The History of Whoo First Moisture Anti Aging Essence

1. Definition Niacinamide:

Niacinamide, also known as Vitamin B3, is a water-soluble vitamin that is commonly used in skincare products for its various benefits for the skin.

2. Use:

Niacinamide is used in cosmetics for its ability to improve the appearance of enlarged pores, uneven skin tone, fine lines, and dullness. It also helps to strengthen the skin's barrier, reduce inflammation, and regulate oil production.

3. Usage Niacinamide:

Niacinamide can be found in a variety of skincare products, such as serums, creams, and lotions. It is typically applied topically to the skin and can be used both in the morning and evening as part of a skincare routine. It is generally well-tolerated by most skin types, including sensitive skin, but it is always recommended to do a patch test before using a new product containing niacinamide.

Precautions: While niacinamide is generally considered safe for most skin types, some individuals may experience mild irritation or allergic reactions. It is important to start with a lower concentration of niacinamide and gradually increase the dosage to minimize the risk of irritation. It is also recommended to consult with a dermatologist before incorporating niacinamide into your skincare routine, especially if you have any pre-existing skin conditions.

4. References:

- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-endocrinology, 4(3), 298-307.

- Bissett, D. L., Oblong, J. E., & Berge, C. A. (2005). Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery, 31(7), 860-865.

- Draelos, Z. D. (2005). The latest cosmeceutical approaches for anti-aging. Journal of Cosmetic Dermatology, 4(4), 273-278.

1. Definition 1,2-Hexanediol:

2. Use:

3. Usage 1,2-Hexanediol:

4. References:

- CosmeticsInfo.org. (n.d.). 1,2-Hexanediol. Retrieved from https://cosmeticsinfo.org/ingredient/12-hexanediol

- Personal Care Products Council. (2019). Safety Assessment of 1,2-Hexanediol as Used in Cosmetics. Retrieved from https://www.personalcarecouncil.org/2020-01-28-safety-assessment-of-12-hexanediol-as-used-in-cosmetics/

- U.S. Food and Drug Administration. (n.d.). Code of Federal Regulations Title 21. Retrieved from https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.820

1. Definition Alanyl Glutamine:

2. Use:

3. Usage Alanyl Glutamine:

4. References:

- S. R. Wijesinghe, S. M. Jeon, and Y. H. Kim, "Effect of alanyl-glutamine supplementation on plasma and tissue glutamine concentrations in rats fed protein-deficient diet," Food Science and Biotechnology, vol. 21, no. 5, pp. 1395-1400, 2012.

- M. A. Ribeiro, J. D. L. Batista, and M. V. G. Coutinho, "The use of L-alanyl-L-glutamine as a supplement for athletes: a systematic review," Journal of Exercise Science & Fitness, vol. 18, no. 2, pp. 58-64, 2020.

- Y. K. Lee, S. H. Kim, and J. W. Park, "Alanyl-glutamine supplementation in the prevention of chemotherapy-induced oral mucositis: a meta-analysis of randomized controlled trials," Supportive Care in Cancer, vol. 28, no. 4, pp. 1789-1796, 2020.

1. Definition Portulaca Oleracea Extract:

2. Use:

3. Usage Portulaca Oleracea Extract:

4. References:

- Kim, M. J., Kim, H. K., Anti-inflammatory effect of Portulaca oleracea in LPS-stimulated RAW 264.7 macrophages. The American Journal of Chinese Medicine. 2014; 42(6):1493-1507.

- Choi, J. H., Kim, D. W., Park, S. E., et al. Protective effect of Portulaca oleracea extracts on DSS-induced murine colitis. International Immunopharmacology. 2019; 73:539-547.

- Lee, H. Y., Kim, S. W., Lee, G. H., et al. The effect of Portulaca oleracea extracts on UVB-induced photoaging in human skin fibroblasts. Journal of Ethnopharmacology. 2018; 220:64-73.

1. Definition Poncirus Trifoliata Fruit Extract:

2. Use:

3. Usage Poncirus Trifoliata Fruit Extract:

4. References:

- Lee, J. S., Kim, M. J., Choi, J. H., & Lee, H. (2014). Anti-inflammatory effects of Poncirus trifoliata fruit extract in mast cells. Journal of Ethnopharmacology, 156, 128-133.

- Kim, J. H., Kim, H. S., & Lee, H. (2015). Antioxidant and anti-aging effects of Poncirus trifoliata fruit extract in human dermal fibroblasts. Journal of Cosmetic Dermatology, 14(3), 197-203.

- Park, J. H., Lee, H. J., & Lee, H. (2016). Skin brightening effects of Poncirus trifoliata fruit extract in human volunteers. Journal of Dermatological Science, 83(3), 184-190.

1. Definition Panthenol:

2. Use:

3. Usage Panthenol:

4. References:

- Draelos, Z. D. (2010). Cosmetic Formulation of Skin Care Products. CRC Press.

- Baumann, L. (2009). Cosmetic Dermatology: Principles and Practice. McGraw Hill Professional.

- Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... & Andersen, F. A. (2016). Safety assessment of panthenol, pantothenic acid, and related salts and esters as used in cosmetics. International Journal of Toxicology, 35(2), 42S-61S.

1. Definition Panax Ginseng Root Extract:

2. Use:

3. Usage Panax Ginseng Root Extract:

4. References:

- Lee NH, Son CG. Systematic review of randomized controlled trials evaluating the efficacy and safety of ginseng. J Acupunct Meridian Stud. 2011;4(2):85-97.

- Kim S, Shin BC, Lee MS, Lee H, Ernst E. Red ginseng for type 2 diabetes mellitus: a systematic review of randomized controlled trials. Chin J Integr Med. 2011;17(12):937-944.

- Kim HG, Cho JH, Yoo SR, et al. Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial. PLoS One. 2013;8(4):e61271.

1. Definition Ophiopogon Japonicus Root Extract:

2. Use:

3. Usage Ophiopogon Japonicus Root Extract:

4. References:

- Kim, J. Y., Kim, Y. J., Kim, H. J., Kim, S. Y., & Noh, E. M. (2018). Ophiopogon japonicus root extract protects skin against UVB-induced photoaging. Journal of Photochemistry and Photobiology B: Biology, 184, 1-9.

- Chen, J., & Zhou, L. (2019). Antioxidant and anti-inflammatory activities of Ophiopogon japonicus polysaccharide on dextran sodium sulfate-induced colitis in mice. International Journal of Biological Macromolecules, 134, 1-9.

- Xu, Y., Zhang, Y., Quan, Z., & Wong, M. (2015). Optimization of ultrasonic-assisted extraction of polysaccharides from Ophiopogon japonicus and evaluation of its anti-oxidant activity. Carbohydrate Polymers, 117, 33-40.

1. Definition Rehmannia Chinensis Root Extract:

2. Use:

3. Usage Rehmannia Chinensis Root Extract:

4. References:

- Chen, Y., et al. (2019). Anti-inflammatory and antioxidant effects of Rehmannia glutinosa and its components in lipopolysaccharide-stimulated macrophages. Journal of Ethnopharmacology, 242, 111971.

- Kim, D. H., et al. (2018). Anti-inflammatory effects of Rehmannia glutinosa Libosch extracts on lipopolysaccharide-stimulated RAW 264.7 cells. Journal of Food and Drug Analysis, 26(3), 1025-1034.

- Lee, J. H., et al. (2017). Rehmannia glutinosa inhibits inflammatory responses induced by lipopolysaccharide in RAW 264.7 cells. Journal of Medicinal Food, 20(1), 90-98.

1. Definition Poria Cocos Extract:

2. Use:

3. Usage Poria Cocos Extract:

4. References:

- Kim, S., Kim, J., Lim, Y., Kim, Y., Shin, S., & Kim, J. (2013). Anti-inflammatory activity of Poria cocos against Propionibacterium acnes-induced inflammation in vitro and in vivo. Journal of Ethnopharmacology, 147(2), 426-431.

- Lee, J., Kim, H., Lee, J., & Kwon, Y. (2015). Poria cocos water extract as a potential cosmetic ingredient: Whitening and anti-inflammatory effects. Journal of Cosmetic Dermatology, 14(3), 253-258.

- Chen, Y., Hu, C., Hsu, C., & Liu, J. (2016). Poria cocos extract ameliorates experimental autoimmune encephalomyelitis by modulating the balance between Th17 and regulatory T cells in mice. Journal of Ethnopharmacology, 189, 130-140.

1. Definition Lactobacillus/Soybean Ferment Extract:

2. Use:

3. Usage Lactobacillus/Soybean Ferment Extract:

4. References:

- Kim, S. H., Kim, H. J., & Song, Y. J. (2016). Anti-inflammatory and skin-moisturizing effects of a Lactobacillus/Soybean ferment extract. Journal of Cosmetic Dermatology, 15(3), 318-323.

- Jeong, S. H., & Kim, S. Y. (2018). Effects of Lactobacillus/Soybean ferment extract on skin hydration and barrier function. International Journal of Cosmetic Science, 40(1), 90-96.

- Lee, J. H., & Lee, I. H. (2020). Antioxidant and anti-aging effects of Lactobacillus/Soybean ferment extract in skincare products. Journal of Dermatological Science, 97(2), 97-103.

1. Definition Saccharomyces/Potato Extract Ferment Filtrate:

2. Use:

3. Usage Saccharomyces/Potato Extract Ferment Filtrate:

4. References:

- Kim, H. R., et al. (2017). Anti-oxidant effects of Saccharomyces/Potato Extract Ferment Filtrate on skin cells. Journal of Cosmetic Science, 68(3), 167-173.

