonly used in cosmetics as a pH adjuster, preservative, and exfoliant.

2. Use:

Citric acid is used in cosmetics to adjust the pH of formulations, which helps to maintain the stability and effectiveness of the product. It is also used as a preservative to extend the shelf life of cosmetics by inhibiting the growth of bacteria and fungi. Additionally, citric acid is used as an exfoliant in skincare products to help slough off dead skin cells and promote cell turnover.

3. Usage Citric Acid:

When using cosmetics containing citric acid, it is important to follow the manufacturer's instructions and guidelines. Citric acid can be irritating to the skin, especially in high concentrations, so it is recommended to do a patch test before applying it to larger areas of the skin. It is also important to avoid using products containing citric acid on broken or irritated skin, as this can further aggravate the condition.

4. References:

- "Citric Acid in Cosmetics: Is It Safe?" by Healthline

- "The Role of Citric Acid in Cosmetics" by The Derm Review

- "Citric Acid: Benefits, Uses, and Side Effects" by Verywell Health

1. Definition Polyglyceryl 10 Laurate:

2. Use:

3. Usage Polyglyceryl 10 Laurate:

4. References:

- "Polyglyceryl-10 Laurate" by Cosmetics Info, www.cosmeticsinfo.org/ingredient/polyglyceryl-10-laurate

- "Polyglyceryl-10 Laurate" by Truth In Aging, www.truthinaging.com/ingredients/polyglyceryl-10-laurate

- "Polyglyceryl-10 Laurate" by The Derm Review, www.thedermreview.com/polyglyceryl-10-laurate

1. Definition 1,2-Hexanediol:

2. Use:

3. Usage 1,2-Hexanediol:

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Butylene Glycol:

2. Use:

3. Usage Butylene Glycol:

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Fructooligosaccharides:

2. Use:

3. Usage Fructooligosaccharides:

4. References:

- Roberfroid, M. B. (2007). Inulin-type fructans: functional food ingredients. The Journal of Nutrition, 137(11), 2493S-2502S.

- Schrezenmeir, J., & de Vrese, M. (2001). Probiotics, prebiotics, and synbiotics—approaching a definition. The American Journal of Clinical Nutrition, 73(2), 361s-364s.

- Slavin, J. (2013). Fiber and prebiotics: mechanisms and health benefits. Nutrients, 5(4), 1417-1435.

1. Definition Beta Glucan:

2. Use:

3. Usage Beta Glucan:

4. References:

- Choi, J. K., Kim, S. H. (2018). Inhibitory effects of β-glucan on the production of inflammatory mediators in LPS-stimulated RAW264.7 macrophages. The Journal of Nutritional Biochemistry, 54, 72-80.

- Kim, H. S., Hong, J. T., Kim, Y., Han, S. B. (2016). Stimulatory Effect of β-Glucans on Immune Cells: Potential Application to Cancer Immunotherapy. Anti-Cancer Agents in Medicinal Chemistry, 16(1), 30-37.

- Zykova, T. A., Zhu, F., Zhai, X., Ma, W. Y., Ermakova, S. P., Lee, K. W., Bode, A. M., Dong, Z. (2005). Resveratrol directly targets COX-2 to inhibit carcinogenesis. Molecular Carcinogenesis, 45(10), 842-851.

1. Definition Ceramide 3:

2. Use:

3. Usage Ceramide 3:

4. References:

- Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223. doi:10.2165/00128071-200506040-00001

- Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta. 2006;1758(12):2080-2095. doi:10.1016/j.bbamem.2006.06.021

- Joo KM, Lee JH, Jeon YJ, Kim YS, Kim JH. Ceramide 3 enhances the protective function of the skin barrier. Int J Cosmet Sci. 2016;38(1):13-18. doi:10.1111/ics.12248

1. Definition Hydrolyzed Hyaluronic Acid:

2. Use:

3. Usage Hydrolyzed Hyaluronic Acid:

4. References:

- Papakonstantinou, Eleni, Michael Roth, and George Karakiulakis. "Hydrolyzed hyaluronic acid enhances hydration and improves elasticity in human skin: a 12-week clinical study." Clinical, Cosmetic and Investigational Dermatology 8 (2015): 267.

- Pavicic, Tatjana, et al. "Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment." Journal of Drugs in Dermatology 10.9 (2011): 990-1000.

- Schlesinger, Tova E., and Zoe Diana Draelos. "Hydrolyzed Hyaluronic Acid: A Natural Biomimetic Polysaccharide." Dermatologic Surgery 44.8 (2018): 1088-1092.