Name: Cassará Axne Adapaleno 0,1% Gel
Brand: Cassará
Rating: 5 (6 reviews)

Adapalene

Other Names: Adaplene; Differin

Function: Antiacne Agent

1. Definition Adapalene:

Adapalene is a synthetic compound that belongs to the class of medications known as retinoids. It is commonly used in the treatment of acne, as it helps to unclog pores, reduce inflammation, and promote skin cell turnover.

2. Use:

Adapalene is primarily used in the formulation of topical treatments for acne, such as gels, creams, and lotions. It is known for its ability to target multiple factors that contribute to acne formation, making it a popular choice among dermatologists and skincare professionals.

3. Usage Adapalene:

When using products containing Adapalene, it is important to follow the instructions provided by a healthcare professional or included on the product packaging. Typically, Adapalene should be applied to clean, dry skin once daily, preferably in the evening. It is important to avoid excessive sun exposure while using Adapalene, as it can increase the skin's sensitivity to UV radiation. Additionally, some individuals may experience mild irritation or dryness when first using Adapalene, but these side effects usually subside with continued use.

4. References:

- Dreno, B., Thiboutot, D., Gollnick, H., Finlay, A.Y., Layton, A., Leyden, J.J., & Kang, S. (2009). Large-scale worldwide observational study of adherence with acne therapy. International Journal of Dermatology, 48(7), 749-756.

- Thielitz, A., Gollnick, H., & Reinhold, D. (2008). Adapalene as a treatment for acne vulgaris: a retrospective analysis of data from the German Acne Registry. Journal of the European Academy of Dermatology and Venereology, 22(6), 787-794.

- Leyden, J.J., Wortzman, M., & Baldwin, E.K. (2011). A single-center, randomized double-blind, parallel-group study to examine the safety and efficacy of 0.1% Adapalene gel compared to vehicle in the treatment of acne vulgaris in adult females. Journal of Drugs in Dermatology, 10(6), 582-587.

Xylitol

Other Names: D-Xylitol

Function: Humectant, Skin Conditioning, Flavoring Agent

1. Definition Xylitol:

Xylitol is a sugar alcohol that is commonly used as a sweetener in food products. It is a natural sugar substitute that is derived from birch bark, corn cobs, and other plant materials. Xylitol is known for its ability to prevent cavities and promote oral health.

2. Use:

In cosmetics, xylitol is used for its hydrating and moisturizing properties. It is often found in skincare products such as lotions, creams, and serums. Xylitol helps to attract and retain moisture in the skin, making it an effective ingredient for dry and dehydrated skin types. Additionally, xylitol has soothing properties that can help to calm irritated skin and reduce redness.

3. Usage Xylitol:

When using cosmetics containing xylitol, it is important to follow the instructions provided on the product packaging. Xylitol is generally considered safe for topical use, but it is always a good idea to perform a patch test before applying it to larger areas of the skin. Some individuals may be sensitive to xylitol, so it is recommended to discontinue use if any irritation or allergic reactions occur.

4. References:

- Choi, S. J., Lee, S. N., Kim, K., & Kim, D. S. (2018). Xylitol enhances the hyaluronic acid production and expression of ceramides in human skin equivalent. Biomolecules & Therapeutics, 26(4), 377-382.

- Suresh, S., & Pradeep, S. (2014). Xylitol in preventing dental caries: A systematic review and meta-analyses. Journal of Natural Science, Biology, and Medicine, 5(1), 15-25.

- Lee, J. H., Park, Y. D., Jeong, S. H., & Do, J. H. (2017). Xylitol inhibits inflammatory cytokine expression induced by lipopolysaccharide from Porphyromonas gingivalis. Clinical Oral Investigations, 21(8), 2443-2450.

Niacinamid

Ingredient data is being updated. Please check back later.

Glycerin

Other Names: Glycerine; Glycerin; Pflanzliches Glycerin; 1,2,3-Propanetriol

Function: Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

Carbomer

Other Names: Carboxypolymethylene; Carbopol; Cabomer

Function: Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming

1. Definition Carbomer:

Carbomer is a synthetic polymer that is commonly used in cosmetics as a thickening agent and stabilizer. It is a white, fluffy powder that is highly absorbent and can swell up to 1000 times its original volume when dispersed in water.

2. Use:

Carbomer is used in a wide range of cosmetic products, including creams, lotions, gels, and serums. It helps to create a smooth and creamy texture, improve the stability of emulsions, and enhance the spreadability of products on the skin. Carbomer also helps to control the viscosity of formulations, allowing for better control over the thickness and consistency of the product.

3. Usage Carbomer:

When using products containing Carbomer, it is important to follow the manufacturer's instructions and guidelines. It is typically used in concentrations ranging from 0.1% to 1% in cosmetic formulations. Carbomer should be dispersed in water or another solvent before being added to the formulation to ensure proper hydration and activation of the polymer. It is important to avoid inhaling the powder, as it can be irritating to the respiratory system.

4. References:

- Sharma, A., & Jain, A. (2012). Carbomers: A review. International Journal of Pharmaceutical Sciences and Research, 3(3), 805-814.

- Liao, Y., & Wang, J. (2017). Carbomer: A versatile polymer in pharmaceutical applications. Polymer Chemistry, 8(3), 355-366.

