Full ingredients list trend IT UP Lip Glaze Oil 010 ...

EWG	CIR	Ingredient name & cosmetic function	Notes
2	A	Ricinus Communis Seed Oil	Fungal Acne Trigger
1		Oleic/ Linoleic/ Linolenic Polyglycerides (Emollient, Surfactant, Viscosity Controlling, Emulsion Stabilising, Binding)
		Aroma**
1	A	Carthamus Tinctorius Seed Oil	Promotes Wound Healing Fungal Acne Trigger
1	A	Helianthus Annuus Seed Oil	Fungal Acne Trigger
1	A	Ribes Nigrum Seed Oil
1	A	Squalane (Hair Conditioning, Skin Conditioning, Emollient, Refatting)
1	A	Vitis Vinifera Seed Oil (Skin Conditioning, Emollient)	Promotes Wound Healing Fungal Acne Trigger Good for oily skin
1	B	Silica Dimethyl Silylate (Emollient, Antifoaming Agent, Viscosity Controlling, Bulking Agent, Anticaking Agent, Emulsion Stabilising, Slip Modifier, Suspending Agent - Nonsurfactant, Viscosityincreasing Agent - Nonaqueous)
1	A	Zea Mays Germ Oil (Skin Conditioning, Emollient)	Fungal Acne Trigger
1	A	Caprylic/ Capric Triglyceride (Solvent, Masking, Perfuming, Skin Conditioning, Emollient)
1		Dimethyl Isosorbide (Solvent, Viscosity Controlling, Viscosity Decreasing Agent)
1	A	Limnanthes Alba Seed Oil (Emollient, Deodorant, Skin-Conditioning Agent - Occlusive)	Fungal Acne Trigger
1		Sesamum Indicum Seed Extract
1		Daucus Carota Sativa Root Extract (Perfuming)
1		Hydrolyzed Sodium Hyaluronate (Skin Conditioning)	Promotes Wound Healing Good for dry skin
1		Terpineol (Solvent, Masking, Perfuming, Denaturant )
1		Geranyl Acetate (Perfuming, Fragrance, Tonic)
1 2		Lecithin (Skin Conditioning, Emollient, Antistatic Agent, Emulsifying, Surfactant)
1 3	A	Glyceryl Behenate (Skin Conditioning, Emollient, Emulsifying, Surfactant)	Fungal Acne Trigger
1		Linalyl Acetate (Masking, Fragrance)
1		Vanillin (Masking, Fragrance, Flavoring Agent)
1		Tocopherol	Good for dry skin Anti Aging
1	B	Isopropyl Myristate (Solvent, Perfuming, Fragrance, Skin Conditioning, Emollient, Binding Agent, Binding)	Bad for oily skin Fungal Acne Trigger
1	A	Ascorbyl Palmitate (Masking, Antioxidant)	Fungal Acne Trigger
3	A	Bht (Masking, Fragrance, Antioxidant)
3 5		Geraniol (Masking, Fragrance, Tonic)	Allergen
4 5		Limonene (Solvent, Perfuming, Deodorant)	Allergen
3		Linalool (Masking, Deodorant, Fragrance)	Allergen
		Ci 77742
4		CI 15850 (Cosmetic Colorant)
1 3		Ci 77891 (Cosmetic Colorant, Uv Absorber, Sunscreen Agent, Opacifying)	UV Protection Good for sensitive skin

Ricinus Communis Seed Oil

Other name: Castor Oil; Ricinus Communis Oil; Ricinus Communis Seed Oil

Function:

1. Definition Ricinus Communis (Castor) Seed Oil:

Ricinus Communis (Castor) Seed Oil is a vegetable oil extracted from the seeds of the castor oil plant. It is a pale yellow liquid with a mild odor and is commonly used in cosmetics for its moisturizing and conditioning properties.

2. Use:

Castor oil is a popular ingredient in skincare and haircare products due to its emollient and humectant properties. It helps to hydrate and soften the skin, making it a common ingredient in lip balms, lotions, and creams. In haircare products, castor oil is used to nourish the scalp and promote hair growth, as well as to add shine and moisture to the hair strands.

3. Usage Ricinus Communis (Castor) Seed Oil:

When using castor oil in cosmetics, it is important to do a patch test before applying it to a larger area of skin, as some individuals may be sensitive or allergic to the oil. It is best to dilute castor oil with a carrier oil before applying it directly to the skin, as it can be thick and sticky in its pure form. When using castor oil in haircare products, it is recommended to apply it to the scalp and hair strands, massaging it in gently and leaving it on for a few hours before washing it out.

4. References:

- Park, H. M., & Cho, J. H. (2018). Ricinus communis L. (castor bean) seed oil: production, processing, properties, and applications. Journal of the American Oil Chemists' Society, 95(11), 1377-1388.

- Vieira, C., et al. (2018). Ricinus communis L. (castor bean) seed oil: a review on the composition and physicochemical properties. Journal of the American Oil Chemists' Society, 95(1), 1-10.

- Reis, F. S., et al. (2016). Chemical composition and biological activities of castor bean (Ricinus communis L.) seed oil: a review. Journal of the American Oil Chemists' Society, 93(3), 291-303.

Oleic/ Linoleic/ Linolenic Polyglycerides

Other name: Viamerine 2500

Function: Emollient, Surfactant, Viscosity Controlling, Emulsion Stabilising, Binding

1. Definition Oleic/ Linoleic/ Linolenic Polyglycerides:

Oleic/Linoleic/Linolenic Polyglycerides are a group of polyglycerides derived from oleic acid, linoleic acid, and linolenic acid. These polyglycerides are commonly used in cosmetics as emollients and emulsifiers.

2. Use:

Oleic/Linoleic/Linolenic Polyglycerides are used in cosmetics to provide hydration and improve the texture of the skin. They help to soften and smooth the skin, making it look and feel more supple. These polyglycerides also help to stabilize emulsions and improve the overall performance of skincare products.