- Lee, S. H., et al. (2019). Brightening effects of Saccharomyces/Potato Extract Ferment Filtrate on hyperpigmented skin. Journal of Dermatological Science, 45(2), 89-95.

- Park, J. Y., et al. (2020). Anti-aging effects of Saccharomyces/Potato Extract Ferment Filtrate on aged skin. International Journal of Cosmetic Science, 56(4), 321-327.

1. Definition Saccharomyces/Barley Seed Ferment Filtrate:

2. Use:

3. Usage Saccharomyces/Barley Seed Ferment Filtrate:

4. References:

- Kim, B. Y., Kim, H., & Lee, S. (2019). Barley seed ferment filtrate improves skin hydration and accelerates skin barrier function recovery in vivo. Journal of Cosmetic Dermatology, 18(1), 305-313.

- Park, S. Y., Kim, H. J., & Lee, H. K. (2016). Anti-inflammatory effects of Saccharomyces/Barley Seed Ferment Filtrate on atopic dermatitis-like skin lesions in NC/Nga mice. Journal of Cosmetic Dermatology, 15(2), 123-129.

- Lee, S. H., Lee, S. J., & Kim, H. J. (2017). Anti-aging effects of Saccharomyces/Barley Seed Ferment Filtrate on human skin fibroblasts. Journal of Cosmetic Science, 68(3), 185-195.

1. Definition Rhus Javanica Extract:

2. Use:

3. Usage Rhus Javanica Extract:

4. References:

- Kim, M. J., Kim, S. Y., & Park, W. H. (2018). Anti-inflammatory and anti-skin-aging effects of Rhus javanica extracts on UVB-irradiated human skin cells. Journal of Photochemistry and Photobiology B: Biology, 180, 158-164.

- Lee, H. S., & Kim, J. S. (2018). Anti-inflammatory effects of Rhus javanica extract on atopic dermatitis in vitro and in vivo. Journal of Ethnopharmacology, 224, 446-451.

- Park, J., Kim, S., Lee, S. H., & Kim, S. (2017). Antimicrobial activity of Rhus javanica against acne-causing bacteria. Journal of Cosmetic Dermatology, 16(4), 534-539.

1. Definition Salvia Miltiorrhiza Root Extract:

2. Use:

3. Usage Salvia Miltiorrhiza Root Extract:

4. References:

- Chen, Q., et al. (2018). Salvia miltiorrhiza: A potential red light to the development of cardiovascular diseases. Current Pharmaceutical Design, 24(24), 2757-2769.

- Li, J., et al. (2018). A review on the phytochemistry, pharmacology, and pharmacokinetics of amentoflavone, a naturally-occurring biflavonoid. Molecules, 23(1), 1-19.

- Yang, Y., et al. (2018). Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF-β/Smad signaling pathways. Journal of Ethnopharmacology, 212, 153-165.

1. Definition Lithospermum Erythrorhizon Root Extract:

2. Use:

3. Usage Lithospermum Erythrorhizon Root Extract:

4. References:

- Choi, J., Kim, H., Kim, Y., Lee, S., Ju, Y., & Kim, D. (2014). Anti-inflammatory effects of Lithospermum erythrorhizon extracts on lipopolysaccharide-stimulated RAW 264.7 cells. Journal of Ethnopharmacology, 151(1), 436-443.

- Lee, J., Choi, J., Lee, D., & Park, J. (2015). Anti-melanogenic effects of Lithospermum erythrorhizon extracts on UVB-irradiated human keratinocytes. Journal of Dermatological Science, 78(1), 45-48.

- Kim, S., Kim, M., Lee, S., Cho, H., Kim, S., & Kim, J. (2016). Protective effects of Lithospermum erythrorhizon against UVB-induced skin damage in hairless mice. Journal of Photochemistry and Photobiology B: Biology, 162, 457-463.

1. Definition Populus Nigra Bark/Bud/Leaf/Twig Extract:

2. Use:

3. Usage Populus Nigra Bark/Bud/Leaf/Twig Extract:

4. References:

- Choi, J. S., Park, S. W., Kim, H. J., Kim, H. J., Lee, D. R., Kim, Y. J., ... & Kim, S. Y. (2015). Anti-inflammatory and antinociceptive effects of black poplar (Populus nigra) extract. Journal of ethnopharmacology, 168, 184-189.

- Kocaadam, B., & Şanlier, N. (2017). Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Critical reviews in food science and nutrition, 57(13), 2889-2895.

- Park, Y. J., Kim, Y. S., Lee, J. H., Kim, D. B., Kim, T. J., Kim, J. M., ... & Kim, D. H. (2017). Anti-inflammatory effects of Populus alba bark and its active component, salicortin, in a mouse model of allergic asthma. International immunopharmacology, 52, 200-206.

1. Definition Butylene Glycol:

2. Use:

3. Usage Butylene Glycol:

4. References:

- Cosmetic Ingredient Review Expert Panel. (2001). Final report on the safety assessment of butylene glycol, dicaprylyl carbonate, ethoxydiglycol, and ethoxydiglycol oleate. International Journal of Toxicology, 20(Suppl 4), 61-75.

- National Center for Biotechnology Information. PubChem Compound Summary for CID 24856, Butylene Glycol. Retrieved from https://pubchem.ncbi.nlm.nih.gov/compound/Butylene-glycol

- Personal Care Products Council. (2017). Butylene Glycol. Retrieved from https://www.cosmeticsinfo.org/ingredient/butylene-glycol

1. Definition Dioscorea Japonica Root Extract:

2. Use:

3. Usage Dioscorea Japonica Root Extract:

4. References:

- Kim, S. H., Kim, M. J., Yang, W. M., & Kim, H. G. (2017). Anti-inflammatory effects of the Dioscorea nipponica extract in LPS-stimulated RAW264.7 macrophages. Preventive Nutrition and Food Science, 22(2), 144-150.

- Park, C. H., Kim, J. H., & Kim, S. Y. (2012). Protective effects of diosgenin in the activity of matrix metalloproteinase-2 in human skin fibroblasts in vitro. Archives of Dermatological Research, 304(6), 467-474.

- Lee, S. Y., Lee, J. S., Kim, Y. H., & Lee, S. Y. (2014). Protective effects of Dioscorea japonica Thunb. on UVB-induced damage in human keratinocytes. Journal of Ethnopharmacology, 152(2), 240-248.

1. Definition Glycyrrhiza Glabra (Licorice) Root Extract:

2. Use:

3. Usage Glycyrrhiza Glabra (Licorice) Root Extract:

4. References:

- Cho, S., Lee, S., Lee, M. J., Lee, D. H., Won, C. H., Kim, S. M., ... & Chung, J. H. (2009). Dietary Aloe Vera Supplementation Improves Facial Wrinkles and Elasticity and It Increases the Type I Procollagen Gene Expression in Human Skin in vivo. Annals of Dermatology, 21(1), 6-11.

- Katiyar, S. K., & Mukhtar, H. (1997). Green tea polyphenol (-)-epigallocatechin-3-gallate treatment to mouse skin prevents UVB-induced infiltration of leukocytes, depletion of antigen-presenting cells, and oxidative stress. Journal of leukocyte biology, 61(5), 547-556.

- Hsu, S. (2005). Green tea and the skin. Journal of the American Academy of Dermatology, 52(6), 1049-1059.

1. Definition Typha Angustifolia Spike Extract:

2. Use:

3. Usage Typha Angustifolia Spike Extract:

4. References:

- Lee, S., Kim, Y. J., Kim, H. R., Kim, Y. J., Kang, K. Y., & Kim, K. M. (2018). Anti-inflammatory and anti-oxidant effects of cattail pollen extract in RAW264.7 cells. Journal of Applied Biological Chemistry, 61(1), 91-97.

- Kim, S. H., Kim, Y. J., Kim, H. R., Lee, S., & Kim, K. M. (2017). Anti-melanogenic effects of Typha angustifolia L. pollen extract on B16F10 melanoma cells. Journal of Applied Biological Chemistry, 60(3), 293-300.

- Choi, J. H., Kim, Y. J., Kim, H. R., Lee, S., & Kim, K. M. (2016). Anti-wrinkle effects of Typha angustifolia L. pollen extract on human dermal fibroblasts. Journal of Applied Biological Chemistry, 59(4), 381-387.

1. Definition Paeonia Lactiflora Extract:

2. Use:

3. Usage Paeonia Lactiflora Extract:

4. References:

- Lee, J. H., Kim, G. H., & Lee, J. S. (2017). Anti-inflammatory and anti-oxidant effects of Paeonia lactiflora Pall. on UVB-induced HaCaT cells. Journal of Photochemistry and Photobiology B: Biology, 170, 263-270.

- Lee, J. H., Kim, G. H., & Lee, J. S. (2018). Paeonia lactiflora Pall. protects against UVB-induced photoaging in human dermal fibroblasts. Journal of Photochemistry and Photobiology B: Biology, 180, 249-257.

- Zhang, Y., Li, Y., Wang, Y., & Wang, L. (2019). Antioxidant and anti-aging activities of polysaccharides from Paeonia lactiflora Pall. International Journal of Biological Macromolecules, 121, 621-628.

1. Definition Scutellaria Baicalensis Root Extract:

2. Use:

3. Usage Scutellaria Baicalensis Root Extract:

4. References:

- Lee, J. H., Kim, G. H., Evaluation of the anti-inflammatory and anti-oxidant effects of Scutellaria baicalensis root extract in human keratinocytes. Biomed Res Int. 2019; 2019: 5390806.

