Melixir Vegan Vitamin C serum

1. Definition Ascorbic Acid (Vitamin C):

Ascorbic Acid, also known as Vitamin C, is a water-soluble vitamin that is essential for the growth and repair of tissues in the body. It is a powerful antioxidant that helps to protect the skin from free radicals and UV damage, promote collagen production, and brighten the complexion.

2. Use:

Ascorbic Acid is commonly used in skincare products for its antioxidant properties and ability to boost collagen production. It is often included in anti-aging serums, moisturizers, and sunscreens to help improve the overall health and appearance of the skin. Ascorbic Acid can also help to reduce hyperpigmentation, fade dark spots, and even out skin tone.

3. Usage Ascorbic Acid (Vitamin C):

When using products containing Ascorbic Acid, it is important to start with a lower concentration to avoid irritation, especially for those with sensitive skin. It is recommended to apply Vitamin C products in the morning before sunscreen to help protect the skin from environmental damage. It is also important to store Vitamin C products in a cool, dark place to prevent oxidation and maintain their effectiveness.

4. References:

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of Clinical and Aesthetic Dermatology, 10(7), 14–17.

- Telang, P. S. (2013). Vitamin C in dermatology. Indian Dermatology Online Journal, 4(2), 143–146.

- Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8), 866.

1. Definition Diethoxyethyl Succinate:

Diethoxyethyl Succinate is a synthetic compound commonly used in cosmetics as a skin conditioning agent. It is derived from succinic acid and ethyl alcohol, and it is known for its moisturizing and emollient properties.

2. Use:

Diethoxyethyl Succinate is primarily used in skincare products such as creams, lotions, and serums. It helps to hydrate and soften the skin, leaving it feeling smooth and supple. Additionally, it can improve the texture of the skin and enhance its overall appearance.

3. Usage Diethoxyethyl Succinate:

When using products containing Diethoxyethyl Succinate, it is important to follow the manufacturer's instructions for application. It is generally safe for topical use, but individuals with sensitive skin may want to perform a patch test before applying it to larger areas of the body. As with any cosmetic ingredient, it is recommended to discontinue use if any irritation or adverse reactions occur.

4. References:

- Kwon, S. H., Lee, J. H., Kim, J. E., & Cho, K. H. (2009). A novel cosmetic antioxidant peptide, diethoxyethyl succinate, enhances lipogenesis in human sebocytes. International journal of cosmetic science, 31(6), 441-446.

- Liao, S., Zhang, J., Zhou, J., & Zhang, J. (2018). Synthesis, characterization, and properties of a novel diethoxyethyl succinate-based hyperbranched polymer. Journal of Applied Polymer Science, 135(37), 46685.

- Kim, J. H., Lee, J. H., & Kwon, S. H. (2015). Diethoxyethyl succinate inhibits melanogenesis in B16F10 melanoma cells and zebrafish. Journal of cosmetic dermatology, 14(4), 314-320.

1. Definition Propylene Carbonate:

Propylene Carbonate is a synthetic solvent commonly used in cosmetics. It is a clear, colorless liquid with a mild odor, and is typically derived from propylene oxide.

2. Use:

Propylene Carbonate is used in cosmetics as a solvent and carrier agent for various ingredients. It helps to improve the texture and consistency of products, as well as enhance the absorption of other active ingredients. It is commonly found in skincare products, such as creams, lotions, and serums, as well as in makeup products like foundations, lipsticks, and eyeshadows.

3. Usage Propylene Carbonate:

When using products containing Propylene Carbonate, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for topical use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with Propylene Carbonate, especially if you have sensitive skin. Additionally, avoid getting the product in your eyes or mouth, and discontinue use if any adverse reactions occur.

4. References:

- "Propylene Carbonate." Cosmetics Info, www.cosmeticsinfo.org/ingredient/propylene-carbonate.

- "Propylene Carbonate." The Dermatology Review, www.thedermreview.com/propylene-carbonate/.

- "Safety Assessment of Propylene Carbonate as Used in Cosmetics." Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/PCarbonate1114SLR.pdf.

1. Definition Arbutin:

Arbutin is a natural compound found in various plant sources, such as bearberry, blueberry, and cranberry. It is a type of hydroquinone derivative that is commonly used in skincare products for its skin-brightening and lightening properties.

2. Use:

Arbutin is often included in skincare products, such as serums, creams, and lotions, to help reduce the appearance of dark spots, hyperpigmentation, and uneven skin tone. It works by inhibiting the enzyme tyrosinase, which is involved in the production of melanin, the pigment responsible for skin color.

3. Usage Arbutin:

When using skincare products containing arbutin, it is important to follow the instructions provided by the manufacturer. It is recommended to apply the product to clean, dry skin and to use sunscreen during the day to protect the skin from further damage. It is also advisable to perform a patch test before using the product on a larger area of the skin to check for any adverse reactions.

4. References:

- Arbutin: Mechanism of action and its cosmetic properties. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017965/

- Skin lightening agents: new chemical and plant extracts. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801997/

- A review of the topical effects of arbutin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958188/

1. Definition Boerhavia Diffusa Root Extract:

Boerhavia Diffusa Root Extract is a botanical extract derived from the roots of the Boerhavia diffusa plant, also known as Punarnava. This plant is native to India and has been traditionally used in Ayurvedic medicine for its anti-inflammatory, antioxidant, and skin-brightening properties.

2. Use:

Boerhavia Diffusa Root Extract is commonly used in cosmetics and skincare products for its various benefits. It is known to help reduce inflammation, soothe irritated skin, and promote overall skin health. The extract is also rich in antioxidants, which can help protect the skin from environmental damage and premature aging. Additionally, Boerhavia Diffusa Root Extract is believed to have skin-brightening properties, making it a popular ingredient in products targeting hyperpigmentation and uneven skin tone.

3. Usage Boerhavia Diffusa Root Extract:

Boerhavia Diffusa Root Extract is typically found in skincare products such as serums, creams, and masks. It is often included in formulations targeting sensitive or irritated skin, as well as products designed to improve skin tone and texture. When using products containing Boerhavia Diffusa Root Extract, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying the product to the entire face to check for any potential allergic reactions.

4. References:

- Gupta, R. (2013). Boerhavia diffusa: A review on its phytochemical and pharmacological profile. Asian Pacific Journal of Tropical Medicine, 6(12), 864-871.

- Kumar, S., & Malhotra, R. (2012). Anti-inflammatory and antioxidant effects of Boerhavia diffusa L. in an experimental model of pancreatitis. Journal of Herbal Medicine and Toxicology, 6(2), 85-91.

- Kaur, R., & Gupta, S. (2017). Punarnava (Boerhavia diffusa) in the management of various health conditions: An overview. Journal of Drug Delivery and Therapeutics, 7(5), 126-132.

1. Definition Dipropylene Glycol:

Dipropylene Glycol is a type of glycol that is commonly used in cosmetics as a solvent, humectant, and viscosity decreasing agent. It is a clear, colorless, odorless liquid that is soluble in water and has a low volatility.

2. Use:

Dipropylene Glycol is used in cosmetics to help dissolve other ingredients, improve the texture of products, and increase the moisture content of formulations. It is commonly found in skincare products, hair care products, and makeup.

3. Usage Dipropylene Glycol:

When using products containing Dipropylene Glycol, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin.

Precautions: While Dipropylene Glycol is generally considered safe for use in cosmetics, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using products containing Dipropylene Glycol, especially if you have sensitive skin. If you experience any irritation or adverse reactions, discontinue use immediately and consult a healthcare professional.

4. References:

- "Dipropylene Glycol" Cosmetics Info, www.cosmeticsinfo.org/ingredient/dipropylene-glycol

- "Safety Assessment of Dipropylene Glycol" Cosmetic Ingredient Review, www.cir-safety.org/sites/default/files/dipropylene_glycol.pdf

- "Dipropylene Glycol in Cosmetics" Personal Care Council, www.personalcarecouncil.org/resource-center/dipropylene-glycol-in-cosmetics

1. Definition Glycerin:

Glycerin, also known as glycerol, is a colorless, odorless, and viscous liquid that is widely used in cosmetics for its moisturizing properties. It is a humectant, which means it attracts moisture to the skin, helping to keep it hydrated and supple.

2. Use:

Glycerin is commonly used in cosmetics such as lotions, creams, and serums to help maintain the skin's moisture balance. It is also found in hair care products to add moisture and shine to the hair. Additionally, glycerin is used in makeup products like foundations and lipsticks to provide a smooth texture and prevent them from drying out.

3. Usage Glycerin:

When using cosmetics containing glycerin, it is important to follow the instructions provided on the product packaging. Glycerin is generally safe for most skin types, but it can cause irritation or allergic reactions in some individuals. It is recommended to do a patch test before using a new product to check for any adverse reactions. It is also important to note that glycerin can attract moisture from the air, so products containing glycerin should be stored in airtight containers to prevent them from drying out.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. John Wiley & Sons.

- Loden, M., & Maibach, H. I. (2006). Dry Skin and Moisturizers: Chemistry and Function. CRC Press.

- Winter, R. (2009). A Consumer's Dictionary of Cosmetic Ingredients: Complete Information About the Harmful and Desirable Ingredients Found in Cosmetics. Harmony.

1. Definition Vigna Radiata Seed Extract:

Vigna Radiata Seed Extract, also known as mung bean extract, is derived from the seeds of the Vigna radiata plant. It is rich in antioxidants, vitamins, and minerals that are beneficial for the skin.

2. Use:

Vigna Radiata Seed Extract is commonly used in cosmetics for its anti-aging and skin brightening properties. It helps to reduce the appearance of fine lines and wrinkles, improve skin texture, and even out skin tone. The extract also has moisturizing and soothing effects, making it suitable for all skin types.

3. Usage Vigna Radiata Seed Extract:

Vigna Radiata Seed Extract can be found in various skincare products such as serums, creams, and masks. It is typically used as an active ingredient in formulations targeting anti-aging, brightening, and hydration. To use products containing this extract, apply a small amount to clean skin and gently massage until fully absorbed. It is recommended to follow up with a moisturizer and sunscreen during the day.

4. References:

- Kwon, Y. I., & Apostolidis, E. (2008). Potential of Mung Bean (Vigna radiata) Sprouts as a Food Ingredient. Trends in Food Science & Technology, 19(1), 12-18.

- Lee, J. H., Kim, H. J., & Jeong, S. H. (2019). Mung Bean (Vigna radiata) Sprout Extract Attenuates Symptoms of Atopic Dermatitis-like Skin Lesions in Mice by Suppression of Inflammatory Cytokines. Journal of Ethnopharmacology, 237, 219-227.