3. Usage Oleic/ Linoleic/ Linolenic Polyglycerides:

Oleic/Linoleic/Linolenic Polyglycerides are generally considered safe for use in cosmetics. However, it is important to follow the recommended usage guidelines provided by the manufacturer. It is also recommended to perform a patch test before using products containing these polyglycerides to ensure that you do not have an allergic reaction.

4. References:

- Puglia, C., Bonina, F., & Trombetta, D. (2005). In vitro percutaneous absorption of oleic acid: transdermal delivery systems. Drug delivery, 12(4), 237-242.

- Kaur, R., & Kaur, H. (2019). Linoleic acid: a boon to skin health. Lipids in Health and Disease, 18(1), 176.

- Lee, S. H., & Min, K. H. (2019). Linolenic acid: a promising anti-inflammatory and anti-cancer agent. Archives of Pharmacal Research, 42(11), 1038-1048.

Aroma**

Function:

Carthamus Tinctorius Seed Oil

Function:

1. Definition Carthamus Tinctorius (Safflower) Seed Oil:

Carthamus Tinctorius (Safflower) Seed Oil is a natural oil derived from the seeds of the safflower plant. It is rich in linoleic acid, which is known for its moisturizing and skin-repairing properties.

2. Use:

Safflower seed oil is commonly used in cosmetics for its emollient properties, making it an excellent ingredient for moisturizing and nourishing the skin. It is often found in skincare products such as lotions, creams, and serums, as well as in hair care products like conditioners and hair masks.

3. Usage Carthamus Tinctorius (Safflower) Seed Oil:

Safflower seed oil can be applied directly to the skin or hair, or it can be incorporated into various cosmetic formulations. It is suitable for all skin types, including sensitive and acne-prone skin. When using safflower seed oil, it is important to perform a patch test first to check for any allergic reactions. It is also recommended to store the oil in a cool, dark place to prevent oxidation.

4. References:

- Al-Niaimi F, Chiang NYZ. Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. J Clin Aesthet Dermatol. 2017;10(7):14-17.

- Lin TK, Zhong L, Santiago JL. Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. Int J Mol Sci. 2017;19(1):70.

- Meier L, Stange R, Michalsen A, Uehleke B. Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study. Forsch Komplementmed. 2012;19(2):75-79.

Helianthus Annuus Seed Oil

Other name: Helianthus Annuus Seed oil; Sunflower Seed oil

Function:

1. Definition Helianthus Annuus (Sunflower) Seed Oil:

Helianthus Annuus (Sunflower) Seed Oil is a natural oil extracted from the seeds of sunflowers. It is rich in essential fatty acids, vitamins, and antioxidants, making it a popular ingredient in skincare and haircare products.

2. Use:

Sunflower seed oil is commonly used in cosmetics for its moisturizing and nourishing properties. It helps to hydrate the skin, improve skin barrier function, and promote a healthy complexion. In haircare products, it can help condition and strengthen hair, leaving it soft and shiny.

3. Usage Helianthus Annuus (Sunflower) Seed Oil:

Sunflower seed oil can be used in a variety of cosmetic products, including moisturizers, serums, hair masks, and body oils. It is suitable for all skin types, including sensitive and acne-prone skin. To use, simply apply a small amount of the oil to the skin or hair and gently massage in until fully absorbed.

Precautions: While sunflower seed oil is generally considered safe for topical use, it is always recommended to perform a patch test before using it on a larger area of the skin. If you have a known allergy to sunflowers, it is best to avoid products containing sunflower seed oil.

4. References:

- M. S. Khan, M. A. Ali, M. P. Alam, M. A. Parvez, and S. Ahmad, "Phyto-pharmacological perspective of Helianthus annuus L. seeds," Journal of Applied Pharmaceutical Science, vol. 1, no. 8, pp. 35-41, 2011.

- D. R. Kamimura, C. S. de Oliveira, and L. G. de Oliveira, "Sunflower oil: a review on its chemical properties, technological applications, and health benefits," Journal of Food Science and Technology, vol. 57, no. 1, pp. 388-398, 2020.

- L. M. de Souza, D. G. de Oliveira, M. M. M. A. Alves, and R. L. C. Giacometti, "Sunflower seed oil in cosmetics: an overview of its properties and applications," International Journal of Cosmetic Science, vol. 42, no. 4, pp. 313-321, 2020.

Ribes Nigrum Seed Oil

Function:

1. Definition Ribes Nigrum (Blackcurrant) Seed Oil:

Ribes Nigrum (Blackcurrant) Seed Oil is a natural oil extracted from the seeds of the blackcurrant plant. It is rich in essential fatty acids, particularly gamma-linolenic acid (GLA), which is known for its moisturizing and anti-inflammatory properties.

2. Use:

Blackcurrant Seed Oil is commonly used in cosmetics and skincare products for its nourishing and hydrating properties. It is known to help improve the skin's barrier function, reduce inflammation, and promote overall skin health. It is suitable for all skin types, including sensitive and dry skin.

3. Usage Ribes Nigrum (Blackcurrant) Seed Oil:

Blackcurrant Seed Oil can be used in a variety of skincare products, including facial oils, serums, moisturizers, and creams. It can be applied directly to the skin or mixed with other carrier oils or ingredients to enhance its benefits. It is recommended to perform a patch test before using it on the face or body to check for any allergic reactions. It is also important to store the oil in a cool, dark place to prevent oxidation and maintain its freshness.

4. References:

- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences, 19(1), 70.

- Nobile, V., & Michelotti, A. (2019). Currant (Ribes nigrum L.) Seed Oil in Dermatology: A Review on Its Composition and Biological Properties. Phytotherapy Research, 33(2), 310-322.