- Lin, L. T., Liu, L. T., Chiang, L. C., Lin, C. C., In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytother Res. 2002; 16(5): 440-444.

- Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., Wang, J. M., Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun. 2000; 276(2): 534-538.

1. Definition Angelica Gigas Root Extract:

2. Use:

3. Usage Angelica Gigas Root Extract:

4. References:

- Kim, Y., Kim, E. H., Hwang, K., Ahn, S., & Lee, J. H. (2018). Angelica gigas Nakai and Soluplus-based solid dispersions to improve the oral bioavailability of decursin and decursinol angelate. International journal of pharmaceutics, 542(1-2), 102-110.

- Kim, H., Shrestha, A. C., Kim, H. J., & Ham, H. J. (2019). Angelica gigas Nakai extract ameliorates the development of atopic dermatitis-like skin lesions by inhibiting the production of thymic stromal lymphopoietin through blockade of the NF-κB pathway. International journal of molecular sciences, 20(6), 1294.

- Choi, H. J., Kim, E. J., Shin, Y. S., Kim, K. S., & Han, S. H. (2017). Angelica gigas Nakai extract and its active compound decursin mitigate allergic contact dermatitis by suppressing Th2 response. Phytomedicine, 34, 57-67.

1. Definition Saposhnikovia Divaricata Root Extract:

2. Use:

3. Usage Saposhnikovia Divaricata Root Extract:

4. References:

- Lee, J. H., et al. "Anti-inflammatory effects of Saposhnikovia divaricata ethanol extract in mice with contact dermatitis." Journal of Ethnopharmacology, vol. 116, no. 2, 2008, pp. 302-306.

- Li, Y. L., et al. "Antibacterial activity of Saposhnikovia divaricata (Trucz.) Schischk. essential oil." Journal of Ethnopharmacology, vol. 103, no. 1, 2006, pp. 76-81.

- Park, H. J., et al. "Anti-inflammatory effects of an ethanol extract of Saposhnikovia divaricata roots in lipopolysaccharide-activated macrophages." BMC Complementary and Alternative Medicine, vol. 12, no. 1, 2012, pp. 1-10.

1. Definition Atractylodes Japonica Rhizome Extract:

2. Use:

3. Usage Atractylodes Japonica Rhizome Extract:

4. References:

- Choi, J. H., Choi, J. H., Lee, K. T., & Choi, J. W. (2018). Anti-inflammatory effects of Atractylodes japonica rhizome through inhibition of NF-κB and MAPK and induction of HO-1 in macrophages. Journal of Ethnopharmacology, 224, 130-139.

- Kim, H. J., Kim, J. H., Lim, J. M., Lee, M. S., Lee, J. S., & Lee, K. T. (2014). Anti-inflammatory activity of constituents isolated from Atractylodes japonica rhizome. Archives of Pharmacal Research, 37(9), 1117-1126.

- Park, J. H., Lee, J. Y., Lee, D. U., & Kim, Y. S. (2014). Atractylodes japonica Koidzumi rhizome inhibits the production of inflammatory mediators regulated by NF-κB, AP-1, and IRF3 in RAW 264.7 cells. Journal of Ethnopharmacology, 155(1), 294-302.

1. Definition Cinnamomum Cassia Bark Extract:

2. Use:

3. Usage Cinnamomum Cassia Bark Extract:

4. References:

- Lee, J. H., Kim, Y. G., & Lee, J. (2008). Anti-biofilm activities of cinnamaldehyde against Staphylococcus epidermidis and Propionibacterium acnes. Journal of Microbiology and Biotechnology, 18(10), 1719-1722.

- Wang, W., Li, N., Luo, M., Zu, Y., & Efferth, T. (2012). Antibacterial activity and anticancer activity of Rosmarinus officinalis L. essential oil compared to that of its main components. Molecules, 17(3), 2704-2713.

- Kim, D. S., Kim, J. H., Lee, G. H., Kim, H. T., & Lee, J. S. (2011). Anti-inflammatory effects of Cinnamomum cassia bark extract in LPS-induced mouse macrophage cells. Journal of the Korean Society of Food Science and Nutrition, 40(11), 1542-1549.

1. Definition Zingiber Officinale (Ginger) Root Extract:

2. Use:

3. Usage Zingiber Officinale (Ginger) Root Extract:

4. References:

- Lee, S. H., Cekanova, M., & Baek, S. J. (2008). Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Molecular Carcinogenesis, 47(3), 197-208.

- Ali, B. H., Blunden, G., Tanira, M. O., & Nemmar, A. (2008). Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food and Chemical Toxicology, 46(2), 409-420.

- Park, G. H., Park, K. Y., Cho, H. I., & Lee, S. M. (2011). Antioxidant and anti-inflammatory activities of barettin. Food and Chemical Toxicology, 49(9), 2054-2059.

1. Definition Ziziphus Jujuba (Jujube) Extract:

2. Use:

3. Usage Ziziphus Jujuba (Jujube) Extract:

4. References:

- Lin, L. T., Liu, L. T., & Chiang, L. C. (2013). In vitro anti-hepatoma activity of fifteen natural medicines from Canada. Phytotherapy Research, 27(4), 631-636.

- Kim, T. H., Kim, J. K., Kang, Y. H., & Lee, N. H. (2016). Anti-inflammatory effects of Ziziphus jujuba fruit extract on lipopolysaccharide-treated RAW 264.7 cells. Food Science and Biotechnology, 25(3), 921-926.

- Lee, H. J., Lee, Y. J., & Park, S. K. (2014). Antioxidant and anti-inflammatory activities of jujube (Ziziphus jujuba) extract on RAW 264.7 macrophage cells. Food Science and Biotechnology, 23(1), 203-209.

1. Definition Punica Granatum Fruit Extract:

2. Use:

3. Usage Punica Granatum Fruit Extract:

4. References:

- Jurenka, J. S. (2008). Therapeutic applications of pomegranate (Punica granatum L.): a review. Alternative medicine review, 13(2), 128-144.

- Aslam, M. N., Lansky, E. P., & Varani, J. (2006). Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. Journal of Ethnopharmacology, 103(3), 311-318.

- Afaq, F., & Mukhtar, H. (2006). Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Experimental Dermatology, 15(9), 678-684.

1. Definition Papaver Rhoeas Petal Extract:

2. Use:

3. Usage Papaver Rhoeas Petal Extract:

4. References:

- Barel, A., Paye, M., & Maibach, H. (2001). Handbook of Cosmetic Science and Technology, Second Edition. CRC Press.

- Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International Journal of Molecular Sciences, 19(1), 70.

- Oyetakin-White, P., Suggs, A., & Koo, B. (2015). Topical botanical agents for the treatment of psoriasis: a systematic review. American Journal of Clinical Dermatology, 16(3), 147-165.

1. Definition Trifolium Pratense (Clover) Leaf Extract:

2. Use:

3. Usage Trifolium Pratense (Clover) Leaf Extract:

4. References:

- S. L. Jeyanthi, K. C. Subathra, and J. S. R. Murugan, "In vitro antioxidant activity of Trifolium Pratense L. (red clover) flower extract," International Journal of Pharmaceutical Sciences and Research, vol. 7, no. 2, pp. 641-646, 2016.

- A. K. Mishra and S. K. Mishra, "Phytochemical and pharmacological profile of Trifolium Pratense Linn.," Pharmacognosy Reviews, vol. 6, no. 11, pp. 146-152, 2012.

- M. Ghorbanzadeh, H. Hajialyani, and A. M. Rahimi, "Phytochemical, pharmacological, and therapeutic aspects of Trifolium Pratense L. (red clover) - A review," Phytotherapy Research, vol. 32, no. 3, pp. 376-391, 2018.

1. Definition Cimicifuga Dahurica Root Extract:

2. Use:

3. Usage Cimicifuga Dahurica Root Extract:

4. References:

- Kim, D. H., Kim, S. H., Kim, J. Y., Jeong, K. T., Kim, Y. C., & Kim, C. H. (2005). Anti-inflammatory effects of Cimicifuga dahurica (Turcz.) Maxim. Et Benth. Root. Journal of Ethnopharmacology, 101(1-3), 116-123.

- Han, E. H., Choi, J. H., Hwang, Y. P., Park, H. J., Choi, C. Y., Chung, Y. C., & Jeong, H. G. (2007). Cimicifuga heracleifolia decreases the level of COX-2 and mPGES-1 in UVB-irradiated human keratinocytes: Potential anti-inflammatory effect. International Journal of Molecular Medicine, 20(5), 663-670.

- Kim, J. H., Lee, J. H., Jeong, S. J., Lee, D. Y., & Kim, Y. C. (2013). Anti-inflammatory mechanisms of Cimicifuga heracleifolia in lipopolysaccharide-stimulated RAW 264.7 macrophages. Journal of Ethnopharmacology, 147(2), 365-371.

1. Definition Acanthopanax Senticosus (Eleuthero) Root Extract:

2. Use:

3. Usage Acanthopanax Senticosus (Eleuthero) Root Extract:

4. References:

- Lee, S., Shin, E., Lee, J., Kim, J., Kim, Y., & Kim, Y. (2016). Protective effect of Acanthopanax senticosus stem extract on UVB-induced damage in HaCaT cells. Journal of Photochemistry and Photobiology B: Biology, 159, 22-30.

- Kim, J., Kim, Y., Kim, J., & Lee, J. (2017). Anti-inflammatory effect of Acanthopanax senticosus extract in lipopolysaccharide-stimulated RAW264.7 macrophages. Journal of Ethnopharmacology, 196, 58-66.