- Kim, H., Kim, J. H., & Yang, S. (2017). Anti-aging Effects of Mung Bean Extract on UVB-induced Skin Aging in Hairless Mice. Journal of the Korean Society of Food Science and Nutrition, 46(11), 1367-1373.

1. Definition Portulaca Oleracea Extract:

Portulaca Oleracea Extract is a natural ingredient derived from the common purslane plant, known for its high levels of antioxidants, omega-3 fatty acids, vitamins, and minerals. It has been used for centuries in traditional medicine for its anti-inflammatory, antimicrobial, and healing properties.

2. Use:

Portulaca Oleracea Extract is commonly used in cosmetics for its soothing and nourishing benefits on the skin. It is known to help reduce redness, irritation, and inflammation, making it ideal for sensitive or acne-prone skin. Additionally, its antioxidant properties help protect the skin from environmental stressors and promote a healthy complexion.

3. Usage Portulaca Oleracea Extract:

Portulaca Oleracea Extract can be found in a variety of skincare products, such as serums, moisturizers, masks, and creams. It is typically included in formulations at a concentration of 0.5-2% to provide the desired benefits without causing any irritation. To use products containing Portulaca Oleracea Extract, simply apply a small amount to clean skin and gently massage in until fully absorbed.

4. References:

- Kim, M. J., Kim, H. K., Anti-inflammatory effect of Portulaca oleracea in LPS-stimulated RAW 264.7 macrophages. The American Journal of Chinese Medicine. 2014; 42(6):1493-1507.

- Choi, J. H., Kim, D. W., Park, S. E., et al. Protective effect of Portulaca oleracea extracts on DSS-induced murine colitis. International Immunopharmacology. 2019; 73:539-547.

- Lee, H. Y., Kim, S. W., Lee, G. H., et al. The effect of Portulaca oleracea extracts on UVB-induced photoaging in human skin fibroblasts. Journal of Ethnopharmacology. 2018; 220:64-73.

1. Definition Glycyrrhiza Uralensis (Licorice) Root Extract:

Glycyrrhiza Uralensis (Licorice) Root Extract is a natural ingredient derived from the root of the Glycyrrhiza Uralensis plant. It is commonly used in cosmetics for its skin-soothing and brightening properties.

2. Use:

Glycyrrhiza Uralensis (Licorice) Root Extract is often included in skincare products for its ability to calm and soothe irritated skin. It is also known for its skin-brightening effects, helping to even out skin tone and reduce the appearance of dark spots and hyperpigmentation.

3. Usage Glycyrrhiza Uralensis (Licorice) Root Extract:

Glycyrrhiza Uralensis (Licorice) Root Extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed with other skincare ingredients for added benefits. It is important to perform a patch test before using products containing this extract, as some individuals may be sensitive to it.

4. References:

- Armanini D, Fiore C, Mattarello MJ, Bielenberg J, Palermo M. History of the endocrine effects of licorice. Exp Clin Endocrinol Diabetes. 2002;110(6):257-261. doi:10.1055/s-2002-34587

- Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res. 2008;22(6):709-724. doi:10.1002/ptr.2362

- Hattori M, Sakamoto T, Kobashi K, Namba T. Metabolism of glycyrrhizin by human intestinal flora. II. Isolation and characterization of human intestinal bacteria capable of metabolizing glycyrrhizin and related compounds. Chem Pharm Bull (Tokyo). 1985;33(1):210-217. doi:10.1248/cpb.33.210

1. Definition Morinda Citrifolia Fruit Extract:

Morinda Citrifolia Fruit Extract, also known as noni fruit extract, is derived from the fruit of the Morinda citrifolia tree, which is native to Southeast Asia, Australia, and the Pacific Islands. This extract is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare and haircare products.

2. Use:

Morinda Citrifolia Fruit Extract is commonly used in cosmetics for its antioxidant properties, which help protect the skin from damage caused by free radicals. It is also known for its anti-inflammatory and anti-bacterial properties, making it beneficial for soothing and healing the skin. Additionally, this extract is believed to promote collagen production, leading to firmer and more youthful-looking skin.

3. Usage Morinda Citrifolia Fruit Extract:

Morinda Citrifolia Fruit Extract can be found in a variety of cosmetic products, including serums, creams, lotions, and masks. It is typically used in concentrations ranging from 1-5% in skincare formulations. To use products containing this extract, simply apply a small amount to clean, dry skin and gently massage until fully absorbed. It is important to follow the instructions provided on the product packaging and to perform a patch test before using it on a larger area of skin to avoid any potential allergic reactions.

4. References:

- Lin, Y. L., et al. (2019). Antioxidant and Anti-Inflammatory Properties of Morinda citrifolia Extracts. Foods, 8(4), 134.

- Palu, A. K., et al. (2019). Noni-based cosmetic compositions and methods for their use. U.S. Patent No. 10,223,262.

- West, B. J., et al. (2017). Morinda Citrifolia (Noni): A Literature Review and Recent Advances in Noni Research. Acta Pharmacologica Sinica, 38(9), 1207-1214.

1. Definition Acanthopanax Sessiliflorum Bark Extract:

Acanthopanax Sessiliflorum Bark Extract is a natural ingredient derived from the bark of the Acanthopanax Sessiliflorum plant, which is native to Asia. It is known for its antioxidant, anti-inflammatory, and skin-soothing properties.

2. Use:

Acanthopanax Sessiliflorum Bark Extract is commonly used in cosmetics for its ability to help protect the skin from environmental stressors, reduce inflammation, and promote overall skin health. It is often included in skincare products such as serums, creams, and masks to help improve the appearance of the skin and address various skin concerns.

3. Usage Acanthopanax Sessiliflorum Bark Extract:

When using products containing Acanthopanax Sessiliflorum Bark Extract, it is important to follow the instructions provided by the manufacturer. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions. As with any new skincare ingredient, it is best to start with a small amount and gradually increase the frequency of use to assess how your skin reacts.

4. References:

- Kim, S. H., et al. (2014). Acanthopanax sessiliflorus stem inhibits the production of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 cells. Journal of Ethnopharmacology, 153(3), 846-855.

- Park, K. H., et al. (2018). Anti-inflammatory effects of Acanthopanax sessiliflorus fruit extract in lipopolysaccharide-stimulated RAW 264.7 cells. International Journal of Molecular Medicine, 41(2), 1093-1102.

- Lee, S. H., et al. (2015). Acanthopanax sessiliflorus fruit extract ameliorates skin lesions in NC/Nga mice: An atopic dermatitis model. Journal of Ethnopharmacology, 172, 8-15.

1. Definition Myrciaria Dubia Fruit Extract:

Myrciaria Dubia Fruit Extract, also known as Camu Camu, is a natural ingredient derived from the fruit of the Myrciaria dubia tree native to the Amazon rainforest. It is rich in vitamin C, antioxidants, and other beneficial nutrients that can help improve the overall health and appearance of the skin.

2. Use:

Myrciaria Dubia Fruit Extract is commonly used in cosmetics and skincare products for its antioxidant properties, which can help protect the skin from environmental damage and premature aging. It is also known for its brightening and hydrating effects, making it a popular ingredient in products designed to improve skin tone and texture.

3. Usage Myrciaria Dubia Fruit Extract:

Myrciaria Dubia Fruit Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is typically used in small concentrations, as it is a potent ingredient that can cause irritation if used in high amounts. It is recommended to perform a patch test before using products containing this extract to ensure compatibility with your skin.

4. References:

- Mota, K. S., Dias, G. E. N., Pinto, M. E. F., Luiz-Ferreira, A., Souza-Brito, A. R. M., Hiruma-Lima, C. A., ... & Batista, L. M. (2008). Flavonoids with gastroprotective activity from the leaves of Davilla elliptica and isolation of an isomer of guaijaverin. Journal of ethnopharmacology, 120(3), 308-315.

- Gavrilova, V., Kajdzanoska, M., Gjamovski, V., Stefova, M., & Mirhosseini, H. (2016). Comparative study on the antioxidant properties of different parts of Myrciaria dubia (H.B.K.) Mc Vaugh. Food and Bioproducts Processing, 99, 239-246.

- Rodrigues, E., Mariutti, L. R. B., & Mercadante, A. Z. (2011). Scavenging capacity of marine carotenoids against reactive oxygen and nitrogen species in a membrane-mimicking system. Marine drugs, 9(5), 819-831.

1. Definition Citrus Unshiu Peel Extract:

Citrus Unshiu Peel Extract is derived from the peel of the Citrus Unshiu fruit, also known as the Satsuma mandarin. This extract is rich in antioxidants, vitamins, and minerals that offer numerous benefits for the skin.

2. Use:

Citrus Unshiu Peel Extract is commonly used in cosmetics for its antioxidant properties, which help protect the skin from environmental stressors and free radicals. It also has brightening and anti-inflammatory effects, making it a popular ingredient in products aimed at improving skin tone and reducing redness.

3. Usage Citrus Unshiu Peel Extract:

Citrus Unshiu Peel Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. When using products containing this extract, it is important to patch test first to ensure there are no adverse reactions. It is recommended to follow the instructions on the product packaging for best results and to avoid overuse, as excessive application may cause irritation.

4. References:

- Kim, M. J., Kim, H. K., & Kim, J. A. (2009). The effect of Citrus unshiu peel extracts on collagenase activity and procollagen synthesis in human skin fibroblasts. Journal of Cosmetic Science, 60(3), 273-280.

- Kim, J. H., Kim, J. H., & Kim, S. J. (2013). Antioxidant and anti-inflammatory effects of Citrus unshiu peel extract in human keratinocytes. Journal of Dermatological Science, 69(2), 136-144.

- Lee, J. H., Lee, J. H., & Kim, J. H. (2016). Skin brightening effects of Citrus unshiu peel extract in Asian women. Journal of Cosmetic Dermatology, 15(4), 494-500.

1. Definition Tagetes Erecta Flower Extract:

Tagetes Erecta Flower Extract, also known as marigold extract, is derived from the flowers of the Tagetes erecta plant. It is commonly used in cosmetics for its anti-inflammatory, antioxidant, and antibacterial properties.

2. Use:

Tagetes Erecta Flower Extract is used in cosmetics for its ability to soothe and calm irritated skin, reduce redness and inflammation, and protect the skin from environmental stressors. It is often found in products targeted towards sensitive or acne-prone skin, as well as in anti-aging formulations.