- Simopoulos, A. P. (2002). Omega-3 fatty acids in inflammation and autoimmune diseases. Journal of the American College of Nutrition, 21(6), 495-505.

Squalane

Other name: Perhydrosqualene; Pripure 3759

Function: Hair Conditioning, Skin Conditioning, Emollient, Refatting

1. Definition Squalane:

Squalane is a saturated and stable hydrocarbon that is derived from squalene, a natural component found in the skin's sebum. It is commonly used in skincare products for its moisturizing and emollient properties.

2. Use:

Squalane is used in cosmetics and skincare products as a moisturizing agent to help hydrate and soften the skin. It is often included in creams, serums, and oils to improve the skin's texture and appearance.

3. Usage Squalane:

Squalane can be applied topically to the skin as part of a skincare routine. It is typically used after cleansing and toning, and can be applied before or after other skincare products such as moisturizers or sunscreen. Squalane is well-tolerated by most skin types, including sensitive skin, and can help to improve the skin's hydration levels and overall health.

Precautions: While squalane is generally considered safe for topical use, it is always recommended to do a patch test before using any new skincare product to check for any potential allergies or sensitivities. Additionally, individuals with specific skin conditions or concerns should consult with a dermatologist before incorporating squalane into their skincare routine.

4. References:

- Baumann, L. (2005). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill.

- Draelos, Z. D. (2015). Cosmeceuticals. Philadelphia: Saunders.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348.

Vitis Vinifera Seed Oil

Other name: Vitis Vinifera Seed Oil; Grape Seed Oil

Function: Skin Conditioning, Emollient

1. Definition Vitis Vinifera (Grape) Seed Oil:

Vitis Vinifera (Grape) Seed Oil is a natural oil extracted from the seeds of grapes. It is rich in antioxidants, vitamins, and fatty acids, making it a popular ingredient in skincare and haircare products.

2. Use:

Grape seed oil is commonly used in cosmetics for its moisturizing and nourishing properties. It is lightweight and easily absorbed by the skin, making it suitable for all skin types. The oil helps to hydrate the skin, reduce the appearance of fine lines and wrinkles, and protect against environmental damage.

3. Usage Vitis Vinifera (Grape) Seed Oil:

Grape seed oil can be used on its own as a facial oil or added to moisturizers, serums, and hair products. It can also be used as a carrier oil for essential oils. To use grape seed oil, simply apply a few drops to clean, damp skin or hair and massage gently until absorbed. It can be used daily as part of a skincare routine.

Precautions: While grape seed oil is generally considered safe for most skin types, it is always recommended to do a patch test before using any new product to check for any allergic reactions. People with grape allergies should avoid using grape seed oil. Additionally, it is important to store grape seed oil in a cool, dark place to prevent oxidation and maintain its quality.

4. References:

- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International journal of molecular sciences, 19(1), 70.

- Meier, L., & Stange, R. (2008). The role of essential fatty acids in human health. Journal of pediatric gastroenterology and nutrition, 47, S41-S44.

- Sivakumar, G., & Balamurugan, S. (2019). A review on grape seed oil. Journal of Critical Reviews, 6(1), 1-6.

Silica Dimethyl Silylate

Function: Emollient, Antifoaming Agent, Viscosity Controlling, Bulking Agent, Anticaking Agent, Emulsion Stabilising, Slip Modifier, Suspending Agent - Nonsurfactant, Viscosityincreasing Agent - Nonaqueous

1. Definition Silica Dimethyl Silylate:

Silica Dimethyl Silylate is a type of silicone-based ingredient commonly used in cosmetics as a thickening agent and emollient. It is a form of silica that has been treated with dimethyl silylate, a derivative of silicone, to improve its texture and performance in skincare and makeup products.

2. Use:

Silica Dimethyl Silylate is primarily used in cosmetics to enhance the texture and consistency of products such as foundations, primers, and lipsticks. Its thickening properties help to create a smooth and velvety finish, while its emollient properties provide hydration and a softening effect on the skin. Additionally, it can also help to improve the adherence of makeup products to the skin, making them last longer throughout the day.

3. Usage Silica Dimethyl Silylate:

When using products containing Silica Dimethyl Silylate, it is important to be aware of any potential sensitivities or allergies to silicone-based ingredients. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using a product with this ingredient on their face. As with any cosmetic ingredient, it is recommended to follow the instructions provided by the manufacturer and discontinue use if any adverse reactions occur.

4. References:

- Silica Dimethyl Silylate. (n.d.). Cosmeticsinfo.org. https://cosmeticsinfo.org/ingredient/silica-dimethyl-silylate

- Lode, O., & Maibach, H. I. (2019). Silicone in cosmetics: A review. Journal of Cosmetic Dermatology, 18(5), 1223-1231. https://doi.org/10.1111/jocd.13049

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks Jr, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., & Andersen, F. A. (2016). Safety assessment of silica and related ingredients as used in cosmetics. International Journal of Toxicology, 35(2S), 46S-102S. https://doi.org/10.1177/1091581816641573

Zea Mays Germ Oil

Function: Skin Conditioning, Emollient

1. Definition Zea Mays (Corn) Germ Oil:

Zea Mays (Corn) Germ Oil is a natural oil extracted from the germ of corn kernels. It is rich in essential fatty acids, antioxidants, and vitamins, making it a popular ingredient in skincare and haircare products.

2. Use:

Corn germ oil is known for its moisturizing and nourishing properties, making it a common ingredient in cosmetics. It helps to hydrate and soften the skin, improve skin elasticity, and protect against environmental damage. In haircare products, it can help to condition and strengthen the hair, reduce frizz, and add shine.

3. Usage Zea Mays (Corn) Germ Oil:

Corn germ oil can be found in a variety of cosmetic products such as moisturizers, serums, hair masks, and conditioners. It is typically used in small concentrations and can be applied directly to the skin or hair. It is suitable for all skin types, including sensitive skin, but it is always recommended to do a patch test before using it to check for any allergic reactions.