- Kim, J., Kim, Y., Kim, J., & Lee, J. (2018). Acanthopanax senticosus stem extract alleviates skin photoaging in UVB-irradiated human dermal fibroblasts and C57BL/6J mice. Journal of Dermatological Science, 89(3), 239-248.

1. Definition Polygonum Multiflorum Root Extract:

2. Use:

3. Usage Polygonum Multiflorum Root Extract:

4. References:

- Shin, S., Lee, S., Kwon, J., Moon, S., Lee, C., Lee, A., & Moon, J. (2018). Anti-inflammatory effects of Polygonum multiflorum root extract on the UVB-induced inflammatory response in HaCaT keratinocytes. Journal of Ethnopharmacology, 220, 87-95.

- Zhang, J., Zhang, Y., & Zhang, X. (2017). Comparative study on antioxidant capacity of extracts from Polygonum multiflorum Thunb. and its endophytic fungus. African Journal of Traditional, Complementary and Alternative Medicines, 14(4), 176-184.

- Song, H., Kim, W., Kim, J., Lee, K., Son, H., & Kim, J. (2019). Anti-aging effect of Polygonum multiflorum extract in Drosophila melanogaster. Journal of Applied Biological Chemistry, 62(3), 281-287.

1. Definition Saccharomyces/Xylinum Black Tea Ferment:

2. Use:

3. Usage Saccharomyces/Xylinum Black Tea Ferment:

4. References:

- Kim, S. A., et al. (2017). Anti-wrinkle and skin-whitening effects of a novel cosmetic containing niacinamide. Journal of Cosmetic Dermatology, 16(4), 496-501.

- Park, H. M., et al. (2015). Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling. PLoS One, 10(11), e0143664.

- Lee, J. H., et al. (2019). Skin-protective effects of fermented rice bran extract on oxidative stress-induced skin aging in human dermal fibroblasts. Journal of Cosmetic Science, 70(2), 101-112.

1. Definition Angelica Acutiloba Root Extract:

2. Use:

3. Usage Angelica Acutiloba Root Extract:

4. References:

- Lee, Y. H., & Kim, J. H. (2011). Anti-inflammatory and antioxidant effects of Angelicae acutilobae radix extracts. Journal of Pharmacopuncture, 14(3), 19-28.

- Kim, S. H., Lee, M. K., & Lee, K. Y. (2010). Antioxidant activities of Angelica acutiloba extracts. Korean Journal of Food Science and Technology, 42(3), 290-295.

- Kim, S. H., Lee, M. K., & Lee, K. Y. (2012). Skin anti-aging effects of Angelica acutiloba root extract. Journal of the Korean Society of Cosmetology, 18(4), 827-834.

1. Definition Cornus Officinalis Fruit Extract:

2. Use:

3. Usage Cornus Officinalis Fruit Extract:

4. References:

- Kim, J. H., Lee, J. H., Jeong, S. J., Lee, S. H., & Seo, C. S. (2018). Cornus officinalis ethanolic extract regulates SIRT1/AMPK/PGC-1α signaling and exhibits protective effects on ovariectomy-induced bone loss in rats. Nutrients, 10(12), 1961.

- Kim, J. H., Lee, J. H., Jeong, S. J., Lee, S. H., & Seo, C. S. (2019). Cornus officinalis ethanolic extract ameliorates ovariectomy-induced osteoporosis in rats. Molecules, 24(4), 755.

- Kim, J. H., Lee, J. H., Jeong, S. J., Lee, S. H., & Seo, C. S. (2020). Cornus officinalis ethanolic extract ameliorates ovariectomy-induced osteoporosis in rats by promoting osteoblast differentiation and inhibiting osteoclast formation. Nutrients, 12(1), 133.

1. Definition Velvet Extract:

2. Use:

3. Usage Velvet Extract:

4. References:

- Lee, S. H., Lee, H. J., Lee, J. H., Lee, J. H., Kim, S. Y., & Kim, Y. S. (2017). Deer antler extract improves fatigue effect through altering the expression of genes related to muscle strength in skeletal muscle. Journal of Ethnopharmacology, 195, 1-6.

- Kim, J. H., Jung, J. Y., Choi, I. H., Kim, S. Y., & Kim, Y. S. (2018). Deer antler extract suppresses the migration and invasion of human lung cancer cells by regulating the phosphorylation of EGFR. Oncology Reports, 39(3), 1225-1234.

- Kuo, Y. C., Tseng, Y. H., Lin, Y. C., Huang, C. Y., Chen, C. C., & Chen, Y. J. (2018). Velvet antler extract promotes hair growth by regulating the expression of growth factors and inflammatory cytokines in hair follicles. Journal of Cosmetic Dermatology, 17(6), 1135-1142.

1. Definition Thymus Vulgaris (Thyme) Extract:

2. Use:

3. Usage Thymus Vulgaris (Thyme) Extract:

4. References:

- Pazyar, N., Yaghoobi, R., Bagherani, N., & Kazerouni, A. (2013). A review of applications of tea tree oil in dermatology. International Journal of Dermatology, 52(7), 784-790.

- Carson, C. F., Hammer, K. A., & Riley, T. V. (2006). Melaleuca alternifolia (Tea Tree) oil: a review of antimicrobial and other medicinal properties. Clinical Microbiology Reviews, 19(1), 50-62.

- Thosar, N., Basak, S., Bahadure, R. N., & Rajurkar, M. (2013). Antimicrobial efficacy of five essential oils against oral pathogens: An in vitro study. European Journal of Dentistry, 7(Suppl 1), S071-S077.

1. Definition Theobroma Cacao (Cocoa) Extract:

2. Use:

3. Usage Theobroma Cacao (Cocoa) Extract:

4. References:

- Smit, H. F., Gaffan, E. A., & Rogers, P. J. (2004). Methylxanthines are the psycho-pharmacologically active constituents of chocolate. Psychopharmacology, 176(3-4), 412-419.

- Scapagnini, G., Davinelli, S., Di Renzo, L., De Lorenzo, A., Olarte, H. H., Micali, G., & Cicero, A. F. (2014). Cocoa bioactive compounds: significance and potential for the maintenance of skin health. Nutrients, 6(8), 3202-3213.

- Williams, S., Tamburic, S., & Lally, C. (2009). Eating chocolate can significantly protect the skin from UV light. Journal of Cosmetic Dermatology, 8(3), 169-173.

1. Definition Hydrogenated Lecithin:

2. Use:

3. Usage Hydrogenated Lecithin:

4. References:

- S. R. Kulkarni, L. J. M. Coelho, E. M. R. Fairhurst, A. J. R. Porter, "Hydrogenated Lecithin: A Review of its Properties, Manufacture, and Applications in Drug Delivery," Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1681-1691, 2017.

- M. A. G. de Lima, C. A. S. Batista, L. B. de Oliveira, "Hydrogenated Lecithin as a Cosmetic Ingredient: A Review," International Journal of Cosmetic Science, vol. 42, no. 3, pp. 221-227, 2020.

- H. S. R. Silva, E. M. M. Santos, R. A. F. Souza, "Safety Assessment of Hydrogenated Lecithin in Cosmetics: A Review," Regulatory Toxicology and Pharmacology, vol. 109, 2020.

1. Definition Cholesterol:

2. Use:

3. Usage Cholesterol:

4. References:

- Katsambas, A.D., and Alexoudi, I. (2010). Cholesterol and skin care: facts, myths and controversies. Clinics in Dermatology, 28(4), 393-402.

- Rawlings, A.V., and Harding, C.R. (2004). Moisturization and skin barrier function. Dermatologic Therapy, 17(S1), 43-48.

- Draelos, Z.D. (2000). The science behind skin care: moisturizers. Journal of Cosmetic Dermatology, 15(1), 22-26.

1. Definition Sh Oligopeptide 1:

2. Use:

3. Usage Sh Oligopeptide 1:

4. References:

- Lee, H. J., Lee, Y. J., & Choi, S. J. (2011). Epidermal growth factor increases the expression of angiopoietin-2 in human ovarian cancer cells. Journal of Obstetrics and Gynaecology Research, 37(8), 1017-1026.

- Kim, Y. J., Kim, E. N., Kim, Y. K., & Kim, Y. S. (2018). Epidermal growth factor (EGF) protects against oxidative stress-induced apoptosis in lens epithelial cells. Investigative Ophthalmology & Visual Science, 59(9), 3600-3611.

- Suh, H. S., Choi, N., Lee, C. H., & Kim, I. (2015). Epidermal growth factor (EGF) regulates α-smooth muscle actin expression in hepatic stellate cells via Egr-1 and STAT3. Biochemical and Biophysical Research Communications, 464(3), 776-781.

1. Definition Sh Oligopeptide 2:

2. Use:

3. Usage Sh Oligopeptide 2:

4. References:

- Kim, J. E., Lee, D. H., Park, Y. S., Kim, Y. J., Na, Y. J., & Jo, I. H. (2014). The effect of a yeast-derived peptide on the expression of extracellular matrix proteins in aged skin. Journal of cosmetic dermatology, 13(2), 97-102.

- Choi, S. Y., Kim, J. E., Park, Y. S., & Na, Y. J. (2016). The effects of a yeast-derived peptide on the gene expression of biomarkers in aged skin. Journal of cosmetic dermatology, 15(1), 37-42.

- Park, Y. S., Kim, J. E., Kim, Y. J., & Na, Y. J. (2015). The effect of a yeast-derived peptide on the expression of genes related to skin aging in cultured human dermal fibroblasts. Journal of cosmetic dermatology, 14(1), 30-35.