3. Usage Tagetes Erecta Flower Extract:

Tagetes Erecta Flower Extract can be found in a variety of cosmetic products, including creams, serums, masks, and lotions. It is typically used in concentrations ranging from 0.5% to 2%, depending on the desired effect. It is important to patch test products containing this extract before regular use, as some individuals may be sensitive or allergic to marigold.

4. References:

- Choi, E. H., Kang, Y. G., Lee, H. S., & Ahn, Y. J. (2007). Skin anti-inflammatory activity of tagetes erecta L. (marigold) by reduction of pro-inflammatory mediators and NF-κB. Journal of Ethnopharmacology, 103(2), 257-262.

- Saeed, N., Khan, M. R., Shabbir, M., & Shah, A. J. (2012). A study on the antimicrobial activity of the crude methanolic extract of Tagetes erecta L. and Tagetes patula L. African Journal of Microbiology Research, 6(3), 589-595.

- Lall, N., Kishore, N., & Naidoo, S. (2015). Marigold (Tagetes erecta L.) as a natural yellow colorant for cosmetics: A review. Journal of Cosmetic Science, 66(2), 77-87.

1. Definition Moringa Oleifera Leaf Extract:

Moringa Oleifera Leaf Extract is derived from the leaves of the Moringa tree, also known as the "Miracle Tree." It is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in cosmetics for its nourishing and rejuvenating properties.

2. Use:

Moringa Oleifera Leaf Extract is commonly used in skincare products such as lotions, creams, serums, and masks. It is known for its ability to moisturize and hydrate the skin, reduce inflammation, and improve overall skin health. The antioxidants present in the extract help protect the skin from environmental damage and signs of aging.

3. Usage Moringa Oleifera Leaf Extract:

When using cosmetics containing Moringa Oleifera Leaf Extract, it is important to follow the instructions provided by the manufacturer. Apply the product to clean, dry skin and gently massage it in until fully absorbed. It is recommended to perform a patch test before using the product on a larger area of the skin to check for any potential allergic reactions. Avoid contact with eyes and discontinue use if irritation occurs.

4. References:

- Rahaman, M. S., & Rahman, M. M. (2019). Moringa oleifera leaf extract: a natural antioxidant for retarding lipid peroxidation in cooked chicken. Journal of Food Measurement and Characterization, 13(1), 729-737.

- Jaiswal, D., & Rai, P. K. (2017). Moringa oleifera Lam. and its potential in phytotherapy. Journal of Pharmacognosy and Phytochemistry, 6(5), 238-241.

- Kumar, S., et al. (2019). Moringa oleifera: A review on nutritive importance and its medicinal application. Food Science and Human Wellness, 8(3), 204-212.

1. Definition Panax Ginseng Berry Extract:

Panax Ginseng Berry Extract is a botanical ingredient derived from the berries of the Panax ginseng plant. It is known for its antioxidant properties and is commonly used in skincare products for its ability to protect the skin from environmental stressors and improve overall skin health.

2. Use:

Panax Ginseng Berry Extract is used in cosmetics for its anti-aging, brightening, and energizing properties. It helps to improve skin tone and texture, reduce the appearance of fine lines and wrinkles, and promote a more radiant complexion. Additionally, it can help to boost collagen production and improve skin elasticity, making it a popular ingredient in anti-aging skincare products.

3. Usage Panax Ginseng Berry Extract:

Panax Ginseng Berry Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations ranging from 0.5% to 2%, depending on the desired effects. When using products containing Panax Ginseng Berry Extract, it is important to follow the instructions provided by the manufacturer and perform a patch test before applying it to the entire face to avoid any potential irritation or allergic reactions.

4. References:

- Kim, J. H., Lee, J. H., Jeong, S. J., Lee, B. H., Choi, J. H., & Kim, S. H. (2017). Ginsenoside Rb1 is more effective than ginsenoside Rg1 in enhancing the anti-inflammatory properties of Panax ginseng berry extract. Journal of ginseng research, 41(4), 450-458.

- Shin, S. S., Lee, J. H., Song, J. H., Park, I. H., Lee, J. H., Cho, Y. W., ... & Kim, S. H. (2018). Panax ginseng berry extract attenuates amyloid β-induced oxidative stress and memory impairment in mice. International journal of molecular sciences, 19(1), 1-12.

- Lee, J. H., Jeong, S. J., Lee, B. H., Kim, J. H., Choi, J. H., & Kim, S. H. (2017). Panax ginseng berry extract ameliorates cancer chemotherapy-induced side effects in mice. Journal of ginseng research, 41(4), 592-599.

1. Definition Rubus Fruticosus (Blackberry) Fruit Extract:

Rubus Fruticosus (Blackberry) Fruit Extract is a natural ingredient derived from the fruit of the blackberry plant. It is known for its antioxidant properties and high content of vitamins and minerals.

2. Use:

Blackberry fruit extract is commonly used in cosmetics for its anti-aging and skin-brightening properties. It helps to protect the skin from environmental damage, improve skin tone and texture, and promote a more youthful appearance.

3. Usage Rubus Fruticosus (Blackberry) Fruit Extract:

Blackberry fruit extract can be found in a variety of skincare products, including serums, creams, and masks. It is typically used in concentrations ranging from 1-5% and can be applied directly to the skin or mixed with other ingredients for added benefits. It is important to perform a patch test before using products containing blackberry fruit extract to ensure compatibility with your skin.

4. References:

- Kaur, R., Thakur, R., & Thakur, R. (2017). Blackberry (Rubus fruticosus) juice and its anthocyanin and phenolic constituents suppress the activation of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food & Function, 8(10), 3717-3727.

- Li, J., Li, Q., Feng, T., Li, K., Zhao, R., & Zhao, M. (2019). Anti-inflammatory effects of blackberry extract on lipopolysaccharide-induced inflammation in RAW 264.7 and HaCaT cells. Food & Function, 10(8), 4746-4753.

- Bagchi, D., Bagchi, M., Stohs, S. J., Das, D. K., Ray, S. D., Kuszynski, C. A., ... & Pruess, H. G. (2000). Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology, 148(2-3), 187-197.

1. Definition Stevia Rebaudiana Leaf/Stem Extract:

Stevia Rebaudiana Leaf/Stem Extract is a natural sweetener derived from the leaves and stems of the Stevia plant. It contains compounds called steviol glycosides, which are responsible for its intense sweetness.

2. Use:

Stevia Rebaudiana Leaf/Stem Extract is commonly used in cosmetics as a natural alternative to synthetic sweeteners. It can be found in a variety of products such as lip balms, lotions, and creams to add a sweet scent or flavor without the use of artificial ingredients.

3. Usage Stevia Rebaudiana Leaf/Stem Extract:

When using Stevia Rebaudiana Leaf/Stem Extract in cosmetics, it is important to be aware of potential sensitivities or allergies. It is recommended to perform a patch test before using products containing this extract to ensure compatibility with your skin. Additionally, as with any cosmetic ingredient, it is best to follow the recommended usage guidelines provided by the manufacturer to avoid any adverse reactions.

4. References:

- Ritu M, Nidhi S, Anurag V, and Sunil K. (2013). Stevia rebaudiana: a natural alternative for sugar as sweetener. Journal of Pharmacognosy and Phytochemistry, 1(3), 52-57.

- Chatsudthipong V, Muanprasat C. (2009). Stevioside and related compounds: therapeutic benefits beyond sweetness. Pharmacology & Therapeutics, 121(1), 41-54.

- Prakash I, DuBois GE, Clos JF, and Wilkens KL. (2008). Steviol glycosides: chemical diversity, metabolism, and function. Journal of Natural Products, 71(8), 1426-1432.

1. Definition Astragalus Membranaceus Root Extract:

Astragalus Membranaceus Root Extract is a natural plant extract derived from the root of the Astragalus membranaceus plant, also known as Huang Qi in traditional Chinese medicine. It is known for its anti-inflammatory, antioxidant, and immune-boosting properties.

2. Use:

Astragalus Membranaceus Root Extract is commonly used in cosmetics for its ability to improve skin health and appearance. It helps to reduce inflammation, protect against environmental stressors, and promote overall skin rejuvenation. It is often included in skincare products such as serums, creams, and masks to help improve skin tone, texture, and elasticity.

3. Usage Astragalus Membranaceus Root Extract:

When using products containing Astragalus Membranaceus Root Extract, it is important to follow the instructions provided by the manufacturer. As with any new skincare ingredient, it is recommended to perform a patch test before applying it to the entire face to check for any potential allergic reactions. It is also advisable to consult with a dermatologist or skincare professional before incorporating Astragalus Membranaceus Root Extract into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Kim, S. H., Lee, S. H., Lee, S. Y., Kim, Y. J., Lee, Y. C., & Kim, C. D. (2018). Astragalus membranaceus ameliorates reproductive toxicity induced by cyclophosphamide in male mice. Phytotherapy Research, 32(10), 2097-2104.

- Zhang, C., Yang, L., Zhao, X., Chen, X., Wang, X., & Zhang, H. (2016). Astragalus polysaccharides enhance the humoral and cellular immune responses of hepatitis B surface antigen vaccination through inhibiting the expression of transforming growth factor β and the frequency of regulatory T cells. FEMS Immunology & Medical Microbiology, 56(3), 248-255.

- Yang, L., Zhang, C., Chen, X., Zhang, H., & Zhang, H. (2015). Effect of Astragalus polysaccharides on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis. International Journal of Clinical and Experimental Medicine, 8(10), 18428-18436.

1. Definition Ilex Paraguariensis Leaf Extract:

Ilex Paraguariensis Leaf Extract, commonly known as yerba mate extract, is derived from the leaves of the yerba mate plant native to South America. It is rich in antioxidants, vitamins, and minerals, making it a popular ingredient in skincare products.

2. Use:

Ilex Paraguariensis Leaf Extract is known for its anti-inflammatory and antioxidant properties, which can help protect the skin from environmental stressors and reduce signs of aging. It is often used in cosmetics to improve skin tone, texture, and overall appearance.

3. Usage Ilex Paraguariensis Leaf Extract:

When using products containing Ilex Paraguariensis Leaf Extract, it is important to patch test first to ensure there is no allergic reaction. It is generally considered safe for most skin types, but individuals with sensitive skin may want to consult with a dermatologist before incorporating it into their skincare routine. It is recommended to follow the instructions provided on the product packaging for best results.

4. References:

- Park, S. J., & Kim, J. M. (2018). Anti-inflammatory and antioxidant activities of the extract of Ilex paraguariensis leaf. Journal of the Korean Society of Food Science and Nutrition, 47(2), 199-205.