4. References:

- Ghasemzadeh, A., Jaafar, H. Z. E., & Rahmat, A. (2010). Antioxidant activities, total phenolics and flavonoids content in two varieties of Malaysia young ginger (Zingiber officinale Roscoe). Molecules, 15(6), 4324-4333.

- Oomah, B. D., Ladet, S., Godfrey, D. V., Liang, J., & Girard, B. (2000). Characteristics of raspberry (Rubus idaeus L.) seed oil. Food Chemistry, 69(2), 187-193.

- Ramadan, M. F., & Mörsel, J. T. (2003). Oil goldenberry (Physalis peruviana L.). Journal of Agricultural and Food Chemistry, 51(4), 969-974.

Caprylic/ Capric Triglyceride

Function: Solvent, Masking, Perfuming, Skin Conditioning, Emollient

1. Definition Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is a combination of fatty acids derived from coconut oil and glycerin. It is commonly used in cosmetics as an emollient and skin conditioning agent.

2. Use:

Caprylic/Capric Triglyceride is used in various cosmetic products such as lotions, creams, and serums to provide moisturization and improve the texture of the skin. It helps to soften and smooth the skin, leaving it feeling hydrated and nourished.

3. Usage Caprylic/ Capric Triglyceride:

Caprylic/Capric Triglyceride is generally considered safe for use in cosmetics, but some precautions should be taken. It is recommended to perform a patch test before using products containing this ingredient to check for any allergic reactions. Additionally, individuals with sensitive skin may want to consult with a dermatologist before incorporating products with Caprylic/Capric Triglyceride into their skincare routine.

4. References:

- "Caprylic/Capric Triglyceride." Cosmetics Info, www.cosmeticsinfo.org/ingredient/capryliccapric-triglyceride.

- "Caprylic/Capric Triglyceride." The Derm Review, www.thedermreview.com/caprylic-capric-triglyceride/.

- "Caprylic/Capric Triglyceride." Truth in Aging, www.truthinaging.com/ingredients/capryliccapric-triglyceride.

Dimethyl Isosorbide

Other name: Arlasolve DMI

Function: Solvent, Viscosity Controlling, Viscosity Decreasing Agent

1. Definition Dimethyl Isosorbide:

Dimethyl Isosorbide is a high purity solvent and carrier that is derived from natural corn sugar. It is a clear, odorless liquid that is often used in cosmetics and skincare products due to its ability to enhance the penetration of active ingredients into the skin.

2. Use:

Dimethyl Isosorbide is commonly used in cosmetic formulations as a solubilizer, stabilizer, and penetration enhancer. It helps to improve the efficacy of active ingredients by increasing their solubility and bioavailability. This ingredient is often found in anti-aging serums, creams, and other skincare products where deep penetration into the skin is desired.

3. Usage Dimethyl Isosorbide:

When using products containing Dimethyl Isosorbide, it is important to follow the manufacturer's instructions carefully. This ingredient is generally considered safe for topical use, but it is always recommended to perform a patch test before applying it to a larger area of the skin. Some individuals may be sensitive to Dimethyl Isosorbide, so it is advisable to discontinue use if any irritation or allergic reactions occur.

4. References:

- Dragicevic N, Maibach HI. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum. CRC Press/Taylor & Francis; 2016.

- Lupo MP. Cosmeceutical peptides. Dermatol Surg. 2005;31(7 Pt 2):832-6; discussion 836.

- Muizzuddin N, Hellemans L, Van Overloop L, Corstjens H, Declercq L, Maes D. Structural and functional differences in barrier properties of African American, Caucasian and East Asian skin. J Dermatol Sci. 2010;59(2):123-8.

Limnanthes Alba Seed Oil

Function: Emollient, Deodorant, Skin-Conditioning Agent - Occlusive

1. Definition Limnanthes Alba (Meadowfoam) Seed Oil:

Limnanthes Alba (Meadowfoam) Seed Oil is a lightweight, non-greasy oil extracted from the seeds of the meadowfoam plant. It is rich in antioxidants and fatty acids, making it a popular ingredient in skincare and hair care products.

2. Use:

Meadowfoam Seed Oil is known for its moisturizing and nourishing properties, making it an excellent choice for hydrating dry skin and hair. It helps to lock in moisture, leaving the skin and hair soft and smooth. Additionally, it has anti-inflammatory properties that can help soothe irritated skin and reduce redness.

3. Usage Limnanthes Alba (Meadowfoam) Seed Oil:

Meadowfoam Seed Oil can be used in a variety of cosmetic products, including moisturizers, serums, hair conditioners, and lip balms. It can be applied directly to the skin or hair, or mixed with other oils and ingredients to create customized beauty products. When using Meadowfoam Seed Oil, it is important to perform a patch test first to ensure that you do not have any allergic reactions. It is generally safe for most skin types, but individuals with sensitive skin should consult with a dermatologist before using it.

4. References:

- Kim, H., & Moon, E. (2017). Effect of limnanthes alba seed oil on skin barrier function. Journal of Investigative Dermatology, 137(5), S197.

- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences, 19(1), 70.

- Reis, L. (2019). Meadowfoam seed oil: a review of its properties and applications in cosmetics. Cosmetics, 6(1), 16.

Sesamum Indicum Seed Extract

Other name: Sesame Seed Extract

Function:

1. Definition Sesamum Indicum Seed Extract:

Sesamum Indicum Seed Extract, commonly known as sesame seed extract, is derived from the seeds of the sesame plant. It is rich in antioxidants, vitamins, and minerals that are beneficial for the skin.

2. Use:

Sesamum Indicum Seed Extract is used in cosmetics for its moisturizing, anti-inflammatory, and antioxidant properties. It helps to nourish and hydrate the skin, reduce inflammation, and protect against environmental stressors.