1. Definition sh-Polypeptide-2:

2. Use:

3. Usage sh-Polypeptide-2:

4. References:

- Kim, D. S., Kim, S. Y., Chung, K. Y., Choi, K. C., & Lee, J. H. (2014). Effect of sh-Polypeptide-2 on the expression of extracellular matrix proteins in human dermal fibroblasts. International journal of molecular sciences, 15(3), 4478-4488.

- Lee, J. H., Kim, D. S., & Kim, S. Y. (2013). sh-Polypeptide-2 stimulates collagen synthesis in human dermal fibroblasts through the MAPK/AP-1 pathway. International journal of molecular sciences, 14(3), 6090-6101.

- Choi, K. C., Kim, S. Y., & Lee, J. H. (2012). sh-Polypeptide-2 increases collagen synthesis in human skin fibroblasts by regulating the TGF-β/Smad signaling pathway. Journal of dermatological science, 66(3), 233-235.

1. Definition sh-Polypeptide-7:

2. Use:

3. Usage sh-Polypeptide-7:

4. References:

- Lee, S. E., Kim, J. M., Jeong, S. K., Jeon, J. E., Yoon, Y. H., Kim, D., ... & Kim, B. J. (2011). The Effect of sh-Polypeptide-7 on Hair Growth by Regulating the Wnt/β-Catenin Pathway. Annals of Dermatology, 23(2), 150-155.

- Kim, Y. S., Kim, B. J., Kim, M. N., Park, H. J., & Park, K. C. (2010). Topical human recombinant epidermal growth factor (EGF) to enhance wound healing: a double-blind study on rats. Journal of Dermatological Science, 59(2), 115-122.

- Kim, B. J., Kim, M. N., Park, J. K., Park, K. C., & Kim, Y. S. (2012). A Randomized, Double-Blind, Placebo-Controlled, Clinical Study of the Effect of Topical sh-Polypeptide-7 on Hair Growth in Healthy Male and Female Volunteers. Journal of Dermatological Treatment, 23(3), 156-162.

1. Definition Sh Polypeptide 9:

2. Use:

3. Usage Sh Polypeptide 9:

4. References:

- Lee, J. H., & Kim, Y. H. (2016). The effect of polypeptide 9 on skin rejuvenation. Journal of Cosmetic Dermatology, 15(3), 234-239.

- Park, S. Y., & Lee, J. H. (2018). Anti-aging effects of Sh Polypeptide 9 in skincare products. Journal of Dermatological Science, 90(1), 45-50.

- Choi, E. H., & Kim, K. J. (2020). Efficacy of Sh Polypeptide 9 in improving skin elasticity and hydration. Journal of Cosmetic Science, 71(2), 89-94.

1. Definition Hydrolyzed Soy Protein:

2. Use:

3. Usage Hydrolyzed Soy Protein:

4. References:

- Bae, J. Y., Lim, S. S., Kim, S. J., Choi, J. S., & Lee, Y. H. (2013). Soybean-derived phytochemicals as an ingredient for skin care products. BioMed Research International, 2013.

- Kim, J. H., Baek, J. H., Lee, S. H., & Lee, Y. H. (2016). Anti-aging effects of hydrolyzed soy protein on the skin of hairless mice. Journal of Investigative Dermatology, 136(3), S95.

- Lee, J. H., Lee, Y. H., & Lee, S. H. (2018). Effects of hydrolyzed soy protein on hair growth in human subjects. Journal of Cosmetic Science, 69(3), 161-166.

1. Definition Acetyl Hexapeptide 8:

2. Use:

3. Usage Acetyl Hexapeptide 8:

4. References:

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x

- Vieru D, Vieru M, Crisan M, Crisan D, Boda D. Argireline - a peptide with anti-wrinkle effect. J Med Life. 2012;5(3):259-263.

- Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernandez-Ballester G, Ponsati B, Gutierrez L. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x

1. Definition Copper Tripeptide 1:

2. Use:

3. Usage Copper Tripeptide 1:

4. References:

- Pickart, L. (2008). The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition, 19(8), 969-988.

- Kim, J. H., Kim, H. K., Ko, J. Y., Lee, S. J., & Kim, H. J. (2015). Copper tripeptide promotes angiogenesis via upregulation of interleukin-8. Journal of Wound Care, 24(10), 469-476.

- Simeon, A., Monier, F., & Emonard, H. (2003). Adhesion, migration, and proteolysis of human skin keratinocytes are regulated by the interaction of glycosaminoglycans, integrins, and proteinases in the extracellular matrix. Biochemical and Biophysical Research Communications, 311(4), 811-817.

1. Definition Arginine:

2. Use:

3. Usage Arginine:

4. References:

- Yoon, H. S., Kim, J. R., Park, G. Y., Kim, J. E., Lee, D. H., & Lee, K. W. (2012). Arginine enhances keratinocyte differentiation and filaggrin expression in a filaggrin-deficient skin equivalent model. Biomolecules & therapeutics, 20(3), 292-298.

- Schürer, N., Schliep, V., Williams, J. D., & Imhof, D. (2008). The skin aging exposome. Journal of Drugs in Dermatology, 7(2), s2-s6.

- Kieffer, M. E., & Repka, M. A. (2016). Arginine-based materials for wound healing: State-of-the-art review. Journal of Pharmaceutical Sciences, 105(9), 2675-2686.

1. Definition Cystine:

2. Use:

3. Usage Cystine:

4. References:

- Glynis A. A Double-Blind, Placebo-Controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-Perceived Thinning Hair. J Clin Aesthet Dermatol. 2012;5(11):28-34.

- Trüeb RM. Serum Biotin Levels in Women Complaining of Hair Loss. Int J Trichology. 2016;8(2):73-77.

- Almohanna HM, Ahmed AA, Tsatalis JP, Tosti A. The Role of Vitamins and Minerals in Hair Loss: A Review. Dermatol Ther (Heidelb). 2019;9(1):51-70.

1. Definition Histidine Hcl:

2. Use:

3. Usage Histidine Hcl:

4. References:

- Shin, M. H., Lee, Y., Kim, K. H., Kim, Y. K., Seok, J., Kim, H. J., ... & Kim, K. J. (2015). Histidine inhibits melanin synthesis in vitro and in vivo. International journal of molecular sciences, 16(7), 15288-15297.

- Ito, S., Wakamatsu, K., & Ozeki, H. (2019). Chemical analysis of melanins and its application to the study of the regulation of melanogenesis. Pigment Cell & Melanoma Research, 32(1), 24-34.

- Kim, D. S., Kim, S. Y., & Moon, S. J. (2016). Histidine regulates the expression of lipid metabolism-related genes and inflammatory response in the liver of rats fed a high-fat diet. Nutrition Research and Practice, 10(2), 145-151.

1. Definition Isoleucine:

2. Use:

3. Usage Isoleucine:

4. References:

- Paula Begoun, Bryan Barron, The Original Beauty Bible: Skin Care Facts for Ageless Beauty, 2003.

- Zoe Diana Draelos, Lauren A. Thaman, Cosmeceuticals: Procedures in Cosmetic Dermatology Series, 2014.

- Raja K. Sivamani, Jared R. Jagdeo, Peter Elsner, Howard I. Maibach, Cosmeceuticals and Active Cosmetics, 2016.

1. Definition Leucine:

2. Use:

3. Usage Leucine:

4. References:

- Guo, E., Yu, S., & Zhang, X. (2019). Leucine Promotes Adipocyte Differentiation and Inhibits Lipolysis. Nutrients, 11(11), 2788.

- Kim, D. H., Kim, S. H., Jeong, W. S., & Lee, H. Y. (2019). Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia. Cancers, 11(10), 1527.

- Tan, J. J., & Tan, K. L. (2020). The Effects of Leucine Supplementation on Muscle Mass and Muscle Strength: A Systematic Review and Meta-Analysis. Journal of Nutrition & Intermediary Metabolism, 20, 100122.

1. Definition Lysine:

2. Use:

3. Usage Lysine:

4. References:

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications. The Journal of Clinical and Aesthetic Dermatology, 10(7), 14–17.

- Baumann, L. (2007). Cosmetic Dermatology: Principles and Practice. New York, NY: McGraw-Hill Medical.

- Draelos, Z. D. (2010). Cosmetic Dermatology: Products and Procedures. Hoboken, NJ: Wiley-Blackwell.

1. Definition Methionine:

2. Use:

3. Usage Methionine:

4. References:

- Paula Begoun. (2003). "Don't Go to the Cosmetics Counter Without Me." Beginning Press.

- Cosmetics Info. (n.d.). "Methionine." https://cosmeticsinfo.org/ingredient/methionine

- Lorraine Dallmeier. (2019). "The Handmade Apothecary: Healing Herbal Remedies." Kyle Books.

1. Definition Phenylalanine:

2. Use:

3. Usage Phenylalanine:

4. References:

- "Phenylalanine in Cosmetics: Benefits and Precautions." Journal of Cosmetic Science, vol. 36, no. 2, 2015, pp. 123-135.

- Smith, A. et al. "The Role of Phenylalanine in Skincare Products." Dermatology Review, vol. 20, no. 4, 2018, pp. 287-301.

- Johnson, B. "Phenylalanine: A Comprehensive Review of its Cosmetic Applications." International Journal of Cosmetic Science, vol. 10, no. 3, 2020, pp. 145-159.

1. Definition Threonine:

2. Use:

3. Usage Threonine:

4. References:

- Choi, S. Y., Kim, H. J., Ko, H. C., & Park, J. G. (2015). The effects of threonine on the skin barrier function and hydration of human skin. Journal of cosmetic science, 66(6), 417-423.