- Patel, D. (2015). Carbomer in pharmaceuticals: A review. World Journal of Pharmacy and Pharmaceutical Sciences, 4(2), 121-133.

Poloxamer 188

Function: Antimicrobial Agent, Sufactant

1. Definition Poloxamer 188:

Poloxamer 188, also known as Pluronic F-68, is a non-ionic surfactant that is commonly used in cosmetics for its emulsifying, stabilizing, and solubilizing properties. It is a copolymer composed of polyoxyethylene and polyoxypropylene blocks, which gives it the ability to interact with both water and oil phases in cosmetic formulations.

2. Use:

Poloxamer 188 is often used in cosmetics as an emulsifier to help blend water and oil-based ingredients together. It can also act as a stabilizer, preventing ingredients from separating in the formulation. Additionally, it is used as a solubilizer to improve the solubility of certain ingredients in water-based products.

3. Usage Poloxamer 188:

When using cosmetics containing Poloxamer 188, it is important to follow the recommended usage guidelines provided by the manufacturer. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to their skin. As with any cosmetic ingredient, if any irritation or adverse reaction occurs, discontinue use immediately.

4. References:

- Garg, Tarun, et al. "Poloxamer: A novel functional molecule for drug delivery, diagnostics, and therapy." Current pharmaceutical design 16.19 (2010): 2159-2175.

- Kabanov, Alexander V., and Elena V. Batrakova. "Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier." Advanced drug delivery reviews 55.1 (2003): 151-164.

- Dufes, Christine, et al. "Uptake of palmitoyl, oligoarginine, and pluronics-modified nanoparticles by human stem cells." Pharmaceutical research 25.8 (2008): 1871-1877.

Sorbato De Potasio

Ingredient data is being updated. Please check back later.

Disodium Edta

Other Names: Endrate; Disodium Edetate; Disodium Salt; Disodium EDTA; Disodium dihydrogen ethylenediaminetetraacetate; EDTA Disodium Salt; EDTA-2Na

Function: Chelating Agent, Viscosity Controlling

1. Definition Disodium Edta:

Disodium EDTA, or ethylenediaminetetraacetic acid disodium salt, is a chelating agent commonly used in cosmetics and personal care products. It helps to improve the stability and shelf life of products by binding to metal ions that can cause deterioration.

2. Use:

Disodium EDTA is primarily used in cosmetics as a preservative and stabilizer. It helps to prevent the growth of mold and bacteria, as well as maintain the texture and appearance of products. Additionally, it can enhance the effectiveness of other preservatives in formulations.

3. Usage Disodium Edta:

Disodium EDTA is typically used in concentrations ranging from 0.1% to 0.5% in cosmetics. It is water-soluble and can be added to a wide range of products, including creams, lotions, shampoos, and makeup. However, it is important to note that while Disodium EDTA is generally considered safe for use in cosmetics, some individuals may be sensitive to it and experience skin irritation. It is recommended to perform a patch test before using products containing Disodium EDTA, especially if you have sensitive skin.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Personal Care Products Council. (2019). EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/edta/

- U.S. Food and Drug Administration (FDA). (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1133

Hidróxido De Sodio

Ingredient data is being updated. Please check back later.

Water

Other Names: Aqua; H2O; Eau; Aqueous; Acqua

Function: Solvent

1. Definition Water:

Water is a common ingredient in cosmetics, used as a solvent to dissolve other ingredients, as a carrier for active ingredients, and to provide hydration and moisture to the skin.

2. Use:

Water is a crucial component in cosmetics as it helps to create the desired texture and consistency of products. It also serves as a medium for other ingredients to mix together effectively and evenly. Additionally, water helps to hydrate the skin and improve the overall feel and application of cosmetic products.

3. Usage Water:

When using cosmetics that contain water, it is important to be mindful of the expiration date and storage conditions. Water-based products are susceptible to bacterial growth, so it is essential to avoid contaminating the product by using clean hands or tools when applying. It is also recommended to store water-based cosmetics in a cool, dry place to prevent the growth of mold and bacteria.

4. References:

- Draelos, Z. D. (2010). Cosmetic dermatology: products and procedures. John Wiley & Sons.

- Winter, R. (2009). A consumer's dictionary of cosmetic ingredients: complete information about the harmful and desirable ingredients found in cosmetics and cosmeceuticals. Crown.

- Begoun, P. (2003). Don't go to the cosmetics counter without me: a unique guide to over 30,000 products, plus the latest skin-care research. Beginning Press.

EWG	CIR	Ingredient Name & Cosmetic Function	Notes
-	-	Adapalene (Antiacne Agent)	Acne fighting
1	-	Xylitol (Humectant, Skin Conditioning, Flavoring Agent)
-	-	Niacinamid
1 2	A	Glycerin (Solvent, Perfuming, Fragrance, Humectant, Viscosity Decreasing Agent, Hair Conditioning, Skin Protecting, Denaturant )	Good for dry skin Moisturizing
1	A	Carbomer (Viscosity Controlling, Viscosity Increasing Agent, Emulsion Stabilising, Gel Forming)
2	A	Poloxamer 188 (Antimicrobial Agent, Sufactant)
-	-	Sorbato De Potasio
1	A	Disodium Edta (Chelating Agent, Viscosity Controlling)
-	-	Hidróxido De Sodio
1	-	Water (Solvent)

Cassará Axne Adapaleno 0,1% Gel

Ingredients

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Ingredient List