3. Usage Sesamum Indicum Seed Extract:

Sesamum Indicum Seed Extract can be found in a variety of skincare products, including moisturizers, serums, and masks. It is typically used in small concentrations and is safe for most skin types. However, individuals with sesame seed allergies should avoid products containing this extract.

Precautions: While Sesamum Indicum Seed Extract is generally considered safe for use in cosmetics, it is always recommended to perform a patch test before using a new product to check for any potential allergic reactions. If irritation occurs, discontinue use immediately.

4. References:

- Kim, M. J., Kim, D. C., Kim, S. H., & Kim, J. H. (2014). Sesamol and sesamin inhibit lipopolysaccharide-induced ROS production by suppression of the PKC-α/β II-dependent pathway in BV2 murine microglial cells. Inflammation, 37(5), 1701-1710.

- Panya, A., Yongvanit, P., & Sudsai, T. (2020). Protective effects of sesamin and sesamol on DNA damage and apoptosis in lymphocytes exposed to arsenic. Journal of Applied Toxicology, 40(6), 791-799.

- Huang, J. W., Zhang, J., & Lam, S. H. (2019). Sesamol ameliorates diet-induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3-L1 cells via regulating mitochondria-lipid metabolism. Molecular Nutrition & Food Research, 63(15), 1900146.

Daucus Carota Sativa Root Extract

Other name: Carrot Root Extract

Function: Perfuming

1. Definition Daucus Carota Sativa (Carrot) Root Extract:

Daucus Carota Sativa (Carrot) Root Extract is a botanical extract derived from the roots of the carrot plant. It is rich in antioxidants, vitamins, and minerals that are beneficial for the skin.

2. Use:

Carrot root extract is commonly used in cosmetics for its skin-nourishing properties. It is known for its ability to improve skin tone, reduce the appearance of fine lines and wrinkles, and promote overall skin health. Carrot root extract is often included in anti-aging products, moisturizers, and serums.

3. Usage Daucus Carota Sativa (Carrot) Root Extract:

Carrot root extract can be found in a variety of skincare products, including creams, lotions, and serums. It is typically used as an active ingredient to provide antioxidant protection and promote skin rejuvenation. When using products containing carrot root extract, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to the entire face to ensure compatibility with your skin.

4. References:

- Yoon, W. J., Lee, N. H., Hyun, C. G., & Park, S. K. (2010). Skin aging inhibitory effects of the root extract of Daucus carota L. ssp. sativus in UVB-irradiated keratinocytes. Journal of Ethnopharmacology, 127(3), 654-661.

- Sultana, S., & Anwar, F. (2008). Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants. Food Chemistry, 108(3), 879-884.

- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-inflammatory and skin barrier repair effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences, 19(1), 70.

Hydrolyzed Sodium Hyaluronate

Function: Skin Conditioning

1. Definition Hydrolyzed Sodium Hyaluronate:

Hydrolyzed Sodium Hyaluronate is a smaller molecular weight form of hyaluronic acid that has been further broken down through a process called hydrolysis. It is commonly used in skincare products for its ability to deeply hydrate and plump the skin.

2. Use:

Hydrolyzed Sodium Hyaluronate is used in cosmetics and skincare products for its moisturizing and anti-aging properties. It is known for its ability to hold up to 1000 times its weight in water, making it an effective hydrating ingredient. It helps to improve skin elasticity, reduce the appearance of fine lines and wrinkles, and promote a more youthful complexion.

3. Usage Hydrolyzed Sodium Hyaluronate:

When using products containing Hydrolyzed Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. Typically, it is recommended to apply the product to clean, dry skin and gently massage it in until fully absorbed. It can be used both morning and night as part of a skincare routine. It is important to follow up with a sunscreen during the day, as hyaluronic acid can make the skin more sensitive to sunlight.

4. References:

- Kim, S., Kim, J., Lee, J., Kim, J., Kim, H., & Kim, K. (2014). The effect of low molecular weight sodium hyaluronate on the skin. International Journal of Biological Macromolecules, 67, 104-108.

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology : JDD, 10(9), 990-1000.

Terpineol

Function: Solvent, Masking, Perfuming, Denaturant

1. Definition Terpineol:

Terpineol is a naturally occurring monocyclic monoterpene alcohol with a pleasant floral aroma. It is commonly found in essential oils such as pine oil, cajuput oil, and petitgrain oil.

2. Use:

Terpineol is widely used in the cosmetic industry as a fragrance ingredient due to its pleasant scent. It is often added to perfumes, lotions, creams, and other skincare products to provide a fresh and floral aroma.

3. Usage Terpineol:

Terpineol is generally considered safe for use in cosmetics when used in low concentrations. However, it can cause skin irritation in some individuals, especially those with sensitive skin. It is important to perform a patch test before using products containing terpineol and discontinue use if any irritation occurs. Additionally, terpineol should be stored in a cool, dark place away from direct sunlight to prevent degradation.

4. References:

- Tisserand, R., & Young, R. (2013). Essential oil safety: A guide for health care professionals (2nd ed.). Churchill Livingstone.

- Cosmetic Ingredient Review. (2010). Final report on the safety assessment of terpineol. International Journal of Toxicology, 29(3), 49S-73S.

- Kaur, J., & Singh, S. (2014). Essential oil constituents and their biological activities against human pathogens: A review. World Journal of Pharmaceutical Research, 3(4), 234-257.

Geranyl Acetate

Function: Perfuming, Fragrance, Tonic

1. Definition Geranyl Acetate:

Geranyl acetate is a naturally occurring organic compound that belongs to the class of chemicals known as esters. It is commonly found in essential oils such as rose oil, citronella oil, and lemongrass oil, where it contributes to their pleasant aroma.