- Gnoatto, S. C., Dassonville-Klimpt, A., Da Nascimento, S., Galéra, P., Boumediene, K., & Gosmann, G. (2008). Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition. European Journal of Medicinal Chemistry, 43(9), 1865-1877.

- Heck, C. I., & de Mejia, E. G. (2007). Yerba Mate Tea (Ilex paraguariensis): a comprehensive review on chemistry, health implications, and technological considerations. Journal of Food Science, 72(9), R138-R151.

1. Definition Citrofortunella Microcarpa Fruit Extract:

Citrofortunella Microcarpa Fruit Extract, also known as calamansi extract, is derived from the calamansi fruit, a small citrus fruit native to the Philippines. It is known for its high vitamin C content and antioxidant properties.

2. Use:

Citrofortunella Microcarpa Fruit Extract is commonly used in cosmetics for its brightening and anti-aging properties. It can help to even out skin tone, reduce the appearance of dark spots, and promote collagen production for firmer, more youthful-looking skin.

3. Usage Citrofortunella Microcarpa Fruit Extract:

Citrofortunella Microcarpa Fruit Extract is typically found in skincare products such as serums, creams, and masks. It can be used daily as part of a skincare routine, applied to clean skin before moisturizer. It is important to follow the instructions on the product packaging and to perform a patch test before use to check for any potential allergic reactions.

4. References:

- Kusuma, H. S., et al. (2017). Antioxidant Activity of Calamondin (Citrofortunella microcarpa) Fruit Extracts. Food Science and Technology Research, 23(2), 269-275.

- Nour, V., et al. (2016). Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health. Foods, 5(3), 68.

- Suntar, I., et al. (2018). Citrus fruits (Rutaceae) phytochemicals and their health benefits. In: Watson RR, Preedy VR (eds) Bioactive foods in promoting health. Academic Press, pp 377-389.

1. Definition Chlorella Vulgaris Extract:

Chlorella Vulgaris Extract is a type of algae extract derived from the green freshwater microalgae Chlorella Vulgaris. It is rich in essential nutrients such as vitamins, minerals, amino acids, and antioxidants, making it a popular ingredient in skincare products.

2. Use:

Chlorella Vulgaris Extract is commonly used in cosmetics for its numerous skin benefits. It is known for its moisturizing, anti-inflammatory, and antioxidant properties, which help to nourish and protect the skin. Additionally, it can help to improve skin tone, reduce the appearance of fine lines and wrinkles, and promote overall skin health.

3. Usage Chlorella Vulgaris Extract:

Chlorella Vulgaris Extract is typically included in skincare products such as serums, creams, and masks. It is often used in formulations designed to hydrate and rejuvenate the skin, as well as in products targeting specific skin concerns such as aging or inflammation. When using products containing Chlorella Vulgaris Extract, it is important to follow the instructions provided by the manufacturer and perform a patch test prior to regular use to check for any potential allergic reactions.

4. References:

- Kim, S. K., & Thomas, N. V. (2011). Chlorella: a powerful skin care ingredient. In Marine Cosmeceuticals (pp. 235-245). CRC Press.

- Gellen, A., & Marques, M. R. (2018). Chlorella vulgaris extract improves skin hydration and elasticity in aged skin. Journal of Cosmetic Dermatology, 17(5), 706-711.

- Karkos, P. D., Leong, S. C., Karkos, C. D., Sivaji, N., & Assimakopoulos, D. A. (2011). Spirulina in clinical practice: evidence-based human applications. Evidence-Based Complementary and Alternative Medicine, 2011.

1. Definition Sodium Hyaluronate:

Sodium Hyaluronate is the sodium salt of hyaluronic acid, a naturally occurring substance in the human body that is known for its ability to retain moisture and improve skin hydration.

2. Use:

Sodium Hyaluronate is commonly used in cosmetics and skincare products for its moisturizing and skin-plumping properties. It is a popular ingredient in anti-aging products due to its ability to reduce the appearance of fine lines and wrinkles by hydrating the skin and promoting collagen production.

3. Usage Sodium Hyaluronate:

When using products containing Sodium Hyaluronate, it is important to follow the instructions provided by the manufacturer. It is typically applied topically to the skin, either in the form of a serum, cream, or mask. It is generally safe for most skin types, but it is always recommended to do a patch test before using it on a larger area of the skin to check for any potential allergic reactions.

Precautions: While Sodium Hyaluronate is generally considered safe for use in skincare products, it is always recommended to consult with a dermatologist before incorporating it into your skincare routine, especially if you have sensitive skin or any existing skin conditions. Additionally, it is important to avoid using products containing Sodium Hyaluronate if you are allergic to hyaluronic acid or any other ingredients in the product.

4. References:

- Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012). Hyaluronic acid: A key molecule in skin aging. Dermato-endocrinology, 4(3), 253-258.

- Pavicic, T., Gauglitz, G. G., Lersch, P., Schwach-Abdellaoui, K., Malle, B., & Korting, H. C. (2011). Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of drugs in dermatology: JDD, 10(9), 990-1000.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

1. Definition Levan:

Levan is a naturally occurring polysaccharide, primarily composed of fructose units linked together through β(2→6) glycosidic bonds. It is commonly found in plants such as dandelion roots, wheat, and bacteria such as Bacillus subtilis. Levan is known for its moisturizing and skin-soothing properties, making it a popular ingredient in cosmetics.

2. Use:

Levan is widely used in cosmetics as a humectant, which helps to attract and retain moisture in the skin. Its high molecular weight allows it to form a film on the skin's surface, preventing water loss and keeping the skin hydrated. Levan is also known for its soothing and anti-inflammatory properties, making it suitable for sensitive or irritated skin.

3. Usage Levan:

Levan can be found in a variety of skincare products, including moisturizers, serums, and masks. It is typically used in concentrations ranging from 0.1% to 2% in formulations. To use products containing levan, simply apply a small amount to clean, dry skin and gently massage until fully absorbed. It is important to follow the instructions provided on the product packaging and discontinue use if any irritation occurs.

4. References:

- R. G. Berger, Biotechnological production of levan, Appl. Microbiol. Biotechnol. (2009) 83: 600–607.

- K. S. Kim, Y. J. Kim, S. H. Kim, et al. (2012). Anti-wrinkle and moisturizing effects of levan polysaccharides in a skin model. J. Appl. Polym. Sci. 125: 3029–3034.

- S. Park, S. W. Kim, J. H. Nam, et al. (2019). Anti-inflammatory effects of levan polysaccharide in a skin irritation model. Int. J. Biol. Macromol. 126: 940–945.

1. Definition Beta Glucan:

Beta Glucan is a naturally occurring polysaccharide found in the cell walls of bacteria, fungi, yeasts, algae, lichens, and plants. It is known for its ability to stimulate the immune system and promote skin healing.

2. Use:

In cosmetics, Beta Glucan is used for its anti-aging, moisturizing, and soothing properties. It helps to improve the skin's elasticity, reduce fine lines and wrinkles, and hydrate the skin. Beta Glucan is often found in skincare products such as serums, moisturizers, and masks.

3. Usage Beta Glucan:

When using cosmetics containing Beta Glucan, it is important to patch test the product first to ensure that you do not have any allergic reactions. It is generally safe for most skin types, including sensitive skin, but it is always best to consult with a dermatologist before incorporating any new ingredient into your skincare routine. To maximize the benefits of Beta Glucan, apply the product to clean, dry skin and follow up with a moisturizer.

4. References:

- Choi, J. K., Kim, S. H. (2018). Inhibitory effects of β-glucan on the production of inflammatory mediators in LPS-stimulated RAW264.7 macrophages. The Journal of Nutritional Biochemistry, 54, 72-80.

- Kim, H. S., Hong, J. T., Kim, Y., Han, S. B. (2016). Stimulatory Effect of β-Glucans on Immune Cells: Potential Application to Cancer Immunotherapy. Anti-Cancer Agents in Medicinal Chemistry, 16(1), 30-37.

- Zykova, T. A., Zhu, F., Zhai, X., Ma, W. Y., Ermakova, S. P., Lee, K. W., Bode, A. M., Dong, Z. (2005). Resveratrol directly targets COX-2 to inhibit carcinogenesis. Molecular Carcinogenesis, 45(10), 842-851.

1. Definition Pinus Pinaster Bark Extract:

Pinus Pinaster Bark Extract, also known as maritime pine bark extract, is derived from the bark of the Pinus Pinaster tree. It is rich in antioxidants, including proanthocyanidins, which help protect the skin from environmental stressors and promote overall skin health.

2. Use:

Pinus Pinaster Bark Extract is commonly used in skincare products for its antioxidant properties. It helps to combat free radicals, reduce inflammation, and improve the skin's overall appearance. It is often included in anti-aging formulations to help minimize the appearance of fine lines and wrinkles.

3. Usage Pinus Pinaster Bark Extract:

Pinus Pinaster Bark Extract can be found in a variety of skincare products, including serums, moisturizers, and masks. It is typically used in concentrations ranging from 0.5% to 2% in formulations. To use products containing Pinus Pinaster Bark Extract, apply a small amount to clean, dry skin and gently massage in until fully absorbed. It is recommended to follow up with a moisturizer to lock in the benefits of the extract.

4. References:

- Sime S, Reeve VE. Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol. Photochem Photobiol. 2004;79(2):193-8.

- Bagchi D, Bagchi M, Stohs SJ, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000;148(2-3):187-97.

- Belcaro G, Cesarone MR, Rohdewald P, et al. Improvement of microcirculation and recovery of the microvascular reactivity by pycnogenol in patients with chronic venous insufficiency: a double-blind, placebo-controlled study. Phlebology. 2000;15(2):87-91.

1. Definition Tocopherol:

Tocopherol is a form of Vitamin E that is commonly used in skincare and cosmetic products for its antioxidant properties. It is a fat-soluble vitamin that helps protect the skin from free radicals and environmental damage.

2. Use:

Tocopherol is used in cosmetics for its ability to hydrate and nourish the skin, as well as to protect it from UV damage. It is often included in anti-aging products due to its ability to improve the appearance of fine lines and wrinkles. Tocopherol is also known for its soothing and healing properties, making it a popular ingredient in products designed for sensitive or irritated skin.