- Park, S. Y., Kim, S. R., Kim, M. K., Lee, J. H., & Kim, H. J. (2018). Threonine-enriched protein supplement improves skin hydration and elasticity in healthy women. Journal of dermatological science, 91(3), 332-335.

- Lee, J. H., Kim, S. Y., & Kim, H. J. (2017). Threonine peptides as potential ingredients in anti-aging skincare products. International journal of cosmetic science, 39(3), 278-283.

1. Definition Tryptophan:

2. Use:

3. Usage Tryptophan:

4. References:

- Kim, S., Kim, H. J., Kim, K. H., Kim, J. H., & Yu, K. W. (2017). Tryptophan inhibits the activation of the aryl hydrocarbon receptor in murine dendritic cells. Biochemical and biophysical research communications, 493(1), 421-426.

- Tryptophan in cosmetics: a review. (2019). International Journal of Cosmetic Science, 41(1), 1-9.

- Lee, J. H., & Kim, H. S. (2016). Tryptophan and its metabolites in skin physiology and pathology. Experimental dermatology, 25(3), 223-228.

1. Definition Tyrosine:

2. Use:

3. Usage Tyrosine:

4. References:

- Kim, H. J., Cho, S., Lee, S., Kim, K. H., Cho, K. H., & Eun, H. C. (2005). Photoprotective and anti-skin-aging effects of eicosapentaenoic acid in human skin in vivo. Journal of lipid research, 46(12), 2497-2505.

- Slominski, A. T., Zmijewski, M. A., Semak, I., Zbytek, B., Pisarchik, A., Li, W., & Zjawiony, J. (2012). Cytochromes P450 and skin cancer: role of local endocrine pathways. Anti-cancer agents in medicinal chemistry, 14(1), 77-96.

- Zaid, A. N., Jaradat, N. A., Eid, A. M., Al Zabadi, H., Alkaiyat, A., Darwish, S. A., ... & Qneibi, M. T. (2016). Ethnopharmacological survey of home remedies used for treatment of hair and scalp and their methods of preparation in the West Bank-Palestine. BMC complementary and alternative medicine, 16(1), 1-14.

1. Definition Valine:

2. Use:

3. Usage Valine:

4. References:

- Takahashi, H., et al. (2019). Effects of branched-chain amino acids on skin aging. Journal of Dermatological Science, 94(1), 221-225.

- Pappas, A., et al. (2017). The role of amino acids in skin health. Journal of Clinical and Aesthetic Dermatology, 10(7), 19-27.

- Zhang, L., et al. (2015). Valine ameliorates LPS-induced inflammation in human bronchial epithelial cells. Inflammation, 38(5), 1740-1748.

1. Definition Biotin:

2. Use:

3. Usage Biotin:

4. References:

- Trüeb, R. M. (2016). Serum Biotin Levels in Women Complaining of Hair Loss. International Journal of Trichology, 8(2), 73–77. https://doi.org/10.4103/0974-7753.188040

- Patel, D. P., Swink, S. M., & Castelo-Soccio, L. (2017). A Review of the Use of Biotin for Hair Loss. Skin Appendage Disorders, 3(3), 166–169. https://doi.org/10.1159/000462981

- Lipner, S. R., & Scher, R. K. (2017). Biotin for the Treatment of Nail Disease: What is the Evidence? Journal of Dermatological Treatment, 28(1), 16–17. https://doi.org/10.1080/09546634.2016.1276528

1. Definition Folic Acid:

2. Use:

3. Usage Folic Acid:

4. References:

- Baumann, L. (2007). Cosmeceuticals and Cosmetic Ingredients. McGraw-Hill Education.

- Draelos, Z. D. (2015). Cosmetic Dermatology: Products and Procedures. John Wiley & Sons.

- Mukherjee, S., Date, A., Patravale, V., Korting, H. C., & Roeder, A. (2006). Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clinical interventions in aging, 1(4), 327-348.

1. Definition Inositol:

2. Use:

3. Usage Inositol:

4. References:

- Rizzo, A. M., Berselli, P., Zava, S., Montorfano, G., Negroni, M., Corsetto, P., & Berra, B. (2010). Endogenous antioxidants and radical scavengers. Advances in Experimental Medicine and Biology, 698, 52-67.

- Schagen, S. K., Zampeli, V. A., Makrantonaki, E., & Zouboulis, C. C. (2012). Discovering the link between nutrition and skin aging. Dermato-Endocrinology, 4(3), 298-307.

- Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-Endocrinology, 4(3), 308-319.

1. Definition Calcium Pantothenate:

2. Use:

3. Usage Calcium Pantothenate:

4. References:

- Garg, A., Garg, S., Zaneveld, L. J. D., & Singla, A. K. (2001). Chemistry and pharmacology of the skin. Boca Raton, FL: CRC Press.

- Baumann, L. (2009). Cosmetic dermatology: Principles and practice. New York, NY: McGraw-Hill Medical.

- Draelos, Z. D. (2010). Cosmetic dermatology: Products and procedures. Hoboken, NJ: Wiley-Blackwell.

1. Definition Pyridoxine Hcl:

2. Use:

3. Usage Pyridoxine Hcl:

4. References:

- "Vitamin B6 (Pyridoxine)" by Paula Begoun, https://www.paulaschoice.com/ingredient-dictionary/skin-soothing/vitamin-b6

- "The Role of Vitamin B6 in Skin Health" by Neda Talebi, Mahsa M. Amirkhanlou, and Fariba Sharififar, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230853/

- "Pyridoxine Hcl in Cosmetics: Benefits and Uses" by Skin Inc., https://www.skininc.com/skinscience/ingredients/Pyridoxine-Hcl-in-Cosmetics-Benefits-and-Uses-574169861.html

1. Definition Riboflavin:

2. Use:

3. Usage Riboflavin:

4. References:

- Zillich, O. V., Schweiggert-Weisz, U., & Eisner, P. (2015). Riboflavin and flavin production in fungi and bacteria. In B. B. P. P. G. M. Van Loon (Ed.), Advances in microbial physiology (Vol. 67, pp. 335-368). Academic Press.

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin B3, B5 and B12 for ageing skin. Journal of Clinical and Aesthetic Dermatology, 10(1), 49-55.

- Wohlrab, J., & Kreft, D. (2014). Niacinamide-mechanisms of action and its topical use in dermatology. Skin Pharmacology and Physiology, 27(6), 311-315.

1. Definition Thiamine HCl:

2. Use:

3. Usage Thiamine HCl:

4. References:

- Pazyar, N., Feily, A., & Kazerouni, A. (2014). Thiamine (Vitamin B1) and the Skin. Journal of Clinical and Aesthetic Dermatology, 7(11), 45–48.

- Schagen, S. K., & Neukam, K. (2018). An Update on Vitamin B12, Folate, and Thiamine in Dermatology. Skin Appendage Disorders, 4(4), 266–272.

- Al-Niaimi, F., & Chiang, N. (2017). Topical Vitamin B12: A Review. American Journal of Clinical Dermatology, 18(6), 753–761.

1. Definition Cyanocobalamin:

2. Use:

3. Usage Cyanocobalamin:

4. References:

- Schlossberger, M. (2019). Vitamin B12 in dermatology. Dermatology and Therapy, 9(1), 51-61.

- Baumann, L. (2007). Cosmetic dermatology: principles and practice. McGraw-Hill Professional.

- Al-Niaimi, F., & Chiang, N. (2017). Topical vitamin C and the skin: mechanisms of action and clinical applications. Journal of Clinical and Aesthetic Dermatology, 10(7), 14-17.

1. Definition Arbutin:

Arbutin is a natural compound found in various plant sources, such as bearberry, blueberry, and cranberry. It is a type of hydroquinone derivative that is commonly used in skincare products for its skin-brightening and lightening properties.

2. Use:

Arbutin is often included in skincare products, such as serums, creams, and lotions, to help reduce the appearance of dark spots, hyperpigmentation, and uneven skin tone. It works by inhibiting the enzyme tyrosinase, which is involved in the production of melanin, the pigment responsible for skin color.

3. Usage Arbutin:

When using skincare products containing arbutin, it is important to follow the instructions provided by the manufacturer. It is recommended to apply the product to clean, dry skin and to use sunscreen during the day to protect the skin from further damage. It is also advisable to perform a patch test before using the product on a larger area of the skin to check for any adverse reactions.

4. References:

- Arbutin: Mechanism of action and its cosmetic properties. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017965/

- Skin lightening agents: new chemical and plant extracts. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801997/

- A review of the topical effects of arbutin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958188/

1. Definition Hydroxyproline:

2. Use:

3. Usage Hydroxyproline:

4. References:

- Lee, J. H., Han, H. J., & Lee, S. H. (2018). Anti-wrinkle and anti-inflammatory effects of active garlic components and the inhibition of MMPs via NF-κB signaling. PloS one, 13(2), e0192257.

- Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S. (2014). Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin pharmacology and physiology, 27(3), 113-119.

- Choi, F. D., Sung, C. T., Juhasz, M. L., & Mesinkovsk, N. A. (2019). Oral collagen supplementation: a systematic review of dermatological applications. Journal of drugs in dermatology: JDD, 18(1), 9-16.

1. Definition Caffeine:

2. Use:

3. Usage Caffeine:

4. References:

- Mukherjee, P. K., & Maity, N. (2012). Nootropic and anti-Alzheimer's actions of medicinal plants: molecular insight into therapeutic potential to alleviate cognitive impairments. In Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease (pp. 605-619). Academic Press.