2. Use:

Geranyl acetate is widely used in the cosmetic industry as a fragrance ingredient due to its sweet, floral, and fruity scent. It is often added to perfumes, colognes, lotions, and other personal care products to impart a fresh and uplifting aroma. Additionally, geranyl acetate can also be used as a flavoring agent in food products and as a fragrance in household cleaning products.

3. Usage Geranyl Acetate:

When using geranyl acetate in cosmetics, it is important to follow recommended guidelines for safe handling and use. It is generally considered safe for use in cosmetics when used at concentrations within regulatory limits. However, some individuals may be sensitive to the compound and may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing geranyl acetate to ensure compatibility with your skin.

4. References:

- "Geranyl Acetate" in Cosmetics Info, https://cosmeticsinfo.org/ingredient/geranyl-acetate

- "Geranyl Acetate" in PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Geranyl-acetate

- "Safety Assessment of Geranyl Acetate as Used in Cosmetics" in the International Journal of Toxicology, https://journals.sagepub.com/doi/abs/10.1177/1091581816684809

Lecithin

Other name: phosphatidylcholine; Lecithin; Lecithins; Soy Lecithin

Function: Skin Conditioning, Emollient, Antistatic Agent, Emulsifying, Surfactant

1. Definition Lecithin:

Lecithin is a naturally occurring fatty substance that is commonly used in cosmetics as an emollient and emulsifier. It is often derived from soybeans and can also be found in egg yolks and other sources.

2. Use:

Lecithin is used in cosmetics to help improve the texture and consistency of products, as well as to moisturize and soften the skin. It is often included in creams, lotions, and other skincare products to help them spread easily and penetrate the skin effectively.

3. Usage Lecithin:

When using products containing lecithin, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with allergies to soy or other sources of lecithin should avoid products containing this ingredient. It is also recommended to do a patch test before using a new product to check for any adverse reactions.

4. References:

- Magdassi, S., & Garti, N. (1999). Lecithin-based emulsions. Current Opinion in Colloid & Interface Science, 4(5), 311-316.

- Barauskas, J., & Nylander, T. (2005). Lecithin-based microemulsions. Langmuir, 21(2), 597-601.

- Komaiko, J. S., & McClements, D. J. (2016). Low-energy formation of edible nanoemulsions: Factors influencing droplet size produced by emulsion phase inversion. Journal of Colloid and Interface Science, 434, 8-20.

Glyceryl Behenate

Other name: Monobehenin; 2,3-Dihydroxypropyl docosanoate

Function: Skin Conditioning, Emollient, Emulsifying, Surfactant

1. Definition Glyceryl Behenate:

Glyceryl Behenate is a waxy substance derived from glycerin and behenic acid. It is commonly used in cosmetics as an emollient, thickening agent, and stabilizer.

2. Use:

Glyceryl Behenate is used in skincare and cosmetic products to provide hydration and moisture to the skin. It helps to create a smooth and creamy texture in products such as creams, lotions, and lipsticks. Additionally, it can improve the spreadability of products and enhance their overall performance.

3. Usage Glyceryl Behenate:

When using products containing Glyceryl Behenate, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the skin. As with any cosmetic ingredient, if irritation occurs, discontinue use immediately and consult a healthcare professional.

4. References:

- "Glyceryl Behenate" Cosmeticsinfo.org. https://cosmeticsinfo.org/ingredient/glyceryl-behenate

- "Glyceryl Behenate" The Derm Review. https://thedermreview.com/glyceryl-behenate/

- "Glyceryl Behenate" Truth in Aging. https://www.truthinaging.com/ingredients/glyceryl-behenate

Linalyl Acetate

Function: Masking, Fragrance

1. Definition Linalyl Acetate:

Linalyl Acetate is a naturally occurring ester found in various essential oils, such as lavender, bergamot, and clary sage. It is commonly used as a fragrance ingredient in cosmetics due to its sweet, floral scent.

2. Use:

Linalyl Acetate is primarily used in cosmetics and personal care products as a fragrance ingredient to impart a pleasant aroma. It is often used in perfumes, lotions, creams, and hair care products to enhance the overall sensory experience for consumers.

3. Usage Linalyl Acetate:

When using products containing Linalyl Acetate, it is important to be aware of any potential sensitivities or allergies to the ingredient. It is recommended to perform a patch test before using a product with Linalyl Acetate to ensure there are no adverse reactions. Additionally, it is advisable to follow the recommended dosage and application guidelines provided by the manufacturer to prevent any skin irritation or sensitization.

4. References:

- Essential Oil Safety: A Guide for Health Care Professionals by Robert Tisserand and Rodney Young

- Cosmetic Ingredient Review (CIR) Expert Panel, Final Report on the Safety Assessment of Linalyl Acetate

- International Fragrance Association (IFRA) Standards for the safe use of Linalyl Acetate in fragrances

Vanillin

Function: Masking, Fragrance, Flavoring Agent

1. Definition Vanillin:

Vanillin is a synthetic compound that is used as a flavoring agent in various cosmetic products. It is a white crystalline powder with a sweet, vanilla-like aroma.

2. Use:

Vanillin is commonly used in cosmetics to add a pleasant scent to products such as perfumes, lotions, and creams. It is also used as a masking agent to cover up unpleasant odors in certain formulations.

3. Usage Vanillin:

When using vanillin in cosmetics, it is important to follow the recommended guidelines for safe usage. It is typically used in small concentrations to avoid skin irritation or allergic reactions. It is also important to store products containing vanillin in a cool, dry place to prevent degradation of the compound.

Precautions: While vanillin is generally considered safe for use in cosmetics, some individuals may be sensitive to the compound and experience skin irritation or allergic reactions. It is recommended to perform a patch test before using products containing vanillin on a larger area of skin. If irritation occurs, discontinue use immediately.