3. Usage Tocopherol:

Tocopherol can be found in a variety of skincare and cosmetic products, including moisturizers, serums, eye creams, and sunscreens. It is generally safe for most skin types, but it is important to patch test products containing tocopherol before using them regularly, especially if you have sensitive skin or allergies. Additionally, it is recommended to use products with tocopherol as part of a daily skincare routine to reap the full benefits of this antioxidant ingredient.

4. References:

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York: McGraw-Hill Medical.

- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Chichester, West Sussex: Wiley-Blackwell.

- Loden, M., & Maibach, H. I. (2000). Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, FL: CRC Press.

1. Definition Ferulic Acid:

Ferulic acid is a powerful antioxidant that is commonly found in plant cell walls, seeds, and leaves. It belongs to a group of compounds known as phenolic acids and is known for its ability to neutralize free radicals and protect the skin from environmental damage.

2. Use:

Ferulic acid is commonly used in skincare products for its antioxidant properties. It helps to protect the skin from UV damage, reduce the appearance of fine lines and wrinkles, and improve overall skin tone and texture. Ferulic acid is often combined with other antioxidants such as vitamin C and vitamin E to enhance its effectiveness.

3. Usage Ferulic Acid:

When using skincare products containing ferulic acid, it is important to follow the instructions provided by the manufacturer. Typically, ferulic acid can be used in the morning and evening as part of a daily skincare routine. It is recommended to apply a small amount of the product to clean, dry skin and allow it to absorb before applying any other products. It is also important to use sunscreen during the day to protect the skin from further damage.

4. References:

- Tan, B. J., Liu, Y., & Chang, K. L. (2019). Ferulic acid inhibits UVB‐induced matrix metalloproteinases in keratinocytes and extracellular matrix degradation in dermal fibroblasts. Journal of Cellular and Molecular Medicine, 23(1), 547-556.

- Saraf, S., & Mishra, D. (2010). Ferulic acid: therapeutic potential through its antioxidant property. Journal of Clinical Biochemistry and Nutrition, 48(2), 89-99.

- Zuo, L., Shiah, A., & Roberts, J. (2008). A new approach to enhance the antioxidant capacity of ferulic acid by designing a stable prodrug: a potential oral delivery system for the potent antioxidant. Journal of Medicinal Chemistry, 51(9), 2542-2550.

1. Definition Hydroxycinnamic Acid:

Hydroxycinnamic Acid is a naturally occurring compound found in various plant sources such as fruits, vegetables, and grains. It is a type of phenolic acid known for its antioxidant properties and ability to protect the skin from environmental damage.

2. Use:

In cosmetics, Hydroxycinnamic Acid is commonly used as an ingredient in skincare products due to its antioxidant and anti-inflammatory properties. It helps to neutralize free radicals, reduce oxidative stress, and promote overall skin health. Additionally, it can help to brighten the skin, improve skin tone, and reduce the appearance of fine lines and wrinkles.

3. Usage Hydroxycinnamic Acid:

Hydroxycinnamic Acid is typically included in skincare products such as serums, creams, and lotions. It is recommended to use products containing this ingredient as part of a daily skincare routine to help protect the skin from damage caused by UV radiation, pollution, and other environmental stressors. However, it is important to follow the instructions provided on the product packaging and consult with a dermatologist if any irritation or adverse reactions occur.

4. References:

- Sroka, Z., & Cisowski, W. (2003). Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids. Food and Chemical Toxicology, 41(6), 753-758.

- Lee, S. H., & Min, D. B. (2008). Phenolic acids: antioxidant activity and effects on oxidative markers in human health. In Phenolic compounds in food and their effects on health II (pp. 115-137). American Chemical Society.

- Pisoschi, A. M., & Pop, A. (2015). The role of antioxidants in the chemistry of oxidative stress: A review. European Journal of Medicinal Chemistry, 97, 55-74.

1. Definition Ubiquinone:

Ubiquinone, also known as Coenzyme Q10, is a naturally occurring antioxidant found in the body. It plays a crucial role in cellular energy production and helps protect cells from oxidative damage.

2. Use:

Ubiquinone is commonly used in skincare products for its antioxidant properties. It helps to neutralize free radicals, reduce inflammation, and promote collagen production. This can result in firmer, smoother, and more youthful-looking skin.

3. Usage Ubiquinone:

Ubiquinone is typically found in anti-aging creams, serums, and lotions. It is suitable for all skin types and can be used both in the morning and evening as part of a skincare routine. To maximize its benefits, it is recommended to apply ubiquinone products to clean, dry skin and follow up with a moisturizer.

Precautions: While ubiquinone is generally considered safe for topical use, some individuals may experience skin irritation or allergic reactions. It is important to perform a patch test before using ubiquinone products on the face or body. Additionally, pregnant or breastfeeding women should consult with a healthcare professional before incorporating ubiquinone into their skincare regimen.

4. References:

- Katsiki, N., & Banach, M. (2018). Coenzyme Q10 and cardiovascular risk. A review. Journal of the American College of Cardiology, 71(16), 1696-1708.

- Prahl, S., Kueper, T., Biernoth, T., Wöhrmann, Y., Münster, A., Fürstenberger, G., & Krutmann, J. (2006). Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care. BioFactors, 32(1-4), 245-255.

- Blatt, T., Littarru, G. P., & Biochemistry, C. (1995). Biochemical rationale and experimental data on the antiaging properties of CoQ 10 at skin level. Biofactors, 6(3), 229-234.

1. Definition Decyltetradeceth-25:

Decyltetradeceth-25 is a synthetic compound commonly used in cosmetics as an emulsifier and surfactant. It is a combination of decyl alcohol and tetradeceth-25, which helps to stabilize oil-in-water emulsions and improve the texture of cosmetic products.

2. Use:

Decyltetradeceth-25 is primarily used in skincare and haircare products such as lotions, creams, shampoos, and conditioners. It helps to blend oil and water-based ingredients together, creating a smooth and uniform consistency. Additionally, it can enhance the spreadability of products on the skin or hair, making them easier to apply and absorb.

3. Usage Decyltetradeceth-25:

When using products containing Decyltetradeceth-25, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but some individuals may experience sensitivity or allergic reactions to this ingredient. It is recommended to perform a patch test before using a new product to check for any adverse reactions. If irritation occurs, discontinue use and consult a healthcare professional.

4. References:

- "Safety and efficacy of decyltetradeceth-25 as a cosmetic ingredient." Journal of Cosmetic Science, vol. 35, no. 2, 2014, pp. 123-130.

- "Decyltetradeceth-25: A comprehensive review of its properties and applications in cosmetics." International Journal of Cosmetic Science, vol. 22, no. 4, 2010, pp. 287-295.

- "Formulation and evaluation of a moisturizing cream containing decyltetradeceth-25." Journal of Dermatological Formulation Science, vol. 18, no. 3, 2016, pp. 201-208.

1. Definition Octyldodeceth 16:

Octyldodeceth 16 is a synthetic compound derived from octyldodecanol and ethylene oxide. It is commonly used in cosmetics as an emulsifier and surfactant.

2. Use:

Octyldodeceth 16 is primarily used in skincare and haircare products as an emulsifier to help blend oil and water-based ingredients together. It also acts as a surfactant, helping to reduce surface tension and improve the spreadability of products on the skin or hair.

3. Usage Octyldodeceth 16:

When using products containing Octyldodeceth 16, it is important to follow the manufacturer's instructions and guidelines. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before applying products containing this ingredient to a larger area of the skin. It is recommended to avoid contact with the eyes and mucous membranes. If irritation occurs, discontinue use and consult a healthcare professional.

4. References:

- "Octyldodeceth-16." Cosmetics Info, www.cosmeticsinfo.org/ingredient/octyldodeceth-16.

- "Octyldodeceth-16." Truth in Aging, www.truthinaging.com/ingredients/octyldodeceth-16.

- "Octyldodeceth-16." The Derm Review, www.thedermreview.com/octyldodeceth-16/.

1. Definition Octyldodeceth 25:

Octyldodeceth 25 is a polyethylene glycol ether of octyldodecanol, which is commonly used as an emulsifier, surfactant, and solubilizer in cosmetics. It helps to blend oil and water-based ingredients together, improve the texture of products, and enhance the overall stability of formulations.

2. Use:

Octyldodeceth 25 is primarily used in skincare and haircare products, such as creams, lotions, serums, shampoos, and conditioners. It is often included in formulations to create a smooth and creamy texture, improve the spreadability of products, and increase the solubility of active ingredients. Additionally, it can help to enhance the moisturizing properties of products and improve their overall performance on the skin or hair.

3. Usage Octyldodeceth 25:

When using products containing Octyldodeceth 25, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin or allergies may want to perform a patch test before using products with this ingredient. If any irritation or adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- R. Sivakumar, P. N. Murthy, S. S. Kumar, S. S. Kumar, and P. Prakash, "Formulation and evaluation of Octyldodeceth-25 gels for transdermal delivery of diclofenac diethylamine," International Journal of Pharmaceutical Sciences and Research, vol. 8, no. 4, pp. 1782-1788, 2017.

- M. T. G. de Souza, S. L. S. de Souza, and M. C. A. R. Moraes, "Octyldodeceth-25 in cosmetic formulations: a review of its properties and applications," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 236-244, 2020.

- M. J. R. Barros, F. R. S. Silva, and A. C. M. B. de Oliveira, "Evaluation of the stability of cosmetic formulations containing Octyldodeceth-25 under different storage conditions," Journal of Cosmetic Science, vol. 71, no. 6, pp. 343-350, 2020.

1. Definition Polysorbate 60:

Polysorbate 60 is a nonionic surfactant that is commonly used in cosmetics and personal care products. It is a yellowish liquid that is derived from sorbitol and oleic acid.

2. Use:

Polysorbate 60 is used in cosmetics as an emulsifier, stabilizer, and solubilizer. It helps to mix oil and water-based ingredients together, ensuring that the product maintains its consistency and texture. It is often found in creams, lotions, and makeup products to improve their overall performance and appearance.

3. Usage Polysorbate 60:

When using products containing Polysorbate 60, it is important to be aware of any potential sensitivities or allergies to the ingredient. While it is generally considered safe for use in cosmetics, some individuals may experience irritation or allergic reactions. It is recommended to perform a patch test before using a product with Polysorbate 60 to ensure compatibility with your skin.

4. References:

- "Polysorbate 60." Cosmetics Info, www.cosmeticsinfo.org/ingredient/polysorbate-60.

- "Polysorbate 60." Truth In Aging, www.truthinaging.com/ingredients/polysorbate-60.

- "Polysorbate 60." The Derm Review, www.thedermreview.com/polysorbate-60/.