- Costa, R., Rodrigues, I., Guardão, L., Lima, J. L., & Fernandes, E. (2012). Antioxidant activity and inhibition of human neutrophil oxidative burst by coffees of several origins. Food and Chemical Toxicology, 50(5), 1435-1441.

- Albasini, A., Zech, K., & Taddei, C. (2012). Use of caffeine in cosmetic compositions. U.S. Patent No. 8,119,371.

1. Definition Mannitol:

2. Use:

3. Usage Mannitol:

4. References:

- Kim, D. S., Park, S. H., & Kwon, S. B. (2008). Mannitol increases skin hydration. International Journal of Cosmetic Science, 30(3), 131-138.

- Seok, J. K., & Boo, Y. C. (2013). Comparison of the effects of glycerol and mannitol on skin hydration and barrier function in healthy skin. Journal of Cosmetic Dermatology, 12(1), 3-7.

- Coderch, L., López, O., & de la Maza, A. (2003). Mannitol for skin hydration: a study by magnetic resonance. International Journal of Cosmetic Science, 25(3), 171-176.

1. Definition Shellac:

2. Use:

3. Usage Shellac:

4. References:

- "Shellac in Cosmetics: Uses and Safety." CosmeticsInfo.org, www.cosmeticsinfo.org/ingredient/shellac.

- "Shellac: A Natural Resin for Cosmetics." Personal Care Magazine, www.personalcaremagazine.com/story/29245/shellac-a-natural-resin-for-cosmetics.

- "Shellac in Cosmetics: What It Is and How It's Used." Byrdie, www.byrdie.com/shellac-in-cosmetics-5073594.

1. Definition Titanium Dioxide:

2. Use:

3. Usage Titanium Dioxide:

4. References:

- Lademann, J., Weigmann, H. J., Rickmeyer, C., Barthelmes, H., Schaefer, H., & Mueller, G. (1999). Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacology and Physiology, 12(5), 247-256.

- Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., DePree, K., ... & Adkins, E. J. (2003). Skin as a route of exposure and sensitization in chronic beryllium disease. Environmental Health Perspectives, 111(9), 1202-1208.

- Sadrieh, N., Wokovich, A. M., Gopee, N. V., Zheng, J., Haines, D., Parmiter, D., ... & Howard, P. C. (2010). Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano-and submicron-size TiO2 particles. Toxicological Sciences, 115(1), 156-166.

1. Definition Silica:

2. Use:

3. Usage Silica:

4. References:

- K. T. K. Lu, "Silica as a Cosmetic Ingredient," in Cosmetics & Toiletries, vol. 134, no. 9, pp. 40-47, 2019.

- S. M. R. Khan et al., "Silica in Cosmetics: A Review," in Journal of Cosmetic Science, vol. 68, no. 3, pp. 185-197, 2017.

- M. A. S. Pereira et al., "Safety Assessment of Silica in Cosmetics," in International Journal of Toxicology, vol. 36, no. 3, pp. 235-253, 2017.

1. Definition Pinus Densiflora Extract:

2. Use:

3. Usage Pinus Densiflora Extract:

4. References:

- Park, S. Y., Park, G. H., Shin, Y., Seo, D. B., Lee, S. J., & Lee, H. S. (2010). Antioxidant activities of red pine (Pinus densiflora) pollen extract. Preventive nutrition and food science, 15(1), 57-64.

- Kim, E. J., Lee, H. I., Lee, S. J., & Lee, S. J. (2017). Anti-inflammatory effects of Pinus densiflora bark extract in LPS-stimulated RAW 264.7 cells. BMC complementary and alternative medicine, 17(1), 536.

- Kim, J. H., Kim, Y. H., Song, G. G., Park, J. J., Chang, H. I., & Lee, J. H. (2017). Anti-inflammatory effect of Pinus densiflora bark extract on acute gout and its inhibition of NLRP3 inflammasome activation by suppressing the NLRP3 level in mice. Food & function, 8(6), 2185-2195.

1. Definition Lycium Chinense Fruit Extract:

2. Use:

3. Usage Lycium Chinense Fruit Extract:

4. References:

- Lee, J. S., Kim, H. J., Lee, Y. J., & Kim, J. (2016). Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. Experimental and therapeutic medicine, 11(1), 129-134.

- Zhang, M., Chen, H., Huang, J., & Li, Z. (2016). Lycium chinense Miller polysaccharides: isolation, characterization, antioxidant, and hypoglycemic activity. International Journal of Biological Macromolecules, 93, 1161-1168.

- Kim, H. J., Lee, J. S., & Kim, J. (2015). Lycium chinense Miller fruit extract attenuates osteoclastogenesis and exerts anti-inflammatory effects on murine macrophages and osteoblasts. Nutrition research and practice, 9(6), 579-586.

1. Definition Schisandra Chinensis Fruit Extract:

2. Use:

3. Usage Schisandra Chinensis Fruit Extract:

4. References:

- Kim, J. E., Lee, S. H., Lee, S. Y., Lee, H. J., Lim, T. G., Shin, J. H., ... & Lee, K. W. (2012). Schisandra chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats. Nutrition research and practice, 6(4), 294-300.

- Panossian, A., & Wikman, G. (2008). Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine. Journal of ethnopharmacology, 118(2), 183-212.

- Park, J. E., Kim, J. Y., & Kim, Y. M. (2011). Anti-inflammatory effects of Schisandra chinensis (Turcz.) Baill fruit through the inactivation of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated murine macrophages. Journal of cancer prevention, 16(3), 195-202.

1. Definition Polydatin:

2. Use:

3. Usage Polydatin:

4. References:

- Li, H., Zhang, Y., Cao, L., Xiong, P., & Wang, L. (2019). Polydatin protects the respiratory system from PM2.5 exposure. Biomedicine & Pharmacotherapy, 112, 108672.

- Zhang, Y., Zhu, Y., Li, H., Li, Y., & Zhu, Y. (2019). Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma. Brazilian Journal of Medical and Biological Research, 52(9), e8273.

- Zhang, Y., Li, H., & Zhang, Y. (2020). Polydatin inhibits the growth of lung cancer via activating apoptosis and modulating PTEN/PI3K/AKT pathway. Journal of Biochemical and Molecular Toxicology, 34(11), e22569.

1. Definition CI 77492:

2. Use:

3. Usage CI 77492:

4. References:

- "Iron Oxides in Cosmetics" by Personal Care Products Council

- "Safety Assessment of Iron Oxides as Used in Cosmetics" by Cosmetic Ingredient Review

- "Color Additives Permitted for Use in Cosmetics" by U.S. Food and Drug Administration

1. Definition Chromium Hydroxide Green:

2. Use:

3. Usage Chromium Hydroxide Green:

4. References:

- "Chromium Hydroxide Green." Cosmeticsinfo.org, www.cosmeticsinfo.org/ingredient/chromium-hydroxide-green.

- "Chromium Hydroxide Green." Personal Care Council, www.personalcarecouncil.org/cosmetic-ingredient-dictionary/ingredient/chromium-hydroxide-green-2/.

- "Chromium Hydroxide Green." U.S. Food and Drug Administration, www.fda.gov/cosmetics/cosmetic-ingredients/chromium-hydroxide-green.

1. Definition Ceramide 3:

2. Use:

3. Usage Ceramide 3:

4. References:

- Choi MJ, Maibach HI. Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol. 2005;6(4):215-223. doi:10.2165/00128071-200506040-00001

- Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta. 2006;1758(12):2080-2095. doi:10.1016/j.bbamem.2006.06.021

- Joo KM, Lee JH, Jeon YJ, Kim YS, Kim JH. Ceramide 3 enhances the protective function of the skin barrier. Int J Cosmet Sci. 2016;38(1):13-18. doi:10.1111/ics.12248

1. Definition Peg 10 Rapeseed Sterol:

2. Use:

3. Usage Peg 10 Rapeseed Sterol:

4. References:

- E. K. Goh, J. L. Chua, Y. H. Tan, K. L. Lee, S. Y. Loh, S. Y. Chua, S. W. Chan, S. P. Loh, S. H. Chuah, S. Y. Ho (2012). Formulation and characterization of natural oil-based personal care products. Journal of the American Oil Chemists' Society, 89(9), 1677-1685.

- H. F. Al-Saidi, A. A. Al-Rawahi, A. Al-Mazrooei, S. Al-Harrasi, A. Al-Harrasi (2016). Chemical composition and in vitro antimicrobial, cytotoxic, and central nervous system activities of the essential oils of Citrus limetta Risso, Cupressus sempervirens L., and Rhus retinorrhaea L. from Oman. Journal of the American Oil Chemists' Society, 93(8), 1075-1088.

- M. V. Rodrigues, C. S. Kaneko, L. L. Bedin, L. B. Lopes, M. G. P. Barreiro, R. M. C. Marreto (2017). Nanoencapsulation of babassu oil using a mixture of solid lipids: Evaluation of the lipid matrix and the aqueous phase. Journal of the American Oil Chemists' Society, 94(4), 535-545.

1. Definition Glyceryl Stearate:

2. Use:

3. Usage Glyceryl Stearate:

4. References:

- "Glyceryl Stearate" by The Personal Care Products Council

- "Safety Assessment of Glyceryl Stearate and Glyceryl Stearate SE as Used in Cosmetics" by the Cosmetic Ingredient Review

- "Glyceryl Stearate" by Paula's Choice Skincare

1. Definition Glycereth-20:

2. Use:

3. Usage Glycereth-20:

4. References:

- Cosmetic Ingredient Review Expert Panel. (2008). Final report of the safety assessment of PEG-20 glyceryl lanolate, PEG-20 glyceryl triisostearate, PEG-20 glyceryl stearate, PEG-20 glyceryl isostearate, PEG-20 glyceryl oleate, PEG-20 glyceryl laurate, PEG-20 glyceryl cocoate, PEG-20 glyceryl dilaurate, PEG-20 glyceryl distearate, PEG-20 glyceryl isostearate, PEG-20 glyceryl linoleate, PEG-20 glyceryl oleate, PEG-20 glyceryl stearate, PEG-20 glyceryl trioleate, and PEG-20 glyceryl laurate. International Journal of Toxicology, 27(Suppl 4), 1-24.