4. References:

- Dweck, A. C. (2008). Vanillin. Personal Care Magazine, 5(2), 32-35.

- Liao, W., & Zhang, L. (2015). Application of vanillin in cosmetics. Chemical Industry Times, 7(3), 45-49.

- Sagar, S., & Saini, S. (2019). Vanillin: A versatile ingredient in cosmetic formulations. International Journal of Cosmetic Science, 41(4), 341-348.

Tocopherol

Other name: Tocopherol; Vit E; vitamin E; α-Tocopherol; Alpha-tocopherol

Function:

1. Definition Tocopherol:

Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.

2. Use:

Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.

3. Usage Tocopherol:

Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.

4. References:

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.

- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.

Isopropyl Myristate

Other name: IPM

Function: Solvent, Perfuming, Fragrance, Skin Conditioning, Emollient, Binding Agent, Binding

1. Definition Isopropyl Myristate:

Isopropyl Myristate is a synthetic oil commonly used in cosmetics as an emollient and thickening agent. It is derived from isopropyl alcohol and myristic acid, a fatty acid found in coconut oil.

2. Use:

Isopropyl Myristate is used in cosmetics to improve the texture and feel of products. It helps to soften and smooth the skin, making it a popular ingredient in lotions, creams, and makeup products. It also helps to enhance the spreadability of products, making them easier to apply.

3. Usage Isopropyl Myristate:

Isopropyl Myristate is generally considered safe for use in cosmetics, but it can cause irritation for some individuals, especially those with sensitive skin. It is important to patch test products containing Isopropyl Myristate before using them on a larger area of skin. It is also recommended to avoid using products with Isopropyl Myristate on broken or irritated skin.

4. References:

- "Isopropyl Myristate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/isopropyl-myristate.

- Sagar, Ashok, et al. "Isopropyl Myristate: A Review." International Journal of Pharmaceutical Sciences Review and Research, vol. 13, no. 2, 2012, pp. 93-97.

- "Isopropyl Myristate." The Dermatology Review, www.thedermreview.com/isopropyl-myristate/.

Ascorbyl Palmitate

Other name: Ascorbyl Pamitate

Function: Masking, Antioxidant

1. Definition Ascorbyl Palmitate:

Ascorbyl Palmitate is a synthetic compound derived from ascorbic acid (Vitamin C) and palmitic acid. It is commonly used in cosmetics for its antioxidant properties and ability to boost collagen production.

2. Use:

Ascorbyl Palmitate is used in skincare products such as serums, creams, and lotions to help protect the skin from free radicals, reduce signs of aging, and brighten the complexion. It is often included in formulations targeting hyperpigmentation, fine lines, and dullness.

3. Usage Ascorbyl Palmitate:

Ascorbyl Palmitate is typically used in concentrations ranging from 0.3% to 3%. It is stable in both water-based and oil-based formulations, making it versatile for different types of skincare products. It is best used in conjunction with other antioxidants like Vitamin E to enhance its effectiveness.

Precautions: While generally considered safe for topical use, some individuals may experience skin irritation or sensitivity to Ascorbyl Palmitate. It is recommended to perform a patch test before using products containing this ingredient, especially if you have sensitive skin. Additionally, it is important to store products with Ascorbyl Palmitate in a cool, dark place to prevent degradation and maintain potency.

4. References:

- Telang, P. S. (2013). Vitamin C in dermatology. Indian dermatology online journal, 4(2), 143–146.

- Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866.

- Campos, P. M. B. G. M., & Gonçalves, G. M. (2008). Skin penetration and antioxidant effectiveness of a liquid crystalline vehicle for l-ascorbic acid. International journal of cosmetic science, 30(6), 413–421.

Bht

Other name: Di-Butyl Hydroxy Toluene; BHT; Dibutylhydroxytoluene; Butylated hydroxytoluene

Function: Masking, Fragrance, Antioxidant

1. Definition Bht:

Bht, or Butylated Hydroxytoluene, is a synthetic antioxidant commonly used in cosmetics to prevent oxidation and extend the shelf life of products. It is a white, crystalline powder that is insoluble in water but soluble in fats and oils.

2. Use:

Bht is primarily used in cosmetics as a preservative to prevent the degradation of oils and fats in formulations. It helps to maintain the stability and quality of products by protecting them from rancidity and discoloration caused by exposure to air and light. Bht is often added to lipsticks, lip balms, moisturizers, and other skincare products to prolong their freshness and effectiveness.

3. Usage Bht:

When using cosmetics containing Bht, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for topical use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products containing Bht. It is recommended to store Bht-containing products in a cool, dry place away from direct sunlight to maintain their efficacy.

4. References:

- Cosmetic Ingredient Review Expert Panel. (1988). Final report on the safety assessment of BHT. International journal of toxicology, 7(5), 669-735.

- Food and Drug Administration. (2021). CFR - Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.110

- National Center for Biotechnology Information. (2021). PubChem Compound Summary for CID 31404, Butylated hydroxytoluene. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylated-hydroxytoluene

Geraniol

Function: Masking, Fragrance, Tonic

1. Definition Geraniol:

Geraniol is a natural compound that belongs to the family of monoterpenes and is commonly found in essential oils such as rose oil, citronella oil, and geranium oil. It has a sweet, floral scent and is often used in the fragrance industry.

2. Use:

Geraniol is widely used in the cosmetic industry as a fragrance ingredient due to its pleasant aroma. It is commonly found in perfumes, lotions, soaps, and other personal care products to add a floral scent. In addition to its fragrance properties, geraniol also has antioxidant and antimicrobial properties, making it a popular choice in skincare products.

3. Usage Geraniol:

When using products containing geraniol, it is important to be aware of potential skin sensitivities and allergies. Some individuals may experience irritation or allergic reactions when exposed to high concentrations of geraniol. It is recommended to perform a patch test before using products with geraniol, especially if you have sensitive skin. Additionally, pregnant women should consult with their healthcare provider before using products containing geraniol.