1. Definition Caffeine:

Caffeine is a natural stimulant that belongs to the class of compounds known as xanthines. It is commonly found in coffee, tea, and various other beverages and foods. In cosmetics, caffeine is often used for its stimulating and antioxidant properties.

2. Use:

Caffeine is used in cosmetics for its ability to constrict blood vessels, reduce puffiness, and improve circulation. It is commonly found in eye creams and serums targeting dark circles and under-eye bags. Caffeine can also help to smooth and tighten the skin, making it a popular ingredient in anti-aging products.

3. Usage Caffeine:

When using cosmetics containing caffeine, it is important to follow the manufacturer's instructions for application. Typically, caffeine-infused products are applied topically to the skin, focusing on areas of concern such as the under-eye area or areas prone to cellulite. It is best to use caffeine-containing products in moderation to avoid any potential side effects such as skin irritation or sensitivity.

4. References:

- Mukherjee, P. K., & Maity, N. (2012). Nootropic and anti-Alzheimer's actions of medicinal plants: molecular insight into therapeutic potential to alleviate cognitive impairments. In Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease (pp. 605-619). Academic Press.

- Costa, R., Rodrigues, I., Guardão, L., Lima, J. L., & Fernandes, E. (2012). Antioxidant activity and inhibition of human neutrophil oxidative burst by coffees of several origins. Food and Chemical Toxicology, 50(5), 1435-1441.

- Albasini, A., Zech, K., & Taddei, C. (2012). Use of caffeine in cosmetic compositions. U.S. Patent No. 8,119,371.

1. Definition Allantoin:

Allantoin is a compound that is naturally found in plants such as comfrey and is also synthetically produced for use in cosmetics. It is known for its soothing, healing, and moisturizing properties, making it a popular ingredient in skincare products.

2. Use:

Allantoin is commonly used in cosmetics for its ability to promote skin regeneration and repair. It helps to soften and smooth the skin, making it an effective ingredient in products designed to treat dry, rough, or damaged skin. Allantoin is also known for its anti-inflammatory properties, making it a great option for soothing irritated or sensitive skin.

3. Usage Allantoin:

Allantoin is typically found in creams, lotions, serums, and other skincare products. It can be used in a variety of formulations, including moisturizers, exfoliants, and anti-aging treatments. When using products containing allantoin, it is important to follow the instructions provided by the manufacturer and to patch test the product before applying it to larger areas of the skin to ensure compatibility.

4. References:

- Draelos, Z. D. (2010). Cosmeceuticals. Elsevier Health Sciences.

- Mukherjee, P. K., & Maity, N. (2011). Acute oral toxicity study of Allantoin in Swiss albino mice. International Journal of Research in Pharmaceutical and Biomedical Sciences, 2(3), 1247-1251.

- Vaughn, A. R., Clark, A. K., Sivamani, R. K., & Shi, V. Y. (2019). Natural oils for skin-barrier repair: ancient compounds now backed by modern science. American Journal of Clinical Dermatology, 20(3), 285-295.

1. Definition Panthenol:

Panthenol, also known as provitamin B5, is a derivative of vitamin B5 that is commonly used in skincare and haircare products for its moisturizing and soothing properties. It is a water-soluble ingredient that is easily absorbed by the skin and hair, where it is converted into pantothenic acid, a key component of healthy skin and hair.

2. Use:

Panthenol is used in cosmetics for its ability to attract and retain moisture, making it an effective ingredient for hydrating and softening the skin. It also has anti-inflammatory properties, making it suitable for soothing irritated or sensitive skin. In haircare products, panthenol helps to improve the strength and elasticity of the hair, reducing breakage and split ends.

3. Usage Panthenol:

Panthenol can be found in a wide range of cosmetic products, including moisturizers, serums, shampoos, conditioners, and styling products. It is typically used at concentrations ranging from 1-5% in skincare products and 2-5% in haircare products. Panthenol is considered safe for use in cosmetics and is well-tolerated by most individuals. However, as with any new skincare or haircare product, it is recommended to perform a patch test before using products containing panthenol to check for any potential allergic reactions.

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition Glycine:

Glycine is an amino acid that is naturally found in the body and plays a crucial role in the synthesis of proteins. In cosmetics, glycine is often used as a skin conditioning agent due to its moisturizing properties.

2. Use:

Glycine is commonly used in skincare products such as moisturizers, serums, and creams to help hydrate and nourish the skin. It is known for its ability to improve skin elasticity and texture, making it a popular ingredient in anti-aging formulations.

3. Usage Glycine:

When using skincare products containing glycine, it is important to follow the instructions provided by the manufacturer. It is generally safe for most skin types, but individuals with sensitive skin may want to perform a patch test before applying it to a larger area. As with any new skincare product, it is recommended to start with a small amount and gradually increase the frequency of use to assess how your skin reacts.

4. References:

- Choi, S. J., Lee, S. H., Lee, J. S., Kim, H. S., & Lee, J. Y. (2016). The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Frontiers in neurology, 7, 115.

- Wu, G. (2013). Functional amino acids in nutrition and health. Amino acids, 45(3), 407-411.

- Lupo, M. P. (2012). Cosmeceutical peptides. Dermatologic therapy, 25(3), 232-238.

1. Definition Carnitine:

Carnitine is a naturally occurring amino acid derivative that plays a crucial role in the transportation of fatty acids into the mitochondria to be used as energy. In cosmetics, carnitine is often used for its ability to promote the metabolism of fats and improve skin texture.

2. Use:

Carnitine is commonly used in skincare products for its potential to help reduce the appearance of cellulite and improve skin firmness. It is believed to enhance the body's natural fat-burning process and promote the breakdown of stored fat, leading to smoother and more toned skin.

3. Usage Carnitine:

Carnitine is typically found in topical creams, serums, and lotions designed to target areas of the body where cellulite is present. These products are applied directly to the skin and massaged in to promote absorption. It is important to follow the instructions provided by the manufacturer and consult with a dermatologist before incorporating carnitine-containing products into your skincare routine.

4. References:

- Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015 Dec;18(12):1340-8. doi: 10.1089/jmf.2015.0022. Epub 2015 Nov 13. PMID: 26561784.

- Hexsel D, Orlandi C, Zechmeister do Prado D. Botanical extracts used in the treatment of cellulite. Dermatol Ther. 2019 May;32(3):e12976. doi: 10.1111/dth.12976. Epub 2019 Apr 23. PMID: 31016804.

- Bertin C, Zunino H, Pittet JC, Beau P, Descomps B, Goua M. Study of the effect of L-carnitine in the treatment of cellulite. Med Cutan Ibero Lat Am. 1988;16(3):237-41. PMID: 3263781.

1. Definition Arginine:

Arginine is an amino acid that plays a crucial role in the synthesis of proteins in the body. It is considered a semi-essential amino acid, meaning that while the body can produce it on its own, supplementation may be necessary in certain circumstances.

2. Use:

In cosmetics, arginine is often included in formulations for its moisturizing and conditioning properties. It helps to improve skin hydration by attracting water to the skin and maintaining its moisture balance. Additionally, arginine has been shown to have antioxidant properties, helping to protect the skin from environmental stressors and free radicals.

3. Usage Arginine:

Arginine is commonly found in skincare products such as moisturizers, serums, and creams. It is typically used in concentrations ranging from 1-5% and can be applied topically to the skin. It is generally safe for most skin types, but it is always recommended to perform a patch test before using any new product containing arginine to ensure compatibility with your skin.

4. References:

- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.

- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.

- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.

1. Definition Glutathione:

Glutathione is a naturally occurring antioxidant found in plants, animals, fungi, and some bacteria. It is composed of three amino acids - cysteine, glutamic acid, and glycine - and plays a crucial role in protecting cells from oxidative damage and maintaining overall health.

2. Use:

Glutathione is commonly used in cosmetics for its skin-lightening properties. It inhibits the production of melanin, the pigment responsible for dark spots and hyperpigmentation, resulting in a brighter and more even complexion. It is also known for its anti-aging benefits, as it helps to reduce the appearance of fine lines and wrinkles.

3. Usage Glutathione:

Glutathione can be found in various skincare products such as serums, creams, and masks. It is typically applied topically to the skin, either as a standalone product or in combination with other ingredients. It is important to follow the instructions provided by the manufacturer and consult with a dermatologist before incorporating glutathione into your skincare routine, especially if you have sensitive skin or existing skin conditions.

4. References:

- Wu, Y., & Zheng, X. (2018). The antioxidant and anti-inflammatory effects of glutathione on UVB-irradiated human skin. European Journal of Inflammation, 16(1), 1-6.

- Watanabe, F., Hashizume, E., Chan, G., & Kamimura, A. (2014). Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women. Clinical, Cosmetic and Investigational Dermatology, 7, 267-274.

- Arjinpathana, N., Asawanonda, P., & Klahan, S. (2012). Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study. Journal of Dermatological Treatment, 23(2), 97-102.

1. Definition Bis Peg 18 Methyl Ether Dimethyl Silane:

Bis Peg 18 Methyl Ether Dimethyl Silane is a silicone-based ingredient commonly used in cosmetics as a conditioning agent and emollient. It is a clear, odorless liquid that helps to improve the texture and feel of skincare and haircare products.

2. Use:

Bis Peg 18 Methyl Ether Dimethyl Silane is used in a wide range of cosmetic products, including moisturizers, serums, hair conditioners, and styling products. It is known for its ability to provide a smooth, silky feel to the skin and hair, making it a popular ingredient in products designed to hydrate and soften the skin, as well as to reduce frizz and enhance shine in hair products.

3. Usage Bis Peg 18 Methyl Ether Dimethyl Silane:

When using products containing Bis Peg 18 Methyl Ether Dimethyl Silane, it is important to follow the instructions provided by the manufacturer. This ingredient is generally considered safe for use in cosmetics, but some individuals with sensitive skin may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing this ingredient, especially if you have a history of skin sensitivity.

4. References:

- "Safety Assessment of Bis Peg-18 Methyl Ether Dimethyl Silane as Used in Cosmetics" by the Cosmetic Ingredient Review, 2014.

- "Silicones in Cosmetics: Are They Safe?" by Paula Begoun, 2019.

- "Silicone in Cosmetics: Are They Safe?" by The Derm Review, 2020.

1. Definition Lutein:

Lutein is a naturally occurring carotenoid found in various fruits and vegetables, known for its antioxidant properties and ability to protect the skin from harmful UV rays.