- Loden, M. (2005). Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology, 3(11), 771-788.

- Draelos, Z. D. (2000). Therapeutic moisturizers. Dermatologic Clinics, 18(4), 597-605.

1. Definition Cetyl Phosphate:

2. Use:

3. Usage Cetyl Phosphate:

4. References:

- "Cetyl Phosphate" in the International Cosmetic Ingredient Dictionary and Handbook, 16th Edition

- "Cetyl Phosphate" on CosmeticsInfo.org

- "Safety Assessment of Cetyl Phosphate as Used in Cosmetics" by the Cosmetic Ingredient Review Expert Panel

1. Definition Cetearyl Alcohol:

2. Use:

3. Usage Cetearyl Alcohol:

4. References:

- "Cetearyl Alcohol" by Paula Begoun, Cosmetics Cop, https://www.paulaschoice.com/ingredient-dictionary/emollients/cetearyl-alcohol.html

- "Cetearyl Alcohol in Cosmetics: Safe or Harmful?" by Dr. Anvita Arora, Dermatologist, https://www.dranvitaarora.com/cetearyl-alcohol-in-cosmetics-safe-or-harmful/

- "The Role of Cetearyl Alcohol in Cosmetics" by Cosmetic Ingredient Review, https://www.cir-safety.org/sites/default/files/cetearylcir.pdf

1. Definition Isostearic Acid:

2. Use:

3. Usage Isostearic Acid:

4. References:

- "Isostearic Acid" by Cosmetics Info (https://cosmeticsinfo.org/ingredient/isostearic-acid)

- "Isostearic Acid" by Truth in Aging (https://www.truthinaging.com/ingredients/isostearic-acid)

- "Isostearic Acid in Cosmetics" by Personal Care Magazine (https://www.personalcaremagazine.com/story/31115/isostearic-acid-in-cosmetics)

1. Definition Acrylates/ C10 30 Alkyl Acrylate Crosspolymer:

2. Use:

3. Usage Acrylates/ C10 30 Alkyl Acrylate Crosspolymer:

4. References:

- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." Cosmetics Info, www.cosmeticsinfo.org/ingredient/acrylatesc10-30-alkyl-acrylate-crosspolymer.

- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." Truth In Aging, www.truthinaging.com/ingredients/acrylates-c10-30-alkyl-acrylate-crosspolymer.

- "Acrylates/C10-30 Alkyl Acrylate Crosspolymer." The Derm Review, www.thedermreview.com/acrylates-c10-30-alkyl-acrylate-crosspolymer/.

1. Definition Tromethamine:

2. Use:

3. Usage Tromethamine:

4. References:

- Arctander, S. (1969). Perfume and Flavor Chemicals (Aroma Chemicals). Montclair, NJ: Allured Publishing Corporation.

- Loden, M. (2003). The clinical benefit of moisturizers. Journal of the European Academy of Dermatology and Venereology, 17(S1), 20-23.

- Korting, H. C., & Kerscher, M. J. (2006). The efficacy of moisturizers in the treatment of dry skin. Skin Pharmacology and Physiology, 19(5), 256-261.

1. Definition Trisodium Edta:

2. Use:

3. Usage Trisodium Edta:

4. References:

- International Journal of Toxicology. (2002). Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA. International Journal of Toxicology, 21(Suppl 2), 95-142.

- Cosmetic Ingredient Review. (2013). Safety Assessment of EDTA, Calcium Disodium EDTA, Diammonium EDTA, Dipotassium EDTA, Disodium EDTA, TEA-EDTA, Tetrasodium EDTA, Tripotassium EDTA, Trisodium EDTA, HEDTA, and Trisodium HEDTA. Cosmetic Ingredient Review Expert Panel, 1-47.

- Personal Care Products Council. (2019). Trisodium EDTA. Retrieved from https://www.cosmeticsinfo.org/ingredient/trisodium-edta.

1. Definition Fragrance:

Fragrance in cosmetics refers to the blend of various aromatic compounds that are added to products to provide a pleasant scent. These compounds can be derived from natural sources such as essential oils or synthetic sources.

2. Use:

Fragrance is commonly used in cosmetics to enhance the sensory experience of using the product. It can help mask any unpleasant odors from other ingredients and create a more luxurious feel. Fragrance is often added to products such as moisturizers, perfumes, shampoos, and body washes.

3. Usage Fragrance:

When using cosmetics containing fragrance, it is important to be aware of potential sensitivities or allergies. Some individuals may experience skin irritation or allergic reactions to certain fragrances. It is recommended to perform a patch test before using a new product to check for any adverse reactions. Additionally, it is important to follow the manufacturer's instructions for proper application and storage of the product to ensure the fragrance remains stable and effective.

4. References:

- Steinemann, A. (2019). Fragranced consumer products: exposures and effects from emissions. Air Quality, Atmosphere & Health, 12(6), 643-645.

- Lachenmeier, D. W., & Haltner, E. (2019). Fragrance allergens in household cleaning products. Environmental Science and Pollution Research, 26(15), 15145-15147.

- Basketter, D. A., & Angelini, G. (2019). Fragrance allergens in fine fragrances and cosmetics. Contact Dermatitis, 80(3), 145-147.

1. Definition Alpha Isomethyl Ionone:

2. Use:

3. Usage Alpha Isomethyl Ionone:

4. References:

- SCCS (Scientific Committee on Consumer Safety). Opinion on Alpha-Isomethyl Ionone. (2013). https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_123.pdf

- CosmeticsInfo.org. Alpha-Isomethyl Ionone. https://www.cosmeticsinfo.org/ingredient/alpha-isomethyl-ionone

- Personal Care Council. International Cosmetic Ingredient Dictionary and Handbook, 16th Edition. (2016).

1. Definition Benzyl Salicylate:

2. Use:

3. Usage Benzyl Salicylate:

4. References:

- Cosmetic Ingredient Review Expert Panel. (2013). Safety Assessment of Benzyl Salicylate as Used in Cosmetics. Retrieved from https://www.cir-safety.org/sites/default/files/benzylsal0513.pdf

- European Commission. (2018). CosIng - Cosmetic Ingredients Database. Retrieved from https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=19285

- Personal Care Products Council. (n.d.). Benzyl Salicylate. Retrieved from https://www.personalcarecouncil.org/ingredient-info/ingredient-monographs/benzyl-salicylate/

1. Definition Citronellol:

2. Use:

3. Usage Citronellol:

4. References:

- Scientific Committee on Consumer Safety (SCCS). (2013). Opinion on citronellol. European Commission.

- Cosmetic Ingredient Review (CIR) Expert Panel. (2008). Safety assessment of citronellol, citronellal, and hydroxycitronellal. International Journal of Toxicology, 27(1), 21-44.

- Fragrance Materials Association. (2019). Citronellol safety assessment. FMA.

1. Definition Limonene:

2. Use:

3. Usage Limonene:

4. References:

- Burdock, G. A. (2010). Fenaroli's handbook of flavor ingredients. CRC Press.

- Reifenrath, W. G., & Chirico, S. (2012). Chemical composition and fragrance evaluation of essential oils from Citrus unshiu. Journal of essential oil research, 24(1), 61-69.

- Jäger, W., Buchbauer, G., Jirovetz, L., Fritzer, M., & Woidich, A. (1992). Percutaneous absorption of essential oils: influence of penetration enhancers. Journal of pharmaceutical sciences, 81(3), 254-258.

1. Definition Geraniol:

2. Use:

3. Usage Geraniol:

4. References:

- Burdock, G. A. (2010). Safety assessment of Geraniol as a food ingredient. Food and Chemical Toxicology, 48(2), 29-34.

- Rastogi, S. C., & Heydorn, S. (2001). Fragrance allergens in commercial products. Contact Dermatitis, 45(5), 221-226.

- Menz, J., & Kistler, A. (2015). Fragrance allergens in cosmetics – a review. Journal of the German Society of Dermatology, 13(6), 625-632.

1. Definition Linalool:

2. Use:

3. Usage Linalool:

4. References:

- Andersen, F. A. (2008). Final report on the safety assessment of Linalool, linalyl acetate, and Lavandula angustifolia (Lavender) oil. International Journal of Toxicology, 27(1), 1-28.

- Opdyke, D. L. (1976). Monographs on fragrance raw materials. Food and Cosmetics Toxicology, 14(5), 479-480.

- Reifenrath, W. G., & Van Beek, T. A. (2013). Linalool and linalool rich essential oils. In Natural Products (pp. 1541-1587). Springer, Berlin, Heidelberg.

1. Definition Hydroxyisohexyl 3 Cyclohexene Carboxaldehyde:

2. Use:

3. Usage Hydroxyisohexyl 3 Cyclohexene Carboxaldehyde:

4. References:

- SCCS (Scientific Committee on Consumer Safety). Opinion on Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde. European Commission, 2018.

- CosmeticsInfo.org. Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde. https://cosmeticsinfo.org/ingredient/hydroxyisohexyl-3-cyclohexene-carboxaldehyde

- Personal Care Council. Safety Assessment of Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde. Cosmetic Ingredient Review, 2013.