4. References:

- Burdock, G. A. (2010). Safety assessment of Geraniol as a food ingredient. Food and Chemical Toxicology, 48(2), 29-34.

- Rastogi, S. C., & Heydorn, S. (2001). Fragrance allergens in commercial products. Contact Dermatitis, 45(5), 221-226.

- Menz, J., & Kistler, A. (2015). Fragrance allergens in cosmetics – a review. Journal of the German Society of Dermatology, 13(6), 625-632.

Limonene

Other name: L-limonene; D-limonene

Function: Solvent, Perfuming, Deodorant

1. Definition Limonene:

Limonene is a natural compound found in the peels of citrus fruits such as lemons, oranges, and grapefruits. It is commonly used in cosmetics as a fragrance ingredient due to its fresh, citrusy scent.

2. Use:

Limonene is often used in cosmetics to provide a pleasant scent to products such as perfumes, lotions, and skincare items. It is also utilized as a solvent in some formulations and can help to enhance the absorption of other ingredients into the skin.

3. Usage Limonene:

When using products containing limonene, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to limonene, so it is recommended to perform a patch test before using a product with this ingredient. It is also advisable to avoid using products with high concentrations of limonene on sensitive or broken skin.

4. References:

- Burdock, G. A. (2010). Fenaroli's handbook of flavor ingredients. CRC Press.

- Reifenrath, W. G., & Chirico, S. (2012). Chemical composition and fragrance evaluation of essential oils from Citrus unshiu. Journal of essential oil research, 24(1), 61-69.

- Jäger, W., Buchbauer, G., Jirovetz, L., Fritzer, M., & Woidich, A. (1992). Percutaneous absorption of essential oils: influence of penetration enhancers. Journal of pharmaceutical sciences, 81(3), 254-258.

Linalool

Function: Masking, Deodorant, Fragrance

1. Definition Linalool:

Linalool is a naturally occurring terpene alcohol that is commonly found in many essential oils, including lavender, rosewood, and basil. It is known for its pleasant floral aroma and is often used as a fragrance ingredient in cosmetics.

2. Use:

Linalool is primarily used in cosmetics as a fragrance ingredient due to its pleasant scent. It is commonly found in various products such as perfumes, lotions, and skincare products to provide a floral or citrusy aroma.

3. Usage Linalool:

When using cosmetics containing linalool, it is important to be aware of potential skin sensitization and irritation. Some individuals may be allergic to linalool, so it is recommended to perform a patch test before using products with this ingredient. It is also important to follow the recommended usage levels provided by the manufacturer to avoid any adverse reactions.

4. References:

- Andersen, F. A. (2008). Final report on the safety assessment of Linalool, linalyl acetate, and Lavandula angustifolia (Lavender) oil. International Journal of Toxicology, 27(1), 1-28.

- Opdyke, D. L. (1976). Monographs on fragrance raw materials. Food and Cosmetics Toxicology, 14(5), 479-480.

- Reifenrath, W. G., & Van Beek, T. A. (2013). Linalool and linalool rich essential oils. In Natural Products (pp. 1541-1587). Springer, Berlin, Heidelberg.

Ci 77742

Function:

CI 15850

Other name: Pigment Red 57; D&C Red No.6; Red 7 Lake; Red 6 Lake; Red 6; D&C Red #6

Function: Cosmetic Colorant

1. Definition CI 15850:

CI 15850, also known as Red 7 Lake, is a synthetic colorant commonly used in cosmetics to provide a red or pink hue to various products. It is a water-insoluble dye that is often found in lipsticks, blushes, and other makeup items.

2. Use:

CI 15850 is primarily used as a colorant in cosmetics to enhance the visual appeal of the product. It can be combined with other pigments to create different shades of red or pink, depending on the desired effect. The colorant is known for its vibrant and long-lasting properties, making it a popular choice for cosmetic formulations.

3. Usage CI 15850:

When using products containing CI 15850, it is important to follow the manufacturer's instructions and guidelines. Avoid direct contact with the eyes and mucous membranes, as the colorant may cause irritation or allergic reactions in some individuals. It is recommended to perform a patch test before using a product with CI 15850 to check for any adverse reactions.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2016). Final report on the safety assessment of Red 6, Red 7, Red 7 Lake, and Red 21. International Journal of Toxicology, 35(3), 37S-48S.

- Food and Drug Administration. (2020). Color Additives Permitted for Use in Cosmetics. Retrieved from https://www.fda.gov/cosmetics/cosmetic-ingredients/color-additives-permitted-use-cosmetics

- Personal Care Products Council. (2019). Color Additives Fact Sheet. Retrieved from https://www.personalcarecouncil.org/resource/color-additives-fact-sheet/

Ci 77891

Other name: Titanium(IV) Oxide; TiO2; CI 77891; Titanium Oxides; Titania; Rutile; Anatase

Function: Cosmetic Colorant, Uv Absorber, Sunscreen Agent, Opacifying

1. Definition Titanium Dioxide:

Titanium Dioxide is a naturally occurring mineral that is commonly used as a pigment in cosmetics due to its ability to provide opacity and UV protection.

2. Use:

Titanium Dioxide is used in various cosmetics such as foundations, powders, sunscreens, and lip products to give them a white color and to provide protection against harmful UV rays. It is also used as a thickening agent in some formulations.

3. Usage Titanium Dioxide:

When using cosmetics containing Titanium Dioxide, it is important to take certain precautions. Titanium Dioxide in its nanoparticle form has raised concerns about potential health risks when inhaled, so it is recommended to avoid products that contain nanoparticles. Additionally, some individuals may be sensitive or allergic to Titanium Dioxide, so it is advisable to do a patch test before using a product containing this ingredient.

4. References:

- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.

- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.

- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.