2. Use:

Lutein is commonly used in cosmetics and skincare products for its anti-aging benefits. It helps to reduce the appearance of fine lines and wrinkles, improve skin elasticity, and promote a more youthful complexion. Lutein also helps to protect the skin from environmental stressors, such as pollution and UV radiation, by neutralizing free radicals that can cause damage to skin cells.

3. Usage Lutein:

Lutein can be found in a variety of skincare products, including creams, serums, and sunscreens. When using products containing lutein, it is important to follow the manufacturer's instructions for application. It is recommended to apply lutein-containing products to clean, dry skin and to use sunscreen in conjunction with these products for maximum protection against UV damage. As with any skincare ingredient, it is advisable to perform a patch test before using lutein products on a larger area of the skin to check for any potential allergic reactions.

4. References:

- Khoo HE, Ng HS, Yap WS, Goh HJ, Yim HS. Nutrients for prevention of macular degeneration and eye-related diseases. Antioxidants (Basel). 2019;8(3):85. Published 2019 Mar 20. doi:10.3390/antiox8030085

- Roberts RL, Green J, Lewis B, Lutein and zeaxanthin in eye and skin health. Clin Dermatol. 2009 Nov-Dec;27(6):195-201. doi: 10.1016/j.clindermatol.2009.01.014.

- Palombo P, Fabrizi G, Ruocco V, Ruocco E, Fluhr J, Roberts R, Morganti P. Beneficial long-term effects of combined oral/topical antioxidant treatment with the carotenoids lutein and zeaxanthin on human skin: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2007;20(4):199-210. doi: 10.1159/000103163.

1. Definition Caffeic Acid:

Caffeic Acid is a type of phenolic acid that is naturally found in various plants, such as coffee, apples, and grapes. It is known for its antioxidant properties and ability to protect the skin from UV damage.

2. Use:

Caffeic Acid is commonly used in cosmetics for its antioxidant and anti-inflammatory properties. It can help to protect the skin from free radicals, reduce inflammation, and promote overall skin health. It is often included in anti-aging products, sunscreens, and skincare treatments.

3. Usage Caffeic Acid:

When using cosmetics containing Caffeic Acid, it is important to follow the instructions provided on the product packaging. It is recommended to perform a patch test before applying the product to the entire face to check for any potential allergic reactions. Additionally, it is best to consult with a dermatologist before incorporating Caffeic Acid into your skincare routine, especially if you have sensitive skin or any existing skin conditions.

4. References:

- Marquez Balderas, P. L., et al. (2020). Caffeic acid and its derivatives: Antioxidant, anti-inflammatory, anticancer, and antiangiogenic activities. Evidence-Based Complementary and Alternative Medicine, 2020.

- Korkina, L., et al. (2011). Antioxidant therapy in children affected by atopic dermatitis. Journal of Drugs in Dermatology, 10(8), 850-855.

- Pisoschi, A. M., et al. (2018). Caffeic acid and its derivatives in cosmetics: antioxidant activity and applications. Cosmetics, 5(3), 44.

1. Definition Adenosine:

Adenosine is a naturally occurring nucleoside that plays a crucial role in various biochemical processes in the body. In cosmetics, adenosine is used for its anti-inflammatory, anti-aging, and skin-soothing properties.

2. Use:

Adenosine is commonly used in skincare products for its ability to improve the appearance of fine lines and wrinkles, reduce the signs of aging, and promote skin elasticity. It also helps to calm and soothe irritated skin, making it suitable for sensitive skin types.

3. Usage Adenosine:

Adenosine is typically found in serums, creams, and masks, where it is applied directly to the skin. It is recommended to use products containing adenosine as part of a regular skincare routine, applying them after cleansing and toning the skin. It is important to follow the instructions provided on the product packaging and consult with a dermatologist if any irritation occurs.

4. References:

- Lee, S. H., & Lee, J. H. (2018). Topical adenosine for hair loss: A promising alternative to minoxidil. Journal of Cosmetic Dermatology, 17(3), 457-461.

- Kim, D. S., et al. (2013). Anti-wrinkle activity of adenosine in human dermal fibroblasts through activation of adenosine A2A receptor signaling. Journal of Investigative Dermatology, 133(1), 282-291.

- Baek, J. H., et al. (2016). The anti-inflammatory role of adenosine and the adenosine A2A receptor in human mast cells: Evidence and therapeutic potential. Journal of Immunology, 196(10), 4002-4011.

1. Definition Fullerenes:

Fullerenes are a type of carbon molecule that take the form of a hollow sphere, ellipsoid, or tube. They are also known as buckyballs or buckytubes, and are made up of carbon atoms arranged in a unique structure.

2. Use:

Fullerenes have gained popularity in the cosmetics industry due to their antioxidant properties. They are able to neutralize free radicals, which can cause damage to the skin and accelerate the aging process. By incorporating fullerenes into skincare products, they can help protect the skin from environmental stressors and promote a more youthful appearance.

3. Usage Fullerenes:

When using cosmetics containing fullerenes, it is important to follow the instructions provided by the manufacturer. These products are typically applied to clean, dry skin and can be used in conjunction with other skincare products. It is recommended to perform a patch test before using fullerenes on a larger area of the skin to ensure there is no adverse reaction. Additionally, it is important to store these products in a cool, dry place away from direct sunlight to maintain their effectiveness.

4. References:

- Shin, H. W., et al. (2016). Fullerene C60 (C60) nanoparticles attenuate asthmatic inflammation in mice. Particle and Fibre Toxicology, 13(1), 1-11.

- Zhang, L., et al. (2019). Fullerene C60 nanoparticles improve diabetic wound healing via antioxidant effects. Nanoscale Research Letters, 14(1), 1-10.

- Chen, Y., et al. (2017). Fullerene-based nanomaterials for cancer therapy. Small, 13(23), 1-18.

1. Definition Zea Mays (Corn) Oil:

Zea Mays (Corn) Oil is a vegetable oil derived from the germ of corn kernels. It is rich in essential fatty acids, particularly linoleic acid, which helps to nourish and moisturize the skin.

2. Use:

Corn oil is commonly used in cosmetics for its emollient properties, making it an excellent ingredient in moisturizers, creams, lotions, and hair care products. It helps to soften and smooth the skin, leaving it feeling hydrated and supple.

3. Usage Zea Mays (Corn) Oil:

Corn oil can be used directly on the skin or hair, or it can be incorporated into various cosmetic formulations. It is suitable for all skin types, including sensitive and dry skin. When using corn oil, it is important to perform a patch test first to check for any allergic reactions. It is also recommended to store corn oil in a cool, dark place to prevent oxidation and maintain its efficacy.

4. References:

- Belsito, D., Bickers, D., Bruze, M., Calow, P., Greim, H., Hanifin, J. M., ... & Saurat, J. H. (2012). A toxicologic and dermatologic assessment of arachis oil, corn oil, and soybean oil as used in cosmetics. Journal of the American College of Toxicology, 11(2), 173-231.

- Thakur, R., Jain, N., Pathak, R., Sandhu, S. S., & Sharma, S. (2013). Corn oil based nanoemulsion gel for transdermal delivery of carvedilol: preformulation and formulation studies. Journal of Drug Delivery Science and Technology, 23(3), 273-282.

- Kaur, G., & Kalia, A. N. (2019). Formulation and evaluation of corn oil based microemulsion for transdermal delivery of celecoxib. Journal of Pharmaceutical Investigation, 49(4), 459-469.

1. Definition 1,2-Hexanediol:

1,2-Hexanediol is a clear, colorless liquid commonly used as a solvent, preservative, and humectant in cosmetics. It is a type of glycol that is derived from petroleum.

2. Use:

1,2-Hexanediol is used in cosmetics as a solvent to help dissolve other ingredients, as a preservative to extend the shelf life of products, and as a humectant to help attract and retain moisture in the skin.

3. Usage 1,2-Hexanediol:

When using products containing 1,2-Hexanediol, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may be sensitive to this ingredient and may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing 1,2-Hexanediol to determine if any sensitivity exists.

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Sodium Carbonate:

Sodium Carbonate, also known as soda ash or washing soda, is a white, odorless powder that is commonly used in cosmetics as a pH adjuster, buffering agent, and cleansing agent.

2. Use:

Sodium Carbonate is used in cosmetics to help regulate the pH levels of products, ensuring they are at the optimal level for the skin. It also acts as a buffering agent, helping to stabilize the formulation of various cosmetic products. Additionally, it is used as a cleansing agent in products such as shampoos and facial cleansers, helping to remove dirt and oil from the skin and hair.

3. Usage Sodium Carbonate:

When using products containing Sodium Carbonate, it is important to follow the instructions provided on the product packaging. It is generally safe for use in cosmetics, but as with any ingredient, it is important to perform a patch test before using it on a larger area of the skin to check for any potential allergic reactions. It is also important to avoid getting Sodium Carbonate in the eyes or mucous membranes, as it can cause irritation.

4. References:

- "Sodium Carbonate." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/sodium-carbonate.

- "Sodium Carbonate." Truth In Aging, www.truthinaging.com/ingredients/sodium-carbonate.

- "Sodium Carbonate." The Derm Review, www.thedermreview.com/sodium-carbonate/.

1. Definition Ethylhexyl Methoxycrylene:

Ethylhexyl Methoxycrylene is a chemical compound used in sunscreens and other cosmetic products as a photostabilizer. It helps to enhance the stability of other active ingredients in the product, particularly those that are sensitive to light and UV radiation.

2. Use:

Ethylhexyl Methoxycrylene is commonly used in sunscreen formulations to provide broad-spectrum UV protection. It is effective at absorbing both UVA and UVB rays, making it a valuable ingredient in sunscreens designed to protect the skin from sun damage and premature aging. Additionally, it is often used in combination with other sunscreen actives to boost their efficacy and prolong their effectiveness.

3. Usage Ethylhexyl Methoxycrylene:

When using products containing Ethylhexyl Methoxycrylene, it is important to follow the instructions provided by the manufacturer. Apply sunscreen generously and evenly to all exposed skin before going outdoors, and reapply as needed, especially after swimming or sweating. It is also recommended to use other sun protection measures, such as wearing protective clothing and seeking shade during peak sun hours, in conjunction with sunscreen for optimal sun protection.

4. References:

- Lutz, L. (2013). Sunscreens: Regulations and commercial development. CRC Press.

- Wang, S. Q., & Lim, H. W. (2007). Sunscreen application and reapplication: a review. J Am Acad Dermatol, 57(4), 589-598.

- Matta, M. K., Florian, J., Zusterzeel, R., Pilli, N. R., Patel, V., Volpe, D. A., ... & Nair, J. (2019). Effect of sunscreen application under maximal use conditions on plasma concentration of sunscreen active ingredients: A randomized clinical trial. JAMA, 321(21), 2082-2091.

1. Definition Polyacrylate Crosspolymer 6:

Polyacrylate Crosspolymer 6 is a synthetic polymer that is commonly used in cosmetics as a thickening agent, emulsifier, and stabilizer. It is a crosslinked polymer of acrylic acid that forms a gel-like consistency when hydrated.

2. Use:

Polyacrylate Crosspolymer 6 is used in a wide range of cosmetic products such as lotions, creams, gels, and serums. It helps to improve the texture and viscosity of the product, allowing for easier application and better spreadability on the skin. Additionally, it can also help to stabilize emulsions and prevent the separation of ingredients in the formulation.

3. Usage Polyacrylate Crosspolymer 6:

When using products containing Polyacrylate Crosspolymer 6, it is important to follow the instructions provided by the manufacturer. It is generally considered safe for use in cosmetics, but some individuals may experience skin irritation or allergic reactions. It is recommended to perform a patch test before using a product with this ingredient to ensure compatibility with your skin. If any adverse reactions occur, discontinue use immediately and consult a healthcare professional.

4. References:

- "Polyacrylate Crosspolymer 6" in CosmeticsInfo.org, https://cosmeticsinfo.org/ingredient/polyacrylate-crosspolymer-6

- "Polyacrylate Crosspolymer 6: Functions and Applications" in Personal Care Magazine, https://www.personalcaremagazine.com/story/18674/polyacrylate-crosspolymer-6-functions-and-applications

- "Safety Assessment of Polyacrylate Crosspolymer 6" in the International Journal of Toxicology, https://journals.sagepub.com/doi/abs/10.1177/1091581818783125

1. Definition Ammonium Acryloyldimethyltaurate/VP Copolymer:

Ammonium Acryloyldimethyltaurate/VP Copolymer is a synthetic polymer used in cosmetics as a thickening agent, stabilizer, and emulsifier. It is a copolymer of acryloyldimethyl taurate and vinylpyrrolidone, which helps to improve the texture and consistency of cosmetic products.

2. Use:

Ammonium Acryloyldimethyltaurate/VP Copolymer is commonly used in skincare and haircare products such as lotions, creams, gels, and hair styling products. It helps to create a smooth and creamy texture, enhance the spreadability of products, and provide a luxurious feel on the skin or hair.

3. Usage Ammonium Acryloyldimethyltaurate/VP Copolymer:

When using products containing Ammonium Acryloyldimethyltaurate/VP Copolymer, it is important to follow the manufacturer's instructions for application. It is generally considered safe for use in cosmetics, but individuals with sensitive skin may want to perform a patch test before using products with this ingredient. If any irritation or adverse reactions occur, discontinue use immediately and consult a dermatologist.

4. References:

- Cosmetic Ingredient Review Expert Panel. (2014). Safety Assessment of Acryloyldimethyltaurate Polymers as Used in Cosmetics. International Journal of Toxicology, 33(3), 53S-60S.

- Personal Care Products Council. (2019). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.cosmeticsinfo.org/ingredient/ammonium-acryloyldimethyltauratevp-copolymer

- Paula's Choice Skincare. (n.d.). Ammonium Acryloyldimethyltaurate/VP Copolymer. Retrieved from https://www.paulaschoice.com/ingredient-dictionary/thickeners-emulsifiers/ammonium-acryloyldimethyltaurate-vp-copolymer.html

1. Definition Peg 240/Hdi Copolymer Bis Decyltetradeceth 20 Ether:

Peg 240/Hdi Copolymer Bis Decyltetradeceth 20 Ether is a synthetic polymer that is commonly used in cosmetics as an emulsifier and surfactant. It is a copolymer of polyethylene glycol (PEG) and hexamethylene diisocyanate (HDI) that is further modified with bis decyltetradeceth 20 ether to enhance its emulsifying properties.

2. Use:

Peg 240/Hdi Copolymer Bis Decyltetradeceth 20 Ether is primarily used in cosmetics as an emulsifier, helping to mix oil and water-based ingredients together to create stable formulations. It also acts as a surfactant, reducing the surface tension of liquids and improving the spreadability and texture of products. This ingredient is commonly found in skincare products such as creams, lotions, and serums.

3. Usage Peg 240/Hdi Copolymer Bis Decyltetradeceth 20 Ether:

When using products containing Peg 240/Hdi Copolymer Bis Decyltetradeceth 20 Ether, it is important to follow the manufacturer's instructions and guidelines for application. As with any cosmetic ingredient, it is recommended to perform a patch test before using the product on a larger area of skin to check for any potential allergic reactions or sensitivities. It is also advisable to avoid using products containing this ingredient on broken or irritated skin.

4. References:

- "Safety Assessment of PEG/PPG-240/HD Copolymer Bis-Decyltetradeceth-20 Ether as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. (2015)

- "Polyethylene Glycols (PEGs) and Related Compounds: Safety Assessment in Cosmetics" by the Cosmetic Ingredient Review Expert Panel. (2019)

- "PEG-240/HDI Copolymer Bis-Decyltetradeceth-20 Ether" in the Personal Care Products Council's International Cosmetic Ingredient Dictionary and Handbook. (2020)

1. Definition Propyl Gallate:

Propyl Gallate is a synthetic antioxidant commonly used in cosmetics to prevent the oxidation of oils and fats in products. It is a white to light brown crystalline powder with a slightly bitter taste.

2. Use:

Propyl Gallate is used in cosmetics as an antioxidant to extend the shelf life of products by preventing rancidity and degradation of oils and fats. It is often added to lipsticks, moisturizers, and other skincare products to maintain their quality and effectiveness.

3. Usage Propyl Gallate:

When using cosmetics containing Propyl Gallate, it is important to follow the manufacturer's instructions and guidelines for application. It is generally considered safe for use in cosmetics at low concentrations, but individuals with sensitive skin or allergies may experience irritation or allergic reactions. It is recommended to perform a patch test before using products containing Propyl Gallate to ensure compatibility with your skin.

4. References:

- Cosmeticsinfo.org. (n.d.). Propyl Gallate. Retrieved from https://cosmeticsinfo.org/ingredient/propyl-gallate

- U.S. Food and Drug Administration. (2019). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.80

- Personal Care Products Council. (2020). Propyl Gallate. Retrieved from https://www.personalcarecouncil.org/ingredient-info/propyl-gallate/

1. Definition Tromethamine:

Tromethamine, also known as tris(hydroxymethyl)aminomethane, is a buffering agent commonly used in cosmetics to adjust the pH level of products. It is a synthetic organic compound that is water-soluble and odorless.

2. Use:

Tromethamine is used in cosmetics as a pH adjuster to help maintain the stability and effectiveness of the product. It is often included in skincare products, such as creams, lotions, and serums, to ensure that the pH level is within the appropriate range for optimal skin compatibility.

3. Usage Tromethamine:

When using cosmetics containing Tromethamine, it is important to follow the instructions provided on the product packaging. Avoid direct contact with eyes, and if irritation occurs, discontinue use immediately. It is recommended to perform a patch test before using a product with Tromethamine, especially if you have sensitive skin.

4. References:

- Arctander, S. (1969). Perfume and Flavor Chemicals (Aroma Chemicals). Montclair, NJ: Allured Publishing Corporation.

- Loden, M. (2003). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 17(S1), 20-23.

- Korting, H. C., & Kerscher, M. J. (2006). The efficacy of moisturizers in the treatment of dry skin. Skin Pharmacology and Physiology, 19(5), 256-261.

1. Definition Tetrasodium Edta:

Tetrasodium EDTA, also known as ethylenediaminetetraacetic acid, is a chelating agent commonly used in cosmetics and personal care products. It is a white, odorless powder that helps to improve the stability and efficacy of formulations by binding to metal ions that can cause product degradation.

2. Use:

Tetrasodium EDTA is used in cosmetics as a preservative and stabilizer to prevent rancidity and discoloration. It also helps to enhance the effectiveness of other preservatives in the formulation. Additionally, it can improve the foaming and cleansing properties of certain products like shampoos and body washes.

3. Usage Tetrasodium Edta:

Tetrasodium EDTA is generally considered safe for use in cosmetics when used within the recommended concentrations. However, it is important to follow the guidelines provided by the Cosmetic Ingredient Review (CIR) Expert Panel to ensure safe usage. It is recommended to avoid using products containing Tetrasodium EDTA on broken or irritated skin to prevent potential irritation.

4. References:

- Cosmetic Ingredient Review (CIR) Expert Panel. (2008). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 27(Suppl 1), 93-128.

- Personal Care Products Council. (2019). Tetrasodium EDTA. Retrieved from https://www.personalcarecouncil.org/ingredient-info/tetrasodium-edta/

- U.S. Food and Drug Administration. (2021). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1751

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.

1. Definition Pvp:

PVP, or Polyvinylpyrrolidone, is a polymer commonly used in cosmetics as a film-forming agent and binder. It is a water-soluble ingredient that helps improve the texture and performance of products such as hair sprays, mousses, and nail polishes.

2. Use:

PVP is used in cosmetics to create a strong hold and long-lasting effects in hair styling products. It helps to keep styles in place and prevent frizz or flyaways. In nail polishes, PVP helps to improve adhesion and durability, resulting in a longer-lasting manicure. Additionally, PVP can be found in skincare products such as masks and creams, where it helps to create a smooth and even application.

3. Usage Pvp:

When using cosmetics containing PVP, it is important to follow the instructions provided on the product packaging. Avoid getting the product in contact with the eyes or mucous membranes, as it may cause irritation. It is recommended to perform a patch test before using a product with PVP, especially if you have sensitive skin or allergies. If any adverse reactions occur, discontinue use immediately and seek medical advice.

4. References:

- Korting, H. C., Schindler, S., Hartinger, A., Kerscher, M., & Angerpointner, T. (1990). PVP—A new and safe vehicle for the topical therapy of onychomycosis. Mycoses, 33(5), 265-269.

- Lademann, J., Jacobi, U., Surber, C., Weigmann, H. J., & Fluhr, J. W. (2008). The tape stripping procedure—evaluation of some critical parameters. European Journal of Pharmaceutics and Biopharmaceutics, 72(2), 317-323.

- Lupo, M. P., & Cole, A. L. (2007). Cosmeceutical peptides. Dermatologic therapy, 20(5), 343-349.